1. Molecular imprinting of boronate functionalized polyaniline for enzyme-free selective detection of saccharides and hydroxy acids
- Author
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Arkady A. Karyakin, Vita N. Nikitina, Anatoly K. Yatsimirsky, Ivan Kochetkov, Elena E. Karyakina, and Nikolay V. Zaryanov
- Subjects
chemistry.chemical_classification ,Conductive polymer ,Analyte ,Metals and Alloys ,02 engineering and technology ,Polymer ,Conductivity ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,chemistry ,Polyaniline ,Polymer chemistry ,Materials Chemistry ,Electrical and Electronic Engineering ,Imprinting (psychology) ,0210 nano-technology ,Selectivity ,Molecular imprinting ,Instrumentation - Abstract
The majority of reagentless affinity sensors suffer from poor selectivity because specific binding and non-specific interactions generate responses in the same direction, commonly causing resistance increase. We report on the advanced transducer, synthesized in course of molecular imprinting, which generates conductivity increase as a result of specific binding. Electropolymerization of 3-aminophenylboronic acid (3-APBA) known to yield conductive polyaniline only in the presence of F−, has been carried substituted the latter for hydroxy acids. The achieved synthesis of conductive polymer in course of fluoride-free 3-APBA electropolymerization indicates successful imprinting of hydroxy acids. Imprinting poly(3-APBA) provides as 10–15 times increased, as even decreased binding constants towards target analytes as compared to the non-imprinted polymer. This allows one to achieve the desired selectivity among polyols. Tuning binding properties of boronate functionalized polyaniline we’ve demonstrated the enzyme-free selective detection of saccharides and hydroxy acids via conductivity increase of the conductive polymer.
- Published
- 2017