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Copyright of Acta Medica Croatica is the property of Croatian Academy of Medical Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Introduction: The number of adolescents with a severe chronic disease has increased in high-income countries due to improvements in the prognosis of childhood-onset chronic conditions. The transition from childhood to adulthood is a critical period that may be associated with increased mortality and morbidity. We aimed to estimate the prevalence of adolescents with a long-term disease (LTD) in France and assess their mortality and hospitalization risks relative to the general population. Materials and methods: We extracted a population-based cohort from the French national health insurance database that included 61,119 subjects who reached 14 years of age between 2005 and 2014. LTDs are diagnosed by patients’ physicians and then confirmed and registered by a physician of the national health insurance system. We assessed mortality and hospitalizations using data of patients who were between 14 and 21 years-old. Results: Among 14-year-old adolescents, 3.30% (95% confidence interval: 3.16–3.44) had a LTD. Their mortality rate between the ages of 14 and 21 years was 20.9/10,000 person-years (13.7–32.1) versus 1.9 (1.5–2.5) for adolescents without a LTD. Mortality was higher in males than females in youths without a LTD, but not in those with a LTD. We found a similar pattern for the risk of hospitalization for an external cause. The five-year probability of hospitalization was 61.8% among youths with a LTD versus 42.7% for those without. The rate of planned hospitalizations sharply fell at 19 years-of-age among youths with a LTD, whereas the rate of unplanned hospitalizations remained stable. Conclusion: The 3% of youths with a LTD have ten-fold higher mortality than those without and a high risk of hospitalization. The decrease in the rate of planned hospitalizations at age 19 among youths with a LTD may indicate differences in medical practice after transfer to adult care or a break in medical care. [ABSTRACT FROM AUTHOR]

Background: Traumatic brain injury (TBI) is the leading cause of disability and mortality in children and young adults worldwide. It remains unclear, however, how TBI in childhood and adolescence is associated with adult mortality, psychiatric morbidity, and social outcomes.Methods and Findings: In a Swedish birth cohort between 1973 and 1985 of 1,143,470 individuals, we identified all those who had sustained at least one TBI (n = 104,290 or 9.1%) up to age 25 y and their unaffected siblings (n = 68,268) using patient registers. We subsequently assessed these individuals for the following outcomes using multiple national registries: disability pension, specialist diagnoses of psychiatric disorders and psychiatric inpatient hospitalisation, premature mortality (before age 41 y), low educational attainment (not having achieved secondary school qualifications), and receiving means-tested welfare benefits. We used logistic and Cox regression models to quantify the association between TBI and specified adverse outcomes on the individual level. We further estimated population attributable fractions (PAF) for each outcome measure. We also compared differentially exposed siblings to account for unobserved genetic and environmental confounding. In addition to relative risk estimates, we examined absolute risks by calculating prevalence and Kaplan-Meier estimates. In complementary analyses, we tested whether the findings were moderated by injury severity, recurrence, and age at first injury (ages 0-4, 5-9, 6-10, 15-19, and 20-24 y). TBI exposure was associated with elevated risks of impaired adult functioning across all outcome measures. After a median follow-up period of 8 y from age 26 y, we found that TBI contributed to absolute risks of over 10% for specialist diagnoses of psychiatric disorders and low educational attainment, approximately 5% for disability pension, and 2% for premature mortality. The highest relative risks, adjusted for sex, birth year, and birth order, were found for psychiatric inpatient hospitalisation (adjusted relative risk [aRR] = 2.0; 95% CI: 1.9-2.0; 6,632 versus 37,095 events), disability pension (aRR = 1.8; 95% CI: 1.7-1.8; 4,691 versus 29,778 events), and premature mortality (aRR = 1.7; 95% CI: 1.6-1.9; 799 versus 4,695 events). These risks were only marginally attenuated when the comparisons were made with their unaffected siblings, which implies that the effects of TBI were consistent with a causal inference. A dose-response relationship was observed with injury severity. Injury recurrence was also associated with higher risks-in particular, for disability pension we found that recurrent TBI was associated with a 3-fold risk increase (aRR = 2.6; 95% CI: 2.4-2.8) compared to a single-episode TBI. Higher risks for all outcomes were observed for those who had sustained their first injury at an older age (ages 20-24 y) with more than 25% increase in relative risk across all outcomes compared to the youngest age group (ages 0-4 y). On the population level, TBI explained between 2%-6% of the variance in the examined outcomes. Using hospital data underestimates milder forms of TBI, but such misclassification bias suggests that the reported estimates are likely conservative. The sibling-comparison design accounts for unmeasured familial confounders shared by siblings, including half of their genes. Thus, residual genetic confounding remains a possibility but will unlikely alter our main findings, as associations were only marginally attenuated within families.Conclusions: Given our findings, which indicate potentially causal effects between TBI exposure in childhood and later impairments across a range of health and social outcomes, age-sensitive clinical guidelines should be considered and preventive strategies should be targeted at children and adolescents. [ABSTRACT FROM AUTHOR]

Building on evidence of the vulnerability of migrants to disadvantages in morbidity and mortality, we examine the relationships between internal migration and early life mortality. We apply the Cox-proportional hazards model on the nationally representative data from the 2008 Demographic and Health Surveys in Kenya and Nigeria to predict the hazard of dying between birth and age 14. We find more deaths in Nigeria than Kenya, with the highest mortality burdens among rural and urban non-migrants in both countries. We also find urban-rural and rural-urban migrants in Kenya and rural-urban migrants in Nigeria showing elevated mortality burdens than other migrant categories. Consistent with evidence that social and biological disadvantages trail individuals through the life course, we find that distinct mortality patterns displayed after 2 years of life gradually enlarge till age 14 in both countries. Beyond migration, we find commonalities in more deaths among children with shorter birth intervals, multiple than singleton births, children whose mothers have no/preschool education, with shortest duration of stay in current place of residence, divorced/separated, and from the poorest households. On differentials, we find in Kenya higher mortality burdens among ethnic Somali children, in Northeastern and Western regions. In Nigeria, we find more deaths among boys, children of mothers under 20 years old, unemployed, Muslim, and from North-west and North-east regions. Our study is a critical step in providing credible evidence that can guide discourse and actions in addressing the health challenges of migrants and non-migrants in two major African countries. Copyright © 2014 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Background: Daily throughout 2011, about 900 new HIV infections occurred in children and 630 children died as a result of AIDS-related complications worldwide. Late diagnosis, mortality trends, causes of and risk factors for death were evaluated in vertically HIV-infected children. Methods: A retrospective 11-year study was conducted with Brazilian vertically HIV-infected children and adolescents using patients' charts. Medical records, death certificates and the Ministry of Health's mortality database were verified for mortality and cause of death. Diagnoses were made according to the CDC Revised Classification System for HIV infection. Results: Of 177 patients included, 97 were female (54.8%). Median age at admission was 30 months (IQR: 5-72 months). Median follow-up was 5 years (IQR: 2-8 years). After 11 years, 132 (74,6%) patients continued in follow-up, 11 (6.2%) had been transferred and 8 (4.5%) were lost to follow-up. Twenty-six deaths occurred (14,7%), the majority (16/26; 61.5%) in children <3 years of age. Death cases decreased over time and the distribution of deaths was homogenous over the years of evaluation. In 17/26 (65.4%) of the children who died, diagnosis had been made as the result of their becoming ill. Beginning antiretroviral therapy before 6 months of age was associated with being alive (OR = 2.86; 95% CI: 1.12-7.25; p = 0.027). The principal causes of death were severe bacterial infections (57%) and opportunistic infections (33.3%). Conclusions: In most of the HIV-infected children, diagnosis was late, increasing the risk of progression to AIDS and death due to delayed treatment. The mortality trend was constant, decreasing in the final two years of the study. Bacterial infections remain as the major cause of death. Improvements in prenatal care and pediatric monitoring are mandatory. [ABSTRACT FROM AUTHOR]

Injury is the leading cause of death and disability in children and adolescents in Poland. In 2009, 1220 children age 0-19 years died as a result of injury. If the rate of injury deaths in Poland could be reduced to the level of the Netherlands, it is estimated that 703 (58%) of these lives could have been saved. The aim of this study was to assess child and adolescent unintentional injury prevention in Poland through national law and policy. The study was based on an examination of law and policies existing and implemented or enforced in Poland which support child safety, including specific injury areas such as road safety, water safety, fall prevention, poisoning prevention, burn and scalds prevention, choking and strangulation prevention. The review of law and policy documents, as well as interviews by phone or e-mail with representatives of government departments was conducted. The questionnaire developed in the frame of the European Project TACTICS (Tools to Address Childhood Trauma, Injury and Children's Safety) was applied. Each policy and law as a marker for specific injury areas was assessed on 3-points scale. The following scores were obtained for each of the areas of child and adolescent injury prevention in Poland (out of possible 100%): 89% in moped and motor scooter safety, 86% in poisoning prevention, 75% in pedestrian safety, 75% in cycling safety, 75% in water safety and drowning prevention, 64% in burn and scalds prevention, 59% in passenger and driver safety, 59% in choking and strangulation prevention, 50% in fall safety. Child home safety related to prevention of falls, burns and scalds, choking and strangulation has not received the adequate attention. The greatest gains in injury prevention have been made in road safety and poisoning prevention. It is important to both continue these efforts and give equal attention to injuries occurring in and around the home, sport and leisure environments. There is a need to support and fund good practices injury prevention measures based on community level targeting families with low socio-economic status. [ABSTRACT FROM AUTHOR]

The objectives of the study were to estimate mortality rate trends due to road traffic, drowning and fire/burns in children aged 0-14 years and in adolescents aged 15-19 years in Lithuania between the years 1971-2005. The data were obtained from Statistics Lithuania and the Health Information Centre. Trends were estimated by linear and polynomial regression. The study revealed that the child and adolescent unintentional injury mortality rates show declining trends. For children, the significant decreasing trends of mortality rates due to road traffic, drowning and fire/burns were observed. For adolescents there were significant decreasing trends for drowning deaths, and insignificant decreasing tendencies for deaths from fire/burns. There was an insignificant increased road traffic mortality rate trend for adolescent girls. For the adolescent boys group and for boys and girls together from the beginning of the study period there were increasing trends, followed by declining trends. In the last years, the increase was observed again. [ABSTRACT FROM AUTHOR]