1. Distinct Neurodevelopmental Trajectories in Groups of Very Preterm Children Screening Positively for Autism Spectrum Conditions.
- Author
-
Hadaya L, Vanes L, Karolis V, Kanel D, Leoni M, Happé F, Edwards AD, Counsell SJ, Batalle D, and Nosarti C
- Subjects
- Infant, Newborn, Child, Humans, Infant, Infant, Extremely Premature, Mass Screening, Developmental Disabilities, Autism Spectrum Disorder diagnosis, Autistic Disorder diagnosis, Child Development Disorders, Pervasive diagnosis, Cerebellum abnormalities, Nervous System Malformations
- Abstract
Very preterm (VPT; < 33 weeks' gestation) toddlers screening positively for autism spectrum conditions (ASC) may display heterogenous neurodevelopmental trajectories. Here we studied neonatal brain volumes and childhood ASC traits evaluated with the Social Responsiveness Scale (SRS-2) in VPT-born toddlers (N = 371; median age 20.17 months) sub-divided into three groups based on their Modified-Checklist for Autism in Toddlers scores. These were: those screening positively failing at least 2 critical items (critical-positive); failing any 3 items, but less than 2 critical items (non-critical-positive); and screening negatively. Critical-positive scorers had smaller neonatal cerebellar volumes compared to non-critical-positive and negative scorers. However, both positive screening groups exhibited higher childhood ASC traits compared to the negative screening group, suggesting distinct aetiological trajectories associated with ASC outcomes., (© 2022. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF