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Syntheses of new lithio hexavinylogation reagents are described starting either from ω-bromo polyenacetal, ω-bromo polyenol ether or ω-bromo non conjugated aldehyde. The reactivity of the lithio reagents has been tested by condensation with benzaldehyde; the resulting hexaenal has been obtained in a one or two steps procedure.

Syntheses of 5-halogeno-2,4-dienals 1a–c are described starting either from the glutaconaldehyde potassium salt or from furan. The 5-bromopenta-2,4-dienal 1b can be transformed efficiently into homologous ω-bromo polyenals 2–4, precursors of ω-bromo polyenol ethers 5b,d, 6 and 7. After bromine–lithium exchange, followed by condensation with carbonyl compounds, 1-bromo-6-methoxyhexa-1,3,5-triene 5b, 1-bromo-8-methoxyocta-1,3,5,7-tetraene 6 and 1-bromo-10-methoxydeca-1,3,5,7,9-pentene 7 lead to various conjugated tri-, tetra- and penta-enals in good yields, in a one-pot procedure.

Syntheses of 5-halogeno-2,4-dienals 1a–c are described starting either from the glutaconaldehyde potassium salt or from furan. The 5-bromopenta-2,4-dienal 1b can be transformed efficiently into homologous ω-bromo polyenals 2–4, precursors of ω-bromo polyenol ethers 5b,d, 6 and 7. After bromine–lithium exchange, followed by condensation with carbonyl compounds, 1-bromo-6-methoxyhexa-1,3,5-triene 5b, 1-bromo-8-methoxyocta-1,3,5,7-tetraene 6 and 1-bromo-10-methoxydeca-1,3,5,7,9-pentene 7 lead to various conjugated tri-, tetra- and penta-enals in good yields, in a one-pot procedure.

Syntheses of new lithio hexavinylogation reagents are described starting either from ω-bromo polyenacetal, ω-bromo polyenol ether or ω-bromo non conjugated aldehyde. The reactivity of the lithio reagents has been tested by condensation with benzaldehyde; the resulting hexaenal has been obtained in a one or two steps procedure.

A series of symmetrically substituted 1,4-bis(3-aminopropyl)piperazines was synthesized and tested towards trypanothione reductase and for its in vitro trypanocidal potency. The most trypanocidal amongst them was found to be totally inactive towards the enzyme and thus constitutes a lead structure for the identification of new potential Trypanosoma cruzi target(s).

5-Bromopentadienal 1b(n= 2), easily obtained from the potassium glutaconaldehyde salt, is used as precursor of ω-bromoheptatrienal 1d, ω-bromomethoxyhexatriene 2, diene diols 4, diene diones 5, 1,6-dibromohexa-1,3,5-triene 6 and 1,8 triene diol 8, of controlled configuration.