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Your search keyword '"Joseph Lautru"' showing total 5 results
Start Over Author "Joseph Lautru" Topic chemistry.chemical_classification
5 results on '"Joseph Lautru"'

1. UV/ozone surface treatment increases hydrophilicity and enhances functionality of SU-8 photoresist polymer

Author

Malcolm Buckle, Hervé Leh, Claude Nogues, Etienne Henry, Aleksandra Delplanque, Joseph Lautru, Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Etude de la Matière en Mode Environnemental (L2ME), Institut de Chimie Séparative de Marcoule (ICSM - UMR 5257), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Centre du Médicament [Nancy], Université Henri Poincaré - Nancy 1 (UHP), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Materials science, [SDV]Life Sciences [q-bio], General Physics and Astronomy, 02 engineering and technology, Surface finish, Photoresist, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Polymer chemistry, Monolayer, Surface roughness, [CHIM]Chemical Sciences, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, SU-8 photoresist, chemistry.chemical_classification, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Surfaces and Interfaces, General Chemistry, Polymer, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Surfaces, Coatings and Films, chemistry, Chemical engineering, Surface modification, [SDV.IB]Life Sciences [q-bio]/Bioengineering, 0210 nano-technology, Ethylene glycol
Abstract

International audience; SU-8 photoresist polymer is widely used in the fabrication of microdevices. However, for biological applications , the problem of efficiently modifying SU-8 surfaces without perturbing roughness has not been successfully resolved. We present UV/ozone (UVO) surface pre-treatment as an effective method to increase the hydrophilicity of SU-8 films without affecting surface roughness, thus improving specific covalent binding of bio-molecules. We demonstrate that 30 s UVO treatment suffices to create carboxyl groups at the surface that can then be used for high density binding of molecules via amide bond formation. We further demonstrate that a two-step surface modification where the surface is first protected with an ethylene glycol monolayer leads to an increase in binding specificity. Finally, to illustrate the controlled binding and accessibility of immobilized molecules, we show three cycles of reversible interactions between anti-tamra antibody and tamra-cadaverine immobilized on the surface of SU-8.

Published
2014
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2. Association of vertically coupled polymer micro-resonator and phase-sensitive optical low coherence interferometer for label-free biosensing applications

Author

Yacouba Sanogo, Anne-Françoise Obaton, Jimmy Dubard, Joseph Lautru, Cedric Lyathaud, Catherine Yardin, and Nicolas Fischer

Subjects
chemistry.chemical_classification, Materials science, business.industry, General Engineering, Michelson interferometer, Polymer, law.invention, Interferometry, Finesse, Resonator, Optics, chemistry, law, Broadband, business, Biosensor, Coherence (physics)
Abstract

We report on a new accurate investigation tool whose principle is that of a Michelson interferometer with a broadband source, namely a phase-sensitive optical low-coherence interferometer, used to interrogate an optical micro-resonator based sensor for label-free biosensing applications. This set-up, which is able to provide the amplitude and also the phase of the guided mode in a single measurement, is also used to evaluate the performances of the micro-resonators. The best vertically coupled polymer racetrack micro-resonator fabricated displays a Q-factor higher than 38 000 and a finesse of 21 at 1527.7 nm when immersed in deionized water. The association of the phase-sensitive optical low coherence interferometer and the vertically coupled polymer micro-resonator in an opto-fluidic cell for biosensing applications was tested and allowed the detection of a concentration of glucose in water solution around 0.23 mg ml−1.

Published
2013
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3. Dual-polarization optofluidic biodetection based on polymer microring resonators

Author

Rigoberto Gregorio Sanabria Castro, Joseph Zyss, Joseph Lautru, Malcolm Buckle, Isabelle Ledoux-Rak, Claude Nogues, Chi Thanh Nguyen, and Camille Delezoide

Subjects
chemistry.chemical_classification, Resonator, Transducer, Dual-polarization interferometry, Materials science, chemistry, Biocompatibility, Microfluidics, Nanotechnology, Polymer, Sensitivity (control systems), Biosensor
Abstract

We previously demonstrated that vertically-coupled polymer microring resonators are good candidates as transducers in label-free biosensing instruments, for several reasons: good optical performances, low production costs, excellent biocompatibility and state-of-the-art surface sensitivity. We later presented the association of our original opto-electronic setup to microfluidics to perform homogeneous optofluidic detection, using glucose solutions to characterize the behavior of the microring transducer. In parallel, the same transducer devices have been associated to another detection scheme, phase-sensitive OLCI, with promising results.

Published
2013
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4. Vertically Coupled Polymer Microracetrack Resonators for Label-Free Biochemical Sensors

Author

Joseph Zyss, Hervé Leh, Malcolm Buckle, Camille Delezoide, Isabelle Ledoux-Rak, Marion Salsac, Claude Nogues, Chi Thanh Nguyen, Joseph Lautru, Laboratoire de Photonique Quantique et Moléculaire (LPQM), École normale supérieure - Cachan (ENS Cachan)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Etude de la Matière en Mode Environnemental (L2ME), Institut de Chimie Séparative de Marcoule (ICSM - UMR 5257), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre du Médicament [Nancy], Université Henri Poincaré - Nancy 1 (UHP), Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Institut Parisien de Recherche Architecture Urbanistique Société (IPRAUS), Architecture Urbanisme Société : Savoir Enseignement Recherche (UMR AUSser), Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture et de la Communication (MCC)-École nationale supérieure d'architecture de Paris-Belleville (ENSA PB)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris-Malaquais (ENSAPM)-École Nationale Supérieure d'Architecture de la Ville et des Territoires à Marne-la-Vallée (éavt&t)-Centre National de la Recherche Scientifique (CNRS)-Ministère de la Culture et de la Communication (MCC)-École nationale supérieure d'architecture de Paris-Belleville (ENSA PB)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV)-École nationale supérieure d'architecture de Paris-Malaquais (ENSAPM)-École Nationale Supérieure d'Architecture de la Ville et des Territoires à Marne-la-Vallée (éavt&t), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-École nationale supérieure d'architecture de Paris-Belleville (ENSA PB)-Ministère de la Culture et de la Communication (MCC)-École nationale supérieure d'architecture de Paris-Malaquais (ENSAPM)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Architecture de la Ville et des Territoires à Marne-la-Vallée (éavt&t)-École nationale supérieure d'architecture de Paris-La Villette (ENSAPLV), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-École nationale supérieure d'architecture de Paris-Belleville (ENSA PB)-Ministère de la Culture et de la Communication (MCC)-École nationale supérieure d'architecture de Paris-Malaquais (ENSAPM)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Architecture de la Ville et des Territoires à Marne-la-Vallée (éavt&t)

Subjects
Fabrication, Materials science, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV]Life Sciences [q-bio], FOS: Physical sciences, 02 engineering and technology, 01 natural sciences, 010309 optics, Resonator, 0103 physical sciences, Electrical and Electronic Engineering, Label free, chemistry.chemical_classification, Detection limit, business.industry, Optical polymers, Polymer, 021001 nanoscience & nanotechnology, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, chemistry, Optoelectronics, 0210 nano-technology, business, Biosensor, Optics (physics.optics), Physics - Optics
Abstract

International audience; We report on the efficient design and fabrication of polymeric microracetrack optical resonators for label-free biosensing purposes. Vertically-coupled microresonators immersed in deionised water display high Q-factors (>35000) and finesses up to 25. A surface sensing experiment performed with these microresonators using 5-TAMRA cadaverine as a test molecule demonstrated both the high sensitivity and low detection limit of our device.

Published
2011
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5. Efficient Antifouling Surface for Quantitative Surface Plasmon Resonance Based Biosensor Analysis

Author

Malcolm Buckle, Hervé Leh, Joseph Lautru, Olivier Delelis, Claude Nogues, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Etude de la Matière en Mode Environnemental (L2ME), Institut de Chimie Séparative de Marcoule (ICSM - UMR 5257), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)

Subjects
Macromolecular Assemblies, Models, Molecular, Analyte, Time Factors, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Biofouling, Surface Properties, [SDV]Life Sciences [q-bio], Biophysics, Immobilized Nucleic Acids, lcsh:Medicine, Nanotechnology, 02 engineering and technology, 010402 general chemistry, Biochemistry, 01 natural sciences, Biomaterials, DNA-binding proteins, Chemical Biology, Monolayer, Molecule, Biomacromolecule-Ligand Interactions, Surface plasmon resonance, lcsh:Science, Biology, chemistry.chemical_classification, Multidisciplinary, Integrases, Chemistry, Biomolecule, lcsh:R, Proteins, DNA, Surface Plasmon Resonance, 021001 nanoscience & nanotechnology, Molecular biology, 0104 chemical sciences, Kinetics, Retroviridae, lcsh:Q, Adsorption, 0210 nano-technology, Biosensor, Research Article, Biotechnology, Protein Binding, Macromolecule
Abstract

International audience; Non-specific binding to biosensor surfaces is a major obstacle to quantitative analysis of selective retention of analytes at immobilized target molecules. Although a range of chemical antifouling monolayers has been developed to address this problem, many macromolecular interactions still remain refractive to analysis due to the prevalent high degree of non-specific binding. In this manuscript we explore the dynamic process of the formation of self-assembled monolayers and optimize physical and chemical properties thus reducing considerably non-specific binding while maintaining the integrity of the immobilized biomolecules. As a result, analysis of specific binding of analytes to immobilized target molecules is significantly facilitated.

Published
2012
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