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Research has been conducted on the cathepsin V, a lysosomal cysteine protease expressed in the thymus. The crystal structure of this cathepsin which is associated with the irreversible vinyl sulfone inhibitor has been investigated.

A simple method was developed for access to molecules that contain both ketone and N-H aziridine functionalities. The compounds have undergone highly selective reduction and carbonyl addition reactions, thus making them versatile precursors to complex amines.

Efforts towards the synthesis and functionalization of aziridines, involved in nitrogen transfer reactions, are highlighted. The electrochemical aziridination of olefins, the acid-catalyzed ring opening of aziridines and the development of transition metal mediated nitrogen allylation, arylation and alkenylation of unprotected aziridines are investigated.