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Comparably large laboratory scale synthetic method of homogeneous POE nonylphenyl ethers was investigated by using williamson synthesis. Nonylphenol and dichloride of homogeneous polyethylenglycol were used as starting materials and the products with high purity were obtained by centrifugal molecular distillation or column chromatography. Their EO adducts of 4, 6, 8, 12 were prepared and some of their corresponding physical properties were determined.

Effects of levamisole (LMS) and adriamycin (ADR) on the growth of rat mammary cancer induced by 7,12-DMBA were studied. Both LMS and ADR, when administered alone, significantly inhibited growth of small tumors. When the tumor was large, however, LMS alone or ADR alone was not effective while concurrent administration of LMS and ADR resulted in inhibition of tumor growth.

Partition isotherms of hexaoxyethylene nonylphenylether (NPE 6 ), octaoxyethylene nonylphenylether (NPE 8 ), and their mixtures in the water-cyclohexane system have been determined at 25°C. The isotherms exhibited an abrupt change of slope at the critical micelle concentration (CMC). In the equilibrated two-phase system, the micellization of homogeneous NPE 6 occurred in the oil phase, while that of homogeneous NPE 8 occurred in the water phase. For the system containing NPE 6 -NPE 8 (1:1 w/w) mixture the partition isotherms of each component were obtained, and the relation between the composition of mixed monomers and their concentration both at and above the CMC was explained by the theory based on the assumptions of ideal mixing in the micelle and of a phase separation model for the micelle. The phase inversion temperatures of emulsions stabilized with mixed surfactants increased with decreasing surfactant concentration. This can be explained in terms of the changes in composition of the mixed surfactants extracted to the water phase with total surfactant concentration.

Several fungal pigments were isolated by cultivation of a strain of Aspergillus fumigatus which was isolated from the dust of asthmatic patients' rooms. Spinulosin, fumigatin and its quinol (m.p. 107.5∼109°) were determined, though the melting point of the quinol was rather much different from the literature (99∼101°). The chemical structure of a new metabolite, m.p. 74°(II) was determined as 2-methyl-5-methoxy-6-hydroxy-p-benzoquinone 2, 3-epoxide. Another compound, m.p.182°(IV) was found to have a closely related structure to II. Compound, m.p.204° had p-quinone moiety in the structure, but not the C8 compound different from all other metabolites.