27 results on '"Clavel, Jacqueline"'
Search Results
2. Maternal and perinatal characteristics, congenital malformations and the risk of wilms tumor: the ESTELLE study
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Bauer, Hélène, Rios, Paula, Schleiermacher, Gudrun, Valteau-Couanet, Dominique, Bertozzi, Anne-Isabelle, Thebaud, Estelle, Gandemer, Virginie, Pellier, Isabelle, Verschuur, Arnauld, Spiegel, Alexandra, Notz-Carrere, Anne, Bergeron, Christophe, Orsi, Laurent, Lacour, Brigitte, and Clavel, Jacqueline
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- 2020
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3. Family history of cancer and the risk of childhood brain tumors: a pooled analysis of the ESCALE and ESTELLE studies (SFCE)
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Vidart d’Egurbide Bagazgoïtia, Nicolas, Bailey, Helen D., Orsi, Laurent, Guerrini-Rousseau, Léa, Bertozzi, Anne-Isabelle, Faure-Conter, Cécile, Leblond, Pierre, Pellier, Isabelle, Freycon, Claire, Doz, François, Puget, Stéphanie, Ducassou, Stéphane, Lacour, Brigitte, and Clavel, Jacqueline
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- 2019
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4. Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15 000 leukemia cases and 46 000 controls from the Childhood Cancer and Leukemia International Consortium.
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Lupo, Philip J., Chambers, Tiffany M., Mueller, Beth A., Clavel, Jacqueline, Dockerty, John D., Doody, David R., Erdmann, Friederike, Ezzat, Sameera, Filippini, Tommaso, Hansen, Johnni, Heck, Julia E., Infante‐Rivard, Claire, Kang, Alice Y., Magnani, Corrado, Malagoli, Carlotta, Marcotte, Erin L., Metayer, Catherine, Bailey, Helen D., Mora, Ana M., and Ntzani, Evangelia
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CONGENITAL disorders ,CHILDHOOD cancer ,ACUTE leukemia ,HUMAN abnormalities ,CONSORTIA ,LEUKEMIA - Abstract
Although recent studies have demonstrated associations between nonchromosomal birth defects and several pediatric cancers, less is known about their role on childhood leukemia susceptibility. Using data from the Childhood Cancer and Leukemia International Consortium, we evaluated associations between nonchromosomal birth defects and childhood leukemia. Pooling consortium data from 18 questionnaire‐based and three registry‐based case‐control studies across 13 countries, we used multivariable logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between a spectrum of birth defects and leukemia. Our analyses included acute lymphoblastic leukemia (ALL, n = 13 115) and acute myeloid leukemia (AML, n = 2120) cases, along with 46 172 controls. We used the false discovery rate to account for multiple comparisons. In the questionnaire‐based studies, the prevalence of birth defects was 5% among cases vs 4% in controls, whereas, in the registry‐based studies, the prevalence was 11% among cases vs 7% in controls. In pooled adjusted analyses, there were several notable associations, including (1) digestive system defects and ALL (OR = 2.70, 95% CI: 1.46‐4.98); (2) congenital anomalies of the heart and circulatory system and AML (OR = 2.86, 95% CI: 1.81‐4.52) and (3) nervous system defects and AML (OR = 4.23, 95% CI: 1.50‐11.89). Effect sizes were generally larger in registry‐based studies. Overall, our results could point to novel genetic and environmental factors associated with birth defects that could also increase leukemia susceptibility. Additionally, differences between questionnaire‐ and registry‐based studies point to the importance of complementary sources of birth defect phenotype data when exploring these associations. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Maternal use of household pesticides during pregnancy and risk of neuroblastoma in offspring. A pooled analysis of the ESTELLE and ESCALE French studies (SFCE)
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Rios, Paula, Bailey, Helen D., Lacour, Brigitte, Valteau-Couanet, Dominique, Michon, Jean, Bergeron, Christophe, Boutroux, Hélène, Defachelles, Anne-Sophie, Gambart, Marion, Sirvent, Nicolas, Thebaud, Estelle, Ducassou, Stéphane, Orsi, Laurent, and Clavel, Jacqueline
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- 2017
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6. Maternal Supplementation with Folic Acid and Other Vitamins and Risk of Leukemia in Offspring: A Childhood Leukemia International Consortium Study
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Metayer, Catherine, Milne, Elizabeth, Dockerty, John D., Clavel, Jacqueline, Pombo-de-Oliveira, Maria S., Wesseling, Catharina, Spector, Logan G., Schüz, Joachim, Petridou, Eleni, Ezzat, Sameera, Armstrong, Bruce K., Rudant, Jérémie, Koifman, Sergio, Kaatsch, Peter, Moschovi, Maria, Rashed, Wafaa M., Selvin, Steve, McCauley, Kathryn, Hung, Rayjean J., Kang, Alice Y., and Infante-Rivard, Claire
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- 2014
7. Seasonality of main childhood embryonal tumours and rhabdomyosarcoma, France, 2000–2015.
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Awounou, Danielle, Lacour, Brigitte, Desandes, Emmanuel, Guissou, Sandra, Cassoux, Nathalie, Doz, François, Dufour, Christelle, Minard‐Colin, Véronique, Schleiermacher, Gudrun, Taque, Sophie, Verschuur, Arnauld, Clavel, Jacqueline, and Goujon, Stéphanie
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RHABDOMYOSARCOMA ,SEASONAL variations of diseases ,SCAN statistic ,TUMORS ,POISSON regression ,CHILDHOOD cancer - Abstract
Few studies have investigated the seasonal patterns of embryonal tumours. Based on data from the French National Registry of Childhood Cancers, the present study aimed to investigate seasonal variations in embryonal tumour incidence rates by month of birth and by month of diagnosis. The study included 6635 primary embryonal tumour cases diagnosed before the age of 15 years over the period 2000‐2015 in mainland France. Assuming monthly variations in incidence rates were homogeneous over 2000‐2015, we used a Poisson regression model to test for overall heterogeneity in standardised incidence ratios (SIRs) by month of birth or diagnosis. The seasonal scan statistic method was used to detect monthly excesses or deficits of embryonal tumour cases over the whole study period. The annual reproducibility of the observed monthly variations was formally tested. An overall heterogeneity in incidence rates by month of birth was observed for rhabdomyosarcoma in boys only. Based on the month of diagnosis, a seasonality was evidenced for unilateral retinoblastoma, with a lower incidence rate in the summer (SIRJul‐Aug = 0.68, 95% CI = 0.52‐0.87), whilst the incidence rate of rhabdomyosarcoma tended to be lower in August (SIRAug = 0.68, 95% CI = 0.52‐0.89). No seasonality was detected for the other embryonal tumour groups by month of birth or month of diagnosis. This study is one of the largest to have investigated the seasonality of childhood embryonal tumours. The study showed a seasonal variation in the incidence rates by month of diagnosis for unilateral retinoblastoma and rhabdomyosarcoma. Our findings are likely to reflect a delay in consultation during the summer months. However, the role of seasonally varying environmental exposures cannot be ruled out. [ABSTRACT FROM AUTHOR]
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- 2023
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8. Health care expenditures among long-term survivors of pediatric solid tumors: Results from the French Childhood Cancer Survivor Study (FCCSS) and the French network of cancer registries (FRANCIM)
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Schraw, Jeremy, Bailey, Helen, Bonaventure, Audrey, Mora, Ana, Roman, Eve, Mueller, Beth, Clavel, Jacqueline, Petridou, Eleni, Karalexi, Maria, Ntzani, Evangelia, Ezzat, Sameera, Rashed, Wafaa, Marcotte, Erin, Spector, Logan, Metayer, Catherine, Kang, Alice, Magnani, Corrado, Miligi, Lucia, Dockerty, John, Mejίa-Aranguré, Juan Manuel, Nuñez-Enriquez, Juan Carlos, Infante-Rivard, Claire, Milne, Elizabeth, Scheurer, Michael, Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Registre National des Cancers de l'Enfant - National Registry of Childhood Cancers [Villejuif & CHU Nancy] (RNCE), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM), and HAL UVSQ, Équipe
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Male ,Multidisciplinary ,breastfeeding ,acute lymphoblastic leukemia ,acute myeloid leukemia ,Cancer Survivors ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Neoplasms ,Humans ,childhood cancer ,Female ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Registries ,Survivors ,Health Expenditures ,Child - Abstract
Background Childhood cancer survivors (CCS) may require lifelong medical care due to late effects of cancer treatments. Little is known about of their healthcare utilization and expenditures at long-term especially in publicly funded health care system. We aim to estimate and describe the health care expenditures among long-term CCS in France. Methods A total of 5319 five-year solid CCS diagnosed before the age of 21 between 1945 and 2000 in France were identified in the French Childhood Cancer Survivors Study cohort (FCCSS) and the French cancer registry. Information about health care expenditure was taken from the French national health data system between 2011 and 2016, and was described according to survivors’ characteristics. Generalized linear models were used to determine associations between health care expenditures and survivors’ characteristics. Results Mean annual amount of healthcare expenditures was € 4,255. Expenditures on hospitalizations and pharmacy represents 60% of total expenditures. Mean annual of healthcare expenditures were higher at increasing age, among women survivors (€ 4,795 vs € 3,814 in men) and in central nervous system (CNS) tumor survivors (€ 7,116 vs € 3,366 in lymphoma and € 3,363 in other solid tumor survivors). Conclusions Childhood cancer survivorship is associated with a substantial economic burden in France. We found that female gender and CNS primary cancer were associated with increased healthcare expenditures.
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- 2022
9. Answering Cluster Investigation Requests: The Value of Simple Simulations and Statistical Tools
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Bellec, Stéphanie, Hémon, Denis, and Clavel, Jacqueline
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- 2005
10. Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium.
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Schraw, Jeremy M., Bailey, Helen D., Bonaventure, Audrey, Mora, Ana M., Roman, Eve, Mueller, Beth A., Clavel, Jacqueline, Petridou, Eleni T., Karalexi, Maria, Ntzani, Evangelia, Ezzat, Sameera, Rashed, Wafaa M., Marcotte, Erin L., Spector, Logan G., Metayer, Catherine, Kang, Alice Y., Magnani, Corrado, Miligi, Lucia, Dockerty, John D., and Mejίa‐Aranguré, Juan Manuel
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CHILDHOOD cancer ,ACUTE leukemia ,CONSORTIA ,LEUKEMIA ,LYMPHOBLASTIC leukemia ,ANKYLOGLOSSIA - Abstract
Increasing evidence suggests that breastfeeding may protect from childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). However, most studies have limited their analyses to any breastfeeding, and only a few data have examined exclusive breastfeeding, or other exposures such as formula milk. We performed pooled analyses and individual participant data metaanalyses of data from 16 studies (N = 17 189 controls; N = 10 782 ALL and N = 1690 AML cases) from the Childhood Leukemia International Consortium (CLIC) to characterize the associations of breastfeeding duration with ALL and AML, as well as exclusive breastfeeding duration and age at introduction to formula with ALL. In unconditional multivariable logistic regression analyses of pooled data, we observed decreased odds of ALL among children breastfed 4 to 6 months (0.88, 95% CI 0.81‐0.96) or 7 to 12 months (OR 0.85, 0.79‐0.92). We observed a similar inverse association between breastfeeding ≥4 months and AML (0.82, 95% CI 0.71‐0.95). Odds of ALL were reduced among children exclusively breastfed 4 to 6 months (OR 0.73, 95% CI 0.63‐0.85) or 7 to 12 months (OR 0.70, 95% CI 0.53‐0.92). Random effects metaanalyses produced similar estimates, and findings were unchanged in sensitivity analyses adjusted for race/ethnicity or mode of delivery, restricted to children diagnosed ≥1 year of age or diagnosed with B‐ALL. Our pooled analyses indicate that longer breastfeeding is associated with decreased odds of ALL and AML. Few risk factors for ALL and AML have been described, therefore our findings highlight the need to promote breastfeeding for leukemia prevention. [ABSTRACT FROM AUTHOR]
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- 2022
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11. The Psychological Consequences of the COVID-19 Pandemic in Adults Treated for Childhood Cancer.
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Janah, Asmaa, Haddy, Nadia, Demoor-Goldschmidt, Charlotte, Bougas, Nicolas, Clavel, Jacqueline, Poulalhon, Claire, Lacour, Brigitte, Souchard, Vincent, Jackson, Angela, Casagranda, Leonie, Berger, Claire, Allodji, Rodrigue, El Fayech, Chiraz, Fresneau, Brice, De Vathaire, Florent, and Dumas, Agnes
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COVID-19 pandemic ,CHILDHOOD cancer ,MENTAL health ,PSYCHOLOGICAL distress ,CANCER patient care ,ONCOLOGY - Abstract
Background: Compared with the general population, childhood cancer survivors (CCS) could be at greater risk of psychological distress following the emergence of the COVID-19 pandemic. Purpose: This cross-sectional study assessed the psychological consequences of COVID-19 on the mental health of CCS. Design and participants: In December 2020, we interviewed through an online self-report questionnaire, 580 5-year CCS participating in the French Childhood Cancer Survivor Study (FCCSS) cohort. Methods: We first compared the mental health score of CCS with that observed in the French general population of the same age and gender. Subsequently, we studied predictors of the mental health score of CCS. Results: External comparisons revealed that the mental health score of CCS was similar to that of the general population. Among CCS, almost 42% stated that their psychological state had been worse during the lockdown. Predictors of poorer mental health included, among others, female gender, reporting a change in the occupational situation, having a relative who had been hospitalized or had died following COVID-19, and a greater perceived infection risk. Interpretation and Implications: Given the pre-existing vulnerability of some CCS to mental distress, the additional psychological consequences of COVID-19 in vulnerable survivors should receive attention from health care providers. [ABSTRACT FROM AUTHOR]
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- 2022
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12. Environmental exposures related to parental habits in the perinatal period and the risk of Wilms' tumor in children
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Notz-Carrere, Anne, Rios, Paula, Bauer, Helene, Schleiermacher, Gudrun, Pasqualini, Claudia, Boulanger, Cecile, Thébaud, Estelle, Gandemer, Virginie, Pellier, Isabelle, Verschuur, Arnauld, Sudour-Bonnange, Hélène, Coulomb-L'Hermine, Aurore, Spiegel, Alexandra, Notz- Carrere, Anne, Bergeron, Christophe, Orsi, Laurent, Lacour, Brigitte, Clavel, Jacqueline, CHU Bordeaux [Bordeaux], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Curie [Paris], Université Paris-Saclay, Institut Gustave Roussy (IGR), Département de cancérologie de l'enfant et de l'adolescent [Gustave Roussy], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pontchaillou [Rennes], Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Assistance Publique - Hôpitaux de Marseille (APHM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Strasbourg, Centre Léon Bérard [Lyon], INSERMInstitut National de la Sante et de la Recherche Medicale (Inserm), Ligue National Contre le Cancer (LNCC), Fondation de FranceFondation de France, Fondation ARC, Agence nationale de securite sanitaire de l'alimentation, de l'environnement et du travail (ANSES)French National Research Agency (ANR), association Cent pour sang la vie, Agence Nationale de la Recherche (ANR)French National Research Agency (ANR), Institut National du Cancer (INCa)Institut National du Cancer (INCA) France, Canceropole Ile de FranceRegion Ile-de-France, Investment for the future [ANR-10-COHO-0009], ANR-10-COHO-0009,HOPE-EPI,HOPE-Epidémiologie – Recherche épidémiologique en Hémato-Oncologie Pediatrique(2010), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Toulouse [Toulouse], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Assistance Publique-Hôpitaux de Marseille (AP-HM), UNICANCER-Université Lille Nord de France (COMUE), Service de pathologie [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université-Sorbonne Université, Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université Lille Nord de France (COMUE)-UNICANCER, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and CCA - Cancer Treatment and Quality of Life
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Male ,Parents ,Cancer Research ,Etiology ,Epidemiology ,Logistic regression ,[SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology ,Habits ,0302 clinical medicine ,Wilms' tumor ,Risk Factors ,Pregnancy ,Medicine ,030212 general & internal medicine ,Child ,education.field_of_study ,Obstetrics ,Confounding ,Smoking ,Case-control study ,Kidney Neoplasms ,3. Good health ,Perinatal Care ,Oncology ,030220 oncology & carcinogenesis ,Child, Preschool ,Female ,Alcohol ,Childhood cancer ,Adult ,medicine.medical_specialty ,Alcohol Drinking ,Population ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,Wilms Tumor ,03 medical and health sciences ,Humans ,Pesticides ,education ,[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,business.industry ,Odds ratio ,Environmental Exposure ,medicine.disease ,Confidence interval ,Case-Control Studies ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business - Abstract
International audience; Introduction Wilms' tumor is the most frequently diagnosed renal tumor in children. Little is known about its etiology. The aim of this study was to investigate the potential role of specific exposures related to parental habits such as parental smoking, maternal alcohol consumption and the use of household pesticides during pregnancy.Methods The ESTELLE study was a nationwide case-control study that included 117 Wilms' tumor cases and 1100 control children from the general French population, frequency-matched by age and gender. Unconditional logistic regression was used to estimate odds ratios and 95 % confidence intervals.Results After controlling for matching variables and potential confounders, the maternal use of any type of pesticide during pregnancy was associated with the risk of Wilms' tumor in children (OR 1.6 [95 % CI 1.1-2.3]). Insecticides were the most commonly reported type of pesticide and there was a positive association with their use (OR 1.7 [95 % CI 1.1-2.6]. The association was stronger when they were used more often than once a month (OR 1.9 [95 % CI 1.2-3.0]. Neither maternal smoking during pregnancy nor paternal smoking during preconception/pregnancy was associated with a risk of Wilms' tumor (ORs 1.1[95 % CI 0.7-1.8] and 1.1 [95 % CI 0.7-1.7], respectively). No association was observed with maternal alcohol intake during pregnancy (OR 1.2 [95 % CI 0.8-2.0]).Conclusion Our findings suggest an association between the maternal use of household pesticides during pregnancy and the risk of Wilms' tumor.
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- 2020
13. Seasonal variations in childhood leukaemia incidence in France, 1990-2014.
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Bamouni, Sophie, Hémon, Denis, Faure, Laure, Clavel, Jacqueline, and Goujon, Stéphanie
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LEUKEMIA ,ACUTE leukemia ,CHILDHOOD cancer ,POISSON regression ,DIAGNOSIS ,SEASONAL variations of diseases - Abstract
Background: Several studies have addressed the potential seasonality of childhood acute leukaemia (AL) without conclusive results. Using data from the National Registry of Childhood Cancers over 1990-2014 in mainland France, we investigated the seasonal variations in childhood AL taken together, and lymphoblastic (ALL) and myeloid (AML) leukaemia separately.Methods: Assuming constant variations over 1990-2014, we used a Poisson regression model to evaluate variations in standardized incidence ratios (SIRs) by month of birth or diagnosis. A scan method for temporal cluster detection was used to identify windows of several consecutive months with high or low SIR. The yearly reproducibility of the observed monthly variations was then evaluated.Results: We included 11,528 AL, of which 9493 ALL and 1,843 AML. No seasonal variation was detected for ALL. With a clear seasonal pattern, differences in AML incidence rates were evidenced between January-April and May-December birth periods (SIR = 0.85, 95% CI 0.77-0.94 and SIR = 1.07, 95% CI 1.01-1.14, respectively). AML incidence variations by month of diagnosis were less clear-cut.Conclusion: Based on a large number of cases from a high-quality registry, we did not evidence any seasonality in ALL incidence rates but evidenced seasonal variations in AML incidence rates by month of birth. [ABSTRACT FROM AUTHOR]- Published
- 2021
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14. Parental Tobacco Smoking and Acute Myeloid Leukemia: The Childhood Leukemia International Consortium
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Metayer, Catherine, Petridou, Eleni, Aranguré, Juan Manuel Mejía, Roman, Eve, Schüz, Joachim, Magnani, Corrado, Mora, Ana Maria, Mueller, Beth A., De Oliveira, Maria S.Pombo, Dockerty, John D., McCauley, Kathryn, Lightfoot, Tracy, Hatzipantelis, Emmanouel, Rudant, Jérémie, Flores-Lujano, Janet, Kaatsch, Peter, Miligi, Lucia, Wesseling, Catharina, Doody, David R., Moschovi, Maria, Orsi, Laurent, Mattioli, Stefano, Selvin, Steve, Kang, Alice Y., Clavel, Jacqueline, Nuñez-Enriquez, Juan Carlos, Jiménez-Hernández, Elva, Paredes-Aguilera, Rogelio, Metayer, Catherine, Petridou, Eleni, Aranguré, Juan Manuel Mejía, Roman, Eve, Schüz, Joachim, Magnani, Corrado, Mora, Ana Maria, Mueller, Beth A., De Oliveira, Maria S. Pombo, Dockerty, John D., Mccauley, Kathryn, Lightfoot, Tracy, Hatzipantelis, Emmanouel, Rudant, Jérémie, Flores-Lujano, Janet, Kaatsch, Peter, Miligi, Lucia, Wesseling, Catharina, Doody, David R., Moschovi, Maria, Orsi, Laurent, Mattioli, Stefano, Selvin, Steve, Kang, Alice Y., Clavel, Jacqueline, Nuñez-Enriquez, Juan Carlo, Jiménez-Hernández, Elva, and Paredes-Aguilera, Rogelio
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Adult ,Male ,Parents ,Risk ,medicine.medical_specialty ,Adolescent ,Childhood leukemia ,Epidemiology ,Socio-culturale ,acute myeloid leukemia ,Tobacco smoke ,03 medical and health sciences ,0302 clinical medicine ,Economica ,Pregnancy ,Internal medicine ,Odds Ratio ,medicine ,Humans ,childhood cancer ,030212 general & internal medicine ,Child ,Psychiatry ,parental smoking ,business.industry ,Medicine (all) ,Case-control study ,Infant ,Myeloid leukemia ,Ambientale ,Odds ratio ,medicine.disease ,Confidence interval ,Leukemia, Myeloid, Acute ,Socioeconomic Factors ,Case-Control Studies ,Child, Preschool ,Prenatal Exposure Delayed Effects ,030220 oncology & carcinogenesis ,international collaboration ,Female ,Tobacco Smoke Pollution ,business ,Systematic Reviews and Meta- and Pooled Analyses - Abstract
The association between tobacco smoke and acute myeloid leukemia (AML) is well established in adults but not in children. Individual-level data on parental cigarette smoking were obtained from 12 case-control studies from the Childhood Leukemia International Consortium (CLIC, 1974-2012), including 1,330 AML cases diagnosed at age
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- 2016
15. Parental smoking, maternal alcohol consumption during pregnancy and the risk of neuroblastoma in children. A pooled analysis of the ESCALE and ESTELLE French studies.
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Rios, Paula, Bailey, Helen D., Poulalhon, Claire, Valteau‐Couanet, Dominique, Schleiermacher, Gudrun, Bergeron, Christophe, Petit, Arnaud, Defachelles, Anne‐Sophie, Marion, Gambart, Sirvent, Nicolas, Ducassou, Stéphane, Munzer, Caroline, Orsi, Laurent, Lacour, Brigitte, and Clavel, Jacqueline
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NEUROBLASTOMA ,ALCOHOL drinking ,SMOKING ,CHILDBIRTH ,PREGNANCY ,ALCOHOL - Abstract
Neuroblastoma (NB) is the most common extra‐cranial tumour in children. Little is known about the aetiology of NB. The early age at onset and the embryonic nature suggest a role for perinatal exposures. We conducted a pooled analysis of two French national population‐based case–control studies to explore whether there was an association between parental smoking and alcohol consumption and the risk of NB. The mothers of 357 NB cases and 1,783 controls from general population, frequency matched by age and sex, were interviewed on demographic, socioeconomic and perinatal characteristics, maternal reproductive story, and life‐style and childhood environment. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. A meta‐analysis of our findings with those of previous studies was also conducted. Maternal smoking during pregnancy was slightly more often reported for the cases (24.1%) than for the controls (19.7%) (OR 1.3 [95% CI 0.9–1.7]; summary OR from meta‐analysis 1.1 [95% CI 1.0–1.3]. Paternal smoking in the year before child's birth were not associated with NB as independent exposure (OR 1.1 [95% CI 0.9–1.4] but the association was stronger when both parents reported having smoked during pregnancy (OR 1.5 [95% CI 1.1–2.1]. No association was observed with maternal alcohol intake during pregnancy (OR 1.0 [95% CI 0.8–1.4], summary OR from meta‐analysis 1.0 [95% CI 0.9–1.2]. Our findings provide some evidence of an association between maternal smoking during pregnancy and NB and add another reason to recommend that women refrain from smoking during pregnancy. What's new? Neuroblastoma strikes early in life, which suggests an influence from risk factors that occur before birth. Here, the authors looked at parental smoking and alcohol drinking in a large population sample in France. Cases were collected by a nationwide registry, so the sample was very complete, and included 357 cases of neuroblastoma. The analysis revealed no association between maternal alcohol drinking and the cancer, nor between neuroblastoma and paternal smoking. They did identify a slight positive association with maternal smoking, and the effect was stronger if both parents smoked. [ABSTRACT FROM AUTHOR]
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- 2019
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16. Risk of cancer in children exposed to antiretroviral nucleoside analogues in utero: The french experience.
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Hleyhel, Mira, Goujon, Stéphanie, Sibiude, Jeanne, Tubiana, Roland, Dollfus, Catherine, Faye, Albert, Mandelbrot, Laurent, Clavel, Jacqueline, Warszawski, Josiane, Blanche, Stéphane, and Olivero, O.
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CHILDHOOD cancer ,ANTIRETROVIRAL agents ,REVERSE transcriptase inhibitors ,HIV infections - Abstract
All nucleoside analogues for treating HIV infection, due to their capacity to integrate into and alter human DNA, are experimentally genotoxic to some extent. The long‐term oncogenic risk after in utero exposure remains to be determined. Cancer incidence in uninfected children exposed to nucleos(t)ide reverse transcriptase inhibitors (NRTIs) was evaluated, by cross‐checking against the National Cancer Registry, in the French perinatal study of children born to HIV+ mothers. Twenty‐one cancers were identified in 15,163 children (median age: 9.9 years [interquartile range (IQR): 5.8–14.2]) exposed to at least one NRTI in utero between 1990 and 2014. Five of these children were exposed to zidovudine monotherapy, and 15 to various combinations, seven of which included didanosine. Overall, the total number of cases was not significantly different from that expected for the general population (SIR = 0.8[0.47–1.24]), but the number of cases after didanosine exposure was twice that expected (SIR = 2.5 [1.01–5.19]). Didanosine accounted for only 10% of prescriptions but was associated with one‐third of cancers. In multivariate analysis, didanosine exposure was significantly associated with higher risk (HR = 3.0 [0.9–9.8]). This risk was specifically linked to first‐trimester exposure (HR = 5.5 [2.1–14.4]). Three cases of pineoblastoma, a very rare cancer, were observed, whereas 0.03 were expected. Two were associated with didanosine exposure. Despite reassuring data overall, there is strong evidence to suggest that didanosine displays transplacental oncogenicity. These findings cannot be extrapolated to other NRTIs, but they highlight the need for comprehensive evaluations of the transplacental genotoxicity of this antiretroviral class. Environ. Mol. Mutagen., 60:404–409, 2019. © 2017 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
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- 2019
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17. The International Childhood Cancer Cohort Consortium (I4C): A research platform of prospective cohorts for studying the aetiology of childhood cancers.
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Tikellis, Gabriella, Dwyer, Terence, Paltiel, Ora, Phillips, Gary S., Lemeshow, Stanley, Golding, Jean, Northstone, Kate, Boyd, Andy, Olsen, Sjurdur, Ghantous, Akram, Herceg, Zdenko, Ward, Mary H., Håberg, Siri E., Magnus, Per, Olsen, Jørn, Ström, Marin, Mahabir, Somdat, Jones, Rena R., Ponsonby, Anne‐Louise, and Clavel, Jacqueline
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CHILDHOOD cancer ,ETIOLOGY of diseases ,ENVIRONMENTAL exposure ,LEUKEMIA ,CANCER-related mortality ,AGE factors in disease ,COMPARATIVE studies ,DATABASES ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RESEARCH funding ,TUMORS ,EVALUATION research ,LIFESTYLES ,HEALTH & social status ,ODDS ratio - Abstract
Background: Childhood cancer is a rare but leading cause of morbidity and mortality. Established risk factors, accounting for <10% of incidence, have been identified primarily from case-control studies. However, recall, selection and other potential biases impact interpretations particularly, for modest associations. A consortium of pregnancy and birth cohorts (I4C) was established to utilise prospective, pre-diagnostic exposure assessments and biological samples.Methods: Eligibility criteria, follow-up methods and identification of paediatric cancer cases are described for cohorts currently participating or planning future participation. Also described are exposure assessments, harmonisation methods, biological samples potentially available for I4C research, the role of the I4C data and biospecimen coordinating centres and statistical approaches used in the pooled analyses.Results: Currently, six cohorts recruited over six decades (1950s-2000s) contribute data on 388 120 mother-child pairs. Nine new cohorts from seven countries are anticipated to contribute data on 627 500 additional projected mother-child pairs within 5 years. Harmonised data currently includes over 20 "core" variables, with notable variability in mother/child characteristics within and across cohorts, reflecting in part, secular changes in pregnancy and birth characteristics over the decades.Conclusions: The I4C is the first cohort consortium to have published findings on paediatric cancer using harmonised variables across six pregnancy/birth cohorts. Projected increases in sample size, expanding sources of exposure data (eg, linkages to environmental and administrative databases), incorporation of biological measures to clarify exposures and underlying molecular mechanisms and forthcoming joint efforts to complement case-control studies offer the potential for breakthroughs in paediatric cancer aetiologic research. [ABSTRACT FROM AUTHOR]- Published
- 2018
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18. Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium.
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Orsi, Laurent, Magnani, Corrado, Petridou, Eleni T., Dockerty, John D., Metayer, Catherine, Milne, Elizabeth, Bailey, Helen D., Dessypris, Nick, Kang, Alice Y., Wesseling, Catharina, Infante‐rivard, Claire, Wünsch‐filho, Victor, Mora, Ana M., Spector, Logan G., and Clavel, Jacqueline
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LYMPHOBLASTIC leukemia in children ,DOMESTIC animal genetics ,CHILDHOOD cancer ,PARENTAL influences ,PROGNOSIS ,LEUKEMIA treatment ,CANCER risk factors - Abstract
Abstract: The associations between childhood acute lymphoblastic leukemia (ALL) and several factors related to early stimulation of the immune system, that is, farm residence and regular contacts with farm animals (livestock, poultry) or pets in early childhood, were investigated using data from 13 case–control studies participating in the Childhood Leukemia International Consortium. The sample included 7847 ALL cases and 11,667 controls aged 1–14 years. In all studies, the data were obtained from case and control parents using standardized questionnaires. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by unconditional logistic regression adjusted for age, sex, study, maternal education, and maternal age. Contact with livestock in the first year of life was inversely associated with ALL (OR = 0.65, 95% CI: 0.50, 0.85). Inverse associations were also observed for contact with dogs (OR = 0.92, 95% CI: 0.86, 0.99) and cats (OR = 0.87, 95% CI: 0.80, 0.94) in the first year of life. There was no evidence of a significant association with farm residence in the first year of life. The findings of these large pooled and meta‐analyses add additional evidence to the hypothesis that regular contact with animals in early childhood is inversely associated with childhood ALL occurrence which is consistent with Greaves’ delayed infection hypothesis. [ABSTRACT FROM AUTHOR]
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- 2018
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19. Maternal residential pesticide use during pregnancy and risk of malignant childhood brain tumors: A pooled analysis of the ESCALE and ESTELLE studies (SFCE).
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Vidart d'Egurbide Bagazgoïtia, Nicolas, Bailey, Helen D., Orsi, Laurent, Lacour, Brigitte, Guerrini‐Rousseau, Léa, Bertozzi, Anne‐Isabelle, Leblond, Pierre, Faure‐Conter, Cécile, Pellier, Isabelle, Freycon, Claire, Doz, François, Puget, Stéphanie, Ducassou, Stéphane, and Clavel, Jacqueline
- Abstract
Some previous epidemiological studies have suggested that pesticide exposure during pregnancy may have a possible role in the development of childhood brain tumors (CBT). We pooled data from two French national population-based, case-control studies to investigate the association between maternal residential use of pesticides during pregnancy and the risk of CBT. The mothers of 437 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency-matched by age and gender, answered a structured telephone interview conducted by trained interviewers. Unconditional logistic regression was used to estimate pooled odds ratio (OR) and 95% confidence intervals (95% CI). CBT was significantly associated with the maternal home use of pesticides during pregnancy (OR 1.4, 95% CI 1.2-1.8) and, more specifically, with insecticide (OR 1.4, 1.2-1.8). We could not draw any conclusions about herbicides and/or fungicides because few women used them during pregnancy and most of these mothers also used insecticides. Although potential recall bias cannot be excluded, our findings of this pooled analysis support the hypothesis that residential maternal use of pesticides during pregnancy and particularly insecticides may increase the risk of CBT. Future investigations to verify these findings and to explore for CBT subtypes and dose-response are necessary to have a better understanding of the possible role of pesticides in etiology of CBT. [ABSTRACT FROM AUTHOR]
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- 2018
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20. Risk of Childhood Cancer and Socio-economic Disparities: Results of the French Nationwide Study Geocap 2002-2010.
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Marquant, Fabienne, Goujon, Stéphanie, Faure, Laure, Guissou, Sandra, Orsi, Laurent, Hémon, Denis, Lacour, Brigitte, and Clavel, Jacqueline
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CHILDHOOD cancer ,TUMORS in children ,SOCIAL status ,SOCIOECONOMIC factors ,HEMATOLOGIC malignancies ,CANCER risk factors ,COMPARATIVE studies ,DEMOGRAPHY ,LYMPHOBLASTIC leukemia ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RURAL health ,TUMORS ,URBAN health ,RESIDENTIAL patterns ,EVALUATION research ,LIFESTYLES ,ACQUISITION of data ,CASE-control method - Abstract
Background: Socio-economic status is related to many life style and environmental factors, some of which have been suggested to influence the risk of childhood cancer. Studies requiring subject participation are usually hampered by selection of more educated parents. To prevent such bias, we used unselected nationwide Geographical Information System (GIS)-based registry data, to investigate the influence of socio-economic disparities on the risk of childhood cancer.Methods: The Geocap study included all French residents diagnosed with cancer aged up to 15 years over the period 2002-2010 (15 111 cases) and 45 000 contemporaneous controls representative of the childhood population. Area socio-economic characteristics used to calculate the European Deprivation Index (EDI) were based on census data collected on the fine scale of the Merged Islet for Statistical Information (IRIS).Results: Overall, the risk of acute lymphoblastic leukaemia (ALL) was lower in the most deprived quintile than in the other quintiles of EDI (ORQ5vsConclusion: Living in the most deprived areas was inversely associated with the risk of ALL in childhood. There was no indication that the risk of childhood cancer of any site could be increased by deprivation. Life style or environmental factors potentially underlying the association need further investigation. [ABSTRACT FROM AUTHOR] - Published
- 2016
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21. Risk of neuroblastoma, birth-related characteristics, congenital malformations and perinatal exposures: A pooled analysis of the ESCALE and ESTELLE French studies (SFCE).
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Rios, Paula, Bailey, Helen D, Orsi, Laurent, Lacour, Brigitte, Valteau‐Couanet, Dominique, Levy, Dominique, Corradini, Nadège, Leverger, Guy, Defachelles, Anne‐Sophie, Gambart, Marion, Sirvent, Nicolas, Thebaud, Estelle, Ducassou, Stéphane, and Clavel, Jacqueline
- Abstract
Neuroblastoma (NB), an embryonic tumour arising from neural crest cells, is the most common malignancy among infants. The aetiology of NB is largely unknown. We conducted a pooled analysis to explore whether there is an association between NB and preconception and perinatal factors using data from two French national population-based case-control studies. The mothers of 357 NB cases and 1783 controls younger than 6 years, frequency-matched by age and gender, responded to a telephone interview that focused on demographic, socioeconomic and perinatal characteristics, childhood environment, life-style and maternal reproductive history. Unconditional logistic regression was used to estimate pooled odds ratios and 95% confidence intervals. After controlling for matching variables, study of origin and potential confounders, being born either small (OR 1.4 95% CI 1.0-2.0) or large (OR 1.5 95% CI 1.1-2.2) for gestational age and, among children younger than 18 months, having congenital malformations (OR 3.6 95% CI 1.3-8.9), were significantly associated with NB. Inverse associations were observed with breastfeeding (OR 0.7 95% CI 0.5-1.0) and maternal use of any supplements containing folic acid, vitamins or minerals (OR 0.5 95% CI 0.3-0.9) during the preconception period. Our findings reinforce the hypothesis that fetal growth anomalies and congenital malformations may be associated with an increased risk of NB. Further investigations are needed in order to clarify the role of folic acid supplementation and breastfeeding, given their potential importance in NB prevention. [ABSTRACT FROM AUTHOR]
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- 2016
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22. Data Resource Profile: The French Childhood Cancer Observation Platform (CCOP).
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Poulalhon, Claire, Vignon, Lucie, Idbrik, Latifa, Bernier-Chastagner, Valérie, Fabre, Monique, Schleiermacher, Gudrun, Dijoud, Frédérique, Perrin, Corinne, Varlet, Pascale, Faure, Laure, Guissou, Sandra, Désandes, Emmanuel, Hémon, Denis, Berger, Claire, Lacour, Brigitte, and Clavel, Jacqueline
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CHILDHOOD cancer ,MEDICAL care ,GEOGRAPHIC information systems ,PUBLIC health surveillance ,TUMOR markers ,SICK leave ,FERTILITY preservation - Published
- 2020
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23. Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries
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Bonaventure, Audrey, Harewood, Rhea, Stiller, Charles A, Gatta, Gemma, Clavel, Jacqueline, Stefan, Daniela C, Carreira, Helena, Spika, Devon, Marcos-Gragera, Rafael, Peris-Bonet, Rafael, Piã±eros, Marion, Sant, Milena, Kuehni, Claudia E, Murphy, Michael F. G, Coleman, Michel P, Allemani, Claudia, Bouzbid, S., Hamdi-Chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S. H., El Mistiri, M. M., Bayo, S., Malle, B., Manraj, S. S., Sewpaul-Sungkur, R., Fabowale, Null, Ogunbiyi, O. J., Bradshaw, D., Somdyala, N. I. M., Stefan, D. C., Abdel-Rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., Gonzã¡lez, M. S., Laura, E. A., Espinola, S. B., Calabrano, G. H., Carballo Quintero, B., Fita, R., Garcilazo, D. A., Giacciani, P. L., Diumenjo, M. C., Laspada, W. D., Green, M. A., Lanza, M. F., Ibaã±ez, S. G., Lima, C. A., de Oliveira, E. Lobo, Daniel, C., Scandiuzzi, C., De Souza, P. C. F., Melo, C. D., Del Pino, K., Laporte, C., Curado, M. P., de Oliveira, J. C., Veneziano, C. L. A., Veneziano, D. B., Alexandre, T. S., Verdugo, A. S., Azevedo e. Silva, G., Galaz, J. C., Moya, J. A., Herrmann, D. A., Vargas, S., Herrera, V. M., Uribe, C. J., Bravo, L. E., Arias-Ortiz, N. E., Jurado, D. M., Yã©pez, M. C., Galã¡n, Y. H., Torres, P., MartÃnez-Reyes, F., Pérez-Meza, M. L., Jaramillo, L., Quinto, R., Cueva, P., Yã©pez, J. G., Torres-Cintrón, C. R., Tortolero-Luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A. J., Woods, R. R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F. R., Ryan, S., Hannah, H., Dewar, R. A. D., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D. E., Mcclure, C., Vriends, K. A., Bertrand, C., Louchini, R., Robb, K. I., Stuart-Panko, H., Demers, S., Wright, S., George, J. T., Shen, X., Brockhouse, J. T., O'Brien, D. K., Ward, K. C., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A. G., Vigneau, F., Mackinnon, J. A., Wohler, B., Bayakly, A. R., Clarke, C. A., Glaser, S. L., West, D., Green, M. D., Hernandez, B. Y., Johnson, C. J., Jozwik, D., Charlton, M. E., Lynch, C. F., Huang, B., Tucker, T. C., Deapen, D., Liu, L., Hsieh, M. C., X. C., Wu, Stern, K., Gershman, S. T., Knowlton, R. C., Alverson, J., Copeland, G. E., Rogers, D. B., Lemons, D., Williamson, L. L., Hood, M., Hosain, G. M., Rees, J. R., Pawlish, K. S., Stroup, A., Key, C., Wiggins, C., Kahn, A. R., Schymura, M. J., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S. S., Rubertone, J. J., Slack, S. J., Fulton, J. P., Rousseau, D. L., Janes, T. A., Schwartz, S. M., Bolick, S. W., Hurley, D. M., Richards, J., Whiteside, M. A., Nogueira, L. M., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D. G., Cheteri, MB Keitheri, Farley, S., Hudson, A. G., Borchers, R., Stephenson, L., Espinoza, J. R., Weir, H. K., Edwards, B. K., Wang, N., Yang, L., Chen, J. S., Song, G. H., X. P., Gu, Zhang, P., H. M., Ge, Zhao, D. L., Zhang, J. H., Zhu, F. D., Tang, J. G., Shen, Y., Wang, J., Q. L., Li, Yang, X. P., Dong, J., Li, W., Cheng, L. P., Chen, J. G., Huang, Q. H., Huang, S. Q., Guo, G. P., Wei, K., Chen, W. Q., Zeng, H., Demetriou, A. V., Pavlou, P., Mang, W. K., Ngan, K. C., Kataki, A. C., Krishnatreya, M., Jayalekshmi, P. A., Sebastian, P., Sapkota, S. D., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-Boker, L., Silverman, B. G., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Pathy, N. Bhoo, Chimedsuren, O., Tuvshingerel, S., Al Khater, A. H. M., Al-Eid, H., Jung, K. W., Won, Y. J., Chiang, C. J., Lai, M. S., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S. L., Sriplung, H., Eser, S., Yakut, C. I., Hackl, M., Mã¼hlbã¶ck, H., Oberaigner, W., Zborovskaya, A. A., Aleinikova, O. V., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Å ekerija, M., Zvolskã½, M., Engholm, G., Storm, H., Innos, K., Mã¤gi, M., Malila, N., Seppã¤, K., Jã©gu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A. M., Faivre, J., Guizard, A. V., Bouvier, V., Launoy, G., Arveux, P., Maynadiã©, M., Mounier, M., Fournier, E., Woronoff, A. S., Daoulas, M., Clavel, J., Le Guyader-Peyrou, S., Monnereau, A., Trã©tarre, B., Colonna, M., Cowppli-Bony, A., Moliniã©, F., Bara, S., Degrã©, D., Ganry, O., Lapôtre-Ledoux, B., Grosclaude, P., Estãve, J., Bray, F., Piã±eros, M., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S. R., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R. A., Kumar, V., Ã'lafsdóttir, E. J., Tryggvadã³ttir, L., Comber, H., Walsh, P. M., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M. F., Usala, M., Cusimano, R., Mazzucco, Walter, Michiara, M., Sgargi, P., Maule, M. M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M. L., Tisano, F., Fanetti, A. C., Maspero, S., Candela, G., Scuderi, T., Gentilini, M. A., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A. P., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Gatta, G., Sant, M., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larã¸nningen, S., Mã¸ller, B., Dyzmann-Sroka, A., Trojanowski, M., Gã³zdz, S., Mezyk, R., Gradalska-Lampart, M., Radziszewska, A. U., Didkowska, J. A., Wojciechowska, U., Blaszczyk, J., Kepska, K., Bielska-Lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R. A., Bastos, J., Silva, M. A., Antunes, L., Bento, M. J., Mayer-da-Silva, A., Miranda, A., Coza, D., Todescu, A. I., Valkov, M. Y., Adamcik, J., Safaei Diba, C., Primic-Žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirã³s, J. R., Bidaurrazaga, J., Larraã±aga, N., DÃaz GarcÃa, J. M., Marcos, A. I., Marcos-Gragera, R., Vilardell Gil, M. L., Molina, E., Sã¡nchez, M. J., Sureda, P. Franch, Montserrat, M. Ramos, Chirlaque, M. D., Navarro, C., Ardanaz, E. E., Moreno-Iribas, C. C., Fernández-Delgado, R., Peris-Bonet, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S. M., Herrmann, C., Bulliard, J. L., Maspoli-Conconi, M., Frick, H., Kuehni, C. E., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S. I., Matthes, K. L., Rashbass, J., Stiller, C. A., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R. J., Brewster, D. H., Huws, D. W., White, C., Finan, P., Allemani, C., Bonaventure, A., Carreira, H., Coleman, M. P., Di Carlo, V., Harewood, R., Liu, K., Matz, M., Montel, L., Nikå¡ic, M., Rachet, B., Sanz, N., Spika, D., Stephens, R., Peake, M., Murphy, M. F. G., Chalker, E., Newman, L., Baker, D., Soeberg, M. J., Aitken, J., Scott, C., Stokes, B. C., Venn, A., Farrugia, H., Giles, G. G., Threlfall, T., Currow, D., You, H., Hendrix, J., Lewis, C., Latorre, M. R. D. O., Tanaka, L. F., Bonaventure, A., Harewood, R., Stiller, C., Gatta, G., Clavel, J., Stefan, D., Carreira, H., Spika, D., Marcos-gragera, R., Peris-bonet, R., Piñeros, M., Sant, M., Kuehni, C., Murphy, M., Coleman, M., Allemani, C., Bouzbid, S., Hamdi-chérif, M., Zaidi, Z., Bah, E., Swaminathan, R., Nortje, S., El Mistiri, M., Bayo, S., Malle, B., Manraj, S., Sewpaul-sungkur, R., Fabowale, A., Ogunbiyi, O., Bradshaw, D., Somdyala, N., Abdel-rahman, M., Jaidane, L., Mokni, M., Kumcher, I., Moreno, F., González, M., Laura, E., Espinola, S., Calabrano, G., Carballo Quintero, B., Fita, R., Garcilazo, D., Giacciani, P., Diumenjo, M., Laspada, W., Green, M., Lanza, M., Ibañez, S., Lima, C., Lobo De Oliveira, E., Daniel, C., Scandiuzzi, C., De Souza, P., Melo, C., Del Pino, K., Laporte, C., Curado, M., De Oliveira, J., Veneziano, C., Veneziano, D., Latorre, M., Tanaka, L., Azevedo E. Silva, G., Galaz, J., Moya, J., Herrmann, D., Vargas, S., Herrera, V., Uribe, C., Bravo, L., Arias-ortiz, N., Jurado, D., Yépez, M., Galán, Y., Torres, P., Martínez-reyes, F., Pérez-meza, M., Jaramillo, L., Quinto, R., Cueva, P., Yépez, J., Torres-cintrón, C., Tortolero-luna, G., Alonso, R., Barrios, E., Nikiforuk, C., Shack, L., Coldman, A., Woods, R., Noonan, G., Turner, D., Kumar, E., Zhang, B., Mccrate, F., Ryan, S., Hannah, H., Dewar, R., Macintyre, M., Lalany, A., Ruta, M., Marrett, L., Nishri, D., Mcclure, C., Vriends, K., Bertrand, C., Louchini, R., Robb, K., Stuart-panko, H., Demers, S., Wright, S., George, J., Shen, X., Brockhouse, J., O'Brien, D., Ward, K., Almon, L., Bates, J., Rycroft, R., Mueller, L., Phillips, C., Brown, H., Cromartie, B., Schwartz, A., Vigneau, F., Mackinnon, J., Wohler, B., Bayakly, A., Clarke, C., Glaser, S., West, D., Hernandez, B., Johnson, C., Jozwik, D., Charlton, M., Lynch, C., Huang, B., Tucker, T., Deapen, D., Liu, L., Hsieh, M., Xc, W., Stern, K., Gershman, S., Knowlton, R., Alverson, J., Copeland, G., Rogers, D., Lemons, D., Williamson, L., Hood, M., Hosain, G., Rees, J., Pawlish, K., Stroup, A., Key, C., Wiggins, C., Kahn, A., Schymura, M., Leung, G., Rao, C., Giljahn, L., Warther, B., Pate, A., Patil, M., Schubert, S., Rubertone, J., Slack, S., Fulton, J., Rousseau, D., Janes, Ta:, S., Sm, Bolick, S., Hurley, D., Richards, J., Whiteside, M., Nogueira, L., Herget, K., Sweeney, C., Martin, J., Wang, S., Harrelson, D., Keitheri Cheteri, M., Farley, S., Hudson, A., Borchers, R., Stephenson, L., Espinoza, J., Weir, H., Edwards, B., Wang, N., Yang, L., Chen, J., Song, G., Xp, G., Zhang, P., Hm, G., Zhao, D., Zhang, J., Zhu, F., Tang, J., Shen, Y., Wang, J., Ql, L., Yang, X., Dong, J., Li, W., Cheng, L., Huang, Q., Huang, S., Guo, G., Wei, K., Chen, W., Zeng, H., Demetriou, A., Pavlou, P., Mang, W., Ngan, K., Kataki, A., Krishnatreya, M., Jayalekshmi, P., Sebastian, P., Sapkota, S., Verma, Y., Nandakumar, A., Suzanna, E., Keinan-boker, L., Silverman, B., Ito, H., Nakagawa, H., Hattori, M., Kaizaki, Y., Sugiyama, H., Utada, M., Katayama, K., Narimatsu, H., Kanemura, S., Koike, T., Miyashiro, I., Yoshii, M., Oki, I., Shibata, A., Matsuda, T., Nimri, O., Ab Manan, A., Bhoo-pathy, N., Tuvshingerel, S., Chimedsuren, O., Al Khater, A., Al-eid, H., Jung, K., Won, Y., Chiang, C., Lai, M., Suwanrungruang, K., Wiangnon, S., Daoprasert, K., Pongnikorn, D., Geater, S., Sriplung, H., Eser, S., Yakut, C., Hackl, M., Mühlböck, H., Oberaigner, W., Zborovskaya, A., Aleinikova, O., Henau, K., Van Eycken, L., Dimitrova, N., Valerianova, Z., Šekerija, M., Zvolský, M., Engholm, G., Storm, H., Innos, K., Mägi, M., Malila, N., Seppä, K., Jégu, J., Velten, M., Cornet, E., Troussard, X., Bouvier, A., Faivre, J., Guizard, A., Bouvier, V., Launoy, G., Arveux, P., Maynadié, M., Mounier, M., Fournier, E., Woronoff, A., Daoulas, M., Le Guyader-peyrou, S., Monnereau, A., Trétarre, B., Colonna, M., Cowppli-bony, A., Molinié, F., Bara, S., Degré, D., Ganry, O., Lapôtre-ledoux, B., Grosclaude, P., Estève, J., Bray, F., Sassi, F., Stabenow, R., Eberle, A., Erb, C., Nennecke, A., Kieschke, J., Sirri, E., Kajueter, H., Emrich, K., Zeissig, S., Holleczek, B., Eisemann, N., Katalinic, A., Brenner, H., Asquez, R., Kumar, V., Ólafsdóttir, E., Tryggvadóttir, L., Comber, H., Walsh, P., Sundseth, H., Devigili, E., Mazzoleni, G., Giacomin, A., Bella, F., Castaing, M., Sutera, A., Gola, G., Ferretti, S., Serraino, D., Zucchetto, A., Lillini, R., Vercelli, M., Busco, S., Pannozzo, F., Vitarelli, S., Ricci, P., Pascucci, C., Autelitano, M., Cirilli, C., Federico, M., Fusco, M., Vitale, M., Usala, M., Cusimano, R., Mazzucco, W., Michiara, M., Sgargi, P., Maule, M., Sacerdote, C., Tumino, R., Di Felice, E., Vicentini, M., Falcini, F., Cremone, L., Budroni, M., Cesaraccio, R., Contrino, M., Tisano, F., Fanetti, A., Maspero, S., Candela, G., Scuderi, T., Gentilini, M., Piffer, S., Rosso, S., Sacchetto, L., Caldarella, A., La Rosa, F., Stracci, F., Contiero, P., Tagliabue, G., Dei Tos, A., Zorzi, M., Zanetti, R., Baili, P., Berrino, F., Capocaccia, R., De Angelis, R., Liepina, E., Maurina, A., Smailyte, G., Agius, D., Calleja, N., Siesling, S., Visser, O., Larønningen, S., Møller, B., Dyzmann-sroka, A., Trojanowski, M., Góźdż, S., Mężyk, R., Grądalska-lampart, M., Radziszewska, A., Didkowska, J., Wojciechowska, U., Błaszczyk, J., Kępska, K., Bielska-lasota, M., Kwiatkowska, K., Forjaz, G., Rego, R., Bastos, J., Silva, M., Antunes, L., Bento, M., Mayer-da-silva, A., Miranda, A., Coza, D., Todescu, A., Valkov, M., Adamcik, J., Safaei Diba, C., Primic-žakelj, M., Žagar, T., Stare, J., Almar, E., Mateos, A., Quirós, J., Bidaurrazaga, J., Larrañaga, N., Díaz García, J., Marcos, A., Vilardell Gil, M., Molina, E., Sánchez, M., Franch Sureda, P., Ramos Montserrat, M., Chirlaque, M., Navarro, C., Ardanaz, E., Moreno-iribas, C., Fernández-delgado, R., Galceran, J., Khan, S., Lambe, M., Camey, B., Bouchardy, C., Usel, M., Ess, S., Herrmann, C., Bulliard, J., Maspoli-conconi, M., Frick, H., Schindler, M., Bordoni, A., Spitale, A., Chiolero, A., Konzelmann, I., Dehler, S., Matthes, K., Rashbass, J., Fitzpatrick, D., Gavin, A., Bannon, F., Black, R., Brewster, D., Huws, D., White, C., Finan, P., Di Carlo, V., Liu, K., Matz, M., Montel, L., Nikšić, M., Rachet, B., Sanz, N., Stephens, R., Peake, M., Chalker, E., Newman, L., Baker, D., Soeberg, M., Aitken, J., Scott, C., Stokes, B., Venn, A., Farrugia, H., Giles, G., Threlfall, T., Currow, D., You, H., Hendrix, J., and Lewis, C.
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childhood leukaemia ,Cancer registrie ,leukemia ,cancer ,childhood cancer ,Socio-culturale ,Hematology ,Settore MED/42 - Igiene Generale E Applicata ,Hematology, childhood leukaemia, cancer survival ,cancer survival - Abstract
BACKGROUND: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia. METHODS: Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for Oncology, third revision. We excluded data from registries from which the data were judged to be less reliable, or included only lymphomas, and data from countries in which data for fewer than ten children were available for analysis. We also excluded records because of a missing date of birth, diagnosis, or last known vital status. We estimated 5-year net survival (ie, the probability of surviving at least 5 years after diagnosis, after controlling for deaths from other causes [background mortality]) for children by calendar period of diagnosis (1995-99, 2000-04, and 2005-09), sex, and age at diagnosis (
24. Parental occupational exposure to combustion products, metals, silica and asbestos and risk of childhood leukaemia: Findings from the Childhood Cancer and Leukaemia International Consortium (CLIC).
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Onyije, Felix M., Olsson, Ann, Erdmann, Friederike, Magnani, Corrado, Petridou, Eleni, Clavel, Jacqueline, Miligi, Lucia, Bonaventure, Audrey, Ferrante, Daniela, Piro, Sara, Peters, Susan, Vermeulen, Roel, Kromhout, Hans, and Schüz, Joachim
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ASBESTOS , *OCCUPATIONAL exposure , *CHILDHOOD cancer , *COMBUSTION products , *DIESEL motor exhaust gas , *LEUKEMIA - Abstract
Parental occupational exposures around conception (father) or during pregnancy (mother) have been hypothesized as potential predisposing factors for childhood leukaemia. We investigated parental exposure to several known occupational carcinogens and childhood leukaemia risk. We conducted a pooled analysis using case-control data from four European countries (3362 childhood leukemia cases and 6268 controls). Parental occupational exposures to polycyclic aromatic hydrocarbons (PAH), diesel engine exhaust (DEE), chromium, nickel, crystalline silica, and asbestos were assessed by a general population job-exposure matrix. We estimated odd ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression models for all childhood leukaemia combined, by leukaemia type (ALL and AML) and by ALL subtype (B-lineage and T-lineage). We found an association between high paternal occupational exposure to crystalline silica and childhood ALL (OR 2.20, CI 1.60–3.01) with increasing trend from no exposure to high exposure (P = <0.001), and also for AML (OR 2.03, CI 1.04–3.97; P for trend = 0.008). ORs were similar for B- and T-lineage ALL. For ALL, ORs were also slightly elevated with wide confidence intervals for high paternal occupational exposure to chromium (OR 1.23, CI 0.77–1.96), and DEE (OR 1.21, CI 0.82–1.77). No associations were observed for paternal exposures to nickel, PAH and asbestos. For maternal occupational exposure we found several slightly elevated odds ratios but mostly with very wide confidence intervals due to low numbers of exposed mothers. This is a first study suggesting an association between fathers' occupational exposure to crystalline silica and an increased risk of childhood leukaemia in their offspring. As this association was driven by certain occupations (field crop farmers and miners) where other potentially relevant exposures like pesticides and radon may also occur, more research is needed to confirm our findings of an association with crystalline silica, and if so, mechanistic studies to understand the pathways. [ABSTRACT FROM AUTHOR]
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- 2022
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25. Childhood cancer survival in Europe 1999–2007: results of EUROCARE-5—a population-based study.
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Gatta, Gemma, Botta, Laura, Rossi, Silvia, Aareleid, Tiiu, Bielska-Lasota, Magdalena, Clavel, Jacqueline, Dimitrova, Nadya, Jakab, Zsuzsanna, Kaatsch, Peter, Lacour, Brigitte, Mallone, Sandra, Marcos-Gragera, Rafael, Minicozzi, Pamela, Sánchez-Pérez, Maria-José, Sant, Milena, Santaquilani, Mariano, Stiller, Charles, Tavilla, Andrea, Trama, Annalisa, and Visser, Otto
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CANCER patients , *HEALTH surveys , *CHILDHOOD cancer , *PROGNOSIS , *DIAGNOSIS , *CANCER treatment - Abstract
Summary: Background: Survival and cure rates for childhood cancers in Europe have greatly improved over the past 40 years and are mostly good, although not in all European countries. The EUROCARE-5 survival study estimates survival of children diagnosed with cancer between 2000 and 2007, assesses whether survival differences among European countries have changed, and investigates changes from 1999 to 2007. Methods: We analysed survival data for 157 499 children (age 0–14 years) diagnosed between Jan 1, 1978 and Dec 31, 2007. They came from 74 population-based cancer registries in 29 countries. We calculated observed, country-weighted 1-year, 3-year, and 5-year survival for major cancers and all cancers combined. For comparison between countries, we used the corrected group prognosis method to provide survival probabilities adjusted for multiple confounders (sex, age, period of diagnosis, and, for all cancers combined without CNS cancers, casemix). Age-adjusted survival differences by area and calendar period were calculated with period analysis and were given for all cancers combined and the major cancers. Findings: We analysed 59 579 cases. For all cancers combined for children diagnosed in 2000–07, 1-year survival was 90·6% (95% CI 90·2–90·9), 3-year survival was 81·0 % (95% CI 80·5–81·4), and 5-year survival was 77·9% (95% CI 77·4–78·3). For all cancers combined, 5-year survival rose from 76·1% (74·4–77·7) for 1999–2001, to 79·1% (77·3–80·7) for 2005–07 (hazard ratio 0·973, 95% CI 0·965–0·982, p<0·0001). The greatest improvements were in eastern Europe, where 5-year survival rose from 65·2% (95% CI 63·1–67·3) in 1999–2001, to 70·2% (67·9–72·3) in 2005–07. Europe-wide average yearly change in mortality (hazard ratio) was 0·939 (95% CI 0·919–0·960) for acute lymphoid leukaemia, 0·959 (0·933–0·986) for acute myeloid leukaemia, and 0·940 (0·897–0·984) for non-Hodgkin lymphoma. Mortality for all of Europe did not change significantly for Hodgkin's lymphoma, Burkitt's lymphoma, CNS tumours, neuroblastoma, Wilms' tumour, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. Disparities for 5-year survival persisted between countries and regions, ranging from 70% to 82% (for 2005–07). Interpretation: Several reasons might explain persisting inequalities. The lack of health-care resources is probably most important, especially in some eastern European countries with limited drug supply, lack of specialised centres with multidisciplinary teams, delayed diagnosis and treatment, poor management of treatment, and drug toxicity. In the short term, cross-border care and collaborative programmes could help to narrow the survival gaps in Europe. Funding: Italian Ministry of Health, European Commission, Compagnia di San Paolo Foundation. [ABSTRACT FROM AUTHOR]
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- 2014
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26. Residential exposure to natural background radiation at birth and risk of childhood acute leukemia in France, 1990–2009.
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Berlivet, Justine, Hémon, Denis, Cléro, Énora, Ielsch, Geraldine, Laurier, Dominique, Faure, Laure, Clavel, Jacqueline, and Goujon, Stéphanie
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BACKGROUND radiation , *ACUTE leukemia , *GEOLOGICAL maps , *POISSON regression , *RADIATION exposure - Abstract
The role of natural background radiation (NBR) in childhood acute leukemia (AL) remains unclear. Several large record based studies have recently reported heterogeneous results. Differences in exposure assessment timing may explain this heterogeneity. In a previous ecological study we did not observe any association between childhood AL incidence in France and NBR exposure at the time of diagnosis. With the same methodology, the present study focused on NBR exposure at the time of birth. Based on data from the French national registry of childhood cancer, we analyzed all AL together, and lymphoblastic and myeloid AL, separately. We included 6,059 childhood AL cases born and diagnosed in mainland France between 1990 and 2009. NBR levels in municipalities of residence at birth were estimated by cokriging models, using NBR measurements and precise geological data. The incidence rate ratio (IRR) per unit variation of exposure was estimated with Poisson regression models, with adjustment for socio-demographic indicators and ultraviolet radiation levels. NBR exposures were considered at the time of birth, and cumulatively from birth to diagnosis. We also estimated a total NBR dose to red-bone marrow (RBM). There was no evidence for an association between NBR exposure at birth and childhood AL incidence, neither overall (gamma radiation: IRR = 0.99 (0.94,1.05) per 50 nSv/h; radon: IRR = 0.97 (0.91,1.03) per 100 Bq/m3) nor for the main AL types. The conclusions were similar with the cumulative exposures, and the total RBM dose. The study was based on high quality incidence data, large numbers of AL cases, and validated models of NBR exposure assessment. In all, the results further support the hypothesis that NBR are not associated to childhood AL in France. • The initiation process of childhood leukemia might begin during the perinatal term. • Nationwide study on background radiation exposure at birth and childhood leukemia. • Complete registration of childhood leukemia in France (6,059 cases over 1990–2009). • Cockriging models based on radiation measurements (>10,000 sites) and geological maps. • Exposure to background radiation at birth not associated with childhood leukemia. [ABSTRACT FROM AUTHOR]
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- 2021
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27. Ecological association between residential natural background radiation exposure and the incidence rate of childhood central nervous system tumors in France, 2000–2012.
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Berlivet, Justine, Hémon, Denis, Cléro, Énora, Ielsch, Géraldine, Laurier, Dominique, Guissou, Sandra, Lacour, Brigitte, Clavel, Jacqueline, and Goujon, Stéphanie
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RADIATION exposure , *GAMMA rays , *ENVIRONMENTAL exposure , *IONIZING radiation , *BRAIN tumors , *BACKGROUND radiation ,CENTRAL nervous system tumors - Abstract
High-dose ionizing radiation is an established risk factor for childhood central nervous system tumors (CNST) but the role of low doses remains debated. In particular, there are few studies of natural background radiation (NBR, gamma radiation and radon) and childhood CNST, and their results are inconclusive. This study aimed to investigate the ecological association between NBR exposure and childhood CNST incidence in France, considering childhood CNST overall and by subgroups. Incidence data were provided by the French national registry of childhood cancers, which has high completeness. We included 5471 childhood CNST cases registered over the period 2000-2012, and their municipality of residence at diagnosis was recorded. Municipality NBR exposures were estimated by cokriging models, using NBR measurements and additional geographic data. The incidence rate ratio (IRR) per unit variation of exposure was estimated with Poisson regression models. NBR exposures were considered at the time of diagnosis, and cumulatively from birth to diagnosis. In an exploratory analysis, the total brain dose due to NBR was used. Overall, there was no association between NBR exposure and childhood CNST incidence (IRR = 1.03 (0.98,1.09) per 50 nSv/h for gamma radiation, and IRR = 1.02 (0,96,1.07) per 100 Bq/m3 for radon). An association was suggested between pilocytic astrocytomas and gamma radiation (IRR = 1.12 (1.00,1.24) per 50 nSv/h) but not with radon (IRR = 1.07 (0.95,1.20) per 100 Bq/m3). Upward trends for this CNST subtype were also suggested with the cumulative exposures to gamma radiation and the total brain dose. NBR exposure was not associated with other CNST subgroups (ependymomas, embryonal tumors, and gliomas other than pilocytic astrocytomas). Adjustment for socio-demographic factors did not change the findings. Our study was based on high quality incidence data, large numbers of CNST cases, and validated models of NBR exposure assessment. Results suggest an association between gamma radiation, as a component of NBR, and pilocytic astrocytomas incidence in France. • Ecological study on childhood brain tumors and natural radiation in France. • Complete nationwide recording of childhood brain tumors (5471 cases, 2000-2012). • Cokriging models based on radiation measurements (>10,000 sites) and geological maps. • Gamma radiation associated with pilocytic astrocytoma incidence rate, not radon. • Natural radiation not associated to ependymomas, embryonal tumors and other gliomas. [ABSTRACT FROM AUTHOR]
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- 2020
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