1. Recent Progress in Metal Catalyzed Direct Carboxylation of Aryl Halides and Pseudo Halides Employing CO2: Opportunities for11C Radiochemistry
- Author
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Joost Verbeek, Muneer Ahamed, Uta Funke, Alfons Verbruggen, Joan Lecina, and Guy Bormans
- Subjects
010405 organic chemistry ,Chemistry ,Reducing agent ,Aryl ,Organic Chemistry ,Synthon ,Aryl carboxylates ,PET tracers ,chemistry.chemical_element ,Halide ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,Carboxylation ,Transition metal ,Organic chemistry ,radiochemistry ,Physical and Theoretical Chemistry ,[11C]CO2 ,Carbon - Abstract
Carbon dioxide (CO2) as a synthon in organic transformations is very useful, especially when combined with transition metal catalysts. CO2 insertion on carbon(Aryl)-metal bonds are an elegant way to construct carbon-carbon bonds. A limited number of reports has been published to date on direct conversion of aryl halides (or pseudo halides) to aryl carboxylic acids using transition metal catalysts. These reactions place great demand on the choice of catalyst, starting material and reducing agent being used. However, these approaches could be of interest for the synthesis of a wide range of biologically active small molecules. Such transformations have already been applied for the synthesis of radiolabeled compounds for imaging with positron emission tomography (PET) using cyclotron produced [11C]CO2 and may be applicable to produce diverse range of PET tracers in the future. ispartof: ChemCatChem vol:8 issue:24 pages:3692-3700 status: published more...
- Published
- 2016
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