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A series of disperse dyes, 9,10-anthraquinone containing dithiocarbamate, thiourea and triazole fragments, were prepared via consecutive refunctionalization of aminoanthraquinones in our previous studies and their structures were confirmed by the 1H, 13C NMR, IR spectra, LC-MS and elemental analysis data. The obtained compounds were applied on polyester fabrics by the exhaustion method at 130°C at pH 4.0-5.0, and their dyeing properties were evaluated by color measurements, the washing fastness test and the light fastness test. Many of these dyes gave solid and level dyeings on polyester fabric with low % concentration of dye. The dyed samples displayed very good color fastnesses. The color change and staining test results were quite good with ratings of “4-5” or above. The light fastness test results were also satisfactory for the most of the dyed samples.

Objective: The present study was designed to study the anticancer activity of a series of novel analogs of phenothiazine with dithiocarbamate as a side chain. Methods: A novel series of derivatives containing dithiocarbamate as a side chain at the tenth position of phenothiazine nucleus were synthesized, characterized by spectral analysis, and evaluated for their antimitotic and antioxidant activity using germinated Bengal gram seeds and 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, respectively. A quantitative estimate of drug-likeness was also performed, which calculated the molecular properties and screened the molecules based on drug-likeness rules. Further, molecular docking study was performed for finding the binding affinity with tubulin protein to rationalize their anticancer activity. Results: The results revealed that the antioxidant activity of compounds 3e, 3g, 3i, 3j and standard Ascorbic acid were 10 mmol, 14 mmol, 16 mmol, 16 mmol and 35 mmol, respectively. Further compounds 3e, 3g, 3h and 3i have shown promising antimitotic activity. Compound 3i (-9 K. Cal/mol) showed the highest binding energies towards tubulin protein when compared to standard drug colchicine (-8.6 K. Cal/mol). Among all, compound 3i showed promising antimitotic and antioxidant activity, which correlated with insilico docking studies. Conclusion: Dithiocarbamate substituted phenothiazine derivatives proved to be encouraging leads as tubulin inhibitors.

A dithiocarbamate ligand, FLXDTC, has been synthesized from fluoxetine drug along with its complexes of some bivalent metal ions such as Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Mn(II) and Cu(II). The ligand and the complexes have been characterized by various analytical and spectroscopic methods in addition to some voltammetry studies. The studies propose the formation M(FLXDTC)2 complex for all where M = Zn(II), Cd(II), Hg(II), Co(II), Ni(II), Mn(II) and Cu(II) ions. It is also found that Cu(FLXDTC)2 takes in more CuCl2 to result in a Cu2(FLXDTC)2Cl2 kind binuclear complex with sulfur atom bridges Antimicrobial, antioxidant, antifungal, anti-malarial and antitumor capabilities have been tested for both FLXDTC and M(FLXDTC)2 complexes. Molecular docking studies on Cu(FLXDTC)2 with the intercession of EGFR protein show good antimicrobial and antifungal activities. Biological studies of manganese and nickel complexes have shown excellent antioxidant activity with IC50 values of 11.29 ± 1.85 and 11.51 ± 1.38 μM. Three different cancer cell lines, viz., MCF-7, HepG-2 and HEK 293 have been subjected to the anticancer screening for FLXDTC and it metal complexes whereby it is revealed that Cd(FLXDTC)2 has greater activity against MCF-7 (IC50 = 23.08 ± 0.12 µM), HepG-2 (IC50 = 12.30 ± 0.25 µM) whereas Zn(FLXDTC)2 exhibits good anticancer activity against MCF-7 (IC50 = 28.63 ± 1.36 µM), HepG-2 (IC50 = 19.24 ± 1.04 µM).

Dithiocarbamate (DTC) was synthesized using tetraethylenepentamine (TEPA) and carbon disulfide as raw materials. The product was characterized by FTIR and its chelating performance of removing lead ion in water was evaluated. The results are shown as follows. Characterization results from the FTIR spectra suggest the target product DTC has been successfully synthesized. The efficiency of removing lead ion or degree of removal increases with removing time, pH value, and DTC dosage, respectively, and then keeps almost unchanged when continuously increasing each of these factors. On the other hand, the degree of removal decreases with the initial concentration of lead ion. Meanwhile, the amount of sorption decreases with the DTC dosage and increases with the initial concentration of lead ion. 99.9% of degree of removal is obtained under a condition including 6 of pH, 220 min of removing time, 3.2 g L–1 of DTC dosage, and 40 mg L–1 of initial ion concentration. The relationship between the amount of sorption and equilibrium lead concentration is in good accordance with the isothermal equation of Langmuir model while it is in worse accordance with that of Freundlich model. It suggests that the chelating process is a monolayer coverage resulting from the chemical combination by the DTC groups, namely the chelating active sites. What’s more, the product of chelating reaction between DTC and Pb2+ ion is more stable and insoluble in water so that it can be easily separated from the solution. Accordingly, the synthesized DTC in this work is a good reagent for removing Pb2+ ion in wastewaters and will be widely used in the field of environment protection.

How to efficiently and economically remove heavy metals from sewage has been a huge challenge in the world. This article reports on an adsorbing material with comb-shaped chitosan–grafted polyethyleneimine dithiocarbamate (CC-GP-D), which is prepared by grafting polyethyleneimine on chitosan as main chain via glutaraldehyde, then reduce the generated C=N double bond using NaBH4, and finally functionalizing primary and secondary amino groups with CS2. This comb-shaped structure adsorbent material can better contact with heavy metal ions, so that it can absorb more heavy metal ions at a faster rate. This material is more green, environmentally friendly and economical with chitosan as the main chain. The material can effectively adsorb heavy metals in sewage, such as cadmium (II), copper (II), lead (II), nickel (II), and cobalt (II). After 80 min of adsorption, its adsorption capacity for cadmium (II), copper (II), lead (II), nickel (II), and cobalt (II) reached 178.7 mg/g, 138.9 mg/g, 337.7 mg/g, 109.2 mg/g, 157.6 mg/g respectively.

We report herein a modular class of organic catalysts that, acting as donors, can readily form photoactive electron donor-acceptor (EDA) complexes with a variety of radical precursors. Excitation with visible light generates open-shell intermediates under mild conditions, including nonstabilized carbon radicals and nitrogen-centered radicals. The modular nature of the commercially available xanthogenate and dithiocarbamate anion organocatalysts offers a versatile EDA complex catalytic platform for developing mechanistically distinct radical reactions, encompassing redox-neutral and net-reductive processes. Mechanistic investigations, by means of quantum yield determination, established that a closed catalytic cycle is operational for all of the developed radical processes, highlighting the ability of the organic catalysts to turn over and iteratively drive every catalytic cycle. We also demonstrate how the catalysts' stability and the method's high functional group tolerance could be advantageous for the direct radical functionalization of abundant functional groups, including aliphatic carboxylic acids and amines, and for applications in the late-stage elaboration of biorelevant compounds and enantioselective radical catalysis.

Dithiocarbamate derivatives possess diverse biological activities. This work further expands their activity profile by identifying seven benzylamine-containing dithiocarbamate derivatives with piperazine and piperidine substitutions at the main moiety, and five piperazine-containing dithiocarbamates with various substitutions at the piperazine moiety as new inhibitors of α-glucosidase. Compounds bearing the benzylamine moiety exhibited more potent inhibition of the enzyme than the piperazine derivatives. Majority of the compounds non-competitively inhibited α-glucosidase that led to the identification of a new allosteric site on the enzyme with the help of molecular dynamics and docking studies. These studies suggest that the compounds regulate inhibition of the enzyme by binding to an allosteric site that is located in the vicinity of the active site. This is the first report on the allosteric inhibition of α-glucosidase by dithiocarbamate derivatives that provides insights into the mechanism of inhibition of the enzyme at molecular level. Moreover, it also explores new avenues for drug development of α-glucosidase inhibitors as antidiabetic drugs.

Strongly acidic wastewater produced in nonferrous metal smelting industries often contains high concentrations of Ni(II), which is a valuable metal. In this study, the precipitation of Ni(II) from strongly acidic wastewater using sodium dimethyldithiocarbamate (DDTC) as the precipitant was evaluated. The effects of various factors on precipitation were investigated, and the precipitation mechanism was also identified. Finally, the nickel in the precipitates was recovered following a pyrometallurgical method. The results show that, under optimised conditions (DDTC:Ni(II) molar ratio = 4:1; temperature = 25 °C), the Ni(II) removal efficiency reached 99.3% after 10 min. In strongly acidic wastewater, the dithiocarbamate group of DDTC can react with Ni(II) to form DDTC Ni precipitates. Further recovery experiments revealed that high-purity NiO can be obtained by the calcination of DDTC Ni precipitates, with the nickel recovery efficiency reaching 98.2%. The gas released during the calcination process was composed of NO2, CS2, H2O, CO2, and SO2. These results provide a basis for an effective Ni(II) recovery method from strongly acidic wastewater.

The collecting capacity of xanthate, dithiocarbamate and their combination was studied. The effect of activity with respect to the gas-liquid interface of derivative forms of reagents represented by physically sorbed forms of collector was considered. Flotation experiments of lead-zinc ore from the Gorevsky deposit showed an increase in flotation performance when using reagent combinations. The use of a collector with pronounced chemisorbable properties in combination with a reagent having surface-active properties towards the gas-liquid interface caused an increase in the recovery of useful component. It was determined that activity of the physical form of sorption affects the selectivity of lead and zinc recovery - as activity of the physically sorbed form of reagent decreases, the selectivity of recovery grows.

Three chlorido(triphenylphosphine)ruthenium(II) dithiocarbamate complexes - [RuCl(PPh3)3(Mbzdtc)] 1, [RuCl(PPh3)3(Ppipdtc)] 2, and [RuCl(Ph3)3(Mordtc)] 3 with Mbzdtc = N-methylphenyldithiocarbamate...

Cadmium dithiocarbamate and cadmium ethyl xanthate complexes were synthesized and characterized by microanalysis, Fourier transform infrared (FT-IR) spectroscopy and thermogravimetric analyses. The complexes were employed as molecular precursors for the fabrication of CdS nanoparticles in hexadecylamine (HDA) and oleylamine (OLA) at a temperature of 250 degrees C. Spherical and oval shaped particles with sizes ranging from 9.93 +/- 1.89 to 16.74 +/- 2.78 nm were obtained in OLA while spherical, oval and rod shaped particles with sizes ranging from 9.40 +/- 1.65 to 29.90 +/- 5.32 nm were obtained in HDA. Optical properties of the nanoparticles showed blue shifts as compared to the bulk CdS, with the OLA capped nanoparticles slightly more blue shifted than the corresponding HDA capped nanoparticles. Results of crystallinity patterns revealed hexagonal phase of CdS.

Four new mononuclear/coordination polymeric (CP) zinc(II) complexes (1-4) of ferrocenyl/pyridyl-functionalized dithiocarbamate ligands, N-ferrocenylmethyl-N-butyl dithiocarbamate (L1), N-ferrocenylmethyl-N-ethylmorpholine dithiocarbamate (L2), N-ferrocenylmethyl-N-2-(diethylamino)ethylamine dithiocarbamate (L3), and N-4-methoxybenzyl-N-3-methylpyridyl dithiocarbamate (L4), have been synthesized and characterized by elemental analyses, IR, UV-vis, and 1H and 13C{1H} NMR spectroscopic techniques. The solid-state structures of complexes 1, 3, and 4 have been determined by single-crystal X-ray crystallography as well as powder X-ray diffraction. Single-crystal X-ray crystallography revealed a monomeric structure for complex 1 but 1D polymeric structures for complexes 3 and 4. In all complexes, dithiocarbamate ligands are bonded to the Zn(II) metal ion in a S^S chelating mode, and in the CPs, N atoms on the 2-(diethylamino)ethylamine and 3-pyridyl functionalities in the ligands on the neighboring molecules are also bonded to metal centers, leading to the formation of either a discrete tetrahedral molecule in 1 or 1D CP structures in 3 and 4. The Zn(II) metal centers in the polymeric structures exhibited either square-pyramidal or octahedral geometries. The supramolecular structures in these complexes are sustained via C-H···π (ZnCS2, chelate; 3 and 4), C-H···π, and H···H interactions. The catalytic performances of complexes have also been assessed in the Knoevenagel condensation and one-pot multicomponent reactions. Catalysis results showed that the CP 3 acts as a heterogeneous bifunctional catalyst with excellent transformation efficiency at low catalyst loading.

This article describes the effect of ammonium pyrrolidine dithiocarbamate, an inhibitor of NF-κB activation, on the biomechanical characteristics of femoral bones in rats under the conditions of combined excess intake of fluoride and sodium nitrate. The series of experiments were performed on 30 white Wistar rats weighing 190-240 g, divided into 3 groups: 1st group included intact animals, 2nd group included animals exposed to the combined administration of sodium fluoride (10 mg/kg body weight) and sodium nitrate (500 mg / kg body weight) for 30 days; the 3rd group included rats, who starting from the 15th day of intoxication were injected with an inhibitor of NF-κB activation, ammonium pyrrolidine dithiocarbamate is a dose of 76 mg / kg 3 times a week. The investigation of the biomechanical properties of the femur was performed according to a 2-point scheme (linear rupture test) and a 3-point scheme (bending test) using a rupture machine RMU-0.05-1 with an assessment of rupture load (strength) and bone elongation (elasticity); we also applied a 4-point scheme (bending test) using the deformation test setup MRC-1 with following calculation of the Young's modulus, tensile strength, relative residual deformation to failure and relative elongation to failure. The administration of ammonium pyrrolidine dithiocarbamate under the conditions of the experiment significantly increased the tensile load at linear rupture and bending by 35.3 and 23.5%, respectively, compared with the results in the 2nd group. The relative elongation of the femoral bones in the test for linear rupture and flexion was more pronounced than the values ​​of the 2nd group by 7.9 and 18.6%. When testing for bending according to the 4-point scheme using the deformation setup MRK-1, we revealed a probable increase in the Young's modulus of elasticity by 19.8% compared to the results in the 2nd group. However, the indicators of the limit of elasticity and strength, the relative elongation of the extreme fibers before fracture did not change significantly. This enables us to conclude that ammonium pyrrolidine dithiocarbamate, the inhibitor of the NF-κB transcription factor, used under the conditions of combined administration of fluoride and sodium nitrate can serve an effective osteoprotective agent, which increases the strength and elasticity of the femoral bones.

We report the synthesis and morphological studies of lead sulphide nanoparticles prepared from lead(II) complexes of morpholine dithiocarbamate (PbS1), thiomorpholine dithiocarbamate (PbS2), and N-(2-hydroxyethyl)phenyl dithiocarbamate (PbS3). Powder X-ray diffraction patterns (p-XRD) of the PbS nanoparticles are indexed to face-centered cubic phase of PbS. High-resolution transmission electron microscopy (HRTEM) micrograph revealed quasi-spherical PbS nanoparticles with particle size in the range 13.86–36.06 nm while scanning electron microscopy (SEM) revealed flaky/spherical/rough surface morphology. Photocatalytic degradation of methylene blue dye by the PbS nanoparticles showed degradation efficiency of 72.6 % for PbS1, 75.9 % for PbS2, and 47.4 % for PbS3. The photodegradation efficiency shows a correlation between efficiency and morphological properties. Total organic content removal by PbS2 is 69.5 % while that of PbS1 is 64.2 % and PbS3 is 40.1 %. The as-prepared PbS nanoparticles exhibited remarkable photostability in the recyclability studies.

Background: α-Glucosidase is a hydrolyzing enzyme that plays a crucial role in the degradation of carbohydrates and starch to glucose. Hence, α-glucosidase is an important target in carbohydrate mediated diseases such as diabetes mellitus. Objective: In this study, novel coumarin containing dithiocarbamate derivatives 4a-n were synthesized and evaluated against α-glucosidase in vitro and in silico. Methods: These compounds were obtained from the reaction between 4-(bromomethyl)-7- methoxy-2H-chromen-2-one 1, carbon disulfide 2, and primary or secondary amines 3a-n in the presence of potassium hydroxide and ethanol at room temperature. In vitro α-glucosidase inhibition and kinetic study of these compounds were performed. Furthermore, a docking study of the most potent compounds was also performed by Auto Dock Tools (version 1.5.6). Results: Obtained results showed that all the synthesized compounds exhibited prominent inhibitory activities (IC50 = 85.0 ± 4.0-566.6 ± 8.6 μM) in comparison to acarbose as a standard inhibitor (IC50 = 750.0 ± 9.0 μM). Among them, the secondary amine derivative 4d with pendant indole group was the most potent inhibitor. Enzyme kinetic study of the compound 4d revealed that this compound competes with a substrate to connect to the active site of α-glucosidase and therefore is a competitive inhibitor. Moreover, a molecular docking study predicted that this compound interacted with the α-glucosidase active site pocket. Conclusion: Our results suggest that the coumarin-dithiocarbamate scaffold can be a promising lead structure for designing potent α-glucosidase inhibitors for the treatment of type 2 diabetes.

Diabetes is becoming a major threat to the world. A novel series of hybrids of coumarin-dithiocarbamate were designed and synthesized, as potential alpha-glucosidase inhibitors targeting type 2 dia...

Methionine-gold nanoparticles (MGNs) was synthesized by conjugating methionine via dithiocarbamate linkage to gold nanoparticles (GNPs), prepared simultaneously by one pot modified Burst method. Formation of MGNs was confirmed by UV-visible spectroscopy and appearance of new IR bands in the range of 934 cm−1 to 1086 cm−1 and shifting of N-C,S-S and S-C-S stretching, confirms the involvement of ‘-S-C-S-’ group of methionine dithiocarbamate with GNPs. The presence of Au in MGNs was confirmed by EDXA spectrum, whereas TEM, SAED and XRD revealed that MGNs are nanocrystalline (~13 nm) and have face-centered cubic structure. MGNs was labeled with 99mTc (TMGNs) with radiolabeling efficiency greater than 99% using 300 μg of stannous chloride, pH 7 and 90.6 MBq of 99mTcO4. The stability data showed that the conjugate will remain infrangible in systemic circulation and in acidic microenvironment of tumor. The blood kinetic profile of TMGN in rabbits and biodistribution studies in EAT tumor bearing balb/c mice showed longer in vivo circulation and slow clearance compared to radiolabeled methionine (TM). TMGN demonstrated nearly three-fold higher tumor accumulation (3.9 ± 0.35% ID/g), 2-fold lower tumor saturation dose (1.0 μg/kg) and higher tumor retention compared with TM. Data showed that the TMGN tumor: blood ratio (1.05) is nearly 2.5-fold higher than TM (0.44), whereas TMGN tumor: muscle ratio (97.5) is nearly 8-fold higher than TM (11.6). In conclusion, TMGN showed excellent tumor targeting and has promising prospects as a SPECT-radiopharmaceutical for imaging tumors.

The synthesis and structural characterization of new dithiocarbamate (DTC) ligand and some of its dinuclear transition metal complexes are described. The free dithiocarbamate ligand was prepared through several synthetic routes, including Schiff-base formation. The reaction of 2-aminopropane with terephthaldehyde leads to the formation of Schiff_base which is reduced by methanolic NaBH4 to the corresponding secondary diamine. Diamine( N,N'_ (1,4 phenylenebis (methylene)) bis(propan-2 amine)) reacts with (CS2) in a basic solution of (KOH) to provide the corresponding bis(dithiocarbamate) free_ligand, which undergoes complexation with the appropriate metal (II) chloride to constitute macrocyclic complexes. Characterization of the ligand and its complexes was achieved by FTIR, UV-Vis, melting points, conductance, magnetic susceptibility, and 1H, 13C NMR spectroscopy. The analytical and spectroscopic data were employed to obtain the suggested geometries around metal centres. These studies revealed the formation of dinuclear macrocyclic complexes of the general formula [M(L)]2 (where M= Mn(II) , Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)), with tetrahedral. geometries for Mn(II) , Fe(II), Co(II) and Zn(II), and square. planar geometry with Ni(II) and Cu(II) complexes.

Two new Ni(II) complexes, bis(N-(pyrrol-2-ylmethyl)-N-(2-phenylethyl)dithiocarbamato-S,S′)nickel(II) (1) and (N-(pyrrol-2-ylmethyl)-N-(2-phenylethyl)dithiocarbamato-S,S′)(thiocyanato-κN)(triphenylphosphine)nickel(II) (2) were synthesized and characterized by elemental analysis, IR, UV-vis and NMR spectroscopy. IR and 13C{1H} NMR spectra of both complexes suggest that the dithiocarbamate ligands interact with metal ion as bidentate ligands. Electron spectra reveal square planar geometry for both complexes. A detailed description of crystal structure, DFT calculations and Hirshfeld surface analysis of 2 is also reported. The structure determination of 2 by X-ray crystallography confirmed the presence of four coordinated Ni(II) with distorted square planar geometry. The optimized geometry, HOMO – LUMO energy gap, molecular electrostatic potential (MEP) map and global reactivity descriptors were obtained using DFT calculations. The geometric parameters calculated for 2 using the DFT method are in good agreement with those obtained from single crystal X-ray structure determination. One of the interesting structural features of 2 are the obvious intramolecular and intermolecular C-H···Ni anagostic interactions. Hirshfeld surface analysis showed the nature of intermolecular contacts. The largest contribution to the crystal packing is from H···H interactions.

The reaction of AuCl(SMe2) with equimolar NaO5NCS2 [O5NCS2 = (aza-18-crown-6)dithiocarbamate] in CH3CN gave [Au2(O5NCS2)2]·2CH3CN (2·2CH3CN), where six other 2·solvates (solvates = 2DMF, 2DMSO, 2THF, 2acetone, 1.5toluene, and 1.5anisole) can be successfully isolated from different crystal-growing processes (i.e., ether diffusion, layer method, or evaporation in air) by dissolving the dry powder samples of 2·2CH3CN in the respective solvents, and their crystal structures are all determined by X-ray diffraction as well. It is noted that there are different intermolecular Au(I)···Au(I) contacts in combination with various luminescences for 2·solvates and indeed there is a close relationship between intermolecular Au(I)···Au(I) contacts [i.e., 2.8254(7)-2.9420(5) A] and luminescence energies (i.e., 554-604 nm), including three examples of 2·2CH3CN, 2·0.5m-xylene, and 2·tert-butylbenzene·H2O reported in our previous work. In 2·solvates, the toluene and tert-butylbenzene solvates have the shortest [2.8254(7)-2.8289(7) A] and longest [2.9420(5) A] intermolecular Au(I)···Au(I) contacts, respectively, and consequently they show the respective lowest (604 nm) and highest (554 nm) luminescence energies. Indeed, 2·solvates exhibit different types of time-dependent luminescence upon solvate loss in air. Furthermore, B3LYP/LanL2DZ calculation results can help to clarify the relationship between intermolecular Au(I)···Au(I) contacts and luminescence energies for 2·solvates.

A modular synthetic platform for selective sensing and removal of Hg2+ was developed. This modular system possesses a unique feature to gradually increase the sensitivity even in competitive environments via increasing the number of Hg2+-coordinating units. This was made possible by synthesising a sequence-defined oligomer (SDO) with dithiocarbamate (DTC) as the Hg2+-coordinating unit in its backbone. Because it is a SDO, the Hg2+-coordinating unit was systematically increased to achieve a detection limit of 3 × 10−13 M, which is, to the best of our knowledge, the lowest reported. Any fluorophore can be synthetically attached via post-synthetic modification of the SDO to improve the efficiency of the sensor. Additionally, any functional group can be incorporated via custom synthesis of monomer to modulate the chemical property of the sensor. The same platform was shown as a removal system for Hg2+ with >95% removal efficiency via complexation and precipitation methods.

Three new one dimensional ferrocene decorated Hg(II) based coordination polymers with the general formula of (FcCH2N(C2H4OH)NCS2HgX)n {X = Cl (FcHgCl); Br (FcHgBr); I (FcHgI)} have been synthesized using a functionalized dithiocarbamate ligand with a redox active ferrocene pendant and –C2H4OH and have been characterized by microanalyses, FTIR, 1H, 13C, and 199Hg NMR, electronic absorption and photoluminescence spectroscopy. The redox properties of these compounds have been assessed by cyclic voltammtery which suggested their quasi-reversible redox behaviour. Single crystal X-ray diffraction studies suggested that the geometries around all three Hg(II) polymers are square pyramidal and two such square-pyramids fuse in an antiparallel mode in FcHgCl and FcHgI and in an orthogonal mode in FcHgBr to generate a ferrocene decorated 1D polymeric framework. The adjacent 1D polymeric chains in all three compounds are held by different intermolecular interactions which provide stability to these compounds in the solid state. Also, these compounds exhibit interesting Hg⋯X (X = Cl, Br and I) spodium bonding interactions. The nature of all these interactions have been studied by Hirshfeld surface analyses, density functional theory and quantum theory of atoms in molecules (QTAIM). The QTAIM results indicated that Hg⋯X interactions are moderately strong with interaction energies of 9.32, 44.37 and 19.56 kJ mol−1 for chloro, bromo and iodo derivatives, respectively. Further bond order calculations also suggest the presence of spodium bonding interaction in all three polymers.

The capacity of novel selective dithiocarbamate collectors, namely, morpholine dithiocarbamate (MDTC) and S-cyanoethyl N, N-diethyldithiocarbamate (CEDETC) to form complex compounds with gold on the surface of sulphide minerals containing fine gold under conditions of flotation is experimentally proved. MDTC adsorption at the surface of chalcopyrite without gold takes places due to formation of morpholine dithiocarbamate copper. At chalcopyrite and arsenopyrite containing gold fines, MDTC-Au and CEDETC-Au compounds are formed. MDTC and CEDETC improve floatability of gold-bearing sulphides as against gold-free minerals, which is beneficial for the production of Au–Cu concentrates with lower content of As and Fe by flotation.

Colorectal cancer (CRC) is a common malignant tumour of human digestive tract. The high mortality rate of CRC is closely related to the limitations of existing treatments. Thus, there is an urgent need to search for new anti-CRC agents. In this work, twenty novel coumarin-dithiocarbamate derivatives (IDs) were designed, synthesized and evaluated in vitro. The results suggest that the most active compound ID-11 effectively inhibited the proliferation of CRC cell lines while shown little impact on normal colon epithelial cells. Mechanism studies revealed that ID-11 displayed bromodomain-containing protein 4 inhibitory activity, and induced G2/M phase arrest, apoptosis as well as decreased the expression levels of the key genes such as c-Myc and Bcl-2 in CRC cell lines. Moreover, the ADMET properties prediction results shown that ID-11 possess well metabolic characteristics without obvious toxicities. Our data demonstrated that compound ID-11 may be a promising anti-CRC agent and deserved for further development.

In this article, we reported the hybrid copolymerization of ethylene and cyclic ketene acetals (CKAs) mediated by dithiocarbamate, in which the propagating radicals could open the rings of CKAs to incorporate cleavable ester units into the polyethylene backbone. The molecular weights and ester incorporation in the produced copolymers could be easily regulated. Furthermore, lipase could degrade the ester-containing polyethylene (PE)-based copolymers into short fragments effectively.

Food matrices consist of many components with different physical and chemical properties that may influence instrumental robustness. The soybean contains fatty coextractives which may have a deleterious effect on the gas chromatography (GC) system. In this study, the efficiencies of PSA, C18OH, C18, silica, aluminum oxide, and Florisil, as dSPE clean-up sorbents, were evaluated by the high-performance liquid chromatography (HPLC) diode-array detector and evaporative light-scattering detector analysis. The dithiocarbamates in soybean samples are determined as CS2 using acidic hydrolysis and isooctane partitioning, followed by GC-PFPD and GC-ITD-MS analyses. The linearity of the analytical curves, the instrument limit of detection matrix effects, the trueness and precision, and the method limit of quantification (LOQ) were assessed in the validation study. Milled soybean was spiked with thiram solution at three concentration levels (corresponding to 0.05, 0.1, and 0.5 mg CS2 kg-1) for recovery determination. Silica appeared to be an effective and cheap sorbent to remove coextracted matrix components without causing any CS2 losses. Recoveries were in the range of 68-91%, with relative standard deviations ≤ 8.7%. The method LOQ was 0.05 mg CS2 kg-1, and both GC-ITD-MS and GC-PFPD systems appeared to be appropriate and complementary to determine dithiocarbamate residues in soybean extracts.

Precise control over the monomeric sequence on natural sequence-defined polymers (SDPs) leads to their structural diversity and functions. However, absolute control over the monomeric sequence on a...

Simin Yu,1,* Ning Wu,2,* Jianmin Zhu,3 Ying Liu,4 Jinbin Han1 1Department of Traditional Chinese Medicine, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Oncology, Shanghai Pudong New Area Gongli Hospital, Shanghai, People’s Republic of China; 3Shanghai Clinical Center, Chinese Academy of Sciences/Xuhui Central Hospital, Shanghai, People’s Republic of China; 4Department of Oncology, Yunnan Provincial Hospital of Chinese Medicine, Kunming, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinbin Han Tel +862123271699Fax +862163136856Email 18621100359@163.comPurpose: To investigate whether pyrrolidine dithiocarbamate (PDTC) could facilitate arsenic trioxide (ATO) to induce apoptosis in pancreatic cancer cells via perturbing ubiquitin-proteasome pathway.Methods: Mass spectrometry was performed to examine the interaction between PDTC and ATO, and the data showed they could form a complex termed PDTC-ATO. Inhibiting effects on cell viability were examined by CCK-8 test, and apoptosis was examined by flow cytometry. Four treatment arms (n = 6), including the control, PDTC, ATO, and PDTC-ATO, were evaluated using BALB/c nude mouse models bearing a xenograft tumor of SW1990 human pancreatic cancer line. Western blot, immunohistochemistry assays were to detect the mechanism.Results: The results showed that PDTC-ATO had higher inhibiting effects on proliferation of pancreatic cancer cells than ATO in vitro. In bearing-tumor mice, PDTC-ATO inhibited tumor growth by 79%, being more potent than ATO (by 46%) or PDTC (by 35%) compared to the control. Results of Western blot and immunohistochemistry showed proteasome inhibition and apoptotic cell death, together with obvious suppression of associating E3 ubiquitin ligase activity, occurred more frequently in tumors treated with PDTC-ATO than those with ATO.Conclusion: PDTC demonstrated the function to facilitate ATO against pancreatic cancer due to forming a stable complex to perturb ubiquitin-proteasome pathway.Keywords: arsenite, ubiquitin ligase, pancreatic cancer cell, dithiocarbamate, complex

Fifteen novel dithiocarbamate-derived naphthalimides as a type of potential anticancer and antimicrobial agents were synthesized and characterized by spectral and analytical techniques. The structures of 2b, 5a, and 7b were established by X-ray crystallography. Their in vitro antitumor activities were evaluated by the MTT method against MDA-MB-231, HepG-2, PC12, as well as A549. Based on the results of the MTT assay, compound 7c bearing a morpholinyl substituent displayed the highest activity and selectivity toward HepG-2 cancer cells with an IC50 of 10.86 µM. All new compounds were screened for their antimicrobial activity against Candida albicans, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. The preliminary results showed that compound 7d (an N-methyl piperazine) showed high efficacy against B. subtilis with a minimum inhibitory concentration value of 7.6 µM, which was superior to that of the clinical drug, Cefuroxim. It is found that the anticancer and antibacterial activities of the dithiocarbamate-naphthalimide derivatives were significantly enhanced when bearing a 1,2,3-triazole group.

Improving the charge transfer of quantum dots and the electron transport layer can greatly improve the efficiency of quantum dot sensitized solar cells (QDSSC). In this work, we used the ligand exchange method to improve the electron transfer efficiency between CdSe QDs and electron transport layer. The short chain-ligand containing disulfide bond and benzene ring conjugated structure was selected as the surface ligand of CdSe QDs. Because of its unique disulfide bond and conjugated structure, the stability and electron transfer efficiency of QDs in TiO2 layer can be effectively improved. The surface ligand has good stability and the ability to promote charge transfer, which can effectively improve the efficiency of QDSSC. By characterizing of fluorescence performance and the analysis of fluorescence lifetime, the surface of this ligand behaves fluorescence quenching phenomenon and life decay phenomenon after modification. Furthermore, photovoltaic devices constructed by the as-prepared dithiocarbamate functionalization of CdSe@TiO2 have also been assembled with the highest PCE of 5.22%.

For the first time, 129Xe NMR measurements are utilized to explore adsorption mechanism between porous structures of mesoporous corn starch and Palladium. Dithiocarbamate modified mesoporous corn starch (donated as DTC MS) was synthesized and applied for adsorption of Pd (II) ion successfully. The structural characterization of DTC MS was carried out by FT-IR, 13C solid-state NMR and XRD, respectively. To study the adsorption mechanism, variable temperature 129Xe NMR was measured on samples of DTC MS and Pd adsorbed in DTC mesoporous starch (donated as Pd-DTC MS), respectively. It was found that Pd ions were mainly located inside pores and channels instead of the surface of mesoporous starch. The results not only demonstrate that 129Xe NMR spectroscopy is a powerful tool to assess the porous structure of MS, but also pave the way for investigating the interaction between functional molecules and porous starch.

Hexadecylamine-capped PbS nanoparticles were prepared from lead(II) complexes of dibenzyl dithiocarbamate (Dibzydtc) [PbS 1], imidazolyl dithiocarbamate (Imdtc) [PbS 2], 2-oxo-pyrrolidine dithiocarbamate (Pydtc) [PbS 3], diallyl dithiocarbamate (Diallyldtc) [PbS 4], and dihexyl dithiocarbamate (Dihexdtc) [PbS 5], at 120 °C. Powder X-ray diffraction patterns of the PbS nanoparticles are indexed to the face-centered cubic phase. The average particle sizes obtained from the TEM images are 19.04 ± 5.85 nm for PbS 1, 6.94 ± 1.71 nm PbS 2, 18.77 ± 3.37 nm PbS 3, 2.93 ± 2.20 nm PbS 4 and 22.02 ± 6.68 nm for PbS 5. The PbS nanoparticles are spherical in shape except for PbS 1 and PbS 3 with cubic shapes. The bandgap energies range from 3.0 to 3.8 eV and PbS 1 has the lowest bandgap of 3.0 eV while PbS 3 has the highest bandgap of 3.8 eV. The bandgaps are blue-shifted in comparison to the absorption band edges due to quantum size effect. The photocatalytic degradation of bromothymol blue by the as-prepared PbS nanoparticles showed highest degradation efficiency of 66% for PbS 3.

In this work, dithiocarbamate (-NH-CS2)-functionalized dendritic fibrous nanosilica (KCC-1) with significant adsorbtion capacity was effectively synthesized using the reliable reaction process. Field emission scanning electron microscopy, FT-IR and transmission electron microscopy were used to analyze particle size and morphology of nanoadsorbent. Additionally, the functionalization of bare materials (dendritic fibrous nanosilica) with dithiocarbamate was confirmed with FT-IR and energy-dispersive X-ray spectroscopy. Furthermore, nitrogen adsorption/desorption analysis (BET equation) was utilized to evaluate KCC-1-NH-CS2 porosity (surface are, pore size, pore volume). The UV–Vis spectrophotometric method was used to evaluate organic dye removal from aqueous solutions. It was found that dithiocarbamate-functionalized KCC-1-NH2 with narrow size distribution, high surface area (133 m2/g) and effortlessly available pores had good potential for highly efficient removal of malachite green (MG) from contaminated waters. Electrostatic interactions between the negatively charged dithiocarbamate group (NH-CS2−) of nanoadsorbent and cationic MG in KCC-1-NH-CS2 channels provided a rapid (45 min) removal of this organic contaminated agent from waste water with adsorbtion capacity higher than 98%. Finally, an efficient nanoadsorbent was introduced to remove organic dyes from wastewaters and industrial purification.

This work reports the first investigation on the physical vapor deposition of thin films of tin sulfide doped lead sulfide (SnS:PbS). In-situ synthesis route using diethyldithiocarbamate (DTC) ligand was adopted for SnS-DTC, PbS-DTC and SnS:PbS-DTC complex formation. PbS-DTC and SnS:PbS-DTC expressed an average crystallite size of 30.98 and 29.74 nm, respectively shown by X-ray diffraction (XRD) analysis. A face centered cubic geometry was revealed from XRD. Ultraviolet visible spectrophotometry expressed a direct and indirect band gap of 3.4 and 3.2 eV, respectively for SnS:PbS-DTC. A smooth morphology with presence of larger agglomerated particles was disclosed by scanning electron microscopy for SnS:PbS-DTC thin films with 615 nm thickness. SnS:PbS-DTC thin films expressed remarkable electrochemical behavior explored via cyclic voltammetry, linear sweep voltammetry and chronoamperometry showing an improvement in the photo-current response upon potential bias increment. The results of the current research indicated the potential of SnS:PbS-DTC thin films for utilization in different types of photovoltaic devices.

A series of five dithiocarbamate and their respective Ag(I) and Cu(I) triphenylphosphine complexes of the general formula [Ag/Cu(PPh3)2L] were synthesized and characterized. The dithiocarbamate ligands were synthesized from formamidines with substituents in the 2 and/or 6 positions of the phenyl rings, intentionally keeping substituents on one ring different from those of the second phenyl ring while investigating the structure-activity relationship of Ag(I) and Cu(I) dithiocarbamate complexes. All Ag(I) and Cu(I) complexes with the general formula [Ag(PPh3)2L] (1–5) or [Cu(PPh3)2L] (6–10), displayed distorted tetrahedral geometry around the metal centers with coordination via two S atoms of the dithiocarbamate ligand and two P atoms from the PPh3 units. Complexes 1–5 showed better inhibition values against Gram-positive, Staphylococcus aureus (methicillin resistant) and Staphylococcus aureus than the standard used, ciprofloxacin. Complexes 1 and 2 generally had good activity against all bacterial strains but were not active against Salmonella typhimurium. All Cu(I) complexes were either of low activity or inactive against all bacterial strains tested. Complex 2 was found to be more active with IC50 values of 1.34 × 10−3 mM and 0.25 mM as agents for antioxidant activity against DPPH and NO free radical scavengers, respectively. The metal center played a vital role in their biological activity as the Ag(I) complexes displayed better antibacterial and antioxidant activity than Cu(I) complexes.

Two different octadentate gadolinium chelates based on DO3A and DOTAGA chelates (hydration number q = 1) have been used to prepare a series of bi-, tri-, and tetrametallic d–f mixed-metal complexes. The piperazine-based dithiocarbamate linker ensures that rotation of the gadolinium chelates is restricted, leading to enhanced relaxivity (r1) values, which increase with the overall mass and number of gadolinium units. The r1 value (at 10 MHz, 25 °C) per gadolinium unit rises from 5.0 mM–1 s–1 for the Gd-DO3A-NH2 monogadolinium chelate to 9.2 mM–1 s–1 in a trigadolinium complex with a ruthenium(III) core. Using a 1.5 T clinical scanner operating at 63.87 MHz (25 °C), an 86% increase in the relaxivity per gadolinium unit is observed for this multimetallic compound compared to clinically approved Dotarem. The gadolinium complexes based on the DOTAGA chelate also performed well at 63.87 MHz, with a relaxivity value of 9.5 mM–1 s–1 per gadolinium unit being observed for the trigadolinium d–f mixed-metal complex with a ruthenium(III) core. The versatility of dithiocarbamate coordination chemistry thus provides access to a wide range of d–f hybrids with potential for use as high-performance MRI contrast agents.

Tris(N-methylbenzyldithiocarbamato)iron(III) complex was used to prepare iron sulfide (FeS) nanocrystals, FeS1 at 120, FeS2 at 180 and FeS3 at 240 °C. P-XRD revealed that the nanocrystals FeS1 and ...

Cancer is one of the main causes of mortality in the world. New compounds are currently being synthesized to overcome this disease. Organotin is getting more attention as anticancer agent due to its potent cytotoxic properties towards cancer cells. In this study, a series of newly synthesized organotin compounds known as dimethyltin(IV) (compound 1), dibutyltin(IV) (compound 2) and triphenyltin(IV)methylisoprophyldithiocarbamate (compound 3) have been assessed for their cytotoxic effect towards leukemic cell line K-562. MTT [3-(4,5-dimethylthiozol-2-yl)-2,5-diphenyltetrazolium bromide] assay was employed to determine the cytotoxic effect for each of the compounds at different time points and concentrations. Compound 2 and 3 exhibited potent cytotoxic effects towards K-562 cells with IC50 values less than 2 µM. Compound 3 was found as the most toxic towards K-562 cells based on the lowest IC50 value for 72 h period of treatment at 0.25 µM. Morphological observation was conducted with IC50 values at 24, 48, and 72 h. Results showed that the changes were first observed as early as 24 h and the most significant changes were observed after 72 h period of treatment with the characteristic of apoptosis such as cell shrinkage and membrane blebbing. In addition, necrosis characteristic such as cell lysis and swelling had also been observed. Organotin(IV) methylisopropyldithiocarbamate with different functional groups affect the cytotoxic properties towards leukemic cells K-562 and these compounds have potential to be developed as an anticancer agent through structural modification.

Three new homoleptic cadmium (II) dithiocarbamate complexes having molecular formula [Cd(KL)2], (KL1 = C15H13N1F1S2) (1); (L2 = C13H11N1F1S2) (2); (L3 = C11H14N1O1S2) (3), have been synthesized and characterized by elemental analysis, spectroscopy (IR, 1H and 13CNMR and UV–Vis). Single crystal X-ray studies confirm that the complex 1 crystallises in Orthorhombic with space group Pna21 and holding dimeric structure. In this complex Cd2+ having distorted octahedral geometry about the metal centre forms 1D coordination polymeric structures. The dimeric form of complex 2 and 3 crystallizes in triclinic crystal lattice with space group P-1.

We report the novel thioacyl-transfer ring-expansion polymerization (REP) of thiiranes, using 3H-benzothiazol-2-thione (BTT) as the cyclic dithiocarbamate initiator and tetrabutylammonium chloride ...

International audience; A series of platinum(II) complexes bearing N-heterocyclic carbene NHC of the type [(NHC)PtX(L)] where L is a dithiocarbamate ligand and X iodide were prepared and fully characterized. The molecular structure of one derivative was determined by single-crystal X-ray analyses confirming that the dithiocarbamate is acting as a bidentate ligand to the metal. All complexes demonstrated potent in vitro antiproliferative activities against cancer cells. Mechanistic investigations revealed that mitochondrial dysfunction and ROS (Reactive Oxygen Species) production were correlated with the cytotoxic process induced by these complexes.

Mercury(II) complexes of N,N′-diarylformamidine dithiocarbamate of the general formula [Hg-(L)2] (L = N,N′-bis(2,6-dimethylphenyl)formamidine dithiocarbamate L1 (1), N,N′-bis(2,6-disopropylphenyl) formamidine dithiocarbamate L2 (2), N,N′-mesityl formamidine dithiocarbamate L3 (3), N′-(2,6-dichlorophenyl-N-(2,6-dimethylphenyl) formamidine dithiocarbamate L4 (4), N′-(2,6-dichlorophenyl)-N-(2,6-diisopropylphenyl) formamidine dithiocarbamate L5 (5) and N′-(2,6-dichlorophenyl)-N-mesityl formamidine dithiocarbamate L6 (6)) have been synthesized and characterized by physicochemical and spectroscopic techniques. The molecular structures of 1, 2 and 6 were unequivocally determined using single-crystal X-ray diffraction as mononuclear species in which the Hg(II) centers are coordinated to four sulfur atoms from two dithiocarbamate ligands resulting in distorted square planar geometries. Complexes 1, 3 and 6 were used as single-source precursors to prepare mercury sulfide nanoparticles HgS1, HgS3 and HgS6 in oleylamine which acted as the solvent as well as the capping agent. HR-TEM images of HgS1, HgS3 and HgS6 particles are nanospherical in shape with size distribution between 5 and 16 nm. Powder XRD pattern confirmed the β phase (metacinnabar) of HgS in all the nanoparticles with an average crystallite size similar for HgS1 and HgS3, 9.35 and 9.46 nm, respectively, and smaller crystallite sizes, 5.15 nm for HgS6. The optical properties information obtained from the UV–visible and photoluminescence spectra of the HgS nanoparticles showed evidence of quantum confinement.

The authors find that morpholine dithiocarbamate (MDTC) and S-cyanoethyl N, N-diethyl dithiocarbamate (CEDETC) are capable to form stable compounds with gold in the solution and to form an adsorption layer on the surface of gold-bearing sulphides, which points at them as new selective collectors for gold recovery from rebellious ore. The coating area of MDTC on the surface of chalcopyrite, arsenopyrite and pyrite, with new discrete growths is quantitatively assessed. CEDETC improves floatability of chalcopyrite by 1.5–2.0 times as against butyl xanthate at low consumption of reagents, while difference in floatability of chalcopyrite and arsenopyrite considerably grows, which is indicative of a beneficial effect on production of Au-Cu concentrates with lower As content by flotation.

A novel near-infrared light photothemal-activated H2S-donating nanocomposite hydrogel was developed, through combination of a thermo-labile H2S donor and photothermal nanoparticles in agarose hydrogel. The polyethylenimine dithiocarbamate polymer, a thermo-labile compound, was synthesized as a novel H2S donor. The combination of a thermo-labile hydrogen sulfide donor and photothermal nanoparticles enabled the generation of H2S in agarose hydrogel upon irradiation with near-infrared light. The ability to modulate the photoirradiation for controlled generation and spatiotemporally release of H2S are its specific advantages. This photothermal spatiotemporally controlled H2S-releasing strategy was successfully applied to anti-inflammation treatment in a rat model, demonstrating its utility as a novel H2S-based therapeutic approach.

An efficient method is disclosed for the synthesis of novel α,β-unsaturated sulfonic acid derivatives containing dithiocarbamate/xanthate groups through ring opening of an α,β-unsaturated γ-sultone with dithiocarbamic acid salts or xanthates prepared in situ. Treatment of the primary products with hydrochloric acid afforded the corresponding β-chloro-γ-(dithiocarbamato)propanesulfonic acids in excellent yields.

We report the synthesis and spectroscopic characterization of the first organotin(IV) complexes with cyclic seven-membered dithiocarbamate ligands: the azepane-1-carbodithioate and the homopiperazi...

A fibrous grafted metal adsorbent with a piperazinyl-dithiocarbamate (PZ-DTC) group was synthesized by radiation-induced emulsion grafting of glycidyl methacrylate onto a polyethylene-coated polypropylene nonwoven fabric (PE/PP-NF) and subsequent three-step chemical modifications consisting of amination with N-(tert-butoxycarbonyl)piperazine (N-Boc-piperazine, NBPZ), deprotection of the Boc group with HCl, and dithiocarbamation with carbon disulfide (CS2). By using the NBPZ reagent in the amination step, the self-cross-linking of piperazine (PZ) could be completely suppressed, unlike using the PZ reagent. Consequently, the PZ-DTC group density of the fibrous grafted metal adsorbent synthesized through NBPZ attained 2.122 mmol-PZ-DTC/g-adsorbent, which was approximately 6 times higher than that of the metal adsorbent synthesized through PZ. The fibrous grafted metal adsorbent with the PZ-DTC group selectively adsorbed heavy metal ions over light metal ions. Furthermore, it exhibited high adsorption capacity, particularly for Cu2+. The Cu2+ adsorption capacity was determined to be 1.903 mmol-Cu2+/g-adsorbent by a batchwise adsorption test using a single-metal-ion aqueous solution at pH 6. The order of metal ion selectivity of the fibrous grafted metal adsorbent with the PZ-DTC group was Na+ < Mg2+, Ca2+, Co2+, Cd2+ < Pb2+ ≪ Cu2+, and Co2+ ≈ Ni2+ < Zn2+ ≪ Cu2+. In addition, the fibrous grafted metal adsorbent with the PZ-DTC group did not lose its metal adsorption function even under highly alkaline conditions (pH 15). It could recover Cu2+ efficiently and selectively from a high-concentration Na+ aqueous solution at this pH. The Cu2+ adsorption capacity of the fibrous grafted metal adsorbent with the PZ-DTC group was 0.754 mmol-Cu2+/g-adsorbent under a highly alkaline condition, a 10 M NaOH aqueous solution at pH 15. This value was approximately 2.4 times higher than that of the other grafted adsorbent with an amine-type functional group.

In present investigation, seven copper(II) complexes were synthesized using various aniline dithiocarbamate. The synthesized Cu(II) complexes were studied for different structural and chemical parameters using XRD, EXAFS and XANES. The output obtained from X-ray studies was synthesized using Athena and Origin 6.0 software. The results of the investigation were used in determining the structures of the synthesized complexes. The particle size of the synthesized complexes ranged between 46.7 and 125.3 nm. The lattice constant of Cu(II) complexes was found 3.61-3.62 Å.

Ethylene bis(dithiocarbamates) (EBDTCs) have been used as staple fungicides for over 75 years. The first industrially manufactured EBDTC was zineb, zinc ethylene bis(dithiocarbamate), marketed unde...

A semiconductor photocatalyst was prepared in facile, standard conditions by integrating 1% metal-free, sulphur-doped graphene oxide (sGO) as cocatalyst and Ag3VO4 as photocatalyst and characterised via spectroscopic, microscopic and voltammetric techniques. The catalytic activity was performed on notable water pollutants like textile dyes and fungicide employing various techniques. Cationic dyes such as methylene blue and rhodamine B were degraded > 99% with above 90% organic carbon content removal indicating total mineralisation while anionic dyes were degraded 75–80% in 1 h. For the first time, a dithiocarbamate fungicide thiram is degraded to give thiourea as a product in 1 h. Photocatalysis follows pseudo-first order kinetics with rate 3.67, 49.50 and 3.19 times higher than Ag3VO4, sGO and GO-Ag3VO4 respectively with excellent stability and recyclability. One percent sGO aided excellent carrier separation boosted by electrons and surface defects from sGO, morphology and n-n heterojunction formation. The catalyst efficiently removed 82.8% of the total organic carbon content of a real water sample from the textile mill under 2-h sunlight irradiation.