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A link between atopic dermatitis (AD,eczema) and emotional and behavioral dysfunction is more or less well recognized but concern still exists. Children with a chronic health condition have long been considered at excess risk for psychosocial morbidity. But psychosocial morbidity is less linked and studied in connection with other disease, especially AD. As mentioned before, AD is the most prevalent chronic disease in young children. The aim of the study was assessment of incidence of atopic dermatitis in children of 5-6 years with developmental and behavioral problems. The cross sectional study was conducted. Children with developmental and behavioral problems according to medical records and aged five to six years were recruited consecutively from a preventive care register in M. Iashvili Childrens Hospital Child Developmental Center in 2010-2014 years. Recruitment was done according developmental and behavioral assessment performed on the basis of team approach by pediatrician and psychologist. Parents evaluation of development status: developmental milestones (PEDS:DM) and Pictorial Checklist ( PIK -17) was used for assessment. 639 children with language delays, problems of externalization and internalization were enrolled in study. Children were examined by pediatricians based on the presence of at least three major and three minor criteria of Hanifin and Rajka's diagnostic criteria(HR) and by semi structured, one-to-one interview with the parents. According our study: 1. Significant amount of children with developmental and behavioral problems and symptoms are developing AD(36%). 2. Children with language delay were more frequently developing AD symptoms than children with behavioral problems.3.There was not significant difference in children with language delay and behavioral problems in terms of impact on QL. In both cases everyday activities, sleep and recreational actives were affected and there more affected then in children with developmental and behavioral problems and symptoms with AD comparable to children without AD, especially sleep.4. Date represents that boys are more likely to develop AD than girls, this information is in correlation with known facts about dermatitis. Both boys and girls were similarly affected by QL problems in case of AD and developmental and behavioral problems and symptoms. Chronic diseases and development and behavior of children in further dilemma for researchers. Our study gives us further impulse for more deep insight in factors affecting children with delays and behavioral problems and prospective studies in group with developmental and behavioral problems and symptoms and AD.

The aim of the study was assessment of the general nutrition knowledge and physical activity rate among the first grade school age children and evaluation of their diet and nutritional skills based on the parental interviews. Cross-sectional study was conducted in randomly selected schools of Tbilisi. In each school was selected one group of the second grade children and their parents by cluster selection method. A population of 290 children aged 6-8 years and their parents were interviewed. The statistical analysis was carried out by means of the SPPS 17. Questionnaires, except those with incomplete answers (n=30), were used for the analytical data. The study shows that in general, the level of knowledge related to rich sources of nutrients was poor. The most of the children can't identify the role of calcium (72,6%), proteins (68,1%) and iron (84,6 %). Children prefer to eat and select foods which they like (71,8%), such as sweets and cakes, hamburgers, chips and etc. The study showed that the most of the children (83,3%) have normal weight for age, underweight was revealed in 3,1% of children, more frequent was overweight (12,3%) and obesity (1,4%). There wasn't significant difference of overweight and underweight distribution in boys and girls. The assessment of child dietary intake show, that intake of fruits and vegetables, as well as milk and milk products is quite low, while intake of bread and pastry, and sweets and cakes are quite high. Daily consumption of sweets and snacks was significantly higher in girls (64.2%) than in boys (47.5%) (p0.01). The study revealed that only 62 % of children eat the breakfast, in frequent cases children eat very fast (26,1%), 47,8 % of children need to remind to wash hands before eating, most children 60,4% view TV during the meal time or play computer games. The most of the children play the active games approximately 30-60 minutes, quite often children play active games only 20-30 minutes that is much less then WHO recommendations. The parent questionnaires reveal that most frequent problem that influenced child nutrition is lack of information about healthy feeding (55%), lack of time for preparation of food (33%), inability to control child's feeding (36%), financial deficit (4%). The dietary intake of children does not correspond to WHO recommendations. It is recommended on the one hand to conduct country wide assessment of dietary intake of children and adolescent and on the other hand to implement nutrition education programs.

Purpose of the work was to investigate clinical-allergic peculiarities of allergic rhinitis, together with bronchial asthma in school-age children. There were studied random representative group of children, in total 3000 subjects from 6 to 17. According to the results of epidemiological research in school-age children's population, prevalence of allergic rhinitis was 13,2%. In 19,1% of cases, allergic rhinitis was accompanied with bronchial asthma and in 8% of the patients there was indicated bronchial spasm of physical load (verified as clinically, also through the test with physical load), coughing version of asthma was observed in 4,5% of children. Thus, in children with allergic rhinitis, within the structure of clinical versions (by the criteria of severity) of rare bronchial asthma prevailed (69,8%, among which 65% - intermitting form and 4,8% - persisting form), without statistically significant difference between the boys and girls. Combination of inherited predisposition to allergy with the atopic dermatitis, in the in the anamnesis of children with the increased level of general IgE in the blood serum may be considered as early diagnostic predictor of atopic phenotype as for the allergic rhinitis, also for its combination with the bronchial asthma.

Aims of this study were: to evaluate changes in lung function in wheezing children with detected MP and CP infection according to treatment; to measure the response to inhaled corticosteroids in children with significant wheezing who were selected as having a high risk of progressing into childhood asthma. 54 children were randomly assigned 2:1 into 2 groups-the main group (36 patients), in which inhaled corticosteroids were administered, and the control group (18 patients), without inhaled corticosteroids. Serum IgE levels were determined using the ELISA (reagents: IBL-Hamburg). Serologic studies were performed by the ELISA for IgM and IgG antibodies to MP and for IgG and IgA antibodies to CP (reagents: ImmunoLISA, Orgenics, Israel) on the Hiperion MRIII (USA). Pulmonary function testing was done with SpiroLab II (DEGO GmbH, Medizin-Elektronik, Germany). The patients of both groups were administered macrolides: azitromycin during five days. Patients of the first group received inhaled fluticasone propionate 125 mg twice daily. The parents were asked to record symptoms. Each symptom (wheezing, cough, and shortness of breath) were scored on a scale of 0 to 3--daily symptom score (DSS). Scores were calculated every 4 weeks for a total treatment period 16 weeks. The days within each period on which the DSS equalled zero were pointed as symptom free days (SFD). It had been shown an significant improvement in DSS, an increase in SFD and significant improvement of the lung functions following the treatment with inhaled fluticasone and macrolide in children with wheezing and documented MP or CP infection, compared to control group treated only with antibiotics. In conclusion, the use of ICS should be seriously considered in children with wheezing and the risk of persisting symptoms.

The aim of the study was assessment of incidence of allergic rhinitis and respiratory infections and evaluation of quality of life of first grade school age children with allergic rhinitis. The cross sectional study in randomly selected regions and schools was conducted using specially developed parent questionnaire and mini rhino conjunctivitis quality of life questionnaire (MiniRQLQ). On the first was used special questionnaire, and on the second phase MiniRQLQ was used in cases with allergic rhinitis. Total of 1530 parent of 6-8 years children were interviewed, 1499 first phase questionnaires and 174MiniRQLQ were analyzed by SPSS 19 program. From 1499 children 799 (53.3%) were girls and 700 (46.7%) - boys. The 810 (54%) live in urban, 524 (35%) in rural area and 165 (11%) in high mountains. The study revealed that 2.3% of children have respiratory infections 7-8 times per year, 19.9% 3-5 times, 53.4% 1-2 times and 24.2% became ill very rarely. There was statistically significant difference between the frequency of respiratory infection in rural and urban area (p0,001).The frequency of chronic diseases reported by parents is 18.3% (n=274), from those 201 (73.3%) are allergic disorders (asthma, rhinitis, atopic dermatitis), that is 13.4% of total respondents. The incidence of allergic rhinitis was 11.6%, most frequent symptom was rhinorrhea 168 (11.2%), recurrent sneezing episodes during last year was seen in 153 (10.2%), nasal pruritus was reported in 137 (9.1%), nasal obstruction in 117 (7.8%). The eye symptoms were reported in 62 (4.2%). The symptoms of allergic rhinitis is significantly higher in urban population then in rural area (P0.02), as well as in boys (P0.05). The 109 (62.6%) of respondents answer that symptoms and mostly nasal obstruction affected their quality of life, especially on recreational activities and sleep. In 91 (52.9%) patients with already diagnosed allergic rhinitis treatment was prescribed according international guidelines. In group with symptoms but non-diagnosed allergic rhinitis frequently was used I generation antihistamines 52 (62.6%) and decongestants 57 (68.5%). Incidence of allergic rhinitis in first grade school population is high and it is comparable to indices of developed countries. Allergic rhinitis affects quality of life of children especially outdoor activities and sleep. ARI does not show an impact on severity of allergic rhinitis symptoms.

The aim of the study was to assess nutritional status and anthropometric parameters in children aged 5-6 and to identify possible factors influencing the growth pattern of Georgian children. The cross-sectional study was performed on a sample of 754 children boys and girls aged 5-6 attending preschool facilities and their main caregivers in the study sites. The study covered children population from 16 kindergartens of 2 regions (Gldani-Nadzaladevi, and Vake-Saburtalo) of Tbilisi, with different social-economical status. The following anthropometric parameters were studied--body weight, height, head and mid arm circumferences and body mass index (BMI). Physical parameters were assessed using WHO/NIH standardized growth charts (percentile and Z scores). Collected data was analyzed using the computer program EPI INFO. High weight and height (95 percentile/2 Z score) was found more frequently than low (5 percentile/-2 Z score) parameters. Most children's weight according to their stature was in normal 5-95 percentile range. At the same time in girls was often met low weigh for their stature then in boys. The imbalance between the weight and height is more evident than between weight and age or height and age. The results showed that the abnormal Z scores more or below +/-2 scores were in less percents of children then high and low weight and height by the age in percentiles. The results showed a prevalence of children having normal indices of BMI between 5 and 85 percentiles, approximately 13%of children have low weight (less than 5 percentile), approximately 18% have risk of overweight and 16% have obesity. A multivariate analysis of personal and nutritional variables with the standard nutritional indicators identified age, sex, bottle feeding, and type of solid foods as significant risk factors for stunted growth. Stunting increases with age and males have poorer growth pattern than females. The results of the study emphasize that in Tbilisi 5-6 years old child population more frequent is problem of overweight and obesity than underweight.