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A prospective resource of pharmacological treatment of ischemic brains stroke is rapid interference using potential neuroprotective materials. Cerium oxide nanoparticles have been shown to defend against blood brain barrier damage in cerebral ischemic brain stroke. While cerium oxide nanoparticles is highly permeable across the blood-brain barrier and also these nanoparticles are effective antioxidants, due to its ability to either donate or obtain electrons with alternative +3 and +4 valence states. This oxidation state of cerium oxide has shown efficiency in neutralizing generated free radicals in biological systems has been explored action for cerebral ischemic brain stroke. The nanoparticles are encapsulated on the poly-(lactide-co-glycolide)-polyethyleneglycol copolymer matrixes as nanoparticulate delivery vehicles and it can be enhanced brain targeted drug delivery. Furthermore, the results of spectroscopic and microscopic analysis confirmed that peripheral PEG-PLGA co-polymer chains provide excellent reactivity with nanoparticles which might improve the interface bonds of the nanocomposite formation. Mainly, neuroprotective properties of prepared CeO2-PEG/PLGA matrixes with and without nanoparticles are comparatively studied by using transient middle cerebral artery occlusion (MCAO) model of brain stroke. The prepared CeO2 nanoparticles combined with effective PEG/PLGA matrixes exhibited greater efficacy resulted in a lessening of focal ischemia by 60% and 78% decrease in brain edema in comparable to the control animals. The results are demonstrated that the neuroprotective efficiency of CeO2 nanoparticles with PEG/PLGA has enhanced and primarily protected the brain cortex areas from ischemic damage.

A series of 3-nitro-5-nitroimino-1,2,4-oxadiazole-based energetic salts were synthesized from 3-nitro-5-nitroimino-1,2,4-oxadiazole anion and nitrogen-rich cations. They were fully characterized by IR, elemental analysis and NMR spectroscopy. The structure of triaminoguanidinium salt ( 1-e ) was confirmed by single crystal X-ray diffraction. All salts showed good thermal stability with decomposed temperature ranging from 155 °C to 258 °C, and positive heats of formation from 226.0 kJ/mol to 554.1 kJ/mol. Thus, the theoretic detonation pressure was predicted from 28.70 GPa to 37.60 GPa and velocities from 8526 m/s to 9354 m/s. Among them, guanidinium salt ( 1-c ) exhibited both high decomposition temperature (258 °C) and detonation velocity (9319 m/s).

For the aluminum alloy pipe stable form and buckling capacity, axis compressing test for 4 sections which each specification in three members, total 36 members, thus, we work out the ultimate bearing capacity for a little slenderness ratio alloy round pipe and relation between slenderness ratio and coefficient of stability, to provide test data for drawing pillars curve of the same type member. Through observed aluminum alloy compressing member changing with test process, record test phenomenon, and combined with instruments of test data record, providing the basis for further theoretical analysis.

With the unilateral extending test on 4 teams*12 aluminum alloy round pipes, compressing test on 4 teams*4 pipes and repeating extending/compressing test on 4 teams*4 pipes, get the stress-strain relationship of the aluminum alloy round pipe, and get the elastic modulus f0.1 and f0.2. At the same time, get the conclusion that the damaging type is brittleness. The test result is the foundation for follow-up studies on the loading capacity of the aluminum alloys.

An easy preparation of methoxymethyl ethers of primary and secondary alcohols with dimethoxymethane has been carried out in excellent yield under catalysis of expansive graphite.