1. Design, Synthesis, and Biological Activity Evaluation of New Donepezil-like Compounds Bearing Thiazole Ring for the Treatment of Alzheimer’s Disease
- Author
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Serkan Levent, Ali Savaş Koparal, Betül Kaya Çavuşoğlu, Derya Osmaniye, Zafer Asım Kaplancıklı, Begüm Nurpelin Sağlık, Yusuf Özkay, and Ulviye Acar Çevik
- Subjects
General Chemical Engineering ,Population ,Pharmacology ,01 natural sciences ,beta amyloid plaque inhibition ,Inorganic Chemistry ,03 medical and health sciences ,chemistry.chemical_compound ,anticholinesterase enzyme activity ,medicine ,lcsh:QD901-999 ,General Materials Science ,Donepezil ,education ,Thiazole ,IC50 ,030304 developmental biology ,Cholinesterase ,ADME ,chemistry.chemical_classification ,thiazolylhydrazone ,0303 health sciences ,education.field_of_study ,biology ,010405 organic chemistry ,Biological activity ,molecular docking ,Condensed Matter Physics ,0104 chemical sciences ,donepezil ,Enzyme ,chemistry ,biology.protein ,lcsh:Crystallography ,Alzheimer’s disease ,medicine.drug - Abstract
Alzheimer&rsquo, s disease (AD) is a progressive and neurodegenerative disease that is primarily seen in the elderly population and is clinically characterized by memory and cognitive impairment. The importance of the disease has increased as a result of etiology of the disease having not yet been determined, an increase in patient population over the years, absence of radical treatment, high cost of treatment and care, and significant reduction in the quality of life of the patients, which have led researchers to direct more attention to this field. In a recent study, new indan-thiazolylhydrazone derivatives were designed and synthesized based on the chemical structure of the donepezil molecule, which is the most preferred and has the most appropriate response in the treatment of AD. The structures of the compounds were determined by 1H-NMR and 13C-NMR, and mass spectroscopic methods. Inhibition studies on the cholinesterase (ChE) enzymes and beta amyloid plaque inhibition test of the compounds were performed. Among the synthesized derivatives, compounds 2a, 2e, 2i, and 2l showed potent inhibitory activity on the AChE enzyme. Compound 2e was found to be the most active agent, with an IC50 value of 0.026 µ, M. The mechanism of AChE inhibition by compound 2e was studied using the Lineweaver-Burk plot, and the nature of inhibition was also determined to be mix-typed. Molecular docking studies were also carried out for compound 2e, which was found as the most potent agent within the AChE enzyme active site. Moreover, compounds 2a, 2e, 2i, and 2l displayed the ability to prevent beta amyloid plaque aggregation at varying rates. In addition, ADME (Absorption, Distribution, Metabolism, Elimination) parameters were evaluated for all synthesized compounds using the QikProp 4.8 software (Schrö, dinger Inc., NY, USA).
- Published
- 2020