4 results on '"Hagstrøm, Julie"'
Search Results
2. Dimensional profiling of psychopathology in children and adolescents based on the K-SADS-PL and an analysis of the construct validity of two ADHD symptom dimensions.
- Author
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Hagstrøm, Julie, Nielsen, Tine, Sørensen, Mikkel E., Aagaard, Kristina, Arendt Rasmussen, Morten, Rosenberg, Julie B., Mohammadzadeh, Parisa, Sevelsted, Astrid, Hernández-Lorca, María, Fagerlund, Birgitte, Rydkjær, Jacob, Pagsberg, Anne Katrine, Kaufman, Joan, Ebdrup, Bjørn H., Bilenberg, Niels, and Jepsen, Jens Richardt Møllegaard
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CHILD psychopathology , *ADOLESCENT psychopathology , *TEST validity , *NOSOLOGY , *RASCH models - Abstract
The traditional view on psychiatric disorders as categorical and distinct is being challenged by perspectives emphasizing the relevance of dimensional and transdiagnostic assessment. However, most diagnostic instruments are based on a categorical view with a threshold-approach to disease classification. We here describe algorithms for dimensionalizing the psychopathological ratings of the widely used diagnostic interview for children and adolescents, the Kiddie-Schedule for Affective Disorders and Schizophrenia – Present and Lifetime Version (K-SADS-PL). We further evaluate the criterion-related construct validity of the dimensionalized attention-deficit/hyperactivity disorder (ADHD) scales using Rasch models in a sample of 590 children (mean age 10.29 (.36), 49% girls). The algorithms generate scores of current symptom load, i.e., the sum of clinician-rated symptoms within each disorder assessed with the interview. We found support for counting symptoms of inattention and hyperactivity/impulsivity, respectively, but not for a single combined ADHD scale. The algorithms constitute an initial step in creating a framework for clinician-rated dimensional analyses of symptoms derived from the K-SADS-PL, but future studies are needed to further evaluate the construct validity of the remaining scales and the reliability and clinical utility of the method. We believe that our proposed algorithms offer a novel method of dimensional psychopathological assessment, which can be applied in multiple branches of child and adolescent psychiatry. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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3. Associations Between the Severity of Obsessive-Compulsive Disorder and Vocal Features in Children and Adolescents: Protocol for a Statistical and Machine Learning Analysis.
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Clemmensen, Line Katrine Harder, Lønfeldt, Nicole Nadine, Das, Sneha, Lund, Nicklas Leander, Uhre, Valdemar Funch, Mora-Jensen, Anna-Rosa Cecilie, Pretzmann, Linea, Uhre, Camilla Funch, Ritter, Melanie, Korsbjerg, Nicoline Løcke Jepsen, Hagstrøm, Julie, Thoustrup, Christine Lykke, Clemmesen, Iben Thiemer, Plessen, Kersten Jessica, and Pagsberg, Anne Katrine
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MACHINE learning ,OBSESSIVE-compulsive disorder in children ,SEVERITY of illness index ,PSYCHIATRIC diagnosis ,ARTIFICIAL intelligence ,CLINICAL trials - Abstract
Background: Artificial intelligence tools have the potential to objectively identify youth in need of mental health care. Speech signals have shown promise as a source for predicting various psychiatric conditions and transdiagnostic symptoms. Objective: We designed a study testing the association between obsessive-compulsive disorder (OCD) diagnosis and symptom severity on vocal features in children and adolescents. Here, we present an analysis plan and statistical report for the study to document our a priori hypotheses and increase the robustness of the findings of our planned study. Methods: Audio recordings of clinical interviews of 47 children and adolescents with OCD and 17 children and adolescents without a psychiatric diagnosis will be analyzed. Youths were between 8 and 17 years old. We will test the effect of OCD diagnosis on computationally derived scores of vocal activation using ANOVA. To test the effect of OCD severity classifications on the same computationally derived vocal scores, we will perform a logistic regression. Finally, we will attempt to create an improved indicator of OCD severity by refining the model with more relevant labels. Models will be adjusted for age and gender. Model validation strategies are outlined. Results: Simulated results are presented. The actual results using real data will be presented in future publications. Conclusions: A major strength of this study is that we will include age and gender in our models to increase classification accuracy. A major challenge is the suboptimal quality of the audio recordings, which are representative of in-the-wild data and a large body of recordings collected during other clinical trials. This preregistered analysis plan and statistical report will increase the validity of the interpretations of the upcoming results. [ABSTRACT FROM AUTHOR]
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- 2022
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- View/download PDF
4. A superior ability to suppress fast inappropriate responses in children with Tourette syndrome is further improved by prospect of reward.
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Maigaard, Katrine, Nejad, Ayna Baladi, Andersen, Kasper Winther, Herz, Damian Marc, Hagstrøm, Julie, Pagsberg, Anne Katrine, Skov, Liselotte, Siebner, Hartwig Roman, and Plessen, Kerstin Jessica
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TOURETTE syndrome , *REACTION time , *CHILDREN , *PROSPECTING , *RESPONSE inhibition - Abstract
In children with Tourette syndrome (TS), tics are often attributed to deficient self-control by health-care professionals, parents, and peers. In this behavioural study, we examined response inhibition in TS using a modified Simon task which probes the ability to solve the response conflict between a new non-spatial rule and a highly-overlearned spatial stimulus-response mapping rule. We applied a distributional analysis to the behavioural data, which grouped the trials according to the individual distribution of reaction times in four time bins. Distributional analyses enabled us to probe the children's ability to control fast, impulsive, responses, which corresponded to the trials in the fastest time bin. Additionally, we tested whether the ability to suppress inappropriate action tendencies can be improved further by the prospect of a reward. Forty-one clinically well-characterized medication-naïve children with TS, 20 children with attention-deficit/hyperactivity disorder (ADHD), and 43 typically developing children performed a Simon task during alternating epochs with and without a prospect of reward. We applied repeated measures ANCOVAs to estimate how the prospect of reward modulated reaction times and response accuracy, while taking into account the distribution of the reaction times across trials. We found between-group differences in accuracy when subjects responded relatively fast. The TS group responded more accurately than typically developing control children when resolving the response conflict introduced by the Simon task. The opposite pattern was found in children with ADHD. Prospect of reward improved accuracy rates in all groups. Although the Tourette group performed with superior accuracy in the fast trials, it was still possible for them to benefit from prospect of reward in fast trials. The findings corroborate the notion that children with TS have an enhanced capacity to inhibit fast inappropriate response tendencies. This ability can be improved further by offering a prospect of reward which might be useful during non-pharmacological therapeutic interventions. • Children with Tourette syndrome are more accurate when acting fast in a Simon task. • A prospect of reward further improved inhibitory capacity. • Superior performance may reflect a compensatory increase of global inhibition. • This inhibitory reserve could be harnessed in future treatments. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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