1. Assessment of 17 Pediatric Cases With Colchicine Poisoning in a 2-Year Period
- Author
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Fatih Bolat, Demet Alaygut, Mehmet Burhan Oflaz, Ali Kaya, Suar Çakı Kılıç, Fusun Dilara Icagasioglu, Ömer Cevit, İÇAĞASIOĞLU, DİLARA FÜSUN, and [Alaygut, Demet] Cumhuriyet Univ, Fac Med, Dept Pediat Nephrol, Kayseri Cad, TR-58110 Sivas, Turkey -- [Kilic, Suar Caki] Cumhuriyet Univ, Fac Med, Dept Pediat Hematol, Kayseri Cad, TR-58110 Sivas, Turkey -- [Kaya, Ali -- Bolat, Fatih -- Cevit, Omer -- Icagasioglu, Fusun Dilara] Cumhuriyet Univ, Fac Med, Dept Pediat, Kayseri Cad, TR-58110 Sivas, Turkey -- [Oflaz, Mehmet Burhan] Cumhuriyet Univ, Fac Med, Dept Pediat Cardiol, Kayseri Cad, TR-58110 Sivas, Turkey
- Subjects
Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Drug-Related Side Effects and Adverse Reactions ,Turkey ,Familial Mediterranean fever ,Poison control ,Intensive Care Units, Pediatric ,030226 pharmacology & pharmacy ,colchicine ,law.invention ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,law ,Medicine ,Humans ,Child ,Retrospective Studies ,Pediatric intensive care unit ,business.industry ,Medical record ,Infant, Newborn ,Infant ,030208 emergency & critical care medicine ,Retrospective cohort study ,General Medicine ,medicine.disease ,Intensive care unit ,Familial Mediterranean Fever ,poisoning ,Acute abdomen ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Emergency Medicine ,Female ,medicine.symptom ,business ,Colchicine ,management ,Case series - Abstract
WOS: 000371909200007, PubMed ID: 26928096, Aim The aim of the study is to discuss clinical effects, treatments, and outcomes of pediatric colchicine poisoning. Method This study was designed as an observational case series study. The medical records of children aged between 0 and 18 years, who were hospitalized for colchicine poisoning at the Department of Pediatric Intensive Care Unit, Cumhuriyet University Faculty of Medicine, between January 2010 and January 2012, were retrospectively evaluated. Results We presented 17 children with colchicine poisoning. The mean (SD, range) age of patients was 71.5 (69.19, 18-204) months. The period to apply to the hospital after taking the medications was 7.3 hours (7.97, 30 minutes-26 hours) on average. The use of colchicine was due to diagnosis of Familial Mediterranean fever (FMF) in the families of 8 patients, diagnosis of Behcet disease in 1 patient's father, diagnosis of Behcet disease in 1 patient herself, and diagnosis of FMF in 6 patients themselves. Thirteen patients had taken colchicine at the dose of less than 0.5 mg/kg known as subtoxic and 1 patient had taken colchicine at the dose of greater than 0.8 mg/kg, and doses taken by 3 patients were not known. Fourteen patients (82.4%) had involuntary drug intake. Fifty percent of them were symptomatic at the moment of application and all had gastrointestinal complaints. All patients were observed in intensive care unit upon first admission and received supportive care. One of patients showed total alopecia, one showed leucocytosis, and another one showed acute abdomen picture. None of the patients showed mortality. Conclusions Mortality of colchicine toxicity is high and quick assessment is absolutely required. In regions where FMF is common and the use of colchicine is high, clinicians should pay attention to symptoms and findings related to colchicine intoxication and keep them in mind in differential diagnosis.
- Published
- 2016