1. Association between apolipoprotein E gene polymorphism and Alzheimer's disease in Uighur and Han populations.
- Author
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ZHOU, Xiaohui, MIAO, Haijun, RAUSCH, Wolf Dieter, LONG, Ma, LUO, Xiaomei, YU, Hong, ZHANG, Xiaoning, BAYAHEMAITI, Kumusi, ABULIZI, Palida, and KEYIMU, Kabinur
- Subjects
GENETICS of Alzheimer's disease ,APOLIPOPROTEINS ,CHI-squared test ,CLUSTER analysis (Statistics) ,GENES ,GENETIC polymorphisms ,NEUROPSYCHOLOGICAL tests ,POLYMERASE chain reaction ,STATISTICAL sampling ,STATISTICS ,DATA analysis software - Abstract
Aim: Currently, there are almost 100 genes related to Alzheimer's disease (AD), and studies have indicated that apolipoprotein E (APO E) ε4 allele is a genetic risk factor of AD. However, there have been no reports of the distributions of APO E genotypes and allele frequencies in Uighur and Han AD patients. Methods: We analyzed APO E gene polymorphism in 209 AD cases diagnosed based on National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer's Disease and Related Disorders Association and 220 non-dementia controls. We used polymerase chain reaction-restriction fragment length polymorphism methods as the basis of this epidemiological survey. Results: In the AD and control groups, there are no statistically significant differences in APO E genotypes and allele frequency between the Uighur and Han ethnicities ( P < 0.05). In the AD group, the ε3/4 genotype (28.2%) and ε4 allele frequency (14.8%) occurred at a higher rate than in the control (13.2% and 8.0%, respectively; P < 0.05). This distinction remained true within each ethnicity; the ε3/4 genotype and ε4 allele frequency are higher in the AD groups (Uighur, 30.6% and 15.8%, respectively; Han, 25.5% and 13.8%, respectively) than in the control groups (Uighur, 14.5% and 9.4%, respectively; Han, 11.7% and 6.3%, respectively; P < 0.05). Conclusions: The distribution of APO E genotype and allele frequency does not differ between the Uighur and Han ethnicities. The APO E ε4 allele is a risk factor of AD for both populations. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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