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It is pointed out that the core characteristic of China’s space science mission is science driven, which is embodied in “four science” characteristics, namely, scientific objective, chief scientist, scientific payload, and scientific research institute. This paper expounds the management practice aiming at the characteristics of the “four science”, that is, to persist in taking the scientific objective as the traction, the chief scientist as the scientific direction, the scientific payload as the grasp, scientific research institute as the support; to promote the organic integration of science and technology, science and engineering; to ensure the progress and quality of the project; and to strive to promote the maximize output of the mission. By examining the characteristics of space science missions, combing management practices and countermeasures and putting forward suggestions for follow-up mission management, it is helpful to further enhance management capabilities and to the long-term sustainable development of space science in China. [ABSTRACT FROM AUTHOR]