1. Methisoprinol restoration of leukocyte chemotaxis inhibition by blocking factors in immunoproliferative diseases.
- Author
-
Azzarà A, Polidori R, Petrini M, Margelli M, Vatteroni ML, Grassi B, and Ambrogi F
- Subjects
- Adult, Aged, Antibodies, Binding, Competitive, Female, Hodgkin Disease immunology, Humans, In Vitro Techniques, Leukocytes drug effects, Leukocytes immunology, Male, Middle Aged, Multiple Myeloma immunology, Waldenstrom Macroglobulinemia immunology, Chemotaxis, Leukocyte drug effects, Inosine analogs & derivatives, Inosine Pranobex pharmacology, Lymphoproliferative Disorders immunology
- Abstract
The ability of methisoprinol to antagonize the serum-inhibiting activity present in the sera of patients affected by immunoproliferative diseases (Hodgkin's disease and multiple myeloma) was investigated. Using a chemotaxis test, it was found that whereas donor leukocytes preincubated in patient sera exhibited impaired chemotaxis, the presence of methisoprinol (500 micrograms/ml) during the preincubation caused a significant recovery of this leukocyte function. Since the results exclude the assumption of a non-specific stimulation of cell motility, two hypotheses appeared possible for the action of methisoprinol: either an antagonistic activity against the blocking factor at the receptor or the metabolic level, or a direct inactivation of this factor. The clinical implications, with regard to the prophylaxis of infections and a better response to chemotherapy, are discussed.
- Published
- 1984