1. Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.
- Author
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Xavier J, Alcantara LCJ, Fonseca V, Lima M, Castro E, Fritsch H, Oliveira C, Guimarães N, Adelino T, Evaristo M, Rodrigues ES, Santos EV, de La-Roque D, de Moraes L, Tosta S, Neto A, Rosewell A, Mendonça AF, Leite A, Vasconcelos A, Silva de Mello AL, Vasconcelos B, Montalbano CA, Zanluca C, Freitas C, de Albuquerque CFC, Duarte Dos Santos CN, Santos CS, Dos Santos CA, Gonçalves CCM, Teixeira D, Neto DFL, Cabral D, de Oliveira EC, Noia Maciel EL, Pereira FM, Iani F, de Carvalho FP, Andrade G, Bezerra G, de Castro Lichs GG, Pereira GC, Barroso H, Franz HCF, Ferreira H, Gomes I, Riediger IN, Rodrigues I, de Siqueira IC, Silva J, Rico JM, Lima J, Abrantes J, do Nascimento JPM, Wasserheit JN, Pastor J, de Magalhães JJF, Luz KG, Lima Neto LG, Frutuoso LCV, da Silva LB, Sena L, de Sousa LAF, Pereira LA, Demarchi L, Câmara MCB, Astete MG, Almiron M, Lima M, Umaki Zardin MCS, Presibella MM, Falcão MB, Gale M Jr, Freire N, Marques N, de Moura NFO, Almeida Da Silva PE, Rabinowitz P, da Cunha RV, Trinta KS, do Carmo Said RF, Kato R, Stabeli R, de Jesus R, Hans Santos R, Kashima S, Slavov SN, Andrade T, Rocha T, Carneiro T, Nardy V, da Silva V, Carvalho WG, Van Voorhis WC, Araujo WN, de Filippis AMB, and Giovanetti M
- Subjects
- Animals, Humans, Brazil epidemiology, Nucleotides, Chikungunya virus genetics, Chikungunya Fever epidemiology, Yellow Fever, Zika Virus, Zika Virus Infection
- Abstract
The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021-2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil., (© 2023. The Author(s).)
- Published
- 2023
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