1. [Prevalence of hepatitis B virus genotypes and the occurrence of precore mutation A-1896 and to correlate them with the clinical presentation of chronic hepatitis, in a population group of the Eastern Amazon region]
- Author
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Simone Regina Souza da Silva, Conde, Lizomar de Jesus Pereira, Móia, Maria Silvia Brito, Barbosa, Ivanete do Socorro Abarcado, Amaral, Esther Castello Branco de Mello, Miranda, Manoel do Carmo Pereira, Soares, Elizabete Maria de Figueiredo, Brito, Olglaíze do Socorro Costa, Souza, Marialva Tereza, de Araújo, Sâmia, Demachki, João Renato Pinho, Rebello, Michele Gomes Soares, Mesquita, Alberto Bertollini, Denis, and Ricardo, Ishak
- Subjects
Adult ,Aged, 80 and over ,Male ,Hepatitis B virus ,Hepatitis B Surface Antigens ,Adolescent ,Base Sequence ,Genotype ,Molecular Sequence Data ,Infant ,Middle Aged ,Viral Load ,Hepatitis B Core Antigens ,Polymerase Chain Reaction ,Hepatitis B, Chronic ,Child, Preschool ,DNA, Viral ,Mutation ,Prevalence ,Humans ,Female ,Child ,Brazil ,Aged - Abstract
Hepatitis B virus (HBV) infection presents itself with a variety of clinical manifestations. The present work aims to describe the prevalence of HBV genotypes and the occurrence of precore mutation A-1896 in a population group of the Eastern Amazon region of Brazil and to correlate them with the clinical presentation of chronic HBV infection. 51 HBsAg carriers (HBV-DNA positive) were selected and divided into three groups: A (14 asymptomatic subjects), B (20 HBeAg positive symptomatic patients) and C (17 HBeAg negative symptomatic patients). Using an automa ed DNA sequencer ABI model 377 by sequencing for determined of genotypes and precore mutation. The results showed that the genotype A was the most commonly found (81.1%, 89.5% and 93.7% in groups A, B and C, respectively) and precore mutation A-1896 was described in 11.5% (3/26) of group A subjects. Genotype A of HBV was the most prevalent (89.1%) and low occurrence of precore mutation A-1896, both not associate with the worst outcome of the chronic infection of HBV.
- Published
- 2004