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3 results on '"Brendan J McMullan"'

1. Antifungal use in children with acute leukaemia: state of current evidence and directions for future research

Author

Daniel K. Yeoh, Gabrielle M. Haeusler, Brendan J. McMullan, Coen Butters, Penelope A. Bryant, Julia E. Clark, Celia M. Cooper, Amanda Gwee, Rishi S. Kotecha, Tony Lai, Monica A. Slavin, Karin A. Thursky, and Christopher C. Blyth

Subjects
Pharmacology, Microbiology (medical), Leukemia, Myeloid, Acute, Infectious Diseases, Antifungal Agents, Humans, Pharmacology (medical), Hematology, Mycology, Child, Invasive Fungal Infections
Abstract

Invasive fungal disease (IFD) remains a common and serious complication in children treated for leukaemia. Antifungal prescription in children with leukaemia presents unique challenges, particularly due to variation in IFD risk between and within leukaemia treatment protocols, drug toxicities and interactions between antifungals and chemotherapeutic agents. With recent advances in the understanding of IFD epidemiology and large clinical trials in adults assessing antifungals for IFD treatment and prophylaxis, together with paediatric clinical and pharmacokinetic studies, there is a growing body of data to inform optimal antifungal use in children. A panel of infectious diseases and haematology-oncology clinicians with expertise in IFD management compiled a list of 10 key clinical questions following development of the 2021 Australia and New Zealand Mycology Antifungal Consensus Guidelines. A focused literature review was conducted to explore available evidence and identify gaps in knowledge to direct future research. With the changing epidemiology of IFD globally, the ongoing evolution of paediatric leukaemia treatment and the increasing availability of novel antifungal agents, advocacy for paediatric clinical studies will remain vital to optimize IFD prevention and treatment in children with leukaemia.

Published
2022

2. Disease and economic burden of infections in hospitalised children in New South Wales, Australia

Author

Brendan J. McMullan, Jake C. Valentine, Lisa Hall, and Karin Thursky

Subjects
Hospitalization, Health Policy, Urinary Tract Infections, Australia, Humans, Cellulitis, Financial Stress, Pneumonia, Length of Stay, New South Wales, Appendicitis, Child, Child, Hospitalized
Abstract

Objectives To describe the burden of disease and hospitalisation costs in children with common infections using statewide administrative data. Methods We analysed hospitalisation prevalence and costs for 10 infections: appendicitis, cellulitis, cervical lymphadenitis, meningitis, osteomyelitis, pneumonia, pyelonephritis, sepsis, septic arthritis, and urinary tract infections in children aged

Published
2021

3. Clinical Management of

Author

Brendan J, McMullan, Anita J, Campbell, Christopher C, Blyth, J Chase, McNeil, Christopher P, Montgomery, Steven Y C, Tong, and Asha C, Bowen

Subjects
Methicillin-Resistant Staphylococcus aureus, Staphylococcus aureus, Adolescent, Delphi Technique, Bacteremia, Penicillins, beta-Lactams, Drug Administration Schedule, Vancomycin, Humans, Child, Referral and Consultation, Randomized Controlled Trials as Topic, Incidence, Age Factors, Glycopeptides, Infant, Newborn, Infant, Endocarditis, Bacterial, Staphylococcal Infections, Anti-Bacterial Agents, Cephalosporins, Observational Studies as Topic, Echocardiography, Case-Control Studies, Catheter-Related Infections, Child, Preschool, Injections, Intravenous, Algorithms
Published
2020

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