1. Novel Metabolic Regulation of Bile Acid Responses to Low Cholesterol in Whole-Grain-Diet-Fed Mice
- Author
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Jinxin Liu, Yan Li, Sun Juan, Mingcong Fan, Yu Wang, Lamei Xue, Li Wang, Haifeng Qian, and Chenzhipeng Nie
- Subjects
medicine.medical_specialty ,medicine.drug_class ,Cholesterol 7 alpha-hydroxylase ,Bile Acids and Salts ,Mice ,chemistry.chemical_compound ,Internal medicine ,CYP27A1 ,medicine ,Animals ,Cholesterol 7-alpha-Hydroxylase ,Whole Grains ,biology ,Bile acid ,Cholesterol ,Reverse cholesterol transport ,food and beverages ,Cytochrome P450 ,General Chemistry ,Lipid Metabolism ,Diet ,Endocrinology ,Liver ,chemistry ,biology.protein ,lipids (amino acids, peptides, and proteins) ,Brown rice ,General Agricultural and Biological Sciences ,Lipoprotein - Abstract
Hypercholesterolemia is a major risk factor for chronic metabolic diseases. Nevertheless, a whole-grain diet could ameliorate this issue in a number of ways, including by regulating bile acid metabolism. However, the potential mechanism is unclear. The aim of the current study is to explore the effects of whole-grain diets (brown rice diet and whole wheat diet) on bile acid homeostasis. After intervention for 8 weeks in mouse model, whole-grain diets showed reduced feed conversion ratio, and the lipid levels (total cholesterol (TC) and triglycerides (TG)) were also meliorated in the serum and liver of mice. Moreover, whole-grain diets reduced the expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) (cholesterol synthesis) in the liver of mice. Interestingly, whole-grain diets not only promoted the mRNA expressions of low-density lipoprotein receptor (LDLR), ATP binding cassette transporter G1 (ABCG1), and scavenger receptor class B type I (SR-BI) (reverse cholesterol transport) but also facilitated the expressions of cytochrome P450, family 7, subfamily a, polypeptide 1 (CYP7a1) and cytochrome P450, family 27, subfamily a, polypeptide 1 (CYP27a1) (bile acid synthesis). Further study found that whole-grain diets promoted intestinal bile acid reabsorption and reduced bile acid excretion. Our study provided a novel metabolic regulation of bile acids in response to reduced cholesterol levels induced by whole-grain diets.
- Published
- 2021