1. Genomics Links Inflammation With Neurocognitive Impairment in Children Living With Human Immunodeficiency Virus Type-1
- Author
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Rawat, Pratima, Brummel, Sean S, Singh, Kumud K, Kim, Jihoon, Frazer, Kelly A, Nichols, Sharon, Seage, George R, Williams, Paige L, Van Dyke, Russell B, Harismendy, Olivier, Trout, Rodney N, and Spector, Stephen A
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,Infectious Diseases ,Clinical Research ,HIV/AIDS ,Pediatric ,Genetics ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Infection ,Good Health and Well Being ,14-3-3 Proteins ,Child ,Child ,Preschool ,Female ,Genome-Wide Association Study ,Genomics ,HIV Infections ,HIV-1 ,Humans ,Infant ,Infectious Disease Transmission ,Vertical ,Inflammasomes ,Inflammation ,Intracellular Signaling Peptides and Proteins ,Male ,Membrane Proteins ,Microglia ,Neurocognitive Disorders ,Receptors ,CCR ,IIIV ,neurocognitive impairment ,IIIV perinatal infection ,genome-wide exome sequencing ,CCRL2 ,RETREG1 ,YWHAH ,14-3-3 eta protein ,14-3-3η protein ,HIV ,HIV perinatal infection ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Biological sciences ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundWe identified host single-nucleotide variants (SNVs) associated with neurocognitive impairment (NCI) in perinatally HIV-infected (PHIV) children.MethodsWhole-exome sequencing (WES) was performed on 217 PHIV with cognitive score for age (CSA)
- Published
- 2021