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Your search keyword '"Yuan, Ruijuan"' showing total 2 results
Start Over Author "Yuan, Ruijuan" Topic chemistry
2 results on '"Yuan, Ruijuan"'

1. Review: Separation and Pharmacology of Chiral Compounds in Traditional Chinese Medicine

Author

Wang Xiongfei, Sun Yikun, Sun Ke, Yuan Ruijuan, and Yue-Zhu Ding

Subjects
inorganic chemicals, Active ingredient, 010405 organic chemistry, business.industry, Chemistry, organic chemicals, 010401 analytical chemistry, Biochemistry (medical), Clinical Biochemistry, Traditional Chinese medicine, Pharmacology, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, health occupations, polycyclic compounds, Electrochemistry, heterocyclic compounds, business, Spectroscopy, Pharmaceutical industry
Abstract

More than 60% commonly used pharmaceutical active ingredients are chiral compounds. Developing more effective and safe chiral compounds has become a focus in the pharmaceutical industry. Chiral compounds widely exist in traditional Chinese medicine and include alkaloids, flavonoids, volatile oils, and amino acids. The characterization of chiral compounds used in traditional Chinese medicine remains limited. Here, the characterization of chiral compounds commonly used in traditional Chinese medicine is reviewed focusing upon their separation and pharmacology.

Published
2016

2. Synthesis of chiral SalenZn(II) and its coordination with imidazole derivatives and amino acid ester derivatives.

Author

Yuan, Ruijuan, Ruan, Wenjuan, Wang, Shujun, Zhang, Yinghui, Li, Xiaoli, and Zhu, Zhiang

Subjects
*IMIDAZOLES, *AMINO acids, *ESTERS, *SPECTRUM analysis, *CHEMICAL structure, *CHEMISTRY
Abstract

A chiral complex, SalenZn(II) (S), was synthesized and characterized. Its coordination with imidazole derivatives and amino acid ester derivatives was studied by UV-vis spectrophotometric titrations and CD spectroscopy. The binding constants decreased in the order K (Im)> K (2-MeIm)> K (2-Et-4-MeIm)> K (N-MeIm) for imidazole derivatives, and K (AlaOMe)> K (PheOMe)> K (ValOMe) for amino acid ester derivatives with the same configuration and K D > K L for amino acid esters with different configuration. CD spectra can quantify the strength of SalenZn(II)-ligand interactions, giving results consistent with the magnitudes of the binding constants. Moreover the minimum energy conformations of the adducts were obtained by simulated annealing, and quantum chemical calculations were performed based on those conformations to explain experimental results at the molecular level. [ABSTRACT FROM AUTHOR]

Published
2006
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