536 results on '"Triethylborane"'
Search Results
2. Triethylborane-Assisted Synthesis of Random and Block Poly(ester-carbonate)s through One-Pot Terpolymerization of Epoxides, CO2, and Cyclic Anhydrides
- Author
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Nikos Hadjichristidis, Yves Gnanou, Senthil Boopathi, Vamshi Krishna Chidara, and Xiaoshuang Feng
- Subjects
Phthalic anhydride ,Polymers and Plastics ,Organic Chemistry ,Triethylborane ,Succinic anhydride ,Epoxide ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Polymer chemistry ,Materials Chemistry ,Copolymer ,Reactivity (chemistry) ,Propylene oxide ,0210 nano-technology ,Cyclohexene oxide - Abstract
Poly(ester-carbonate) copolymers were synthesized through triethylborane (TEB)-activated, one-pot copolymerization of epoxides with anhydrides (AH) and CO₂. Depending upon the feeding ratio of AH to the epoxides, poly(ester-carbonate) copolymers with random and tapered ester structures could be derived due to the much higher reactivity of AH toward growing oxanions compared to the reactivity of CO₂. Anhydrides like succinic anhydride (SA) and phthalic anhydride (PA) when tried in terpolymerization with epoxides, like propylene oxide (PO) and cyclohexene oxide (CHO), and CO₂ indeed exhibited such high reactivities in comparison to CO₂ that tapered block structures were eventually obtained for high feeding ratios of AH to PO and random copolymers for the AH-to-epoxide feeding ratio lower than 10%. Terpolymerization with different feeding ratios of anhydrides to epoxides was thus systematically investigated. In an alternate path, diblock poly(ester-b-carbonate)s were prepared by sequential copolymerization of epoxide/anhydride and epoxide/CO₂. All of the obtained copolymers were characterized by ¹H nuclear magnetic resonance (NMR), diffusion-ordered spectroscopy (DOSY), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC). The structures and properties of copolymers obtained by terpolymerizations and block copolymerizations were compared.
- Published
- 2021
3. Boron‐Catalyzed Polymerization of Dienyltriphenylarsonium Ylides: On the Way to Pure C5 Polymerization
- Author
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Nikos Hadjichristidis and Xin Wang
- Subjects
Triethylborane ,Substituent ,Boranes ,010402 general chemistry ,01 natural sciences ,Catalysis ,chemistry.chemical_compound ,ylides ,Polymer chemistry ,polymers ,chemistry.chemical_classification ,010405 organic chemistry ,Communication ,boranes ,General Chemistry ,Polymer ,General Medicine ,Communications ,0104 chemical sciences ,reaction mechanisms ,Monomer ,chemistry ,Polymerization ,Ylide ,Polymers | Hot Paper ,Methyl group ,arsonium - Abstract
The first C5 polymerization is reported, where the main‐chain is growing by five carbon atoms of the monomer at a time. Three dienyltriphenylarsonium ylide monomers were synthesized and polymerized with triethylborane as an initiator, leading to random terpolymers (C1, C3, C5) with mainly C5 repeating units (up to 84.1 %). It has been found that the methyl group (electron‐donating substituent) on the conjugated double bond of the ylides facilitates the formation of C5 segments. A mechanism was proposed based on NMR characterization and DFT calculations. The high C5 content ensures that things are on the right track for pure C5 homopolymerization., Reported for the first time is an unusual borane‐initiated polymerization of arsonium ylide monomers, where the main‐chain grows by five carbon atoms, from the monomer, at a time and leads to unique structures.
- Published
- 2021
4. Forskolin Editing via Radical Iodo- and Hydroalkylation
- Author
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Pruteanu, Elena, Tappin, Nicholas D. C., Gîrbu, Vladilena, Morarescu, Olga, Dénès, Fabrice, Kulciţki, Veaceslav, and Renaud, Philippe
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Forskolin ,010405 organic chemistry ,organic chemicals ,Radical ,Organic Chemistry ,Triethylborane ,chemistry.chemical_element ,010402 general chemistry ,Iodine ,01 natural sciences ,Acetonide ,Medicinal chemistry ,Catalysis ,0104 chemical sciences ,Sulfone ,chemistry.chemical_compound ,chemistry ,540 Chemistry ,570 Life sciences ,biology ,Moiety ,Stereoselectivity - Abstract
The modification of highly oxygenated forskolin as well as manoyl and epi-manoyl oxide, two less functionalized model substrates sharing the same polycyclic skeleton, via intermolecular carbon-centered radical addition to the vinyl moiety has been investigated. Highly regio- and reasonably stereoselective iodine atom transfer radical addition (ATRA) reactions were developed. Unprotected forskolin afforded an unexpected cyclic ether derivative. Protection of the 1,3-diol as an acetonide led the formation of the iodine ATRA product. Interestingly, by changing the mode of initiation of the radical process, in situ protection of the forskolin 1,3-diol moiety as a cyclic boronic ester took place during the iodine ATRA process without disruption of the radical chain process. This very mild radical-mediated in situ protection of 1,3-diol is expected to be of interest for a broad range of radical and non-radical transformations. Finally, by using our recently developed tert-butylcatechol-mediated hydroalkylation procedure, highly efficient preparation of forskolin derivatives bearing an extra ester or sulfone group was achieved.
- Published
- 2021
5. Value-added chemicals from biomass-derived furans: radical functionalisations of 5-chloromethylfurfural (CMF) by metal-free ATRA reactions
- Author
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Lisa Marie Gronbach, Daniel Schmidhuber, Julia Rehbein, Rajesh Dasi, and Malte Brasholz
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Addition reaction ,Atom-transfer radical-polymerization ,Organic Chemistry ,Triethylborane ,Biochemistry ,chemistry.chemical_compound ,5-Chloromethylfurfural ,chemistry ,Computational chemistry ,Yield (chemistry) ,Molecular orbital ,Physical and Theoretical Chemistry ,Selectivity ,Natural bond orbital - Abstract
Biomass-derived 5-chloromethylfurfural (CMF), a congener of the well-known carbohydrate-based platform chemical 5-hydroxymethylfurfural (HMF), can efficiently be functionalised by radical transformations of its benzylic chloromethyl group. We report here the first examples of these radical reactions by way of metal-free, triethylborane/oxygen-induced atom transfer radical addition (ATRA) reactions between CMF and styrenes, which proceed with high yield and selectivity. The key intermediate, the 2-formyl-5-furfuryl radical derived from CMF, and its radical addition reactions were studied with regard to its electronic structure, i.e. spin density distribution and frontier molecular orbitals based on the NBO ansatz and activation barriers of the addition step using DFT and post-HF methods.
- Published
- 2021
6. Activation and Deactivation of Chain-transfer Agent in Controlled Radical Polymerization by Oxygen Initiation and Regulation
- Author
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Chunna Lv, Xiangcheng Pan, Ning Li, Yuxuan Du, and Jia-Hua Li
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chemistry.chemical_classification ,010407 polymers ,Polymers and Plastics ,Autoxidation ,Chemistry ,General Chemical Engineering ,Radical ,Organic Chemistry ,Radical polymerization ,Triethylborane ,chemistry.chemical_element ,Chain transfer ,Polymer ,Photochemistry ,01 natural sciences ,Oxygen ,0104 chemical sciences ,chemistry.chemical_compound ,Molecule - Abstract
The activation and deactivation of the chain-transfer agent were achieved by oxygen initiation and regulation with triethylborane under ambient temperature and atmosphere. The autoxidation of triethylborane overcame the oxygen inhibition and produced initiating radicals that selectively activate the chain-transfer agent for the chain growth or deactivate the active chain-end of polymer in controlled radical polymerization. Both activation and deactivation were highly efficient with broad scope for various polymers with different chain-transfer agents in both organic and aqueous systems. Oxygen molecule was particularly used as an external regulator to initiate and achieve the temporal control of both activation and deactivation by simply feeding the air.
- Published
- 2020
7. Lewis pair catalyzed highly selective polymerization for the one-step synthesis of AzCy(AB)xCyAz pentablock terpolymers
- Author
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Shuaishuai Zhu, Xingping Zhou, Xiaolin Xie, Ding Wanzhi, Yonggui Liao, and Yong Wang
- Subjects
Phthalic anhydride ,Lactide ,Polymers and Plastics ,Organic Chemistry ,Triethylborane ,Bioengineering ,Biochemistry ,chemistry.chemical_compound ,Monomer ,chemistry ,Polymerization ,Polymer chemistry ,Copolymer ,Propylene oxide ,Selectivity - Abstract
A key challenge in polymer chemistry is to regulate the polymer sequence and architecture from versatile monomer mixtures. Here we describe the triethylborane/1,8-diazabicyclo[5.4.0]undec-7-ene (Et3B/DBU) pair catalysed highly selective terpolymerization of mixtures of propylene oxide (PO), phthalic anhydride (PA) and racemic lactide (rac-LA), wherein the catalytic efficiency and the polymerization selectivity are significantly correlated to the Et3B/DBU feed ratio. With H2O as a cheap and efficient initiator, the Et3B/DBU pair (1/1) demonstrates chemoselective control over the ring-opening copolymerization (ROCOP) of PO/PA and the ring-opening polymerization (ROP) of rac-LA, while the Et3B/DBU pair (2/1) additionally allows for the discrimination of rac-LA and PO in ROP via kinetic control, affording one-step access to unique AzCy(AB)xCyAz pentablock terpolymers (Đ < 1.15) without transesterification scrambling.
- Published
- 2020
8. Computational Investigation of β-hydrogen Elimination in the (C2X5)2B(C2H5); X=H, F, Cl, Br Molecules
- Author
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Saideh Ghorbaninezhad and Reza Ghiasi
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Arrhenius equation ,Hydrogen ,Chemistry ,Organic Chemistry ,Triethylborane ,chemistry.chemical_element ,Atmospheric temperature range ,Kinetic energy ,Biochemistry ,Electronegativity ,symbols.namesake ,chemistry.chemical_compound ,Halogen ,symbols ,Physical chemistry ,Molecule - Abstract
In this paper, the DFT methods were applied at the M06-2X/6–311++G(d,p) levels of theory to investigate the β-hydrogen elimination in the (C2X5)2B(C2H5); X=H, F, Cl, Br. It was attempted to show how the electronegativity of halogen affects the barrier height (ΔE‡) and thermodynamic parameters (ΔG‡ and ΔH‡) of this reaction. The Wiberg bond indices were employed to check the progress of the reactions. The synchronicity values of the reactions were determined as well. The kinetic parameters of these reactions were computed in 300-1200 K temperature range. Furthermore, the fitted equations to the gas phase Arrhenius equation were found. Effect of the electronegativity of halogen was exemplified on the kinetic parameters.
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- 2020
9. Properties of Copolymers of Butyl Acrylate with Vinyl Isobutyl Ether Obtained Using the Triethylborane – Oxygen System by the Compensating Method
- Author
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Yu.O. Matkivskaya, L. L. Semenycheva, N. L. Pegeev, T.I. Liogon’kaya, N. B. Valetova, and A.V. Mitin
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chemistry.chemical_compound ,chemistry ,Butyl acrylate ,Triethylborane ,Polymer chemistry ,Copolymer ,Ether ,General Medicine ,Oxygen system - Published
- 2020
10. Asymmetric Allylic Etherification of Vinylethylene Carbonates with Diols via Pd/B Cooperative Catalysis: A Route to Chiral Hemi-Crown Ethers
- Author
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Hongfang Li, Can Zhao, Sardaraz Khan, Yong Jian Zhang, and Xue Wu
- Subjects
Allylic rearrangement ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Triethylborane ,Enantioselective synthesis ,chemistry.chemical_element ,010402 general chemistry ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Stereocenter ,Catalysis ,chemistry.chemical_compound ,Organic chemistry ,Physical and Theoretical Chemistry ,Palladium - Abstract
Pd-catalyzed regio- and enantioselective allylic etherification of vinylethylene carbonates (VECs) with diols has been developed. By using cooperative catalysts of the chiral palladium complex and triethylborane in mild conditions, the process gave monoetherified and bisetherified polyglycol derivatives with tetrasubstituted stereocenters in high yields with complete regioselectivities and high levels of enantio- and diastereoselectivities.
- Published
- 2019
11. A Giese reaction for electron-rich alkenes
- Author
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Qi Huang, Sankar Rao Suravarapu, and Philippe Renaud
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Silylation ,010405 organic chemistry ,Triethylborane ,General Chemistry ,Hydrogen atom ,Electron ,010402 general chemistry ,01 natural sciences ,Enol ,Medicinal chemistry ,0104 chemical sciences ,Chemistry ,chemistry.chemical_compound ,chemistry ,Reagent ,540 Chemistry ,Polar ,570 Life sciences ,biology ,Stereoselectivity - Abstract
A general method for the hydroalkylation of electron-rich terminal and non-terminal alkenes such as enol esters, alkenyl sulfides, enol ethers, silyl enol ethers, enamides and enecarbamates has been developed. The reactions are carried out at room temperature under air initiation in the presence of triethylborane acting as a chain transfer reagent and 4-tert-butylcatechol (TBC) as a source of hydrogen atom. The efficacy of the reaction is best explained by very favorable polar effects supporting the chain process and minimizing undesired polar reactions. The stereoselective hydroalkylation of chiral N-(alk-1-en-1-yl)oxazolidin-2-ones takes place with good to excellent diastereocontrol., Giese reaction not anymore limited to electron poor alkenes! A general method for the radical mediated hydroalkylation of electron rich alkenes including enol ethers, silylenolethers, enamides, and enecarbamates has been developed.
- Published
- 2021
12. One-Step Approach to Polyester–Polyether Block Copolymers Using Highly Tunable Bicomponent Catalyst
- Author
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Guanchen He, Junpeng Zhao, Ye Chen, Guangzhao Zhang, and Heng Li
- Subjects
Phthalic anhydride ,Materials science ,Polymers and Plastics ,Ethylene oxide ,Organic Chemistry ,Triethylborane ,One-Step ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Inorganic Chemistry ,Polyester ,chemistry.chemical_compound ,chemistry ,Polymer chemistry ,Materials Chemistry ,Copolymer ,0210 nano-technology ,Phosphazene - Abstract
Phthalic anhydride and propylene/ethylene oxide are copolymerized at room temperature by a bicomponent metal-free catalyst comprising a mild phosphazene base and triethylborane. Provided with proper loadings of the two catalytic components, block copolymers with strict (AB)
- Published
- 2019
13. Metal-free Lewis pair catalyst synergy for fully alternating copolymerization of norbornene anhydride and epoxides: Biocompatible tests for derived polymers
- Author
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Sreenath Pappuru, Anjaneyulu Kummari, Debashis Chakraborty, Rama Shanker Verma, and Piyush Kumar Gupta
- Subjects
chemistry.chemical_classification ,Materials science ,Triethylborane ,02 engineering and technology ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Polyester ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Polymer chemistry ,Materials Chemistry ,Copolymer ,General Materials Science ,Propylene oxide ,Lewis acids and bases ,0210 nano-technology ,Cyclohexene oxide - Abstract
Synthesis of high molecular weight alternating copolymers from epoxides and norbornene anhydride via metal-free catalyst remains a challenge in aliphatic biodegradable polyester synthesis. Metal-free Lewis pair catalyst system, consisting of Lewis acid B(C2H5)3 (triethylborane) and a Lewis base DMAP (4-dimethylaminopyridine); TBD (1, 5, 7-triazabicyclo[4.4.0]dec-5-ene) and DBU (1,8 diazabicyclo[5.4.0]undec-7-ene) as a cooperative catalyst system for fully alternating polyesters synthesis is described here. By using these simple systems we have obtained, high molecular weight (Mn = 2–31.5 kDa) polyesters with narrow molecular weight distributions (MWD’s = 1.948–1.069) via ring-opening alternating copolymerisation (ROAC) of various epoxides (e.g. CHO, cyclohexene oxide; PO, propylene oxide; tBGE, tert-butyl glycidyl ether and PGE, phenyl glycidyl ether) with cis-5 norbornene-endo 2, 3 dicarboxylic anhydride (NB). Furthermore, we demonstrated that these polyesters are biocompatible in nature when tested on human embryonic kidney cells (HEK-293) showing more than 80% cell viability in 72 h and can be used for different biological applications such as drug delivery, tissue engineering or anti-microbial polymeric coatings on biomedical devices. The use of these green functional polyesters for biological studies was realized for the first time by a metal-free Lewis pair approach.
- Published
- 2019
14. A BEt3-Base Catalyst for Amide Reduction with Silane
- Author
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Qiaoxing He, Huaquan Fang, Dongjie Peng, Guixia Liu, Zheng Huang, and Wubing Yao
- Subjects
010405 organic chemistry ,Hydride ,Hydrosilylation ,Organic Chemistry ,Triethylborane ,Amide reduction ,010402 general chemistry ,01 natural sciences ,Silane ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Amide ,Alkoxide ,Polymer chemistry ,Selective reduction - Abstract
Reported herein is the development of a simple but practical catalytic system for the selective reduction of amides with hydrosilane or hydrosiloxane. Low-cost and readily available triethylborane (1.0 M in THF), in combination with a catalytic amount of an alkali metal base, was found to catalyze the reduction of all three amide classes (tertiary, secondary, and primary amides) to form amines under mild conditions. In addition, the selective transformation of secondary amides to aldimines and primary amides to nitriles can also be achieved by using a proper combination of BEt3 and base. The scope of these BEt3-base-catalyzed amide hydrosilylation reactions has been explored in depth. Preliminary results of mechanistic studies suggest a modified Piers' silane Si-H···B activation mode wherein the hydride abstraction by BEt3 is promoted by the coordination of an alkoxide or hydroxide anion to the Si center.
- Published
- 2019
15. Carboxylate Salts as Ideal Initiators for the Metal-Free Copolymerization of CO2 with Epoxides: Synthesis of Well-Defined Polycarbonates Diols and Polyols
- Author
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Prakash Alagi, Yves Gnanou, Nikos Hadjichristidis, Xiaoshuang Feng, Naganath G. Patil, and Senthil Boopathi
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chemistry.chemical_classification ,Molar mass ,Polymers and Plastics ,Chemistry ,Tetrabutylammonium hydroxide ,Organic Chemistry ,Triethylborane ,Salt (chemistry) ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,visual_art ,Polymer chemistry ,Materials Chemistry ,visual_art.visual_art_medium ,Moiety ,Propylene oxide ,Carboxylate ,Polycarbonate ,0210 nano-technology - Abstract
Tetrabutylammonium carbonate (TBAC) which is obtained by treating CO2 with tetrabutylammonium hydroxide is shown to perform as an ideal difunctional initiator for the copolymerization of carbon dioxide (CO2) and propylene oxide (PO) in the presence of triethylborane (TEB). In this system, CO2 thus serves as the initiating moiety of its own copolymerization with epoxides when used in the form of a carbonate salt. Based on this remarkable result, mono-, tri-, and tetrafunctional ammonium carboxylate initiators and also other difunctional carboxylate initiators were synthesized and used for the synthesis of well-defined ω-hydroxyl-polycarbonates with linear and star structures. Well-defined telechelics, three- and four-armed star samples of molar mass varying from 1 kg/mol to 10 kg/mol, with around 95% carbonate content, were successfully synthesized. The structure of the obtained polycarbonate ω-polyols were characterized by 1H NMR, MALDI-TOF, and GPC. The terminal hydroxyl functionality of polycarbonate di...
- Published
- 2019
16. Tandem arylation and regioselective allylic etherification of 2,3-allenol via Pd/B cooperative catalysis
- Author
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Tao Li, Feng Xu, Xue Wu, Hongfang Li, Yong Jian Zhang, and Yu Jen Hsueh
- Subjects
Allylic rearrangement ,Tandem ,organic chemicals ,Aryl ,Organic Chemistry ,Triethylborane ,Regioselectivity ,chemistry.chemical_element ,Drug molecule ,Biochemistry ,Combinatorial chemistry ,Catalysis ,chemistry.chemical_compound ,chemistry ,Physical and Theoretical Chemistry ,Palladium - Abstract
An efficient method for the construction of arylated allylic ethers was developed via three-component tandem arylation and allylic etherification of 2,3-allenol with aryl iodides and alcohols. In the cooperative catalytic system of a palladium complex and triethylborane, the process allows rapid access to functionalized 1-arylvinylated 1,2-diol derivatives in good to high yields with complete branch-selectivities. The synthetic utility of the present process was demonstrated by the late-stage functionalization of a drug molecule, the gram-scale synthesis and the elaboration of the products.
- Published
- 2019
17. All-Polycarbonate Thermoplastic Elastomers Based on Triblock Copolymers Derived from Triethylborane-Mediated Sequential Copolymerization of CO2 with Various Epoxides
- Author
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Sanjay Rastogi, Xiaoshuang Feng, Dongyue Zhang, Nikos Hadjichristidis, Mingchen Jia, Yves Gnanou, Gijs W. de Kort, Carolus H. R. M. Wilsens, AMIBM, and RS: FSE AMIBM
- Subjects
construction ,Polymers and Plastics ,Allyl glycidyl ether ,Triethylborane ,Oxide ,02 engineering and technology ,010402 general chemistry ,carbon-dioxide ,01 natural sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,glycidyl ethers ,Polymer chemistry ,Materials Chemistry ,Copolymer ,Thermoplastic elastomer ,Polycarbonate ,CATALYST ,COMPLEX ,Organic Chemistry ,selectivity ,PROPYLENE-OXIDE ,FREE ALTERNATING COPOLYMERIZATION ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Monomer ,FUNCTIONAL POLYCARBONATES ,chemistry ,visual_art ,visual_art.visual_art_medium ,0210 nano-technology ,Cyclohexene oxide - Abstract
Various oxirane monomers including alkyl ether or allyl-substituted ones such as 1-butene oxide, 1-hexene oxide, 1-octene oxide, butyl glycidyl ether, allyl glycidyl ether, and 2-ethylhexyl glycidyl ether were anionically copolymerized with CO2 into polycarbonates using onium salts as initiator in the presence of triethylborane. All copolymerizations exhibited a "living" character, and the monomer consumption was monitored by in situ Fourier-transform infrared spectroscopy. The various polycarbonate samples obtained were characterized by H-1 NMR, GPC, and differential scanning calorimetry. In a second step, all-polycarbonate triblock copolymers demonstrating elastomeric behavior were obtained in one pot by sequential copolymerization of CO2 with two different epoxides, using a difunctional initiator. 1-Octene oxide was first copolymerized with CO2 to form the central soft poly(octene carbonate) block which was flanked by two external rigid poly(cyclohexene carbonate) blocks obtained through subsequent copolymerization of cyclohexene oxide with CO2. Upon varying the ratio of 1-octene oxide to cyclohexene oxide and their respective ratios to the initiator, three all-polycarbonate triblock samples were prepared with molar masses of about 350 kg/mol and 22, 26, and 29 mol % hard block content, respectively. The resulting triblock copolymers were analyzed using H-1 NMR, GPC, thermogravimetric analysis, differential scanning calorimetry, and atomic force microscopy. All three samples demonstrated typical elastomeric behavior characterized by a high elongation at break and ultimate tensile strength in the same range as those of other natural and synthetic rubbers, in particular those used in applications such as tissue engineering.
- Published
- 2020
18. Recycling a Borate Complex for Synthesis of Polycarbonate Polyols: Towards an Environmentally Friendly and Cost-Effective Process
- Author
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Senthil Bhoopathi, Nikos Hadjichristidis, Yves Gnanou, Xiaoshuang Feng, Vamshi Krishna Chidara, and Naganath G. Patil
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General Chemical Engineering ,Triethylborane ,Epoxide ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Gel permeation chromatography ,chemistry.chemical_compound ,General Energy ,chemistry ,Polymerization ,visual_art ,Propylene carbonate ,visual_art.visual_art_medium ,Copolymer ,Environmental Chemistry ,Organic chemistry ,General Materials Science ,Carboxylate ,Polycarbonate ,0210 nano-technology - Abstract
In this investigation, a metal-free process was developed that enables the synthesis of poly(propylene carbonate) (PPC) diols/polyols by copolymerization of CO2 with propylene epoxide (PO) under environmentally friendly and cost-effective conditions. This process implies the recycling of triethylborane and of ammonium salts that both enter in the composition of the initiators used to copolymerize CO2 and PO. In complement to the above approach, a polymeric support, poly(diallyl dimethylammonium chloride), was synthesized and modified to carry ammonium carboxylate salts along its chain. The prepared polymeric initiator was utilized to copolymerize CO2 with PO under heterogeneous conditions. Not only were the polymerization results similar to the samples obtained under homogeneous conditions, but the polymer substrate could easily be recovered by simple filtration. The integrity of the polycarbonate diols/polyols and the recycling process were followed by 1 H and 11 B NMR spectroscopy, gel permeation chromatography, and matrix assisted laser desorption ionization time of flight (MALDI-TOF) MS.
- Published
- 2020
19. Heats of Combustion and Formation of Trimethylborane, Triethylborane, and Tri
- Author
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Marthada V. Kilday, Edward J. Prosen, and Walter H. Johnson
- Subjects
Boric acid ,chemistry.chemical_compound ,chemistry ,Mole ,Inorganic chemistry ,Triethylborane ,Carbon dioxide ,Tri-n-butylborane ,Combustion ,Article ,Standard enthalpy of formation ,Trimethylborane - Abstract
The heats of combustion at 25 °C of trimethylborane (liquid), triethylborane (liquid), and tri-n-butylborane (liquid), to form crystalline boric acid, liquid water, and gaseous carbon dioxide have been determined to be −2989.4 ±22.4 kj/mole (−714.48 ±5.36 kcal/mole), −4975.6 ±15.1 kj/mole (−1189.2 ±3.6 kcal/mole), and −8901.0 ±10.2 kj/mole (−2127.4 ±2.4 kcal/mole), respectively. These data, combined with the heats of formation of boric acid, carbon dioxide, and water give −34.79 ±5.40, −47.2 ±3.7, and −83.2 ±2.5 kcal/mole at 25 °C for the standard heats of formation of trimethylborane, triethylborane, and tri-n-butylborane, respectively. The data of other investigators are discussed briefly.
- Published
- 2020
20. N-Heterocyclic carbene/Lewis acid-mediated ring-opening polymerization of propylene oxide. Part 2: Toward dihydroxytelechelic polyethers using triethylborane
- Author
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Qilei Song, Guangzhao Zhang, Frédéric Peruch, Stéphane Carlotti, Junpeng Zhao, Daniel Taton, South China University of Technology [Guangzhou] (SCUT), Team 1 LCPO : Polymerization Catalyses & Engineering, Laboratoire de Chimie des Polymères Organiques (LCPO), and Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)
- Subjects
Molar mass ,Polymers and Plastics ,Organic Chemistry ,Triethylborane ,Dispersity ,General Physics and Astronomy ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Ring-opening polymerization ,0104 chemical sciences ,chemistry.chemical_compound ,[CHIM.POLY]Chemical Sciences/Polymers ,chemistry ,Polymerization ,Polymer chemistry ,Materials Chemistry ,Propylene oxide ,Lewis acids and bases ,0210 nano-technology ,Carbene - Abstract
International audience; Propylene oxide (PO) is polymerized by metal-free ring-opening 11 polymerization (ROP) at 25 °C using N-heterocyclic carbenes (NHCs) and 12 triethylborane (Et 3 B) as a bicomponent catalytic system. Poly(propylene oxide)s with 13 predictable molar mass up to 60 000 g.mol-1 and low dispersity (Ð < 1.10) were 14 obtained without the occurrence of undesirable transfer reaction to the monomer. In 15 presence of an alcohol as the initiator, the ROP of PO follows an anionic mechanism 16 assisted by monomer activation improving the efficiency of NHCs for the 17 polymerization of substituted epoxides. Et 3 B is involved both in the formation of a 18 complexed active center and in the activation of PO. Interestingly, 19 dihydroxytelechelic PPOs can be readily synthesized not only using 1,4-20 benzenedimethanol but also water, both serving as difunctional initiators. Block
- Published
- 2020
21. High Efficiency Organic Lewis Pair Catalyst for Ring-Opening Polymerization of Epoxides with Chemoselectivity
- Author
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Ye Chen, Yucai Wang, Shan Liu, Guangzhao Zhang, Junpeng Zhao, and Jizhou Shen
- Subjects
Polymers and Plastics ,Ethylene oxide ,010405 organic chemistry ,Organic Chemistry ,Triethylborane ,Dispersity ,010402 general chemistry ,01 natural sciences ,Ring-opening polymerization ,0104 chemical sciences ,Catalysis ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Polymerization ,Polymer chemistry ,Materials Chemistry ,Propylene oxide ,Chemoselectivity - Abstract
Ring-opening polymerization (ROP) is a versatile approach to well-defined polymers. Achieving both high efficiency and precise control remains a major challenge. We herein report room-temperature living ROP of epoxides catalyzed by combined organobase and triethylborane (Et3B) with water or alcohols as initiators. Extremely high catalytic efficiency (turnover frequency up to 6000 h–1) is exhibited despite the relatively mild Lewis basicity and acidity, and the catalyst loading can be minimized to 44 ppm. Poly(ethylene oxide) products are noncytotoxic toward a variety of cell lines even without purification. Poly(propylene oxide) with molar mass as high as 210 kg mol–1 and low dispersity (ĐM < 1.1) can be achieved owing to the absence of detrimental transfer reactions. The chemoselectivity allows the catalyst to be readily applied to living ROP of glycidyl ethers, tailored synthesis of diverse functional/block/nonlinear (co)polyether structures, and one-pot one-catalyst synthesis of polyether-based polyure...
- Published
- 2018
22. Temperature and pH-Dual Responsive AIE-Active Core Crosslinked Polyethylene–Poly(methacrylic acid) Multimiktoarm Star Copolymers
- Author
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Nikos Hadjichristidis and Zhen Zhang
- Subjects
Poly(methacrylic acid) ,Polymers and Plastics ,Atom-transfer radical-polymerization ,Organic Chemistry ,Triethylborane ,02 engineering and technology ,Polyethylene ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Methacrylate ,01 natural sciences ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Methacrylic acid ,Amphiphile ,Polymer chemistry ,Materials Chemistry ,Copolymer ,0210 nano-technology - Abstract
A series of aggregation-induced emission (AIE) active core crosslinked miktoarm star copolymers, having multi polyethylene (PE) and poly(methacrylic acid) (PMAA) arms, were synthesized and their thermal/pH responsive properties were studied. The procedure involves (a) the synthesis of PE-Br by polyhomologation of dimethylsulfoxonium methylide with triethylborane as initiator, followed by oxidation-hydrolysis/esterification reactions and of poly(tert-butyl methacrylate) (PtBMA-Br) by atom transfer radical polymerization (ATRP) of tert-butyl methacrylate, (b) the synthesis of (PE)n-(PtBMA)m-P(TPE-2St) by ATRP of a double styrene-functionalized tetraphenylethene (TPE-2St) with PE-Br and PtBMA-Br macroinitiators, and (c) the hydrolysis of (PE)n-(PtBMA)m-P(TPE-2St) to afford the amphiphilic miktoarm star copolymers (PE)n-(PMMA)m-P(TPE-2St). Due to their spherical core–shell structure (temperature-responsive) and the presence of hydrophilic PMAA (pH-responsive) and TPE-2St (AIE), these miktoarm star copolymers ...
- Published
- 2018
23. Oxygen-Initiated and Regulated Controlled Radical Polymerization under Ambient Conditions
- Author
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Chunna Lv, Xiangcheng Pan, and Congze He
- Subjects
chemistry.chemical_classification ,010405 organic chemistry ,Radical ,Dispersity ,Radical polymerization ,Triethylborane ,Chain transfer ,General Medicine ,General Chemistry ,Polymer ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Monomer ,chemistry ,Copolymer - Abstract
A rapid oxygen-initiated and -regulated controlled radical polymerization was conducted under ambient temperature and atmosphere. The reaction between triethylborane and oxygen provides ethyl radicals, which initiate and mediate the radical polymerization. The controlled radical polymerization was achieved using RAFT chain transfer agents (CTA) without any process of removing oxygen, providing well-defined polymers with almost full conversion (>95 %) in a short period (15 min). High-throughput screening was used to discover the suitable conditions for various CTA and monomers. To show the versatility of this method, a polymer library containing 25 well-defined polymers with different compositions (block and statistical copolymers) and molecular weights were synthesized in 1 h via high-throughput synthesis technique. A polymer-painting technique was developed using this method, forming films with spatial control and excellent control in molecular weight and dispersity.
- Published
- 2018
24. 1,1-Carboboration of alkynylgermanes – New germoles
- Author
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Wolfgang Milius, Stefan Bayer, Elena V. Klimkina, and Bernd Wrackmeyer
- Subjects
Thesaurus (information retrieval) ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Triethylborane ,010402 general chemistry ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,Materials Chemistry ,Organic chemistry ,Stereoselectivity ,Physical and Theoretical Chemistry - Abstract
The C≡C bonds of various alkynylgermanes [Cl(H)Ge(C≡C–R1)2, Cl2Ge(C≡C–R1)2 with R1 = nBu, SiMe3, and Ge(C≡C–R1)4 with R1 = SiMe3] undergo 1,1-carboboration when treated with an excess of triethylborane at 80–110 °C. All pure final products with R1 = SiMe3 possess germole-derived structures. Intermediates and side products as a result of lost stereoselectivity of the 1,1-carboborations could be detected and in some cases identified by NMR spectroscopic studies of the reaction solutions.
- Published
- 2018
25. Radical 'On Water' Addition to the C═N Bond of Hydrazones: A Synthesis of Isoindolinone Derivatives
- Author
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Tae Kyu Nam and Doo Ok Jang
- Subjects
chemistry.chemical_classification ,010405 organic chemistry ,Radical ,Organic Chemistry ,Iodide ,Triethylborane ,Hydrazone ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Solvent effects ,Alkyl - Abstract
A radical "on water" addition to the C═N bond of hydrazones has been described. Hydrazone, diphenylsilane, alkyl iodide, and triethylborane afforded the corresponding addition products "on water" in good yields. A significant solvent effect was observed from the water. The developed protocol can be applied to the synthesis of 3-substituted isoindolinone derivatives. Moreover, the process offers environmentally benign tin-free radical reaction conditions.
- Published
- 2018
26. Radical Deuteration with D2O: Catalysis and Mechanistic Insights
- Author
-
Denis Patrick Vollmar, Giorgio Villa, Valentin Soulard, and Philippe Renaud
- Subjects
inorganic chemicals ,chemistry.chemical_classification ,010405 organic chemistry ,Triethylborane ,Enantioselective synthesis ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,chemistry ,Deuterium ,Mechanism (philosophy) ,Molecule ,Deoxygenation ,Alkyl - Abstract
Selective incorporation of deuterium atoms into molecules is of high interest for labeling purposes and for optimizing properties of drug candidates. A mild and environmentally benign method for the deuteration of alkyl iodides via radical pathway using D2O as source of deuterium has been developed. The reaction is initiated and mediated by triethylborane in the presence of dodecanethiol as a catalyst. This method is compatible with a wide range of functional groups and provides the monodeuterated products in good yields and with a high level of deuterium incorporation. It opens promising opportunities for the development of enantioselective radical reactions. Moreover, a revision of the mechanism of the deoxygenation reaction of xanthates using R3B and water (Wood deoxygenation) is presented.
- Published
- 2017
27. Specific features of 'compensating' copolymerization of butyl acrylate with vinyl butyl ether in the presence of triethylboron
- Author
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A. L. Eloyan, Yu. O. Matkivskaia, A. A. Moikin, L. L. Semenycheva, Yu. A. Kursky, N. B. Valetova, N. L. Pegeev, and Yu. O. Chasova
- Subjects
010405 organic chemistry ,Butyl acrylate ,Triethylborane ,Radical polymerization ,Ether ,General Chemistry ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Boiling ,Polymer chemistry ,Copolymer ,Molar mass distribution ,Macromolecule - Abstract
Copolymerization of butyl acrylate with a large excess of boiling vinyl butyl ether was carried out in the presence of triethylborane. The analysis of the composition of the obtained product demonstrated that an alternating low-molecular-weight copolymer was predominantly formed. The formation of macromolecules occurred by both conventional and controlled radical polymerization (CRP), as evidenced by a bimodal molecular weight distribution. As conversion increased, the mode corresponding to the CRP mechanism shifted toward larger molecular masses. The relative activities of comonomers for the process initiated by triethylborane were calculated.
- Published
- 2017
28. Nickel-Catalyzed Hydroalkenylation of Alkynes through C–F Bond Activation: Synthesis of 2-Fluoro-1,3-dienes
- Author
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Kohei Kanazawa, Yota Watabe, Takeshi Fujita, and Junji Ichikawa
- Subjects
Oxidative cyclization ,010405 organic chemistry ,Hydride ,Organic Chemistry ,Triethylborane ,chemistry.chemical_element ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Catalysis ,Coupling reaction ,0104 chemical sciences ,chemistry.chemical_compound ,Nickel ,chemistry ,Polymer chemistry ,Fluorine ,Lithium - Abstract
2-Fluoro-1,3-dienes were synthesized through nickel-catalyzed coupling reactions between β,β-difluorostyrenes and alkynes in the presence of ZrF4 as co-catalyst and a hydride source derived from triethylborane and lithium isopropoxide. Mechanistic studies revealed that the carbon–fluorine bond was cleaved by β-fluorine elimination from intermediary nickelacyclopentenes generated through oxidative cyclization of the two substrates.
- Published
- 2017
29. Core Cross-Linked Multiarm Star Polymers with Aggregation-Induced Emission and Temperature Responsive Fluorescence Characteristics
- Author
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Nikos Hadjichristidis, Panayiotis Bilalis, Hefeng Zhang, Yves Gnanou, and Zhen Zhang
- Subjects
Photoluminescence ,Polymers and Plastics ,Organic Chemistry ,Triethylborane ,02 engineering and technology ,Polyethylene ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Toluene ,0104 chemical sciences ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Polymerization ,Bromide ,Polymer chemistry ,Materials Chemistry ,Copolymer ,Polystyrene ,0210 nano-technology - Abstract
Aggregation-induced emission (AIE) active core cross-linked multiarm star polymers, carrying polystyrene (PS), polyethylene (PE), or polyethylene-b-polycaprolactone (PE-b-PCL) arms, have been synthesized through an “arm-first” strategy, by atom transfer radical copolymerization (ATRP) of a double styrene-functionalized tetraphenylethene (TPE-2St) used as a cross-linker with linear arm precursors possessing terminal ATRP initiating moieties. Polyethylene macroinitiator (PE–Br) was prepared via the polyhomologation of dimethylsulfoxonium methylide with triethylborane followed by oxidation/hydrolysis and esterification of the produced PE–OH with 2-bromoisobutyryl bromide; polyethylene-block-poly(e-caprolactone) diblock macroinitiator was derived by combining polyhomologation with ring-opening polymerization (ROP). All synthesized star polymers showed AIE-behavior either in solution or in bulk. At high concentration in good solvents (e.g., THF, or toluene) they exhibited low photoluminescence (PL) intensity d...
- Published
- 2017
30. An autocatalytic cycle in autoxidation of triethylborane
- Author
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Ryohei Uematsu, Tetsuya Taketsugu, Tomoya Ichino, Satoshi Maeda, Yosuke Sumiya, and Chihiro Saka
- Subjects
Autoxidation ,010405 organic chemistry ,Chemistry ,Triethylborane ,Metals and Alloys ,General Chemistry ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Homolysis ,Autocatalysis ,chemistry.chemical_compound ,Catalytic cycle ,Materials Chemistry ,Ceramics and Composites ,Density functional theory - Abstract
An autocatalytic cycle was found in the mechanism of autoxidation of triethylborane using density functional theory calculations. The reaction starts with the generation of an ethyl radical via slow homolytic substitution. Fast radical propagation then takes place through a catalytic cycle in which the ethyl radical acts as a catalyst.
- Published
- 2017
31. Expanding the scope of Et3B/O2-mediated coupling reactions of O,Te-acetal
- Author
-
Masayuki Inoue, Daigo Kamimura, Daisuke Urabe, and Masanori Nagatomo
- Subjects
chemistry.chemical_classification ,Steric effects ,Double bond ,010405 organic chemistry ,Organic Chemistry ,Triethylborane ,Acetal ,Intermolecular force ,Substrate (chemistry) ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Biochemistry ,Coupling reaction ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Electrophile ,Polymer chemistry - Abstract
Et3B/O2-mediated radical coupling reactions of O,Te-acetal 2 were explored using diverse electrophilic double bonds. Ethyl radical derived from Et3B under air cleaved the C–Te bond of 2 to generate α-alkoxy bridgehead radical I, which reacted with cycloalkenones, cycloalkylidenemalononitriles, allyl halides, and imines at or below ambient temperature. These intermolecular reactions from O,Te-acetal 2 were mild and versatile, and were superior to those of O,Se-acetal 1 in terms of efficiency and substrate scope. A total of 14 new and nine improved coupling reactions are described, all of which realized the installation of the functionalized carbon units at the sterically hindered bridgehead position of trioxaadamantane.
- Published
- 2016
32. Radical-mediated hydroalkylation of 2-vinylpyrrolidine derivatives: a versatile entry into indolizidine alkaloids
- Author
-
Sankar Rao Suravarapu, Bettina Peter, and Philippe Renaud
- Subjects
Catechol ,Bicyclic molecule ,Stereochemistry ,Indolizidine 209D ,Radical ,Triethylborane ,Indolizidine ,General Chemistry ,Alkylation ,chemistry.chemical_compound ,chemistry ,540 Chemistry ,570 Life sciences ,biology ,Monomorine - Abstract
A concise route for the preparation of two simple optically pure indolizidin-5-ones has been developed. The key chain elongation process was achieved using a triethylborane/catechol mediated hydroalkylation of Boc-protected 2-vinylpyrrolidines. By using complementary strategies, these two bicyclic lactams can be alkylated with complete control of the stereochemistry at C(5) and their conversion to a variety of indolizidine alkaloids such as coniceine, indolizidine 209D and 167B, 5-epi-indolizidine 249A and monomorine has been reported in the literature.
- Published
- 2019
- Full Text
- View/download PDF
33. Formal [3 + 2] Cycloadditions via Indole Activation: A Route to Pyrroloindolines and Furoindolines
- Author
-
Mao-Mao Zhang, Liang-Qiu Lu, Wen-Jing Xiao, Bei-Yi Cheng, Ya-Ni Wang, and Tian-Ren Li
- Subjects
Indole test ,chemistry.chemical_compound ,chemistry ,010405 organic chemistry ,Yield (chemistry) ,Organic Chemistry ,Triethylborane ,Organic chemistry ,Lewis acids and bases ,010402 general chemistry ,01 natural sciences ,Cycloaddition ,0104 chemical sciences - Abstract
Here, we describe a novel [3 + 2] cycloaddition of 3-substituted indoles with vinyl aziridines and vinyl epoxides that provides a straightforward approach to pyrroloindolines and furoindolines bearing vinyl groups (up to 96% yield and 9:1 dr). In contrary to previous reports involving Lewis acid activation, this work reports successful reactions based on the activation of indole using t-BuOK and BEt3 (triethylborane), thereby preserving the free N–H group on indoles. In addition, a gram-scale reaction and a ring-closing metatheis reaction are performed to provide good demonstrations of the synthetic utility of this approach.
- Published
- 2016
34. Preparation of the Core Structure of Aspidosperma and Strychnos Alkaloids from Aryl Azides by a Cascade Radical Cyclization
- Author
-
Benjamin Wyler, François Brucelle, and Philippe Renaud
- Subjects
Aspidosperma ,Azides ,Trimethylsilyl ,Triethylborane ,Strychnos ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,Radical cyclization ,Catalysis ,Indole Alkaloids ,Iodoacetamide ,chemistry.chemical_compound ,Alkaloids ,Organic chemistry ,Physical and Theoretical Chemistry ,Molecular Structure ,biology ,010405 organic chemistry ,Aryl ,Organic Chemistry ,Diastereomer ,Stereoisomerism ,Strychnine ,biology.organism_classification ,0104 chemical sciences ,chemistry ,Cyclization ,Quinolines ,Azide - Abstract
A novel approach to prepare the core structure of Aspidosperma and Strychnos alkaloids is described. The strategy is based on a cyclization cascade involving the formation of quaternary carbon center followed by trapping of the radical intermediate by an aryl azide to build the 5-membered ring of the pyrrolocarbazole system. This reaction is run with triethylborane without the need for any hydrogen atom donor such as a tin hydride or tris(trimethylsilyl)silane, and it furnishes the tetracyclic framework as a single diastereomer. The influence of different N-protecting groups on the starting iodoacetamide has been examined.
- Published
- 2016
35. N-Heterocyclic carbenes by tautomerization of mesomeric betaines. Thione, selenone, and borane adduct formations of imidazolium-isocytosinates
- Author
-
Jiaxi Zhang, Eike G. Hübner, Andreas Schmidt, and Matthias Franz
- Subjects
010405 organic chemistry ,Chemistry ,Organic Chemistry ,Triethylborane ,Borane ,010402 general chemistry ,Photochemistry ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,Tautomer ,0104 chemical sciences ,Adduct ,chemistry.chemical_compound ,Deprotonation ,Betaine ,Drug Discovery ,Carbene ,Derivative (chemistry) - Abstract
2-Amino-6-chloropyrimidin-4(3 H )-one (6-chloroisocytosine) reacted with methyl-, vinyl-, phenyl-, and benzylimidazole, respectively, to give isocytosinate-imidazolium salts which were deprotonated with an anion exchange resin to yield the corresponding cross-conjugated mesomeric betaines (imidazolium-isocytosinates). The vinyl derivative, however, polymerized under these conditions. The betaines are in equilibrium with their N -heterocyclic carbenes, isocytosine-imidazol-2-ylidenes. Results of DFT calculations reveal that the betaine tautomer is the most stable tautomer in polar solvents, whereas the carbene is more stable in vacuo. Trapping reactions of the carbene tautomers, including the vinyl derivative, were performed with sulfur and selenium which resulted in the formation of the corresponding thiones and selenones, respectively. The in situ generation of the betaine/carbene tautomers in the presence of triethylborane in a Schlenk tube at elevated temperatures and pressures gave novel zwitterionic 8-amino-10,10-diethyl-6-oxo-6,10-dihydro-1 H -imidazo[2′,1′:3,4][1,4,2]diaza-borolo[1,5-c]pyrimidin-4-ium-10-ides, in which the boron atom bears the negative charge whereas the positive charge is delocalized in the imidazolium ring. This ring system is a formal trapping product of the carbene as well as the betaine tautomer.
- Published
- 2016
36. P4functionalization by hydrides: direct synthesis of P–H bonds
- Author
-
Koyel X. Bhattacharyya, Sébastien Dreyfuss, Nathalie Saffon-Merceron, and Nicolas Mézailles
- Subjects
010405 organic chemistry ,Hydride ,White Phosphorus ,Triethylborane ,Metals and Alloys ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,chemistry.chemical_compound ,chemistry ,Materials Chemistry ,Ceramics and Composites ,Organic chemistry ,Surface modification - Abstract
A direct method for white phosphorus functionalization by hydride sources is presented. Excess BH4(-) in n-butylamine produces HP4(-) as the major P-containing species. Reaction with LiBEt3H forms the borane-stabilized phosphanide Li(PH2)(BEt3)2, which may be used to synthesize various phosphines. Triethylborane may be replaced by BH3, resulting in the formation of LiPH2(BH3)2.
- Published
- 2016
37. Nickel(0)-catalyzed Coupling Reactions of Carbonyls and Alkenes with Reducing Reagents Giving Six- and Seven-membered Benzocycloalkanols
- Author
-
Yukari Hayashi, Ravindra Kumar, Masato Ohashi, Sensuke Ogoshi, and Yoichi Hoshimoto
- Subjects
010405 organic chemistry ,Chemistry ,Triethylborane ,chemistry.chemical_element ,General Chemistry ,Reaction intermediate ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,Coupling reaction ,0104 chemical sciences ,Catalysis ,Nickel ,chemistry.chemical_compound ,Reagent ,Organic chemistry ,Nickel catalyst ,Triethylsilane - Abstract
Nickel(0)-catalyzed coupling reactions of 1,6- and 1,7-enals with triethylsilane have been utilized to synthesize six- and seven-membered silyl-protected benzocycloalkanols. When triethylborane was employed as the reducing reagent, tetralol derivatives were obtained. Results of deuterium-labeling experiments suggest the formation of oxanickelacycles as a key reaction intermediate.
- Published
- 2017
38. Reversible inhibition in the formation of copolymers based on alkyl (meth)acrylates with vinyl butyl ethers under compensation of the active monomer depending on their nature when initiated by the triethylborane–oxygen system
- Author
-
Yu. A. Kurskii, A.V. Mitin, Yu.O. Matkivskaya, L. L. Semenycheva, N. B. Valetova, N. L. Pegeev, and T.I. Liogon’kaya
- Subjects
chemistry.chemical_classification ,Butyl acrylate ,Organic Chemistry ,Triethylborane ,Ether ,Biochemistry ,Inorganic Chemistry ,chemistry.chemical_compound ,Monomer ,chemistry ,Polymer chemistry ,Materials Chemistry ,Copolymer ,Physical and Theoretical Chemistry ,Methyl methacrylate ,Alkyl ,Macromolecule - Abstract
Compensatory (or compensation) copolymerization of alkyl (meth)acrylates (AMA) with boiling vinyl butyl ether (VBE), initiated by the system of triethylborane (TEB)–oxygen, has been studied. The obtained data indicate a partial formation of copolymer macromolecules with close to an alternating structure, according to the reversible inhibition mechanism, along with a copolymer formation on the scheme of conventional bimolecular termination. Specific features of used acrylic monomers have been revealed. Copolymers of methyl methacrylate (MMA) and VBE were applied as macroinitiators for block-copolymer syntheses when adding new portions of butyl acrylate (BA).
- Published
- 2020
39. Purine-substituted imidazolium mesomeric betaines and their tautomeric N-heterocyclic carbenes: Formation of a cyclic borane adduct
- Author
-
Martin Nieger, Eike G. Hübner, Jan C. Namyslo, Andreas Schmidt, and Jiaxi Zhang
- Subjects
010405 organic chemistry ,Chemistry ,Organic Chemistry ,Triethylborane ,article ,Borane ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Medicinal chemistry ,Tautomer ,Caesium carbonate ,0104 chemical sciences ,Adduct ,chemistry.chemical_compound ,Deprotonation ,ddc:540 ,Reactivity (chemistry) ,Physical and Theoretical Chemistry ,Carbene - Abstract
6-Chloropurine and 2,6-dichloropurine were reacted with N1-substituted imidazoles to give purin-6-yl substituted imidazolium salts, respectively. Deprotonation of the 1-methylimidazolium derivative resulted in the formation of the corresponding stable conjugated mesomeric betaine, whereas the 1-phenyl,- 1-vinyl- and 1-(2-hydroxyethyl) derivatives proved to be unstable. In situ generation of the mesomeric betaines by caesium carbonate in the presence of sulfur and selenium, however, gave the thiones and the selenones of the tautomeric purine-substituted imidazol-2-ylidene, respectively. Its anionic N-heterocyclic carbene was formally trapped by reaction with triethylborane at high temperatures as a cyclic boron adduct which is the first representative of a new heterocyclic ring system. DFT calculations gained insight into the electronic properties of the N-heterocyclic carbenes substituted by π-electron donators. Results of a single crystal X-ray analysis of the boron adduct are presented.
- Published
- 2018
40. Triethylborane: A Simple Triorganoborane with Numerous Talents
- Author
-
Bernd Wrackmeyer and Marion Wrackmeyer
- Subjects
chemistry.chemical_compound ,chemistry ,Computer science ,Simple (abstract algebra) ,Triethylborane ,Statistical physics - Published
- 2018
41. Synthesis and Kinetic Resolution of Substituted Tetrahydroquinolines by Lithiation then Electrophilic Quench
- Author
-
Anthony J. H. M. Meijer, Iain Coldham, Lewis Reavey, Xiabing Li, and Nicholas Carter
- Subjects
010405 organic chemistry ,Triethylborane ,Chiral ligand ,Regioselectivity ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Medicinal chemistry ,0104 chemical sciences ,law.invention ,Kinetic resolution ,chemistry.chemical_compound ,chemistry ,law ,Electrophile ,Methyl cyanoformate ,Enantiomer ,Walden inversion - Abstract
Treatment of N-Boc-2-aryl-1,2,3,4-tetrahydroquinolines with n-butyllithium in THF at −78 °C resulted in efficient lithiation at the 2-position and the organolithiums were trapped with a variety of electrophiles to give substituted products. Variable temperature NMR spectroscopy gave kinetic data that showed that the rate of tert-butoxycarbonyl (Boc) rotation was fast (ΔG‡ ≈ 45 kJ mol−1 at −78 °C) and in situ ReactIR spectroscopy showed fast lithiation at −78 °C. By carrying out the lithiation in the presence of the chiral ligand sparteine, kinetic resolutions with very high levels of enantioselectivity were achieved. The resulting enantioenriched N-Boc-2-aryltetrahydroquinolines were converted to 2,2-disubstituted products without significant loss in enantiopurity. Most electrophiles add at the 2-position and the chemistry provides a way to access tetrahydroquinolines that are fully substituted alpha to the nitrogen atom. Notably, either enantiomer of the 2,2-disubstituted tetrahydroquinolines can be obtained with high selectivity from the same enantiomer of the chiral ligand. Unusually, when methyl cyanoformate was used as the electrophile, substitution occurred in the ortho position of the aryl ring attached at C-2. This change in regioselectivity on changing the electrophile was probed by deuterium isotope studies and by DFT calculations which suggested that the binding of the cyanoformate altered the structure of the intermediate organolithium. Secondary amine products can be prepared by removing the Boc group with acid or by inducing the Boc group to rearrange to the 2-position in the presence of triethylborane and this carbonyl N-to-C rearrangement occurs with retention of configuration from the intermediate enantiomerically enriched organolithium species.
- Published
- 2017
42. Conjugation of Bioactive Molecules to a Fluorescent Dithiomaleimide by Photoinduced and BEt3-Initiated Thio-Click Reactions
- Author
-
Miklós Nagy, László Lázár, Sándor Kéki, Miklós Zsuga, Anikó Borbás, and Pál Herczegh
- Subjects
chemistry.chemical_classification ,Chemistry ,Alkene ,Organic Chemistry ,Triethylborane ,Thio ,Vinyl ether ,Photochemistry ,chemistry.chemical_compound ,Click chemistry ,medicine ,Physical and Theoretical Chemistry ,Maleimide ,Tetrahydrofuran ,Derivative (chemistry) ,medicine.drug - Abstract
Two versions of the free-radical thiol–ene addition, a photoinduced reaction in the presence of 2,2-dimethoxy-2-phenylacetophenone, and a UV-light-free hydrothiolation using triethylborane as the initiator, were studied for the conjugation of fluorescent dithiomaleimide to biologically active compounds. A dithiomaleimide derivative bearing a vinyl ether functionality was prepared as the alkene partner. This was coupled with a range of thiols, including thiosugars, captopril, N-acetyl-L-cysteine, and sodium 2-sulfonatoethanethiol. The Et3B-initiated method was superior to the photoinduced reaction, as it minimized decomposition of the sensitive maleimide group. The vinyl ether derivative and the addition products showed green light emission in tetrahydrofuran. The compounds all showed almost identical absorption and emission spectra, proving that the structure of the thiols has no influence on the fluorescence properties of the maleimide part of the molecules. The hydrothiolation products showed relatively high quantum yields.
- Published
- 2015
43. Exploration of Dimethylzinc-Mediated Radical Reactions
- Author
-
Ken-ichi Yamada and Kiyoshi Tomioka
- Subjects
radical reactions ,Free Radicals ,Molecular Structure ,General Chemical Engineering ,Triethylborane ,Dimethylzinc ,General Chemistry ,Photochemistry ,Biochemistry ,Radical cyclization ,umpolung ,dimethylzinc ,Umpolung ,chemistry.chemical_compound ,Zinc ,carbon–carbon bond formation ,chemistry ,Reagent ,Materials Chemistry ,Organometallic Compounds ,Organic chemistry ,C(sp[3])–H bond functionalization ,Boranes - Abstract
In this account, our studies on radical reactions that are promoted by dimethylzinc and air are described. Advantages of this reagent and differences from conventional radical initiators, such as triethylborane, are discussed., Article first published online: 17 JUL 2015
- Published
- 2015
44. Efficient synthesis of pyrrolizidine by Pd-catalyzed consecutive double amphiphilic allylation of nitrile
- Author
-
Gen Onodera, Masanari Kimura, Naoshi Yamada, and Goki Hirata
- Subjects
Nitrile ,Bicyclic molecule ,Organic Chemistry ,Triethylborane ,chemistry.chemical_element ,Biochemistry ,Catalysis ,chemistry.chemical_compound ,chemistry ,Drug Discovery ,Amphiphile ,Pyrrolizidine ,Organic chemistry ,Palladium - Abstract
The combination of a Pd catalyst and triethylborane promotes double amphiphilic allylation of nitriles with 2-methylenepropane-1,3-diol to serve as a 1,3-dipolar equivalent, providing pyrrolizidine derivatives. The resulting bicyclic compounds can be used for efficient synthesis of important pyrrolizidine alkaloids.
- Published
- 2015
45. Ni-Catalyzed Synthesis of Fluoroarenes via [2+2+2] Cycloaddition Involving α-Fluorine Elimination
- Author
-
Yota Watabe, Tomohiro Ichitsuka, Junji Ichikawa, and Takeshi Fujita
- Subjects
Organic Chemistry ,Triethylborane ,chemistry.chemical_element ,General Chemistry ,Cleavage (embryo) ,Photochemistry ,Medicinal chemistry ,Catalysis ,Cycloaddition ,chemistry.chemical_compound ,chemistry ,Catalytic cycle ,Fluorine ,Molecule ,Fluoride - Abstract
A method for direct synthesis of tetrasubstituted fluoroarenes via nickel-catalyzed [2+2+2] cycloaddition is presented. The reaction combines one molecule of 1,1-difluoroethylene with two molecules of alkynes and involves sequential cleavage of the C-F and C-H bonds in difluoroethylene. The catalytic cycle is established by reduction of the intermediary Ni(II) fluoride with a triethylborane-based borate.
- Published
- 2015
46. Contiguous radical pivaloyloxymethylation–directed C(sp 3 )–H iodination of N -tosyl cycloalkanecarbaldimine
- Author
-
Kiyosei Takasu, Ken-ichi Yamada, Mayu Nakano, Shintaro Fujii, Kiyoshi Tomioka, and Yousuke Yamaoka
- Subjects
Stereochemistry ,Radical ,Organic Chemistry ,Triethylborane ,Halogenation ,Regioselectivity ,Pivaloyloxymethyl ,Biochemistry ,Medicinal chemistry ,chemistry.chemical_compound ,Cycloalkane ,chemistry ,Tosyl ,Cleave ,Drug Discovery - Abstract
A reaction of N-tosyl cycloalkanecarbaldimines with iodomethyl pivalate was initiated by triethylborane to give pivaloyloxymethylated products bearing 3-iodocycloalkyl groups. Radical addition of pivaloyloxymethyl to imines generates aminyl radicals, which then regioselectively cleave C H bonds at the 3-position of the cycloalkane moieties. The resulting carbon-centered radicals are trapped with iodine. DFT calculations rationalized stereo- and regioselectivity.
- Published
- 2015
47. Synthesis of bis(indolyl)methanes Catalyzed by Triethylborane
- Author
-
Yliana López, Susana Rojas, Heraclio Lopez Ruiz, and J. Pablo Garcia Merinos
- Subjects
Indole test ,Organic Chemistry ,Triethylborane ,triethylborane ,Biochemistry ,Medicinal chemistry ,Article ,Arsindoline B ,Catalysis ,Electrophilic substitution ,chemistry.chemical_compound ,indole ,chemistry ,bis(indolyl)methanes ,Single crystal ,streptindole - Abstract
Triethylborane (TEB) was found to be a mild, efficient, and acid catalyst in electrophilic substitution reaction of indoles with aldehydes compounds to afford the corresponding bis(indolyl)methanes. Vibrindole A (5) and bis(indolyl)methanes derivatives 16 and 18 were synthesized using this methodology. Compound 16 is an intermediary in the synthesis of the natural bisindoles arsindoline B (2) and streptindole (6). The structure of vibrindole A (5) was unequivocally confirmed by a single crystal X-ray diffraction analysis.
- Published
- 2015
48. Total synthesis of Daphnodorin A
- Author
-
Qingyan Sun, Wei-Dong Zhang, Rongcai Yue, Wanlin Chang, Kaijian Bi, Hu Yuan, Hui-Zi Jin, Bo Li, Lei Shan, and Ji Ye
- Subjects
Organic Chemistry ,Triethylborane ,Total synthesis ,Biochemistry ,Barton–McCombie deoxygenation ,chemistry.chemical_compound ,chemistry ,Heck reaction ,Yield (chemistry) ,Intramolecular force ,Drug Discovery ,Organic chemistry ,Benzofuran ,Deoxygenation - Abstract
A total synthesis of Daphnodorin A, a member of the Daphnodorins, was accomplished. Key features of the synthetic strategy include construction of 2-substituted-3-functionalized benzofuran via intramolecular Heck reaction and a mild Barton–McCombie deoxygenation process mediated by triethylborane. The total synthesis provided Daphnodorin A in 19.7% or 5.6% overall yield over 7 or 15 steps.
- Published
- 2014
49. Radical (2-pyridylsulfonyl)difluoromethylation of terminal alkenes with iododifluoromethyl 2-pyridyl sulfone
- Author
-
Wenjun Miao, Chuanfa Ni, Jinbo Hu, and Yanchuan Zhao
- Subjects
Inorganic Chemistry ,chemistry.chemical_compound ,Terminal (electronics) ,Chemistry ,Organic Chemistry ,Triethylborane ,Environmental Chemistry ,Organic chemistry ,Physical and Theoretical Chemistry ,Biochemistry ,Catalysis ,Sulfone - Abstract
An efficient radical (2-pyridylsulfonyl)difluoromethylation of terminal alkenes with 2-PySO2CF2I has been successfully achieved by using catalytic amount of Et3B/air as initiating system. This methodology was also further extended to the synthesis of 2-PySO2CF2-substituted alkanes and alkenes.
- Published
- 2014
50. Starch-graft-poly(methyl acrylate) copolymer: the new approach to synthesis and copolymer characterization
- Author
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Alexey V. Markin, Dmitrii V. Ludin, Evgenia Salomatina, Yulia L. Kuznetsova, Sergey D. Zaitsev, and Alla E. Mochalova
- Subjects
Materials science ,Polymers and Plastics ,Starch ,Organic Chemistry ,Triethylborane ,02 engineering and technology ,Poly(methyl acrylate) ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Borylation ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Polymerization ,Polymer chemistry ,Materials Chemistry ,Copolymer ,Thermal stability ,0210 nano-technology ,Methyl acrylate - Abstract
The two-stage method for poly(methyl acrylate) grafting starch using triethylborane and 1,4-benzoquinone has been developed. The first stage was borylation of alcohol groups of starch. The second stage was polymerization of methyl acrylate in the inhibitor - 1,4-benzoquinone - presence accompanied by the S H 2-substitution at the boron atom. The advantages of developed method were the homogeneity of the process, the high yield of graft-copolymer, the possibility to control of chain length of synthetic polymer, and the absence of homopolymer in the final product. The molecular weight characteristics of starch-graft-poly(methyl acrylate) copolymer was determined by gel-permeation chromatography. The evidence of the graft-copolymer formation was 11B nuclear magnetic resonance data and its glass-transition temperature. The resulting graft-copolymer has an amphiphilic nature and a high thermal stability compared to the corresponding homopolymers (starch and poly(methyl acrylate)). According to the calculated values of the surface Gibbs energy the surface of starch-graft-poly(methyl acrylate) films is characterized as a high-energy surface.
- Published
- 2017
Catalog
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