Search

Your search keyword '"Gwen Grabowski Krivi"' showing total 1 results
Start Over Author "Gwen Grabowski Krivi" Topic chemistry.chemical_compound
1 results on '"Gwen Grabowski Krivi"'

1. Kelatorphan and related analogs: potent and selective inhibitors of leukotriene A4 hydrolase

Author

Gwen Grabowski Krivi, E.Yvonne Pyla, Stevan W. Djuric, Thomas D. Penning, Richard A. Haack, Leslie J Askonas, Stella S. Yu, and Marshall L. Michener

Subjects
chemistry.chemical_classification, Leukotriene A4, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Peptide, Biochemistry, Aminopeptidase, Leukotriene-A4 hydrolase, chemistry.chemical_compound, Enzyme, chemistry, Drug Discovery, Hydrolase, Molecular Medicine, Kelatorphan, Molecular Biology
Abstract

The hydroxamic acid-containing peptide kelatorphan, a known inhibitor of enkephalin-degrading enzymes, is a potent, non-competitive inhibitor of leukotriene A4 (LTA4) hydrolase. Analogs of kelatorphan were prepared and several significantly and selectively inhibited both the hydrolase and aminopeptidase activity of the enzyme.

Published
1995
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results