1,695 results on '"Hong Yu"'
Search Results
2. LY450139 Inhibited Ti-Particle-Induced Bone Dissolution via Suppressing Notch and NF-κB Signaling Pathways
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Yuanqing Mao, Yingjun Chi, Peng Wu, Yong Zhao, jijian gao, Nan-Yan Song, and Hong-Yu Xu
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musculoskeletal diseases ,Osteolysis ,Endocrinology, Diabetes and Metabolism ,Notch signaling pathway ,Osteoclasts ,Bone resorption ,chemistry.chemical_compound ,Mice ,Endocrinology ,Osteoclast ,Osteogenesis ,medicine ,Animals ,Orthopedics and Sports Medicine ,HES1 ,Bone Resorption ,Titanium ,Alanine ,biology ,Activator (genetics) ,Chemistry ,RANK Ligand ,NF-kappa B ,NF-κB ,Azepines ,medicine.disease ,Mice, Inbred C57BL ,Disease Models, Animal ,medicine.anatomical_structure ,Solubility ,RANKL ,biology.protein ,Cancer research ,Signal Transduction - Abstract
Aseptic loosening of the prosthesis caused by wear-particle-induced osteolysis is a long-term complication and one of the most common reasons for the failure of joint implants. The primary cause of aseptic loosening of the prosthesis is overactive bone resorption caused by wear-particle-activated osteoclasts in both direct and indirect ways. Therefore, drugs that can inhibit differentiation and bone resorption of osteoclasts need investigation as a potential therapeutic strategy to prevent and treat peri-prosthetic osteolysis and thereby prolong the service life of the prosthesis. This study has verified the potential inhibitory effect of LY450139 on inflammatory osteolysis induced by titanium particles in a mice skull model. In addition, we found that LY450139 inhibited receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis, bone resorption, and podosomal actin belt formation in a dose-dependent manner without evidence of cytotoxicity in vitro. In addition, LY450139 significantly decreased the expression of osteoclast-specific markers, including TRAP, CTSK, V-ATPase d2, CTR, DC-STAMP, NFATc1, and the downstream target gene Hes1 in Notch signaling pathway. Further investigation of the molecular mechanism demonstrated that LY450139 inhibited the formation of osteoclasts via inhibition of the NF-κB and Notch signaling pathways. In summary, LY450139 inhibited the formation of RANKL-mediated osteoclasts via NF-κB and Notch signaling and inhibited Ti particle-induced inflammatory osteolysis in vivo. LY450139 is a potential targeted drug for the treatment of peri-prosthetic osteolysis and other osteolytic disease associated with overactive osteoclasts.
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- 2022
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3. Transition metal complexes with functionalized indenyl phosphine ligands: structures and catalytic properties
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Jian Chen, Hong Yu, Chi-Ming Che, Jia Yuan, Sixuan Meng, Cuiying Wang, Guang-Ao Yu, and Ying Zhang
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Organic Chemistry ,Biochemistry ,Catalysis ,chemistry.chemical_compound ,Transition metal ,chemistry ,Cyclopentadienyl complex ,Indenyl effect ,Polymer chemistry ,Reactivity (chemistry) ,Physical and Theoretical Chemistry ,Indene ,Phosphine ,Organometallic chemistry - Abstract
Transition-metal indenyl complexes usually exhibit different reactivity compared with their cyclopentadienyl analogues. Up to now, at least 10 metal-indenyl bonding modes have been reported. Because of the “indenyl effect”, transition-metal indenyl complexes usually display elevated reactivity in substitution and related reactions. This review provides an overview on the use and impact of indenyl phosphines in the organometallic chemistry and transition-metal-catalysed reactions in recent two decades. Some cationic and zwitterionic metal complexes supported by P,N-substituted indene or indenide ligands are descibed. They have been reported to induce the cleavage of the E–H (E = H, Si and B) bonds and could be used as catalysts for addition of E–H bonds to unsaturated substrates. Moreover, 2-aryl indenyl phosphine ligands L3-L12 have proven to be a class of versatile ligands for palladium-catalysed C–C and C–N cross-coupling reactions.
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- 2022
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4. Ergothioneine exhibits longevity-extension effect in Drosophila melanogaster via regulation of cholinergic neurotransmission, tyrosine metabolism, and fatty acid oxidation
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Hong-Yu Pan, Lin Junfang, Bai-Xiong Chen, Fan Yun, Guo Liqiong, Qianwang Zheng, Ming-Zhen Tu, Wei-Guo Hong, and Zhi-Wei Ye
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biology ,fungi ,Autophagy ,General Medicine ,Glutathione ,Peroxisome ,biology.organism_classification ,Cell biology ,Citric acid cycle ,chemistry.chemical_compound ,chemistry ,Ergothioneine ,Drosophila melanogaster ,Beta oxidation ,Function (biology) ,Food Science - Abstract
Many studies have demonstrated the protective effect of ergothioneine (EGT), the unique sulfur-containing antioxidant in mushrooms, on several aging-related diseases. Nevertheless, to date, no single study has explored the potential role of EGT in the lifespan of animal models. We show here that EGT consistently extended fly life span in diverse genetic backgrounds and both sexes, as well as in a dose and gender-dependent manner. Additionally, EGT is shown to increases the climbing activity of flies, enhances AchE activity, and maintains GSH/GSSG ratios of aged flies. An increase in life span by EGT was gut microorganisms dependent. Altogether, we proposed potential mechanisms of lifespan extension in Drosophila by EGT through RNA-seq analysis: preservation of the normal status of the central nervous system via the coordination of cholinergic neurotransmission, tyrosine metabolism, and peroxisomal proteins, regulated autophagic activity by altering the lysosomal protein CTSD, and the preservation of normal mitochondrial function through the controlled substrate feeding into the TCA cycle
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- 2022
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5. Nitrogen-Doped Carbon Supported Co/Ni Bimetallic Catalyst for Selectively Reductive N-Formylation of Nitroso in Guanine Synthesis
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Ke Wang, Peng Liu, Jiquan Zhao, Hong-Yu Zhang, Yuecheng Zhang, and Dongxu Shi
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chemistry.chemical_element ,General Chemistry ,Nitroso ,Catalysis ,Formylation ,chemistry.chemical_compound ,Nickel ,chemistry ,Selectivity ,Bimetallic strip ,Carbon ,Cobalt ,Nuclear chemistry - Abstract
A nitrogen-doped carbon supported Co/Ni bimetallic catalyst 2wt%Co/Ni@NC-700-10 was prepared and found to be efficient in the reductive N-formylation of 2,4-diamino-5-nitroso-6-hydroxypyrimidine (DANHP) to 2,4-diamino-5-formyl-6-hydroxypyrimidine (DAFHP) for the synthesis of guanine. Under optimal conditions, the conversion of DANHP reached up to 95.6% with a DAFHP selectivity of 97.6%. The characterization results revealed that the cobalt/nickel nanoparticles of the catalyst uniformly dispersed and encapsulated in the nitrogen-dopped carbon, and the catalyst has the characters of large surface area, as well as uniform dispersion and small diameters of metal nanoparticles in the form of Co/Ni alloy, which endowed its good catalytic performance in the reaction.
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- 2021
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6. Epoxidation of Olefins with Molecular Oxygen Over Layered Double Hydroxide Catalyst in the Presence of Benzaldehyde
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Yuwei Xin, Ya Liu, Jiquan Zhao, Yuecheng Zhang, and Hong-Yu Zhang
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Benzaldehyde ,chemistry.chemical_compound ,Olefin fiber ,chemistry ,Catalytic oxidation ,Peroxybenzoic acid ,Polymer chemistry ,Cyclohexene ,Epoxide ,Hydroxide ,General Chemistry ,Catalysis - Abstract
A Fe embedded MgAl layered double hydroxide (MgAlFe0.4-LDH) showed excellent performances in the epoxidation of various olefins with O2/benzaldehyde as oxidant at mild conditions. Under optimal conditions, the olefins including terminal aliphatic olefins, cyclohexene and styrene were all converted to the corresponding epoxides in conversions close to 100% and selectivity higher than 95%. The epoxidation is accomplished in two elementary steps, which are catalytic oxidation of benzaldehyde to peroxybenzoic acid, and epoxidation of olefin to epoxide by peroxybenzoic acid generated in situ. The catalyst also exhibited good stability and recyclability. The characterization results revealed that the Fe species are present in the state of Fe3+ fully incorporated into the Mg/Al-LDH layers, and act as active sites in the catalyst. The embedment of Fe into MgAl-LDH largely increased the surface area and pore volume of Mg/Al-LDH, which is another factor enhancing the activity of the catalyst.
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- 2021
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7. Concentrations of CHCl
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Gui-Peng Yang, Zhen He, Jie Ni, Hong Yu, and Jing Zhang
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Chlorophyll a ,Context (language use) ,Zooplankton ,Ozone depletion ,Trace gas ,Salinity ,Atmosphere ,chemistry.chemical_compound ,chemistry ,Geochemistry and Petrology ,Chemistry (miscellaneous) ,Environmental chemistry ,Environmental Chemistry ,Environmental science ,Seawater - Abstract
Environmental context Atmospheric trace gases called volatile halocarbons (VHCs) significantly contribute to ozone depletion and global warming. The oceans are a primary source of VHCs, and concentrations and fluxes of selected VHCs in the Yellow Sea and East China Sea were measured. These data, and the influence of marine environmental factors on these parameters, provide information which will permit the assessment of the marine contribution of VHC behaviour and impact. Abstract Concentrations of five volatile halocarbons (VHCs), that is, chloroform (CHCl3), trichloroethylene (C2HCl3), tetrachloroethylene (C2Cl4), bromoform (CHBr3) and chlorodibromomethane (CHBr2Cl), were measured in the South Yellow Sea (SYS) and East China Sea (ECS) during autumn in 2011. The average (min–max) concentrations of CHCl3, C2HCl3, C2Cl4, CHBr2Cl and CHBr3 in surface seawater were 63.91 (24.63–361.23), 28.46 (1.82–85.77), 21.04 (9.85–89.31), 20.92 (7.98–59.89) and 75.91 (0.04–537.04) pmol L−1 respectively. The five VHCs exhibited a point distribution in autumn with clearly defined patterns in certain areas. In the vertical profiles, the highest concentrations of VHCs generally appeared in the upper mixing layer. Different VHCs were correlated with different environmental parameters, such as temperature, salinity, chlorophyll a (Chl-a), nutrient levels and bacteria. These results revealed that the sources of these VHCs were influenced by the Yangtze River effluent and Kuroshio waters as well as the biogenic release. Diurnal bimodal cycles were obvious in the concentrations of the five VHCs in the ECS. In general, concentrations peaked around noon, likely owing to biological production and photochemical mechanisms, and a secondary peak occurred around midnight, possibly resulting from a combination of respiration, zooplankton feeding and tidal action. The estimated sea-to-air fluxes showed that the study area was a net source of the five VHCs in the atmosphere during the study period.
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- 2021
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8. Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Annulation of Aryl Halides to Furnish Indolines
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Yuecheng Zhang, Hong-Yu Zhang, Yong-Min Liang, Jiquan Zhao, Yuanfeng Li, and Ya-Ping Han
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Phosphoramidite ,chemistry.chemical_compound ,Annulation ,chemistry ,Aryl ,Intramolecular force ,Organic Chemistry ,Chiral ligand ,Indoline ,chemistry.chemical_element ,Medicinal chemistry ,Stereocenter ,Palladium - Abstract
An unprecedented Pd-catalyzed asymmetric intramolecular cascade cyclization of aryl halides with readily available arylboronic acids proceeds through a Heck-type dearomative cyclization terminated with arylation in the presence of Pd2(dba)3 (10 mol %), Cu2O (5 mol %), and Cs2CO3 (2.0 equiv) in 1,2-dichloroethane (1.0 mL) at 100 °C for 15 h in air using BINOL-based phosphoramidite as the chiral ligand. This dearomative Heck protocol, which tolerates a broad variety of functional groups, is amenable to the generation of optically active indoline derivatives bearing all-carbon quaternary stereogenic centers in one step in moderate to excellent yields, with excellent diastereoselectivities (>20:1) and enantioselectivities (up to >99% ee). It is worth mentioning that no decrease in the enantiopurity of the indoline derivatives was observed during the synthetic transformations of the products.
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- 2021
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9. Efficient biocatalysis of trillin through recombinant enzyme hydrolysis for clean diosgenin production
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Xiang Haibo, Wancang Liu, Bai-Ping Ma, Tao Zhang, Li-Yan Yu, Wen-Ni He, Jing Su, Hong-Yu Liu, Xu Pang, and Joseph Shiloach
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Environmental Engineering ,Chromatography ,biology ,Chemistry ,General Chemical Engineering ,Environmental pollution ,Diosgenin ,biology.organism_classification ,Yeast ,Pichia pastoris ,Hydrolysis ,chemistry.chemical_compound ,Biocatalysis ,Bioreactor ,Environmental Chemistry ,Acid hydrolysis ,Safety, Risk, Reliability and Quality - Abstract
Diosgenin has been widely used as a precursor in the pharmaceutical industry. The conventional diosgenin production method, direct acid hydrolysis, can cause severe environmental pollution and has low production efficiency. In this study, the β-glucosidase FBG1 was successfully over-expressed in Pichia pastoris. The engineered yeast was grown in 5- and 50-L bioreactors to a high-cell-density, and the resulting recombinant FBG1 without purification was directly used for trillin biocatalysis. A novel enzymatic biocatalysis method was established through efficient biocatalysis of trillin by recombinant FBG1 and a practical diosgenin purification process. Diosgenin production reached ∼1.7 mg/mL under optimized biocatalysis conditions with a corresponding ∼94 % trillin conversion. The production process was further scaled up from 2 mL to 20, 200, and 2000 mL working volumes, producing equivalent efficiency. This recombinant enzyme biocatalysis process resulted in ∼680 mg diosgenin when 1 g trillin was processed, together with ∼90 % environmental impact elimination and ∼36 % cost reduction. Enzymatic biocatalysis can convert trillin into a high-value-added pharmaceutical precursor of diosgenin with high eco-efficiency, cost-effectiveness, and sustainability is presented here for the first time and is a promising method for future applications in industrial processes.
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- 2021
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10. High Proton Conduction in Two Highly Water-Stable Lanthanide Coordination Polymers from a Triazole Multicarboxylate Ligand
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Yan Liu, Xiaoxin Xie, Gang Li, Xiaoge Niu, Jinpeng Li, Chenyu Mu, Yi-Hong Yu, Linke Li, and Zhongyi Liu
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chemistry.chemical_classification ,Lanthanide ,Proton ,Ligand ,Triazole ,Polymer ,Conductivity ,Inorganic Chemistry ,chemistry.chemical_compound ,Crystallography ,chemistry ,Carboxylate ,Physical and Theoretical Chemistry ,Isostructural - Abstract
Two lanthanide coordination polymers (CPs) {[Er(Hmtbd)(H2mtbd)(H2O)3]·2H2O}n (1) and [Yb(Hmtbd)(H2mtbd)(H2O)3]n (2) carrying an N-heterocyclic carboxylate ligand 5-(3-methylformate-1H-1,2,4-triazole-1-methyl)benzen-1,3-dicarboxylate (H3mtbd) were prepared under solvothermal conditions. The single-crystal X-ray diffraction data demonstrate that 1 and 2 are isostructural and display 1D chain structure. Alternating current (AC) impedance measurements illustrate that the highest proton conductivities of 1 and 2 can attain 5.09 × 10-3 and 3.09 × 10-3 S·cm-1 at 100 °C and 98% relative humidity (RH), respectively. The value of 1 exceeds those of most reported lanthanide-based crystalline materials and ranks second among the described Er-CPs under similar conditions, whereas the value for 2 is the highest proton conductivity among the previous Yb-CPs. Coupled with the structural analyses of the two CPs and H2O vapor adsorption, the calculated Ea values help to deduce their proton conductive mechanisms. Notably, the N-heterocyclic units (triazole), carboxyl, and hydrogen-bonding network all play key roles in the proton-transfer process. The prominent proton conductive abilities of both CPs show great promise as efficient proton conductors.
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- 2021
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11. Visible-Light-Induced C(sp2)–C(sp3) Cross-Dehydrogenative-Coupling Reaction of N-Heterocycles with N-Alkyl-N-methylanilines under Mild Conditions
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Jianjun Chen, Cong-Cong Lu, Jiquan Zhao, Yuecheng Zhang, Hong-Yu Zhang, and Ya-Ping Han
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chemistry.chemical_classification ,chemistry.chemical_compound ,Chemistry ,Atom economy ,Organic Chemistry ,Functional group ,Polymer chemistry ,Coupling reaction ,Alkyl ,Catalysis ,Visible spectrum ,Ambient air - Abstract
Disclosed herein is a cross-dehydrogenative-coupling reaction of N-heterocycles including 1,2,4-triazine-3,5(2H, 4H)-diones and quinoxaline-2(1H)-ones with N-methylanilines to form C(sp2)-C(sp3) under visible-light illumination and ambient air at room temperature. In this process, easily available Ru(bpy)3Cl2·6H2O serves as the catalyst, and air acts as the green oxidant. This method features high atom economy, environmental friendliness, and convenient operation and provides an efficient and practical access to aminomethyl-substituted N-heterocycles with extensive functional group compatibility in 40-86% yields.
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- 2021
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12. Monolignol acyltransferase for lignin p-hydroxybenzoylation in Populus
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Xiao-Hong Yu, Kewei Zhang, Yuki Tobimatsu, Pui Ying Lam, Chang-Jun Liu, and Yunjun Zhao
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Cell wall ,chemistry.chemical_classification ,chemistry.chemical_compound ,Enzyme ,Biochemistry ,chemistry ,Sinapyl alcohol ,Acyltransferase ,Lignin ,Plant Science ,Monolignol ,Secondary metabolism - Abstract
Plant lignification exhibits notable plasticity. Lignin in many species, including Populus spp., has long been known to be decorated with p-hydroxybenzoates. However, the molecular basis for such structural modification remains undetermined. Here, we report the identification and characterization of a Populus BAHD family acyltransferase that catalyses monolignol p-hydroxybenzoylation, thus controlling the formation of p-hydroxybenzoylated lignin structures. We reveal that Populus acyltransferase PHBMT1 kinetically preferentially uses p-hydroxybenzoyl-CoA to acylate syringyl lignin monomer sinapyl alcohol in vitro. Consistently, disrupting PHBMT1 in Populus via CRISPR–Cas9 gene editing nearly completely depletes p-hydroxybenzoates of stem lignin; conversely, overexpression of PHBMT1 enhances stem lignin p-hydroxybenzoylation, suggesting PHBMT1 functions as a prime monolignol p-hydroxybenzoyltransferase in planta. Altering lignin p-hydroxybenzoylation substantially changes the lignin solvent dissolution rate, indicative of its structural significance on lignin physiochemical properties. Identification of monolignol p-hydroxybenzoyltransferase offers a valuable tool for tailoring lignin structure and physiochemical properties and for engineering the industrially important platform chemical in woody biomass. p-Hydroxybenzoylation is a common type of lignin modification but its catalytic mechanism and physiological relevance are unclear. An enzyme that catalyses lignin p-hydroxybenzoylation in poplar sheds light on the role of this specialized modification.
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- 2021
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13. Fabrication of Two-Dimensional Functional Covalent Organic Frameworks via the Thiol-Ene 'Click' Reaction as Lubricant Additives for Antiwear and Friction Reduction
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Xiaozhi Zhang, Sha Liu, Qian Ye, Jingde Gao, Tingting Zhang, Hong Yu, Weimin Liu, and Shujuan Liu
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chemistry.chemical_compound ,Materials science ,Monomer ,chemistry ,Chemical engineering ,Covalent bond ,Dispersion stability ,Click chemistry ,Base oil ,General Materials Science ,Lubricant ,Condensation reaction ,Ene reaction - Abstract
To address the energy wastage problem caused by friction, novel lubricant additives other than the traditional and basic used additives with outstanding performance are urgently needed. A facile and efficient postsynthetic strategy for modification of two-dimensional (2D) covalent organic frameworks (COFs) was proposed to obtain dialkyl dithiophosphate (DDP)-functionalized COFs (DDP@TD-COF) as lubricant additives. The DDP@TD-COF was prepared by amine-aldehyde condensation reaction of the triazine compound and vinyl-functionalized monomers through a solvothermal process to form a vinyl-functionalized 2D COF (TD-COF), followed by covalent bonding of commercial lubricating molecules (DDP) via the UV-induced thiol-ene "click" reaction. The as-obtained DDP@TD-COF with homogeneous distribution of N, P, and S elements exhibits exceptional dispersion stability in the 500SN base oil, which remains stable for over 6 days. With a trace amount addition of 0.05 wt %, superior friction and wear reduction of DDP@TD-COF are observed with the friction coefficient lessened to 0.096 from 0.19, wear volume loss declined by 94.9%, and load carrying ability increased from 150 to 650 N simultaneously. The mechanism studies show that the shear force can induce interlayer slipping during the friction process, and the stripped DDP@TD-COF can get involved in the contacting interface inducing tribo-chemical reactions via N, P, and S elements forming a protective layer on the surfaces. Consequently, the DDP@TD-COF demonstrated remarkable friction diminution and abrasion resistance abilities even with a trace amount addition, and this work provides a dependable and valid route for the design and preparation of functional COF-based nanoadditives.
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- 2021
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14. Effect of dapagliflozin on diabetic patients with cardiovascular disease via MAPK signalling pathway
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Zhao-Di Yue, Yi-Bo Liu, Ren-Jie Zhao, Fangqi Wang, Shao-Hong Yu, Zhongwen Zhang, Yi Ding, Bing-Yu Du, Yan-Yan Yin, Li Li, and Hui Fu
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type 2 diabetes mellitus ,Diabetic Cardiomyopathies ,MAP Kinase Signaling System ,Computational biology ,Disease ,Network Pharmacology ,chemistry.chemical_compound ,Glucosides ,cardiovascular disease ,Protein Interaction Mapping ,OMIM : Online Mendelian Inheritance in Man ,Humans ,Medicine ,Benzhydryl Compounds ,Dapagliflozin ,KEGG ,Sodium-Glucose Transporter 2 Inhibitors ,Mechanism (biology) ,business.industry ,Type 2 Diabetes Mellitus ,Original Articles ,dapagliflozin ,Cell Biology ,Hedgehog signaling pathway ,Molecular Docking Simulation ,chemistry ,Docking (molecular) ,Molecular Medicine ,Original Article ,business - Abstract
Clinical studies have shown that dapagliflozin can reduce cardiovascular outcome in patients with type 2 diabetes mellitus (T2DM), but the exact mechanism is unclear. In this study, we used the molecular docking and network pharmacology methods to explore the potential mechanism of dapagliflozin on T2DM complicated with cardiovascular diseases (CVD). Dapagliflozin's potential targets were predicted via the Swiss Target Prediction platform. The pathogenic targets of T2DM and CVD were screened by the Online Mendelian Inheritance in Man (OMIM) and Gene Cards databases. The common targets of dapagliflozin, T2DM and CVD were used to establish a protein‐protein interaction (PPI) network; the potential protein functional modules in the PPI network were found out by MCODE. Metascape tool was used for Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis. A potential protein functional module with the best score was obtained from the PPI network and 9 targets in the protein functional module all showed good binding properties when docking with dapagliflozin. The results of KEGG pathway enrichment analysis showed that the underlying mechanism mainly involved AGE‐RAGE signalling pathway in diabetic complications, TNF signalling pathway and MAPK signalling pathway. Significantly, the MAPK signalling pathway was considered as the key pathway. In conclusion, we speculated that dapagliflozin played a therapeutic role in T2DM complicated with CVD mainly through MAPK signalling pathway. This study preliminarily reveals the possible mechanism of dapagliflozin in the treatment of T2DM complicated with CVD and provides a theoretical basis for future clinical research.
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- 2021
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15. Active components from Lagotis brachystachya maintain uric acid homeostasis by inhibiting renal TLR4-NLRP3 signaling in hyperuricemic mice
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Hai-Yan Yang, Yang Liu, Hong-Yu Cheng, Jie Cheng, Li-Tao Yi, Ji-Xiao Zhu, and Wei-Qiong Hu
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Male ,Organic anion transporter 1 ,Immunology ,Hyperuricemia ,Pharmacology ,Kidney ,Protein Structure, Secondary ,Excretion ,Mice ,chemistry.chemical_compound ,NLR Family, Pyrin Domain-Containing 3 Protein ,medicine ,Animals ,Homeostasis ,Pharmacology (medical) ,Plants, Medicinal ,Dose-Response Relationship, Drug ,biology ,Glucose transporter ,medicine.disease ,Uric Acid ,Toll-Like Receptor 4 ,medicine.anatomical_structure ,chemistry ,Apigenin ,biology.protein ,Uric acid ,Luteolin ,Drugs, Chinese Herbal ,Signal Transduction - Abstract
Lagotis brachystachya Maxim is an herb widely used in traditional Tibet medicine. Our previous study indicated that total extracts from Lagotis brachystachya could lower uric acid levels. This study aimed to further elucidate the active components (luteolin, luteoloside and apigenin) isolated from Lagotis brachystachya and the underlying mechanism in vitro and vivo. The results showed that treatment with luteolin and luteoloside reversed the reduction of organic anion transporter 1 (OAT1) levels, while apigenin attenuated the elevation of urate transporter 1 (URAT1) and glucose transporter 9 (GLUT9) levels in uric acid-treated HK-2 cells, which were consistent with the finding in the kidney of potassium oxonate (PO)-induced mice. On the other hand, hepatic xanthine oxidase activity was inhibited by the components. In addition, all of these active components improved the morphology of the kidney in hyperuricemic mice. Moreover, molecular docking showed that luteolin, luteoloside and apigenin could bind TLR4 and NLRP3. Consistently, western blot showed that the components inhibited TLR4/MyD88/NLRP3 signaling. In conclusion, these results indicated that luteolin, luteoloside and apigenin could attenuate hyperuricemia by decreasing the production and increasing the excretion of uric acid, which were mediated by the inhibition of inflammatory signaling pathways.
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- 2021
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16. Preparation of conductive and transparent dipeptide hydrogels for wearable biosensor
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Qi Li, Jieling Li, Yafeng Jing, Shuo Bai, Hong-Yu Cao, Qingquan Han, Anhe Wang, and Xue-Fang Zheng
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Dipeptide ,Materials science ,Biocompatibility ,Materials Science (miscellaneous) ,Doping ,Biomedical Engineering ,Nanoparticle ,Nanotechnology ,Polypyrrole ,Industrial and Manufacturing Engineering ,chemistry.chemical_compound ,chemistry ,Self-healing hydrogels ,Biosensor ,Electrical conductor ,Biotechnology - Abstract
Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility, multi-functionality, and physiochemical properties similar to those of body tissues. However, the preparation of such hydrogels featuring high conductivity and transparency is a huge challenge because of the hydrophobic feature of conductive additives making the doping process difficult. To overcome this issue, hydrophilic conductive polydopamine (PDA)-doped polypyrrole (PPy) nanoparticles are introduced into the dipeptide hydrogel networks to form conductive nanofibrils in situ to achieve a good level of hydrophilic templating of the hydrogel networks. This technique creates a complete conductive network and allows visible light to pass through. The strategy proposed herein not only endows the dipeptide hydrogel with good conductivity and high transparency, but also provides a great potential application of conductive dipeptide hydrogels for body-adhered signal detection, as evidenced by the experimental data.
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- 2021
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17. High and Tunable Proton Conduction in Six 3D-Substituted Imidazole Dicarboxylate-Based Lanthanide–Organic Frameworks
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Gang Li, Ruilan Liu, Yu-Yang Liu, Hong-Wei Wang, and Yi-Hong Yu
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Inorganic Chemistry ,Lanthanide ,Crystallography ,chemistry.chemical_compound ,Ionic radius ,Proton ,Chemistry ,Ligand ,Imidazole ,Molecule ,Physical and Theoretical Chemistry ,Conductivity ,Isostructural - Abstract
Six isostructural three-dimensional (3D) Ln(III)-organic frameworks, {[Ln2(HMIDC)2(μ4-C2O4)(H2O)3]·4H2O}n [LnIII = GdIII (1), EuIII (2), SmIII (3), NdIII (4), PrIII (5), and CeIII (6)], have been fabricated by using a multifunctional ligand of 2-methyl-1H-imidazole-4,5-dicarboxylic acid (H3MIDC). Ln-metal-organic frameworks (MOFs) 1-6 present 3D structures and possess abundant H-bonded networks between imidazole-N atoms and coordinated and free water molecules. All the six Ln-MOFs demonstrate humidity- and temperature-dependent proton conductivity (σ) having the optimal values of 2.01 × 10-3, 1.40 × 10-3, 0.93 × 10-3, 2.25 × 10-4, 1.11 × 10-4, and 0.96 × 10-4 S·cm-1 for 1-6, respectively, at 100 °C/98% relative humidity, in the order of CeIII (6) < PrIII (5) < NdIII (4) < SmIII (3) < EuIII (2) < GdIII (1). In particular, the σ for 1 is 1 order of magnitude higher than that for 6, and it enhances systematically according to the decreasing order of the ionic radius, indicating that the lanthanide-contraction tactics can effectively regulate the proton conductivity while retaining the proton conduction routes. This will offer valuable guidance for the acquisition of new proton-conducting materials. In addition, the outstanding water stability and electrochemical stability of such Ln-MOFs will afford a solid material basis for future applications.
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- 2021
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18. A new neolignan and a new biphenylpropanoid from the leaves of Cupressus funebris Endl
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Meng-Ying Liu, Hong-Yu Jiang, Jing Huang, Cheng-Rong Li, Si-Yu Zhong, Li-Ping Wu, and Ya-Rui Yu
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0106 biological sciences ,Circular dichroism ,Free Radical Scavenging Activity ,Antioxidant ,ABTS ,biology ,DPPH ,medicine.medical_treatment ,Plant Science ,biology.organism_classification ,Ascorbic acid ,01 natural sciences ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Cupressus funebris ,medicine ,Ferric ,010606 plant biology & botany ,Nuclear chemistry ,medicine.drug - Abstract
A new neolignan, (-)-(7S, 8R)-3‑methoxy-4', 7-epoxy-8, 5'-neolignane-5, 9, 3', 9′-tetraol (1) and a new biphenylpropanoid, 1, 2-epoxy-1-(3', 4'-dihydroxyphenyl-)-3-(2'', 3'', 5''-trihydroxyphenyl-) propane (2), together with eight known compounds (3-10), were isolated from the 95% EtOH extract of the leaves of Cupressus funebris Endl. Their structures were determined by spectroscopic methods including NMR, circular dichroism (CD) spectra and comparison of the NMR data with reported in references. The antioxidant activities of all compounds were evaluated by DPPH, ABTS, and FRAP methods. Compounds 2 (IC50: 33.98 ± 0.11 μM), 3 (IC50: 32.97 ± 0.63 μM), 8 (IC50: 32.07 ± 1.57 μM), and 9 (IC50: 33.30 ± 2.29 μM) showed stronger DPPH free radical scavenging activity than l -ascorbic acid (IC50: 64.31 ± 1.32 μM). Except for 4, the other compounds showed ABTS radical scavenging abilities comparable to l -ascorbic acid (54.91 ± 1.18 μM) with the IC50 ranged from 24.42 ± 1.78 μM to 138.70 ± 13.58 μM. Compound 3 (0.72 ± 0.02 mmol/g) showed the same ferric reducing antioxidant power (FRAP) as l -ascorbic acid (0.83±0.02 mmol/g).
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- 2021
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19. Synthesis of Tetracyclic Indolines through Palladium‐Catalyzed Asymmetric Dearomative reaction of Aryl Iodides
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Ya-Ping Han, Yong-Min Liang, Yuanfeng Li, M. Sc. Dong-Han, Hong-Yu Zhang, Jiquan Zhao, Yuecheng Zhang, and M. Sc. Yue-Su
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chemistry.chemical_compound ,Chemistry ,Aryl ,Heck reaction ,Enantioselective synthesis ,chemistry.chemical_element ,General Chemistry ,Combinatorial chemistry ,Catalysis ,Palladium - Published
- 2021
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20. Joule-heated carbonized melamine sponge for high-speed absorption of viscous oil spills
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Jin Ge, Shu-Hong Yu, Hao-Yu Zhao, Chao Li, Tao Ma, Bi-Cheng Hu, Lu-An Shi, and Song Yonghong
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Materials science ,Sorbent ,Carbonization ,Sorption ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Viscosity ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,General Materials Science ,Electrical and Electronic Engineering ,Absorption (chemistry) ,0210 nano-technology ,Melamine ,Joule heating ,Pyrolysis - Abstract
Introducing heating function to oil sorbents opens up a new pathway to the fast cleanup of viscous crude oil spills in situ. The oil sorption speed increases with the rise of the temperature, thus oil sorbents with high heating temperature are desirable. Besides, the oil sorbents also need to be produced environment-friendly. Here we present carbonized melamine-formaldehyde sponges (CMSs) that exhibited superior heating performance and the CMSs could be massively fabricated through a non-polluting pyrolysis process. The conductive CMSs could be heated over 300 °C with a low applied voltage of 6.9 V and keep above 250 °C for 30 min in the air without obvious damage. Such high heating performance enabled heating up the oil spills with a high rate of 2.65 °C·s−1 and 14% improvement of oil sorption coefficient compared with the state-of-the-art value. We demonstrated that one joule-heated CMS could continuously and selectively collect viscous oil spills (9,010 mPa·s) 690 times its own weight in one hour. The CMSs will be a highly competitive sorbent material for the fast remediation of future crude oil spills.
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- 2021
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21. HSP17.4 mediates salicylic acid and jasmonic acid pathways in the regulation of resistance to Colletotrichum gloeosporioides in strawberry
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Xianping Fang, Weiguo Chai, Boqiang Zhou, Hong Yu, Xueying Zhang, Xiao Wenfei, Shuigen Li, Jiansheng Shen, Liqing Zhang, and Aichun Liu
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0106 biological sciences ,0301 basic medicine ,salicylic acid ,Soil Science ,Cyclopentanes ,Plant Science ,Acetates ,Biology ,Fragaria ,01 natural sciences ,Microbiology ,03 medical and health sciences ,chemistry.chemical_compound ,Plant Growth Regulators ,Colletotrichum ,Gene silencing ,Oxylipins ,HSP17.4 ,Molecular Biology ,Gene ,Transcription factor ,Heat-Shock Proteins ,Disease Resistance ,Plant Diseases ,Plant Proteins ,Methyl jasmonate ,Jasmonic acid ,jasmonic acid ,fungi ,food and beverages ,Original Articles ,NPR1 ,Colletotrichum gloeosporioides ,030104 developmental biology ,chemistry ,Original Article ,strawberry ,Antagonism ,Agronomy and Crop Science ,Salicylic acid ,Signal Transduction ,010606 plant biology & botany - Abstract
In this study, we used virus‐mediated gene silencing technology and found that the HSP17.4 gene‐silenced cultivar Sweet Charlie plants were more susceptible to Colletotrichum gloeosporioides than the wild‐type Sweet Charlie, and the level of infection was even higher than that of the susceptible cultivar Benihopp. The results of differential quantitative proteomics showed that after infection with the pathogen, the expression of the downstream response genes NPR1, TGA, and PR‐1 of the salicylic acid (SA) signalling pathway was fully up‐regulated in the wild‐type Sweet Charlie, and the expression of the core transcription factor MYC2 of the jasmonic acid (JA) pathway was significantly down‐regulated. The expression of the proteins encoded by these genes did not change significantly in the HSP17.4‐silenced Sweet Charlie, indicating that the expression of HSP17.4 activated the up‐regulation of downstream signals of SA and inhibited the JA signal pathway. The experiments that used SA, methyl jasmonate, and their inhibitors to treat plants provide additional evidence that the antagonism between SA and JA regulates the resistance of strawberry plants to C. gloeosporioides., HSP17.4 can activate the salicylic acid pathway and synergistically suppress the jasmonic acid signal, contributing to the resistance of strawberry plants to Colletotrichum gloeosporioides.
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- 2021
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22. Protein Homochirality May Be Derived from Primitive Peptide Synthesis by RNA
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Hong-Yu Zhang and Xin-Yi Chu
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010504 meteorology & atmospheric sciences ,biology ,Ribozyme ,Proteins ,RNA ,Stereoisomerism ,Computational biology ,Ribosomal RNA ,01 natural sciences ,Agricultural and Biological Sciences (miscellaneous) ,Ribosome ,chemistry.chemical_compound ,RNA world hypothesis ,chemistry ,Space and Planetary Science ,0103 physical sciences ,biology.protein ,Peptide synthesis ,Amino Acids ,Homochirality ,Chirality (chemistry) ,010303 astronomy & astrophysics ,0105 earth and related environmental sciences - Abstract
Homochirality is a feature of life, but its origin is still disputed. Recent theories indicate that the origin of homochirality coincided with that of the RNA world, but proteins have not yet been incorporated into the story. Ribosome is considered a living fossil that survived the RNA world and records the oldest interaction between RNA and proteins. Inspired by several ribosome-related findings, we propose a hypothesis as follows: the substrate chirality preference of some primitive peptide synthesis ribozymes can mediate the chirality transmission from RNA to protein. In return, the chiral preference of protective peptide-RNA interaction can bring these ribozymes an evolutionary advantage and facilitate the expansion of enantiomeric excess in peptides. Monte Carlo simulation results show that this system's chemistry model is plausible. This model can be further tested through investigation of the chirality preference for the interactions between d/l-ribose-composed rRNA homologs and l/d-amino acid-composed peptides.
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- 2021
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23. Structure and Facile Synthesis of Proton-Conducting [Fe(CN)
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Yao Zhao, Feng-Ming Zhang, Wei-Min Ding, and Hong-Yu Zhang
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Crystal ,Crystallography ,chemistry.chemical_compound ,Proton ,Chemistry ,Coordination polymer ,Diffusion ,Molecule ,Proton exchange membrane fuel cell ,General Chemistry ,Crystal structure ,Conductivity - Abstract
Proton-conducting materials are a key component of proton exchange membrane fuel cells (PEMFCs) and the advantage of clear structural information in crystal materials offers a pathway for the investigation of the proton-conducting mechanism and pathway. In this work, a new Cd2+ coordination polymer material (compound 1) with the formula {[Cd3(bipy)3(H2O)4][Fe(CN)6]2·2H2O·2(bipy)}n was successfully synthesized by a solution diffusion method and its proton conduction ability was further determined. Crystal structure analysis confirms the coordination of [Fe(CN)6]3–, 4,4′-bipyridine, and H2O molecules to Cd2+ in the three dimensional structure of compound 1. Also, we confirmed that compound 1 of 500–800 nm particle size could be synthesized on a large scale by a facile stirring method. Proton-conductivity analyses revealed that compound 1 shows a water-mediated proton conduction behaviour because the conductivity increased apparently with the increase of relative humidity. Further investigation shows that the highest proton-conductivity of 8.36 × 10−4 S cm−1 was observed at 60°C and 95 % relative humidity, and the mechanism analysis suggests a Vehicle mechanism exists in the proton conduction process of compound 1.
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- 2021
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24. Comparison of four markers of hepatic fibrosis and hepatic function indices in patients with liver cirrhosis and hepatoma
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Ruo-Yi Li, Shou-Zhen Quan, Lei Dong, Hong-Yu Ma, and Xiang-Rong Wang
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Collagen Type IV ,Liver Cirrhosis ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Cirrhosis ,medicine.drug_class ,Bilirubin ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Fibrosis ,Internal medicine ,medicine ,Humans ,Advanced and Specialized Nursing ,Bile acid ,business.industry ,Albumin ,medicine.disease ,Anesthesiology and Pain Medicine ,Endocrinology ,chemistry ,030220 oncology & carcinogenesis ,Alkaline phosphatase ,030211 gastroenterology & hepatology ,Laminin ,business ,Hepatic fibrosis ,Biomarkers ,TBIL - Abstract
Background The present study aimed to compare four hepatic fibrosis markers [i.e., hyaluronic acid (HA), laminin (LN), procollagen III N-terminal peptide (PIIINP), and collagen type IV (CIV)] and 16 hepatic function indices in patients with liver cirrhosis of varying etiology. Methods The hepatic function indices and hepatic fibrosis markers were measured in 108 patients with liver cirrhosis and hepatoma using an automatic biochemical analyzer and luminescent immune analyzer. Twenty healthy controls were enrolled to compare the differences between liver cirrhosis and hepatoma of varying etiology and to analyze the correlations between the hepatic function indices and fibrosis markers. Results There was no correlation between alanine aminotransferase (ALT), total protein (TP), alkaline phosphatase (ALP), or the four markers of hepatic fibrosis in liver cirrhosis caused by hepatitis B (P>0.05). Aspartate aminotransferase (AST) was positively correlated with HA (r=0.428, P=0.007), LN (r=0.458, P=0.004), and CIV (r=0.374, P=0.021). Total bilirubin (TBIL) and direct bilirubin (DBIL) were positively correlated with LN (TBIL: r=0.480, P=0.002; DBIL: r=0.457, P=0.004), PIIINP (TBIL: r=0.380, P=0.017; DBIL: r=0.406, P=0.011), and CIV (TBIL: r=0.415, P=0.010; DBIL: r=0.400, P=0.013). Total bile acid (TBA) and γ-glutamyltranspeptidase (GGT) were positively correlated with PIIINP (TBA: r=0.363, P=0.025; GGT: r=0.353, P=0.029) and CIV (TBA: r=0.419, P=0.009; GGT: r=0.335, P=0.040). Leucine aminopeptidase (LAP) was positively correlated with LN (r=0.482, P=0.002). Cholinesterase (CHE) (HA: r=-0.452, P=0.004, LN: r=-0.336, P=0.039; PIIINP: r=-0.468, P=0.003; CIV: r=-0.485, P=0.002), prealbumin (PA) (HA: r=-0.575, P=0.000, LN: r=-0.413, P=0.010; PIIINP: r=-0.344, P=0.035; CIV: r=-0.371, P=0.022), albumin (ALB) (HA: r=-0.541, P=0.000, LN: r=-0.373, P=0.021; PIIINP: r=-0.353, P=0.030; CIV: r=-0.415, P=0.010), and superoxide dismutase (SOD) (HA: r=-0.334, P=0.040, LN: r=-0.347, P=0.033; PIIINP: r=-0.487, P=0.002; CIV: r=-0.536, P=0.001) were negatively correlated with the four markers of hepatic fibrosis. There was no correlation between ALT, AST, TBIL, TP, ALP, GGT, or the four hepatic fibrosis markers in hepatoma caused by hepatitis B (P>0.05). Meanwhile, DBIL and TBA were positively correlated with CIV (DBIL: r=0.519, P=0.023; TBA: r=0.563, P=0.012), while CHE (r=-0.604, P=0.006), ALB (r=-0.564, P=0.012), and SOD (r=-0.489, P=0.034) were negatively correlated with CIV. Moreover, PA was negatively correlated with LN (r=-0.510, P=0.026) and CIV (r=-0.696, P=0.001). Conclusions The concentrations of the serological indices differed significantly based on the specific liver cirrhosis etiology. There was a strong correlation between the hepatic function indices and four hepatic fibrosis markers. Thus, the detection of these markers might improve the diagnosis and treatment of hepatoma.
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- 2021
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25. Rosuvastatin Enhances Alveolar Fluid Clearance in Lipopolysaccharide-Induced Acute Lung Injury by Activating the Expression of Sodium Channel and Na,K-ATPase via the PI3K/AKT/Nedd4-2 Pathway
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Yang Ye, Qian Wang, Xi-Ya Ren, Hong-Xia Mei, Fang-gao Smith, Hao-Ran Xu, Qian Yang, Yan Chen, Pu-Hong Zhang, Shengwei Jin, Hong-Yu Ma, Shu-Yang Xiang, Chen-xi Shen, and Ke-Wen Xu
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0301 basic medicine ,ARDS ,Lipopolysaccharide ,Immunology ,Lung injury ,Pharmacology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,In vivo ,medicine ,Immunology and Allergy ,Rosuvastatin ,Na+/K+-ATPase ,Protein kinase B ,PI3K/AKT/mTOR pathway ,Original Research ,alveolar fluid clearance ,nutritional and metabolic diseases ,acute respiratory distress syndrome ,respiratory system ,medicine.disease ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,Na,K-ATPases ,Journal of Inflammation Research ,rosuvastatin ,sodium channel ,medicine.drug - Abstract
Hao-Ran Xu,1 Qian Yang,1 Shu-Yang Xiang,1 Pu-Hong Zhang,1 Yang Ye,1 Yan Chen,1 Ke-Wen Xu,2 Xi-Ya Ren,2 Hong-Xia Mei,1 Chen-Xi Shen,1 Hong-Yu Ma,1 Fang-Gao Smith,1,3 Sheng-Wei Jin,1 Qian Wang1 1Department of Anesthesia and Critical Care, The Second Afï¬liated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, People’s Republic of China; 2Wenzhou Medical University, Wenzhou, People’s Republic of China; 3Institute of Inflammation and Aging, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UKCorrespondence: Sheng-Wei Jin; Qian WangDepartment of Anesthesia and Critical Care, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, 109 Xueyuan Road, Wenzhou, Zhejiang Province, 325027, People’s Republic of ChinaTel +86 577-88002806Fax +86 577-88832693Email jsw@wmu.edu.cn; wqian84@163.comBackground: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are devastating clinical conditions characterized by pulmonary epithelial damage and protein-rich fluid accumulation in the alveolar spaces. Statins are a class of HMG-CoA reductase inhibitors, which exert cholesterol-lowering and anti-inflammatory effects.Methods: Rosuvastatin (1 mg/kg) was injected intravenously in rats 12 h before lipopolysaccharide (LPS, 10 mg/kg) administration. Eight hours later after LPS challenge, alveolar fluid clearance (AFC) was detected in rats (n = 6– 8). Rosuvastatin (0.3 μmol/mL) and LPS were cultured with primary rat alveolar type II epithelial cells for 8 h.Results: Rosuvastatin obviously improved AFC and attenuated lung-tissue damage in ALI model. Moreover, it enhanced AFC by increasing sodium channel and Na,K-ATPase protein expression. It also up-regulated P-Akt via reducing Nedd4-2 in vivo and in vitro. Furthermore, LY294002 blocked the increase in AFC in response to rosuvastatin. Rosuvastatin-induced AFC was found to be partly rely on sodium channel and Na,K-ATPase expression via the PI3K/AKT/Nedd4-2 pathway.Conclusion: In summary, the findings of our study revealed the potential role of rosuvastatin in the management of ALI/ARDS.Keywords: acute respiratory distress syndrome, rosuvastatin, alveolar fluid clearance, sodium channel, Na,K-ATPases
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- 2021
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26. Highly stretchable, soft and sticky PDMS elastomer by solvothermal polymerization process
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Shu-Hong Yu, Chengyuan Xue, Yuchun Cai, Jin Huang, Hao-Yu Zhao, and Jin Ge
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Materials science ,Young's modulus ,02 engineering and technology ,010402 general chemistry ,Elastomer ,01 natural sciences ,chemistry.chemical_compound ,symbols.namesake ,Natural rubber ,General Materials Science ,Electrical and Electronic Engineering ,Elasticity (economics) ,Composite material ,Curing (chemistry) ,Polydimethylsiloxane ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,chemistry ,Polymerization ,visual_art ,Siloxane ,symbols ,visual_art.visual_art_medium ,0210 nano-technology - Abstract
Siloxane rubber shows attractive properties of high stability, elasticity and transparency. Besides, the regulation of its properties renders it widely used in many application fields. However, most of the reported performance improvement methods of siloxane rubber focus on the change of chemical composition of siloxane rubber, including the design of molecular chain and the introduction of other compounds, etc. Such a strategy is still faced with many limitations in practical application. In this work, on the premise of not changing the chemical composition of siloxane rubber, we propose a facile solvothermal polymerization process to change the structure of cross-linking networks, so as to obtain the siloxane rubber with controllable mechanical properties. Compared to the normal curing method, we realized polydimethylsiloxane elastomer (PDMS) with maximum elongation of more than 3,000% (> 10 times of normally cured one) and tensile modulus lower than 0.15 MPa (< 1/10 of normally cured one). In addition to superior stretchability, it gains extra high softness, stickiness and sensitive response to organic solvents. Based on our solvothermal cured PDMS, its applications in oil collection and organic solvent sensor have been demonstrated. It is expected that this method can be readily utilized widely and shows great application potentials.
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- 2021
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27. Integration of Pd nanoparticles with engineered pore walls in MOFs for enhanced catalysis
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Shu-Hong Yu, Junling Lu, Gang Huang, Hai-Long Jiang, Luyan Li, Qiaoqiao Guan, Yemin Dong, Yamin Huang, Weijie Yang, and Zhixin Li
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Chemistry ,General Chemical Engineering ,Biochemistry (medical) ,Substrate (chemistry) ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Heterogeneous catalysis ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,Catalysis ,Nitrobenzene ,Metal ,chemistry.chemical_compound ,visual_art ,Materials Chemistry ,visual_art.visual_art_medium ,Environmental Chemistry ,Metal-organic framework ,Dehydrogenation ,0210 nano-technology ,Selectivity - Abstract
Summary Creating free-access active sites and regulating their interaction with substrates are crucial for efficient catalysis, yet remain a grand challenge. Herein, naked Pd nanoparticles (NPs) have been encapsulated in a metal-organic framework (MOF), MIL-101-NH2, to afford Pd@MIL-101-NH2. The hydrophobic perfluoroalkyls were post-synthetically modified onto -NH2 group to yield Pd@MIL-101-Fx (x = 3, 5, 7, 11, 15), which engineer the MOF pore walls to regulate Pd surrounding microenvironment and interaction with substrates. As a result, both the dehydrogenation coupling of organosilane and hydrogenation of halogenated nitrobenzenes show that their activity and selectivity can be greatly promoted upon hydrophobic modification due to the favorable substrate enrichment and regulated interactions between Pd and the modified MOF hosts, far surpassing the traditional supported or surfactant-protected Pd NPs. We envision metal NPs@MOF composites would be an ideal platform integrating the inherent activity of well-accessible metal sites with engineered microenvironment via readily tunable MOFs.
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- 2021
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28. Light-induced degradation of rhodamine B by tellurium quantum dots
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Manran Guo, Donghui Zhang, Xiuyun Yang, Hong Yu, Leijiao Li, Siqi Bao, and Yue Hou
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dye degradation ,Environmental Engineering ,Materials science ,chemistry.chemical_element ,quantum dots ,02 engineering and technology ,010402 general chemistry ,Photochemistry ,tellurium-based materials ,01 natural sciences ,Environmental technology. Sanitary engineering ,chemistry.chemical_compound ,X-ray photoelectron spectroscopy ,Rhodamine B ,TD1-1066 ,Water Science and Technology ,Rhodamines ,photocatalyst ,Hydrogen Peroxide ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Light intensity ,chemistry ,Quantum dot ,Transmission electron microscopy ,Photocatalysis ,Degradation (geology) ,Tellurium ,0210 nano-technology - Abstract
Tellurium quantum dots (Te QDs) were prepared using bulk tellurium as the precursor. Te QDs can be a highly active photocatalyst for boosting the photocatalytic degradation of rhodamine B (RhB) under visible light irradiation. The morphology and composition of Te QDs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The results showed that in the presence of H2O2, the photocatalytic efficiency of Te QDs on RhB could achieve a good degradation effect within a very short time (30 min). The effects of initial dye concentration, pH value, light intensity, catalyst dosage and H2O2 concentration on dye degradation were successively studied. The effects of inorganic ions (NO3−, Cl−, SO42−, Ca2+, Mg2+ and Fe3+) on photocatalytic degradation were also discussed. Experimental results of free radical capture showed that OH• and O2•− played important roles in photocatalytic degradation. More importantly, Te QDs efficiency still remained above 85% after four cycles of use, indicating good stability, recyclability and utility. This work may inspire further design of other semiconductor QDs for highly efficient dye degradation.
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- 2021
29. Synthesis, Structure, and Optical Properties of Sodium Complex Based on 3-Hydroxyquinoline-4-carboxylic Acid
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Dong-Hui Chen, Song-Hua Xie, Hong-Yu Guo, Hai-Hui Chen, Yan Wu, Ren-Yun Kuang, and Xiu-Guang Yi
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chemistry.chemical_classification ,Photoluminescence ,Hydrogen bond ,Carboxylic acid ,Stacking ,General Chemistry ,Crystal structure ,010402 general chemistry ,010403 inorganic & nuclear chemistry ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Crystallography ,chemistry.chemical_compound ,chemistry ,Orthorhombic crystal system ,Diffuse reflection ,Organometallic chemistry - Abstract
A novel sodium complex [Na2(L)2(Phen)2(H2O)2]·2(H2O) (L = 3-hydroxyquinoline-4-carboxylic acid anion; Phen = 1,10-phenanthroline) is synthesized by solvothermal approach and is structurally determined by single-crystal X-ray diffraction. The title complex crystallizes in the orthorhombic system of the Pbcn space group. The strong π⋯π stacking and hydrogen bonding interactions produce three-dimensional (3D) chains. A series of properties of the title complex were tested by solid-state photoluminescence, CIE analysis and solid-state diffuse reflectance. The results show that the title complex is a blue light emitter, CIE (x = 0.1542, y = 0.0211) and has an energy bandwidth of 1.607 eV. A novel sodium complex is synthesized via solvothermal approach, which is characteristic of an isolated structure. At the same time, it displays a narrow and intense photoluminescence emission band in the blue region and has an energy bandwidth of 1.607 eV.
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- 2021
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30. Effects of different NH4+/NO3- ratios on the photosynthetic and physiology responses of blueberry (Vaccinium spp.) seedlings growth
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Hong Yu-Hui, Cui Jun, Luan Yu-Shi, Zhang Yuan-Yuan, and Tian Jun-Ping
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inorganic chemicals ,0106 biological sciences ,Physiology ,Biomass ,chemistry.chemical_element ,Photosynthesis ,01 natural sciences ,chemistry.chemical_compound ,Nitrate ,Ammonium ,chemistry.chemical_classification ,biology ,fungi ,food and beverages ,04 agricultural and veterinary sciences ,biology.organism_classification ,Nitrogen ,Horticulture ,chemistry ,Chlorophyll ,040103 agronomy & agriculture ,0401 agriculture, forestry, and fisheries ,Essential nutrient ,Agronomy and Crop Science ,010606 plant biology & botany ,Vaccinium - Abstract
Nitrogen (N) is an essential nutrient for plant growth, and ammonium (NH4 +) and nitrate (NO3 -) are two main forms of N that plants absorb from the soil. The total N concentration suitable for blu...
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- 2021
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31. Promotion properties of TLR7 in pediatric meningitis via the NF-κB pathway
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Hong Yu, Xianhua Zhang, Ying Sun, Ping Gong, and Yiwei He
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Male ,0301 basic medicine ,Adolescent ,Physiology ,Inflammation ,Procalcitonin ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Cerebrospinal fluid ,Western blot ,medicine ,Animals ,Humans ,Meningitis ,Child ,medicine.diagnostic_test ,business.industry ,NF-kappa B ,Infant ,virus diseases ,NF-κB ,Cell Biology ,TLR7 ,medicine.disease ,Disease Models, Animal ,030104 developmental biology ,Toll-Like Receptor 7 ,chemistry ,Child, Preschool ,030220 oncology & carcinogenesis ,Immunology ,Female ,medicine.symptom ,Signal transduction ,business ,Signal Transduction - Abstract
Meningitis outcome is associated with the severity of inflammation in the subarachnoid space and that the outcome can be improved through anti-inflammation. However, a comprehensive understanding of the molecular basis underlying inflammatory responses in meningitis remains enigmatic. In the current study, we sought to determine the molecular mechanism of TLR7/NF-κB on the development of meningitis in children. Cerebrospinal fluid of patients with meningitis and children with simple febrile convulsions was collected, and meningitis mouse model was induced. TLR7 expression was determined in the serum of meningitis model mice and the cerebrospinal fluid of patients using RT-qPCR and Western blot. Afterwards, loss- and gain- function assays were conducted to determine the functional role of TLR7 in meningitis mouse model. The level of procalcitonin (PCT) and the number of bacterial colonies in the serum were analyzed. ELISA was used to detect the expression of inflammatory factors. Upregulated level of TLR7 was observed in patients and mice with meningitis. Inhibiting the expression of TLR7 inhibited the development of meningitis. Overexpressing TLR7 can activate the NF-κB signaling pathway and promote mouse meningitis. NF-κB signaling pathway inhibitor reversed promotion of meningitis caused by TLR7 activation. Our study provides evidence that TLR7 elevation can activate the NF-κB signaling pathway and promote meningitis in mice.
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- 2021
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32. A tumor microenvironment responsive nanosystem for chemodynamic/chemical synergistic theranostics of colorectal cancer
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Xia Wu, Min Hou, Hongjie Fan, Huiyang Wang, Ke Zhang, Xiangrui Liu, Xiaoyan Wang, Jihong Sun, Hong Yu, Liying Wang, Liping Cao, Jingya Xia, and Jun Ling
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China ,Colorectal cancer ,medicine.medical_treatment ,Mice, Nude ,Medicine (miscellaneous) ,Theranostic Nanomedicine ,Chemodynamic therapy ,Mice ,chemistry.chemical_compound ,Drug Delivery Systems ,Magnetic resonance imaging ,Cell Line, Tumor ,Neoplasms ,Synergistic therapy ,Tumor Microenvironment ,medicine ,Animals ,Tumor growth ,Precision Medicine ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Microenvironment-responsive ,chemistry.chemical_classification ,Mice, Inbred BALB C ,Chemotherapy ,Tumor microenvironment ,Reactive oxygen species ,Nanotheranostics ,Chemistry ,Drug Synergism ,Hydrogen Peroxide ,Glutathione ,medicine.disease ,Xenograft Model Antitumor Assays ,Controlled release ,Tumor tissue ,Drug Liberation ,Cancer research ,Nanoparticles ,Female ,Colorectal Neoplasms ,Nanoparticle Drug Delivery System ,Reactive Oxygen Species ,Research Paper - Abstract
Rationale: The synergism of new modalities alongside chemodynamic therapy into common chemotherapy has shown promising potential in clinical applications. This paper reports a tumor microenvironment-responsive nanosystem for chemodynamic/chemical synergistic therapy and magnetic resonance imaging (MRI). Methods: The biodegradable nanosystem is synthesized using a surface-modified chain transfer agent for surface-initiated living radical polymerization of the chemotherapeutic drug. Results: In this nanosystem, named CAMNSN@PSN38, the cycling time and solubility of the chemotherapeutic drug are improved. The nanoparticles delivered to tumor tissues gradually release the chemotherapeutic drug and Mn2+ through glutathione (GSH)-triggered biodegradation in the tumor microenvironment. SN38, the released chemotherapeutic drug, not only shows excellent chemical therapy effects but also improves the generation of H2O2. Furthermore, with the Fenton-like agent Mn2+, the generation of reactive oxygen species (ROS) is improved markedly. Finally, CAMNSN@PSN38 shows excellent inhibition of tumor growth in three colorectal cancer tumor models, with an improved accumulation of ROS and controlled release of SN38. Conclusions: The CAMNSN@PSN38-mediated chemodynamic/chemical synergistic therapy provides a promising paradigm for the treatment and MRI-guided therapy of colorectal cancer.
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- 2021
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33. Multicore closely packed ultrathin-MnO2@N-doped carbon-gear yolk–shell micro-nanostructures as highly efficient sulfur hosts for Li–S batteries
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Shu-Hong Yu, Weixi Yan, Shipei Chen, Qingsheng Wu, and Ming Wen
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Battery (electricity) ,Materials science ,Renewable Energy, Sustainability and the Environment ,Composite number ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,Electrolyte ,Conductivity ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Gravimetric analysis ,General Materials Science ,0210 nano-technology ,Carbon ,Polysulfide - Abstract
Suppressing the polysulfide shuttle effect and promoting the conductivity of electrode materials have become efficient ways to achieve high cycling stability for Li–S batteries. However, this still remains a challenge. New multicore closely packed ultrathin-MnO2@N-doped carbon-gear yolk–shell micro-nanostructures are explored as the S host material to trap polysulfides and enhance conductivity. Such composites can accommodate S mass-loading up to 80 wt% via a valid sulfur solution infiltration approach. The cooperation of ultrathin-MnO2 yolks with N-doped carbon internal gear shells can well suppress the polysulfide shuttle effect by strong chemical interactions and physical confinement as well as enhanced conductivity for excellent Li–S battery properties, which enable an initial gravimetric capacity of 1245 mA h g−1 and a low decay rate of 0.03% per cycle over 1000 cycles at 1C. In particular, the composite delivers an initial gravimetric capacity of 1097.8 mA h g−1 and volumetric capacity of 1059.6 mA h cm−3 at 2C rate. Specifically, the electrochemical performance of the designed composite at different electrolyte/S ratios is firstly investigated in this study, and is a promising approach with the high-performance cathode material for Li–S batteries.
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- 2021
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34. Enabling high-performance room-temperature sodium/sulfur batteries with few-layer 2H-MoSe2embellished nitrogen-doped hollow carbon spheres as polysulfide barriers
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Jian-Chen Li, Wang Gao, Xing-You Lang, Qing Jiang, Hong Yu Zhou, Chunwei Dong, and Bo Jin
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Battery (electricity) ,Materials science ,Renewable Energy, Sustainability and the Environment ,Graphene ,Oxide ,chemistry.chemical_element ,Separator (oil production) ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Sulfur ,Energy storage ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,General Materials Science ,0210 nano-technology ,Polysulfide - Abstract
Room-temperature sodium/sulfur (RT-Na/S) batteries are of considerable interest for next-generation energy storage systems because of their earth-abundant electrode materials, low cost, and high energy density. However, the widespread application of RT-Na/S batteries is severely hindered by the dissolution, shuttling, and sluggish kinetics conversion of sodium polysulfides (SPSs) during electrochemical processes. Herein, we prepare a powerful functional separator to suppress the shuttle effect by directly coating 2H-MoSe2/nitrogen-doped hollow carbon spheres/graphene oxide (2H-MoSe2/N-HCS/GO) onto a standard glass fiber separator. The rational design of the functional separator effectively suppresses the migration of SPSs and promotes the conversion reactions of SPSs. Meanwhile, N-HCS decorated with few-layer 2H-MoSe2 nanoflakes is used as the sulfur host. As verified by a series of density functional theory calculations and experimental characterization, a RT-Na/S battery with a functional separator and a high sulfur content of 71.4 wt% delivers a high discharge capacity of 787 mA h g−1 at 0.1C after 100 cycles and exhibits outstanding long-term cycling stability (484 mA h g−1 at 0.5C after 500 cycles), with a low capacity fading rate of 0.077% per cycle. This study demonstrates an effective strategy to develop functional separators for shuttle suppression and provides a promising path for high-performance RT-Na/S batteries.
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- 2021
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35. Ratiometric detection of p-nitrophenol and its derivatives using a dual-emissive neuron cell-like carbonized probe based on a π⋯π stacking quenching mechanism
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Wei Wang, Wen-Juan Wang, Zhong-Xia Wang, Qi-Le Li, Hong-Yu Zhu, Heng-Ye Li, Fen-Ying Kong, Lei Hu, and Feng Li
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Detection limit ,Quenching ,Reproducibility ,Materials science ,Stacking ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Biochemistry ,Fluorescence ,0104 chemical sciences ,Analytical Chemistry ,Nitrophenol ,chemistry.chemical_compound ,chemistry ,Quantum dot ,Electrochemistry ,Environmental Chemistry ,0210 nano-technology ,Spectroscopy ,Excitation - Abstract
p-Nitrophenol and its derivatives can cause serious harm to the health of mankind and the earth's ecosystem. Therefore, it is necessary to develop a novel and rapid detection technology for p-nitrophenol and its derivative. Herein, excellent water-soluble, large-size and dual-emissive neuron cell-analogous carbon-based probes (NCNPs) have been prepared via a solvothermal approach, using o-phenylenediamine as the only precursor, which exhibit two distinctive fluorescence (FL) peaks at 420 and 555 nm under 345 nm excitation. The NCNPs show a neuron cell-like branched structure, are cross-connected, and are in the range of 10-20 nm in skeleton diameter. Interestingly, their blue-green dual-colour fluorescence is quenched by p-nitrophenol or its derivative due to the specific mechanism of the ππ stacking interactions or internal filtration effect. Accordingly, a simple, rapid, direct and free-label ratiometric FL detection of p-nitrophenol is proposed. An excellent linear relationship shows linear regions over the range of 0.1-50 μM between the ratio of the FL intensity (FL555 nm/FL420 nm) and the concentrations of p-nitrophenol. The detection limit is as low as 43 nM (3σ). Importantly, the NCNP-based probe also shows acceptable repeatability and reproducibility for the detection of p-nitrophenol and its derivatives, and the recovery results for p-nitrophenol in real wastewater samples are favourable.
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- 2021
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36. Ni nanoparticles/V4C3Tx MXene heterostructures for electrocatalytic nitrogen fixation
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Chengfeng Du, Xianhu Liu, Kewei Tang, Qinghua Liang, Xiangyuan Zhao, Hong Yu, Weihong Qi, Wei Fang, Lan Yang, and Qingyu Yan
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Materials science ,Nanocomposite ,Nanoparticle ,Electrocatalyst ,Redox ,Ammonia ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Vacancy defect ,Materials Chemistry ,Surface modification ,General Materials Science ,Surface states - Abstract
Electrocatalytic nitrogen reduction reaction (NRR) to generate ammonium is a promising renewable technology for nitrogen cycling. Engineering the composition and surface states of an electrocatalyst is critical to improve the intrinsic NRR performance. Here, a facile preparation of Ni nanoparticles (NPs) loaded on V4C3Tx MXene (denoted as Ni@MX) as a highly efficient NRR electrocatalyst is reported. Remarkably, the Ni@MX nanocomposite presents an ammonia yield rate of 21.29 μg h−1 mgcat−1 at 0.2 mA cm−2. The presented NRR activity is considerably higher than that of the recently reported MXene derivatives and is even comparable to that of the noble-metal-based electrocatalysts. Combined with various characterization methods and the density functional theory (DFT) simulation, we propose that the improved NRR activity was ascribed to a synergistic NRR route by Ni sites in the nanoparticles and the surface O vacancy of V4C3Tx MXene. Given the remarkable improvement of NRR activity on the MXene-based nanocomposites, this work demonstrates the critical role of MXene and its derivatives with surface modification as electrocatalysts.
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- 2021
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37. A new strategy for constructing covalently connected MOF@COF core–shell heterostructures for enhanced photocatalytic hydrogen evolution
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Guiling Zhang, Yan Yang, Chang-Cheng Li, Hong Yan, Feng-Ming Zhang, Hong-Yu Zhang, and Hong-Liang Tang
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Schiff base ,Materials science ,Renewable Energy, Sustainability and the Environment ,Ligand ,fungi ,Heterojunction ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Metal ,chemistry.chemical_compound ,Crystallinity ,chemistry ,Chemical engineering ,Covalent bond ,visual_art ,visual_art.visual_art_medium ,Photocatalysis ,General Materials Science ,0210 nano-technology ,Hybrid material - Abstract
Combining the advantages of porosity and crystallinity of MOF and COF photocatalysts to build a covalently connected MOF–COF hybrid heterostructure has been proved to be an effective way to assemble efficient photocatalysts. However, until now, only MOFs with –NH2 groups in the ligand have been used to build covalently connected MOF–COF hybrid materials by a Schiff base reaction between the components. In this work, we develop a new strategy for constructing covalently connected MOF–COF hybrid materials by post-synthetic modification of metal nodes with MOFs without –NH2 in the ligand. A typical Zr-MOF without –NH2 ligands, MOF-808, was modified by coordination with p-aminobenzoic acid on Zr6 clusters to graft it with –NH2 groups. Then, the core–shell MOF-808@TpPa-1-COF with a covalent linkage between the two components was synthesized by an in situ reaction. The core–shell morphology of the hybrid material and the covalent linkage between the components were confirmed by various characterizations. The results of photocatalytic hydrogen evolution under visible light irradiation confirm that MOF-808@TpPa-1-COF (6/4) shows a hydrogen evolution rate of 11.88 mmol g−1 h−1, which is 5.6 times higher than that of the parent TpPa-1-COF. Further investigations confirm the significant role of the covalent linkage between the components in the efficient separation and transfer of photogenerated electrons in the photocatalytic hydrogen evolution reaction. The strategy of assembling MOF@COF in this work could be applied for constructing more covalently linked MOF–COF hybrid materials with the desired morphology and function.
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- 2021
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38. Inhibition of cardiomyocyte apoptosis post-acute myocardial infarction through the efficient delivery of microRNA-24 by silica nanoparticles
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Jiao Zhang, Mengchen Shen, Ruirui Zhang, Yuting Zhu, Huiliang Liu, Xiaoli Shi, Hong Yu, Dong Han, Yi Li, and Qiang Zhang
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Cardiac function curve ,Polyethylenimine ,business.industry ,General Engineering ,Bioengineering ,General Chemistry ,medicine.disease ,Atomic and Molecular Physics, and Optics ,In vitro ,chemistry.chemical_compound ,chemistry ,In vivo ,Apoptosis ,microRNA ,Cancer research ,medicine ,General Materials Science ,Myocardial infarction ,business ,Ventricular remodeling - Abstract
MicroRNA-24 (miR-24) is an apoptosis suppressor miRNA downregulated in cardiomyocytes after acute myocardial infarction (AMI). However, due to the lack of effective delivery strategies, the role of anti-apoptotic miR-24 in cardiomyocytes post-acute myocardial infarction remains unexplored. Here, we used a silica nanoparticle-based polyelectrolyte (polyethylenimine, PEI) delivery system to study the role of miR-24. These particles with good biocompatibility could be efficiently internalized into cells and release the loaded miR-24 into the cytoplasm. As a result, the overexpression of miR-24 resulted in the inhibition of the pro-apoptotic Bim, thereby inhibiting cardiomyocyte apoptosis in vitro. Furthermore, in vivo experiments revealed that over-expressed miR-24 additionally significantly improves ventricular remodeling and cardiac function in Sprague–Dawley (SD) rats after coronary artery ligation. In summary, our novel delivery system serves as a therapeutic miRNA formulation for cardiovascular disease treatment.
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- 2021
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39. Kinetic model research on drying characteristics of artificial magnetite green pellet
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Cheng-xin Liu, Han-quan Zhang, Man-man Lu, and Hong Yu
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Materials science ,Kinetic model ,digestive, oral, and skin physiology ,Airflow ,0211 other engineering and technologies ,Metals and Alloys ,General Engineering ,02 engineering and technology ,Moisture ratio ,chemistry.chemical_compound ,020401 chemical engineering ,chemistry ,Scientific method ,Pellet ,Metallic materials ,0204 chemical engineering ,Composite material ,021102 mining & metallurgy ,Magnetite - Abstract
In this study, the effects of drying temperature, hot airflow speed and diameter of green pellet on drying rate of artificial magnetite pellet were deeply investigated to clarify the drying characteristics of artificial magnetite green pellet. The results show that the drying process of artificial magnetite green pellet has three stages, accelerated drying stage, constant drying stage and decelerated drying stage. And drying temperature and hot airflow speed both have significant reciprocal effects on moisture ratio and drying rate of green pellet during the drying process. However, the diameter of green pellet has little effect on drying process of green pellet. Then the drying fitting models of Correction Henderson and Pabis, Lewis, Correction Page (III), Wang and Singh are used to describe the drying kinetics of artificial magnetite green pellet. The fitting results indicate that the drying process of artificial magnetite pellet can be described by Correction Page (III) model accurately. Finally, the contrast experiments demonstrate that the fitting model can well describe the actual drying process.
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- 2021
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40. Strengthening and Toughening Hierarchical Nanocellulose via Humidity-Mediated Interface
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Shu-Hong Yu, HengAn Wu, Ping Gu, Ling Zhangchi, YinBo Zhu, Han Zimeng, YuanZhen Hou, Yang Huaibin, Qing-Fang Guan, ZeZhou He, and Jun Xia
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Materials science ,Hydrogen bond ,General Engineering ,food and beverages ,General Physics and Astronomy ,02 engineering and technology ,Strain hardening exponent ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Nanocellulose ,Molecular dynamics ,chemistry.chemical_compound ,chemistry ,General Materials Science ,Relative humidity ,Composite material ,Deformation (engineering) ,Cellulose ,0210 nano-technology ,Slipping - Abstract
Undoubtedly humidity is a non-negligible and sensitive problem for cellulose, which is usually regarded as one disadvantage to cellulose-based materials because of the uncontrolled deformation and mechanical decline. But the lack of an in-depth understanding of the interfacial behavior of nanocellulose in particular makes it challenging to maintain anticipated performance for cellulose-based materials under varied relative humidity (RH). Starting from multiscale mechanics, we herein carry out first-principles calculations and large-scale molecular dynamics simulations to demonstrate the humidity-mediated interface in hierarchical cellulose nanocrystals (CNCs) and associated deformation modes. More intriguingly, the simulations and subsequent experiments reveal that water molecules (moisture) as the interfacial media can strengthen and toughen nanocellulose simultaneously within a suitable range of RH. From the perspective of interfacial design in materials, the anomalous mechanical behavior of nanocellulose with humidity-mediated interfaces indicates that flexible hydrogen bonds (HBs) play a pivotal role in the interfacial sliding. The difference between CNC-CNC HBs and CNC-water-CNC HBs triggers the humidity-mediated interfacial slipping in nanocellulose, resulting in the arising of a pronounced strain hardening stage and the suppression of strain localization during uniaxial tension. This inelastic deformation of nanocellulose with humidity-mediated interfaces is similar to the Velcro-like behavior of a wet wood cell wall. Our investigations give evidence that the humidity-mediated interface can promote the mechanical enhancement of nanocellulose, which would provide a promising strategy for the bottom-up design of cellulose-based materials with tailored mechanical properties.
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- 2020
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41. Diversity and composition of microbiota during fermentation of traditional Nuodeng ham
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Hong Yu, Xiao-Mei Zhang, Dang Xijun, Yao Wang, Yuanbing Wang, Tao Sun, and Yang Wusong
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0303 health sciences ,030306 microbiology ,General Medicine ,Biology ,Applied Microbiology and Biotechnology ,Microbiology ,03 medical and health sciences ,chemistry.chemical_compound ,Nitrate ,chemistry ,Microbial population biology ,Composition (visual arts) ,Fermentation ,Food science ,Nitrite ,Internal transcribed spacer ,Fermentation in food processing ,Flavor ,030304 developmental biology - Abstract
The microbial community is one of the most important factors in shaping the characteristics of fermented food. Nuodeng ham, traditionally produced and subjected to 1-4 years of fermentation, is a dry fermented food product with cultural and economic significance to locals in southwestern China. In this study, we aimed to characterize the microbiota and physicochemical profiles of Nuodeng ham across different stages of fermentation. Ham samples from each of the four years were analyzed by sequencing bacterial 16S rRNA gene and fungal internal transcribed spacer sequence, in order to characterize the diversity and composition of their microflora. A total of 2,679,483 bacterial and 2,983,234 fungal sequences of high quality were obtained and assigned to 514 and 57 genera, respectively. Among these microbes, Staphylococcus and Candida were the most abundant genera observed in the ham samples, though samples from different years showed differences in their microbial abundance. Results of physicochemical properties (pH, water, amino acid, NaCl, nitrate and nitrite contents, and the composition of volatile compounds) revealed differences among the ham samples in the composition of volatile compounds, especially in the third year samples, in which no nitrite was detected. These results suggest that the structure and diversity of microbial communities significantly differed across different stages of fermentation. Moreover, the third year hams exhibits a unique and balanced microbial community, which might contribute to the special flavor in the green and safe food products. Thus, our study lends insights into the production of high quality Nuodeng ham.
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- 2020
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42. Strong and tough graphene papers constructed with pyrene-containing small molecules via π-π/H-bonding synergistic interactions
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Shu-Hong Yu, Hong Yuan, Liangbing Ge, Jieyun Li, Na Shu, Tao Suo, Fang Xu, Kun Ni, Yanwu Zhu, Mengting Gao, Jianglin Ye, Fei Pan, Si-Ming Chen, and Xiukai Kan
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Toughness ,Materials science ,Hydrogen bond ,Graphene ,Oxide ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,Micrometre ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,law ,Molecule ,General Materials Science ,Density functional theory ,0210 nano-technology ,Graphene oxide paper - Abstract
Lightweight yet strong paper with high toughness is desirable especially for impact protection. Herein we demonstrated electrically conductive and mechanically robust paper (AP/PB-GP) made of reduced graphene oxide via interfacial crosslinking with 1-aminopyrene (AP) and 1-pyrenebutyrat (PB) small molecules. The AP/PB-GP with thickness of over ten micrometer delivers a record-high toughness (∼69.67 ± 15.3 MJ m−3 in average), simultaneously with superior strength (close to 1 GPa), allowing an impressive specific penetration energy absorption (∼0.17 MJ kg−1) at high impact velocities when used for ballistic impact protection. Detailed interfacial and structural analysis reveals that the reinforcement is synergistically determined by π-π interaction and H-bonding linkage between adjacent graphene lamellae. Especially, the defective pores within the graphene platelets benefit the favorable adsorption of the pyrene-containing molecules, which imperatively maximizes the interfacial binding, facilitating deflecting crack and plastic deformation under loading. Density functional theory simulation suggests that the coupling between the polar functional groups, e.g., −COOH, at the edges of graphene platelets and −NH2 and −COOH of AP/PB are critical to the formation of hydrogen bonding network.
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- 2020
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43. Formation of magnesium calcite mesocrystals in the inorganic environment only by using Ca2+ and Mg2+ and its biological implications
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Jun Jiang, Li-Mei Shang, and Shu-Hong Yu
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Calcite ,Materials science ,Magnesium ,Nucleation ,chemistry.chemical_element ,02 engineering and technology ,Calcium ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Amorphous calcium carbonate ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,General Materials Science ,Crystallization ,0210 nano-technology ,Mesocrystal ,Single crystal - Abstract
Magnesium calcite (Mg-calcite) mesocrystal is widespread in the biominerals with specific functions. Until now, it remains challenging to obtain Mg-calcite mesocrystals without organic additives and the formation mechanism of Mg-calcite mesocrystals in the ocean is not clear yet. We report here the synthesis of corn-like Mg-calcite mesocrystals from pure amorphous calcium carbonate (ACC) via a facile method only by using Ca2+ and Mg2+. The obtained Mg-calcite is composed of many nanocubes with common crystallographic orientation, which shows very good single crystal feature. In the crystallizing procedure, the ACC nanospheres rapidly agglomerate into Mg-calcite corn-like mesocrystal by oriented attachment (OA) in a certain direction, which belongs to the non-classical nucleation. By this method, the molar ratio of Ca2+ and Mg2+ plays a vital role in the whole crystallization procedure, which may shed a new light on disclosing the mechanism behind for the effect of seawater in the formation of biological Mg-calcite in nature.
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- 2020
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44. Employing sulfur–phosphorus mixed acid as a depressant: a novel investigation in flotation of collophanite
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Feng Zhou, Yanfeng Jin, Hong Yu, Hanquan Zhang, Mingxia Liu, and Linbo Xiao
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Renewable Energy, Sustainability and the Environment ,medicine.drug_class ,020209 energy ,Phosphorus ,Dolomite ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Sulfuric acid ,02 engineering and technology ,Sulfur ,Apatite ,chemistry.chemical_compound ,Fuel Technology ,020401 chemical engineering ,Nuclear Energy and Engineering ,chemistry ,visual_art ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,visual_art.visual_art_medium ,Depressant ,0204 chemical engineering ,Phosphoric acid ,Reverse flotation ,Nuclear chemistry - Abstract
Inorganic acids (sulfuric acid (H2SO4) or phosphoric acid (H3PO4)) are generally employed as depressants in the reverse flotation of collophanite to separate apatite from dolomite. In this study, t...
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- 2020
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45. Investigation of the anti-diabetic nephropathy activity of puerarin
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Hong-Yu Zhang, Yan Yang, Bo Yang, Xin Li, Pei-Yu He, Ming-Hua Duan, and Wen-Feng Zhang
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0301 basic medicine ,Materials science ,Pharmacology ,medicine.disease ,Diabetic nephropathy ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,chemistry ,Puerarin ,030220 oncology & carcinogenesis ,medicine ,General Materials Science - Abstract
Puerarin has potential therapeutic effects on diabetic nephropathy (DN), but the effectiveness as a treatment for DN and the underlying mechanism remain to be elucidated. The DN-like model induced by high glucose in vitro and the DN model induced by streptozotocin in vivo were used to observe the effect of puerarin. The results showed that puerarin can enhance the activity of HBZY-1 cells and reduce apoptosis. in vivo enzymelinked immunosorbent assay and biochemical assay showed that puerarin can improve DN symptoms. Using hematoxylin and eosin staining to stain kidney tissues confirmed that puerarin has a protective effect on DN. Furthermore, puerarin can reduce the content of collagen type IV, laminin LN, tumor necrosis factor, p38, CREB, Fos, Jun, and MMP9 in HBZY-1 cells and DN rats. In conclusion, puerarin can effectively prevent apoptosis in vitro and improve DN-like symptoms by inhibiting the p38/MAPK signaling pathway in vivo. Therefore, puerarin has the potential to treat DN.
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- 2020
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46. Facile microwave-assisted fabrication of CdS/BiOCl nanostructures with enhanced visible-light-driven photocatalytic activity
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JuanJuan Xu, Hanmei Hu, Hong Yu, Li-Li Wang, Mengyi Ci, Zhu San'e, Chonghai Deng, and Wu Yiping
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Nanostructure ,Aqueous solution ,Materials science ,Mechanical Engineering ,Nanoparticle ,Heterojunction ,Chemical reaction ,chemistry.chemical_compound ,Chemical engineering ,chemistry ,Mechanics of Materials ,Methyl red ,Photocatalysis ,General Materials Science ,Visible spectrum - Abstract
Hierarchical binary CdS/BiOCl heterostructures comprised of CdS nanoparticles (NPs) decorating on BiOCl nanoflakes (NFs) for the enhanced photocatalytic activity were fabricated by a facile two-step microwave-assisted aqueous chemical reaction. The chemical composition, morphology, crystal structure, and optical properties of the CdS/BiOCl nanostructures were characterized by various techniques. The results indicated that island-like CdS NPs with 10-30 nm in size are planted on the surface of BiOCl NFs primarily exposed {001}-facets with diameter in the range of 200–600 nm and thickness of about 30 nm. The possible growth mechanism for the satellite-core structured hybrid CdS/BiOCl architectures was proposed. Particularly, CdS/BiOCl-3 exhibited the superior photocatalytic activity for the decomposition of Congo red in high concentration under visible light irradiation, in which the pseudo-first-order kinetic rate constant was 2.33, 8.32 and 2.06 times higher than that of pure CdS, pristine BiOCl and the physical mixture. The promotion mechanism could be ascribed to the perfect band matching and efficient internal charge transfer within the engineered heterojunction, resulting in the lower carrier recombination loss and the longer lifetime of electron–hole pairs. Furthermore, the high photocatalytic performance for the degradation of malachite green and methyl red suggests a promising application in industrial wastewater purification.
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- 2020
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47. TAp63α targeting of Lgr5 mediates colorectal cancer stem cell properties and sulforaphane inhibition
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Chen, Yue, Wang, Meng-huan, Zhu, Jian-yun, Xie, Chun-feng, Li, Xiao-ting, Wu, Jie-shu, Geng, Shan-shan, Han, Hong-yu, and Zhong, Cai-yun
- Subjects
0301 basic medicine ,Cancer Research ,Cancer stem cells ,Chemistry ,Colorectal cancer ,LGR5 ,Cancer ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,lcsh:RC254-282 ,Article ,03 medical and health sciences ,chemistry.chemical_compound ,030104 developmental biology ,0302 clinical medicine ,Downregulation and upregulation ,Cancer stem cell ,030220 oncology & carcinogenesis ,medicine ,Cancer research ,Stem cell ,Molecular Biology ,Transcription factor ,Sulforaphane - Abstract
Cancer stem cells (CSCs) have an established role in cancer progression and therapeutic resistance. The p63 proteins are important transcription factors which belong to the p53 family, but their function and mechanism in CSCs remain elusive. Here, we investigated the role of TAp63α in colorectal CSCs and the effects of sulforaphane on TAp63α. We found that TAp63α was upregulated in spheres with stem cell properties compared to the parental cells. Overexpression of TAp63α promoted self-renewal capacity and enhanced CSC markers expression in colorectal sphere-forming cells. Furthermore, we showed that TAp63α directly bound to the promoter region of Lgr5 to enhance its expression and activate its downstream β-catenin pathway. Functional experiments revealed that sulforaphane suppressed the stemness of colorectal CSCs both in vitro and in vivo. Upregulation of TAp63α attenuated the inhibitory effect of sulforaphane on colorectal CSCs, indicating the role of TAp63α in sulforaphane suppression of the stemness in colorectal cancer. The present study elucidated for the first time that TAp63α promoted CSCs through targeting Lgr5/β-catenin axis and participated in sulforaphane inhibition of the stem cell properties in colorectal cancer.
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- 2020
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48. Ultra-Strong, Ultra-Tough, Transparent, and Sustainable Nanocomposite Films for Plastic Substitute
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Ling Zhangchi, Shu-Hong Yu, Qing-Fang Guan, Yang Huaibin, and Han Zimeng
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Toughness ,chemistry.chemical_compound ,Materials science ,Nanocomposite ,High transmittance ,Fabrication ,chemistry ,Bacterial cellulose ,Composite number ,General Materials Science ,Composite film ,Composite material ,Thermal expansion - Abstract
Summary Plastics play a critical role in daily life but possess a considerably increasing negative impact on the environment and human health. Fabrication of biodegradable and eco-friendly alternatives with competitive properties for plastic substitute is urgently needed. Here, inspired by the hierarchical structure of nacre, we firstly developed a high-performance nacre-inspired composite with high transmittance (83.4% at 550 nm) and high haze (88.8% at 550 nm) via an aerosol-assisted biosynthesis process combined with the hot-press technique. The nacre-inspired composite film combines higher strength (482 MPa) and toughness (17.71 MJ m−3) than most other nacre-inspired films, and can be folded into various shapes without visible failure after unfolding. Moreover, compared with most commercial plastic films, it exhibits a lower thermal expansion coefficient (∼3 ppm K−1) and higher maximum service temperature besides better mechanical properties, which makes it a promising alternative to plastics in many technical fields.
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- 2020
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49. Combination of beneficial bacteria improves blueberry production and soil quality
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Hong Yu, Yi-Yang Yu, Jian Zhong, Jing-Ping Qiu, Jing-Da Xu, Jian-Hua Guo, and Tao-Xiang Huang
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0106 biological sciences ,organic system ,Bacillus amyloliquefaciens ,lcsh:TX341-641 ,01 natural sciences ,Crop ,03 medical and health sciences ,chemistry.chemical_compound ,Soil pH ,Organic matter ,soil quality ,Sugar ,beneficial bacteria consortium ,Original Research ,blueberry ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,biology ,food and beverages ,yield ,biology.organism_classification ,Soil quality ,Horticulture ,chemistry ,Anthocyanin ,lcsh:Nutrition. Foods and food supply ,Bacteria ,010606 plant biology & botany ,Food Science - Abstract
Blueberry is an important agricultural crop with high nutritional, health, and economic value. Despite the well‐studied blueberry cultivation methods and soil requirements, little is known about how beneficial bacteria function in organic blueberry cultivation systems and their effects on acidic soils. In this study, a single bacteria Bacillus amyloliquefaciens JC65 and three biocontrol bacteria consortiums containing JC65 were applied to organic system. The effect of bacteria to blueberry growth, yield, fruit quality, and soil quality was investigated. A consortium of three mixed Bacillus (B. amyloliquefaciens JC65, B. licheniforims HS10 and B. subtilis 7ze3) showed the highest growth improvement efficiency. The bacterial inoculation increased blueberry leaf chlorophyll content, net photosynthetic rate by 21.50%, 13.21% at 30 days, and increased average plant height by 2.72% at 69 days. Compared with the control, the inoculated plants showed an increased yield of 14.56%. Interestingly, blueberry fruit quality was also improved with supplement of the bacterial consortium. Fruit anthocyanin, soluble sugar, vitamin C, soluble solids, and soluble protein content were increased by 5.99%, 4.21%, 17.31%, 2.41%, and 21.65%, respectively. Besides, beneficial bacterial consortium also enables sustainable agriculture by improving soil ammonium nitrogen and organic matter by 3.77% and 2.96% after blueberry planting. In conclusion, the combination of beneficial bacteria showed a synergistic activity in organic system to promote the blueberry yield, fruit quality, and soil nutrient preservation., We conclude that addition of beneficial microbe in organic blueberry production significantly promotes plant growth and improves blueberry fruit quality. Interestingly, by combination of different beneficial microorganism, the promotion effect on blueberry production was enhanced significantly, indicating synergistic activity among specific mixture of bacteria. The soil retention ability of the beneficial microbe is also shown, especially for increase of soil organic matter.
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- 2020
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50. Direct Introduction of Sulfonamide Groups into Quinoxalin‐2(1 H )‐ones by Cu‐Catalyzed C3‐H Functionalization
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Hong-Yu Zhang, Yuecheng Zhang, Jiquan Zhao, Ya-Ping Han, Boyan Liu, and Yushi Tan
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chemistry.chemical_classification ,010405 organic chemistry ,Organic Chemistry ,Salt (chemistry) ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences ,Catalysis ,Sulfonamide ,chemistry.chemical_compound ,chemistry ,Functional group ,Surface modification ,Ammonium persulfate - Abstract
Direct sulfonamidation of quinoxalin-2(1H)-one derivatives has been developed using a readily available Cu salt as the catalyst and inexpensive ammonium persulfate as the oxidant in moderate conditions. Owing to the feature of handy operation and good functional group tolerance, this method provides a convenient and efficient access to curative 3-sulfonamidated quinoxalin-2(1H)-one scaffolds.
- Published
- 2020
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