1,527 results on '"Yang, Gao"'
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2. Development of a Double-Stapled Peptide Stabilizing Both α‑Helix and β‑Sheet Structures for Degrading Transcription Factor AR-V7
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Bohan Ma, Donghua Liu, Mengjun Zheng, Zhe Wang, Dize Zhang, Yanlin Jian, Jian Ma, Yizeng Fan, Yule Chen, Yang Gao, Jing Liu, Xiang Li, and Lei Li
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Chemistry ,QD1-999 - Published
- 2024
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3. Oxygen‐Doped Porous Carbon Nanotubes Encapsulated Bismuth Oxide to Enhance the Performance of Lithium‐Sulfur Battery
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Dr. Xingyan Zeng, Dr. Yakun Tang, Prof. Lang Liu, Dr. Yue Zhang, Yang Gao, and Dr. Mao Qian
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Bi2O3 ,lithium-sulfur batteries ,CNTs ,the encapsulated structure ,oxygen-doped carbon ,Industrial electrochemistry ,TP250-261 ,Chemistry ,QD1-999 - Abstract
Abstract Lithium‐sulfur batteries (LSBs) are greatly promising next‐generation energy storage systems due to their high theoretical specific capacities and energy density. However, the dissolution of lithium polysulfides (LIPs) causees low capacity and short lifespan, impeding the practical application of LSBs. To address this challenge, the composites of oxygen‐doped porous carbon nanotubes (CNTs) wrapped in Bi2O3 were synthesized by the calcinating method (CNTs@Bi2O3). The CNTs@Bi2O3 composites as absorbent immobilize LIPs via the physical limitations of porous CNTs and the chemical adsorption of Bi2O3 and carbon‐oxygen polar bond. After loading sulfur, the CNTs@Bi2O3/S composites with the encapsulated structure can provide a large space to withstand the significant volume expansion during the electrochemical reaction process, ensuring the stability of the electrode structure. Thus, the batteries with CNTs@Bi2O3/S exhibit a high capacity (1232 mA h g−1 at 0.1 C) and good cycle stability (639.1 mA h g−1 after 150 cycles at 0.5 C). This work presents an innovative design suitable for the encapsulated structure of Bi2O3, serving as a valuable reference for the development of Bi2O3 in LSBs.
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- 2024
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4. Enhanced Polyacrylamide Degradation via OH Radical-Initiated Single-Electron Transfer
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Jun Zhang, Ming Hao, Depeng Zhang, Xuesong Zhang, Shijun Guo, Bo Wang, Junping Xiao, Yang Gao, and Xiaoan Li
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Chemistry ,QD1-999 - Published
- 2023
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5. Recent Technologies towards Diagnostic and Therapeutic Applications of Circulating Nucleic Acids in Colorectal Cancers
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Jun Chung, Sophie Xiao, Yang Gao, and Young Hwa Soung
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colorectal cancer (CRC) ,circulating DNAs ,circulating RNAs ,quantitative real-time PCR (q-RT-PCR) ,next-generation sequencing (NGS) ,RNA-sequencing (RNA-seq) ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Liquid biopsy has emerged as a promising noninvasive approach for colorectal cancer (CRC) management. This review focuses on technologies detecting circulating nucleic acids, specifically circulating tumor DNA (ctDNA) and circulating RNA (cfRNA), as CRC biomarkers. Recent advancements in molecular technologies have enabled sensitive and specific detection of tumor-derived genetic material in bodily fluids. These include quantitative real-time PCR, digital PCR, next-generation sequencing (NGS), and emerging nanotechnology-based methods. For ctDNA analysis, techniques such as BEAMing and droplet digital PCR offer high sensitivity in detecting rare mutant alleles, while NGS approaches provide comprehensive genomic profiling. cfRNA detection primarily utilizes qRT-PCR arrays, microarray platforms, and RNA sequencing for profiling circulating microRNAs and discovering novel RNA biomarkers. These technologies show potential in early CRC detection, treatment response monitoring, minimal residual disease assessment, and tumor evolution tracking. However, challenges remain in standardizing procedures, optimizing detection limits, and establishing clinical utility across disease stages. This review summarizes current circulating nucleic acid detection technologies, their CRC applications, and discusses future directions for clinical implementation.
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- 2024
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6. CDC20 Holds Novel Regulation Mechanism in RPA1 during Different Stages of DNA Damage to Induce Radio-Chemoresistance
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Yang Gao, Pengbo Wen, Chenran Shao, Cheng Ye, Yuji Chen, Junyu You, and Zhongjing Su
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CDC20 ,RPA1 ,DNA damage repair ,tumoral cell radio-chemosensitivity ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Targeting CDC20 can enhance the radiosensitivity of tumor cells, but the function and mechanism of CDC20 on DNA damage repair response remains vague. To examine that issue, tumor cell lines, including KYSE200, KYSE450, and HCT116, were utilized to detect the expression, function, and underlying mechanism of CDC20 in radio-chemoresistance. Western blot and immunofluorescence staining were employed to confirm CDC20 expression and location, and radiation could upregulate the expression of CDC20 in the cell nucleus. The homologous recombination (HR) and non-homologous end joining (NHEJ) reporter gene systems were utilized to explore the impact of CDC20 on DNA damage repair, indicating that CDC20 could promote HR repair and radio/chemo-resistance. In the early stages of DNA damage, CDC20 stabilizes the RPA1 protein through protein-protein interactions, activating the ATR-mediated signaling cascade, thereby aiding in genomic repair. In the later stages, CDC20 assists in the subsequent steps of damage repair by the ubiquitin-mediated degradation of RPA1. CCK-8 and colony formation assay were used to detect the function of CDC20 in cell vitality and proliferation, and targeting CDC20 can exacerbate the increase in DNA damage levels caused by cisplatin or etoposide. A tumor xenograft model was conducted in BALB/c-nu/nu mice to confirm the function of CDC20 in vivo, confirming the in vitro results. In conclusion, this study provides further validation of the potential clinical significance of CDC20 as a strategy to overcome radio-chemoresistance via uncovering a novel role of CDC20 in regulating RPA1 during DNA damage repair.
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- 2024
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7. Application of Generalized S-Transform in the Measurement of Dynamic Elastic Modulus
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Lei Wang, Yang Gao, Hongguang Liu, Guoping Fu, and Dunqiang Lu
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dynamic elastic modulus ,resonance frequency ,generalized S-transform ,time-frequency analysis ,concrete ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Resonance is commonly used for in situ measurement of the dynamic elastic modulus to evaluate the strength of concrete samples. Many researchers are also exploring the application of this convenient measurement technology for safety monitoring. Nevertheless, the presence of cracks and variations in curing conditions within samples can impact the resonance frequency range, potentially leading to potential inaccuracies in measurements. In order to improve the measurement accuracy of resonance frequency, this study introduces the Generalized S-Transform (GST) algorithm for measuring the dynamic elastic modulus, which utilizes its high time-frequency resolution to scan the power peak-point in non-stationary and transient excitation signals to determine the resonance frequency. For concrete materials with lower consistency, the experimental results verify the high accuracy of this algorithm in measuring resonance frequency compared with Fast Fourier Transform (FFT). This provides a reference for using the algorithm to measure the dynamic elastic modulus in civil engineering applications, such as buildings and bridges.
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- 2024
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8. Influence of Exogenous Abscisic Acid on Germination and Physiological Traits of Sophora viciifolia Seedlings under Drought Conditions
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Xin Rao, Yujun Zhang, Yang Gao, Lili Zhao, and Puchang Wang
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Sophora viciifolia ,exogenous ABA ,drought stress ,seed germination ,physiological traits ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
This study investigates the role of abscisic acid (ABA) in bolstering drought resistance in plants, employing “Panjiang Sophora viciifolia” as the subject. A simulated drought scenario was created using polyethylene glycol (PEG-6000) to examine the impact of varying drought intensities (0%, 5%, 20% PEG) and ABA concentrations (0, 10, 50, 100, 200 mg·L−1) on the germination and physiological parameters of Sophora viciifolia. The results showed that in the absence of ABA, the germination rate (GR), germination potential (GP), and germination index (GI) of S. viciifolia seeds initially increased and then decreased with escalating PEG-induced drought stress. At PEG-induced drought stress levels of 5% and 20%, the activities of peroxidase (POD) and catalase (CAT), along with the malondialdehyde (MDA) content, were significantly higher than in the control (CK) (p < 0.05). In response to drought stress, S. viciifolia seeds adapted by modulating germination behavior, augmenting the content of osmoregulatory substances, and boosting the activity of protective enzymes. The addition of ABA markedly enhanced GR, GE, GI, activities of POD, superoxide dismutase (SOD), and CAT, as well as the levels of MDA and proline (Pro) under drought conditions (p < 0.05). Relative to CK, low ABA concentrations (10–100 mg·L−1) resulted in increased GR, GP, GI, POD, SOD, CAT, MDA, and Pro levels; whereas, at a higher concentration (200 mg·L−1), although GR, GP, and GI decreased, POD, SOD, CAT, MDA, and Pro levels increased. Through principal component analysis and membership function comprehensive evaluation, it was determined that administering 50 mg·L−1 ABA was most effective in enhancing drought resistance in S. viciifolia seedlings.
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- 2024
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9. Seeds Priming with Melatonin Improves Root Hydraulic Conductivity of Wheat Varieties under Drought, Salinity, and Combined Stress
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Yuanyuan Fu, Penghui Li, Zhuanyun Si, Shoutian Ma, and Yang Gao
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melatonin ,abiotic stress ,priming effects ,root hydraulic conductivity ,aquaporin ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Drought and salinity stress reduce root hydraulic conductivity of plant seedlings, and melatonin application positively mitigates stress-induced damage. However, the underlying effect of melatonin priming on root hydraulic conductivity of seedlings under drought–salinity combined remains greatly unclear. In the current report, we investigated the influence of seeds of three wheat lines’ 12 h priming with 100 μM of melatonin on root hydraulic conductivity (Lpr) and relevant physiological indicators of seedlings under PEG, NaCl, and PEG + NaCl combined stress. A previous study found that the combined PEG and NaCl stress remarkably reduced the Lpr of three wheat varieties, and its value could not be detected. Melatonin priming mitigated the adverse effects of combined PEG + NaCl stress on Lpr of H4399, Y1212, and X19 to 0.0071 mL·h−1·MPa−1, 0.2477 mL·h−1·MPa−1, and 0.4444 mL·h−1·MPa−1, respectively, by modulating translation levels of aquaporin genes and contributed root elongation and seedlings growth. The root length of H4399, Y1212, and X19 was increased by 129.07%, 141.64%, and 497.58%, respectively, after seeds pre-treatment with melatonin under PEG + NaCl combined stress. Melatonin -priming appreciably regulated antioxidant enzyme activities, reduced accumulation of osmotic regulators, decreased levels of malondialdehyde (MDA), and increased K+ content in stems and root of H4399, Y1212, and X19 under PEG + NaCl stress. The path investigation displayed that seeds primed with melatonin altered the modification of the path relationship between Lpr and leaf area under stress. The present study suggested that melatonin priming was a strategy as regards the enhancement of root hydraulic conductivity under PEG, NaCl, and PEG + NaCl stress, which efficiently enhanced wheat resistant to drought–salinity stress.
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- 2024
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10. Adaptive Scale and Correlative Attention PointPillars: An Efficient Real-Time 3D Point Cloud Object Detection Algorithm
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Xinchao Zhai, Yang Gao, Shiwei Chen, and Jingshuai Yang
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autonomous vehicle ,adaptive scale pillars (ASP) ,correlative point attention (CPA) ,object detection ,LiDAR point cloud ,random sampling data augmentation algorithm (RS-Aug) ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Recognizing 3D objects from point clouds is a crucial technology for autonomous vehicles. Nevertheless, LiDAR (Light Detection and Ranging) point clouds are generally sparse, and they provide limited contextual information, resulting in unsatisfactory recognition performance for distant or small objects. Consequently, this article proposes an object recognition algorithm named Adaptive Scale and Correlative Attention PointPillars (ASCA-PointPillars) to address this problem. Firstly, an innovative adaptive scale pillars (ASP) encoding method is proposed, which encodes point clouds using pillars of varying sizes. Secondly, ASCA-PointPillars introduces a feature enhancement mechanism called correlative point attention (CPA) to enhance the feature associations within each pillar. Additionally, a data augmentation algorithm called random sampling data augmentation (RS-Aug) is proposed to solve the class imbalance problem. The experimental results on the KITTI 3D object dataset demonstrate that the proposed ASCA-PointPillars algorithm significantly boosts the recognition performance and RS-Aug effectively enhances the training effects on an imbalanced dataset.
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- 2024
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11. In-situ concentration measurement of soluble-soluble redox couple in molten chlorides utilizing intense natural convection effect
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Fei Zhu, Jianbang Ge, Yang Gao, Biwu Cai, Zichen Zhang, Feifei Jia, and Shuqiang Jiao
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Natural convection ,In-situ concentration measurement ,Cyclic voltammetry ,Molten salts ,Industrial electrochemistry ,TP250-261 ,Chemistry ,QD1-999 - Abstract
Herein we reported the in-situ electrochemical concentration measurement of soluble-soluble redox species (Eu3+/Eu2+ and Sm3+/Sm2+) in molten LiCl-KCl, based on the notable natural convection in molten salts. The combined simulation and experiments confirmed the presence of strong natural convection, which resulted in steady-state current in cyclic voltammetry tests at low scan rates. Interestingly, this natural convection effects offered a novel and simple way to calculate the diffusion coefficient and concentration ratio of soluble redox species.
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- 2023
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12. Optimization of CO2 Injection Huff and Puff Process in Shale Reservoirs Based on NMR Technology
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Yang Gao, Dehua Liu, Sichen Li, Liang Cheng, and Jing Sun
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shale oil ,CO2 ,huff and puff ,on-line NMR ,parameter optimization ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The pore mobilization characteristics of CO2 when in shale reservoirs is an important indicator for evaluating the effectiveness of its application for enhanced recovery in shale reservoirs, and it is important to develop a comprehensive set of physical simulation methods that are consistent with actual field operations. This has underscored the need for efficient development techniques in the energy industry. The huff-n-puff seepage oil recovery method is crucial for developing tight oil reservoirs, including shale oil. However, the small pore size and low permeability of shale render conventional indoor experiments unsuitable for shale oil cores. Consequently, there is a need to establish a fully enclosed experimental method with a high detection accuracy to optimize the huff and puff process parameters. The NMR technique identifies oil and gas transport features in nanogaps, and in this study, we use low-field nuclear magnetic resonance (NMR) online displacement technology to conduct CO2 huff and puff experiments on shale oil, covering the gas injection, well stewing, and production stages. After conducting four rounds of huff-n-puff experiments, key process parameters were optimized, including the simmering time, huff-n-puff timing, number of huff-n-puff rounds, and the amount of percolant injected. The findings reveal that as the number of huff-n-puff rounds increases, the time required for well stabilization decreases correspondingly. However, the enhancement in recovery from additional huff-n-puff rounds becomes negligible after three rounds, showing only a 1.16% improvement. CO2 re-injection is required when the pressure falls to 70% of the initiaformation pressure to ensure efficient shale oil well development. This study also indicates that the most economically beneficial results are achieved when the injection volume of the huff-n-puff process is 0.44 pore volumes (PVs).
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- 2024
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13. Study on High-Precision Tension Control Technology for a Cold-Rolling Pilot Mill with Hydraulic Tension
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Guiqiao Wang, Yang Gao, Jingguo Ding, and Jie Sun
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CRPM with hydraulic tension ,hydraulic servo control ,extraneous force ,redundant feedforward flow ,proportional pressure relief valve ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Tension control in cold-rolling pilot mills (CRPMs) with hydraulic tension is subject to extraneous forces resulting from positional disturbances, strong coupling, and time-varying characteristics, making it challenging to achieve ideal control results using the existing control methods. Therefore, in this study, a mathematical model of tension is first derived and then used to analyze the properties and difficulties associated with tension control. Second, a hydraulic servo-control system based on servovalves and proportional pressure relief valves is developed. In this system, redundant feedforward flow is generated by a servovalve according to the rolling schedule. The surplus flow is absorbed by a proportional pressure relief valve in the closed-loop control of tension. Third, simulation analysis is performed. Under severe friction disturbance (maximum 0.2 kN), and with the wide range of forward and backward slip, an accuracy of ±0.27 kN in tension control can still be achieved using the proposed control strategy, thereby demonstrating its effectiveness. Moreover, it has obvious advantages over existing control methods. Finally, an experimental study of tension is carried out in the cold-rolling mill with a maximum tension capacity of 50 kN, achieving ±0.2 kN tension control precision in the multipass rolling process.
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- 2024
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14. Seismic Resolution Enhancement Using a Cycle Generative Adversarial Neural Network with Pseudo-Well Data
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Xianzheng Zhao, Yang Gao, Shuwen Guo, Weiwei Gu, and Guofa Li
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neural network ,CycleGAN ,data processing ,high-resolution reconstruction ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
High-resolution seismic processing involves the recovery of high-frequency components from seismic data with lower resolution. Traditional methods typically impose prior knowledge or predefined subsurface structures when modeling seismic high-resolution processes, and they are usually model-driven. Nowadays, there has been a growing utilization of deep learning techniques to enhance seismic resolution. These approaches involve feature learning from extensive training datasets through multi-layered neural networks and are fundamentally data-driven. However, the reliance on labeled data has consistently posed a primary challenge for deploying these methods in practical applications. To address this issue, a novel approach for seismic high-resolution reconstruction is introduced, employing a Cycle Generative Adversarial Neural Network (CycleGAN) trained on authentic pseudo-well data. The application of the CycleGAN involves creating dual mappings connecting low-resolution and high-resolution data. This enables the model to comprehend both the forward and inverse processes, ensuring the stability of the inverse process, particularly in the context of high-resolution reconstruction. More importantly, statistical distributions are extracted from well logs and used to randomly generate extensive sets of low-resolution and high-resolution training pairs. This training set captures the structural characteristics of the actual subsurface and leads to significant improvement of the proposed method. The results from experiments conducted on both synthetic and field examples validate the effectiveness of the proposed approach in significantly enhancing seismic resolution and achieving superior recovery of thin layers when compared with the conventional method and the deep-learning-based method.
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- 2023
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15. Perfluorooctanoic Acid (PFOA) Exposure Compromises Fertility by Affecting Ovarian and Oocyte Development
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Han Zhang, Lulu Han, Lijun Qiu, Bo Zhao, Yang Gao, Zhangjie Chu, and Xiaoxin Dai
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zebrafish ,fertilization capability ,oocytes ,perfluorooctanoic acid ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
PFOA, a newly emerging persistent organic pollutant, is widely present in various environmental media. Previous reports have proved that PFOA exposure can accumulate in the ovary and lead to reproductive toxicity in pregnant mice. However, the potential mechanism of PFOA exposure on fertility remains unclear. In this study, we explore how PFOA compromises fertility in the zebrafish. The data show that PFOA (100 mg/L for 15 days) exposure significantly impaired fertilization and hatching capability. Based on tissue sections, we found that PFOA exposure led to ovarian damage and a decrease in the percentage of mature oocytes. Moreover, through in vitro incubation, we determined that PFOA inhibits oocyte development. We also sequenced the transcriptome of the ovary of female zebrafish and a total of 284 overlapping DEGs were obtained. Functional enrichment analysis showed that 284 overlapping DEGs function mainly in complement and coagulation cascades signaling pathways. In addition, we identified genes that may be associated with immunity, such as LOC108191474 and ZGC:173837. We found that exposure to PFOA can cause an inflammatory response that can lead to ovarian damage and delayed oocyte development.
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- 2023
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16. A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1
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Debanu Das, Matthew A. J. Duncton, Taxiarchis M. Georgiadis, Patricia Pellicena, Jennifer Clark, Robert W. Sobol, Millie M. Georgiadis, John King-Underwood, David V. Jobes, Caleb Chang, Yang Gao, Ashley M. Deacon, and David M. Wilson
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fragment-based drug discovery ,structure-based drug discovery ,X-ray crystallography ,cancer therapeutics ,DNA damage response ,polymerases ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
The ability to quickly discover reliable hits from screening and rapidly convert them into lead compounds, which can be verified in functional assays, is central to drug discovery. The expedited validation of novel targets and the identification of modulators to advance to preclinical studies can significantly increase drug development success. Our SaXPyTM (“SAR by X-ray Poses Quickly”) platform, which is applicable to any X-ray crystallography-enabled drug target, couples the established methods of protein X-ray crystallography and fragment-based drug discovery (FBDD) with advanced computational and medicinal chemistry to deliver small molecule modulators or targeted protein degradation ligands in a short timeframe. Our approach, especially for elusive or “undruggable” targets, allows for (i) hit generation; (ii) the mapping of protein–ligand interactions; (iii) the assessment of target ligandability; (iv) the discovery of novel and potential allosteric binding sites; and (v) hit-to-lead execution. These advances inform chemical tractability and downstream biology and generate novel intellectual property. We describe here the application of SaXPy in the discovery and development of DNA damage response inhibitors against DNA polymerase eta (Pol η or POLH) and apurinic/apyrimidinic endonuclease 1 (APE1 or APEX1). Notably, our SaXPy platform allowed us to solve the first crystal structures of these proteins bound to small molecules and to discover novel binding sites for each target.
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- 2023
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17. Characterizing a Cost-Effective Hydrogel-Based Transparent Soil
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Kanghu Li, Lin Ma, Yang Gao, Jiyang Zhang, and Sen Li
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transparent soil ,transmittance ,hardness ,porosity ,shrinkage ,Science ,Chemistry ,QD1-999 ,Inorganic chemistry ,QD146-197 ,General. Including alchemy ,QD1-65 - Abstract
Transparent soil (TS) was specifically designed to support root growth in the presence of air, water, and nutrients and allowed the time-resolved phenotyping of roots in vivo. Nevertheless, it is imperative to further optimize the reagent cost of TS to enable its wider utilization. We substituted the costly Phytagel obtained from Sigma with two more economical alternatives, namely Biodee and Coolaber. TS beads from each brand were prepared using 12 different polymer concentrations and seven distinct crosslinker concentrations. A comprehensive assessment encompassing transparency, mechanical characteristics, particle size, porosity, and stability of TS was undertaken. Compared to the Sigma Phytagel brand, both Biodee and Coolaber significantly reduced the transparency and collapse stress of the TS they produced. Consequently, this led to a significant reduction in the allowable width and height of the growth box, although they could still simultaneously exceed 20 cm and 19 cm. There was no notable difference in porosity and stability among the TS samples prepared using the three Phytagel brands. Therefore, it is feasible to consider replacing the Phytagel brand to reduce TS production costs. This study quantified the differences in TS produced using three Phytagel brands at different prices that will better promote the application of TS to root phenotypes.
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- 2023
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18. Design and Analysis of a New Semiactive Hydraulic Mount for a Wide-Range Tunable Damping without Magneto-Rheological/Electric-Rheological Fluid
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Yuan-Cheng Zhu, Guo-Feng Yao, Min Wang, Hang Yu, Kui-Yang Gao, and Pei-Lei Zhou
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hydraulic engine mount ,semiactive control ,magneto-rheological fluid ,vibration isolation ,dynamic stiffness ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
A hydraulic engine mount (HEM) is an advanced tuned mass damper (TMD) system used to isolate the noise and vibration from the engine to the chassis. This paper aims to design a semiactive HEM based on the TMD model, which only tunes damping without affecting the other lumped parameters of the TMD system. Firstly, the dynamic equations of an HEM modeled as a TMD system are derived based on the linear lumped parameter model (LPM). Each lumped parameter of the HEM is analyzed to identify the relevant parameters that affect damping. Secondly, a newly designed semiactive HEM design is proposed that utilizes a helical moving plate to simultaneously control both the inertia track area and length, resulting in precise damping tuning. To illustrate the dynamic performance of the newly designed HEM, calculations are presented based on various parameters for its tunable damping range and dynamic stiffness spectrum. Additionally, to demonstrate the performance of vibration isolation, this paper determines the optimal length and dynamic stiffness of the inertia track to minimize the transmissibility. Thirdly, to reveal the superiority of the newly designed HEM over the MR fluid mount, an example is presented where the MR fluid medium is used in place of conventional hydraulic fluid in the HEM while keeping all other parameters constant. Specifically, the novel semiactive HEM employs conventional hydraulic fluid and is spiral-driven by a moving plate while the MR fluid-based HEM is controlled by an additional tunable magnetic intensity controller. The nonlinear LPM of the newly designed HEM is verified by comparing the dynamic stiffness spectrum with the experimental results in the published literature. Then, the nonlinear LPM of the MR fluid mount is established, and its dynamic stiffness spectrum is calculated and compared with that of the newly designed HEM. The results indicate that the newly designed HEM and MR fluid mount have similar ranges of dynamic stiffness control, but the newly designed HEM does not require expensive MR/ER fluid or additional continuous external energy input to regulate the dynamic stiffness. Moreover, when using inexpensive low-viscosity hydraulic fluid, the newly designed HEM can provide a wider range of dynamic stiffness control.
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- 2023
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19. Effect of Cross-Linking Density on Non-Linear Viscoelasticity of Vulcanized SBR: A MD Simulation and Experimental Study
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Tian Yan, Ke-Jian Wang, Xiu-Ying Zhao, and Yang-Yang Gao
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vulcanized SBR ,non-linear viscoelasticity ,Payne effect ,MD simulations ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
In recent years, there has been a growing interest in changes in dynamic mechanical properties of mixed rubber during dynamic shear, yet the influence of vulcanized characteristics on the dynamic shear behavior of vulcanized rubber, particularly the effect of cross-linking density, has received little attention. This study focuses on styrene–butadiene rubber (SBR) and aims to investigate the impact of different cross-linking densities (Dc) on dynamic shear behavior using molecular dynamics (MD) simulations. The results reveal a remarkable Payne effect, where the storage modulus experiences a significant drop when the strain amplitude (γ0) exceeds 0.1, which can be attributed to the fracture of the polymer bond and the decrease in the molecular chain’s flexibility. The influence of various Dc values mainly resides at the level of molecular aggregation in the system, where higher Dc values impede molecular chain motion and lead to an increase in the storage modulus of SBR. The MD simulation results are verified through comparisons with existing literature.
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- 2023
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20. Inverse Design and Numerical Investigations of an Ultra-Compact Integrated Optical Switch Based on Phase Change Material
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Kun Yin, Yang Gao, Hao Shi, and Shiqiang Zhu
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integrated optics ,optical switch ,phase change material ,silicon photonics ,Chemistry ,QD1-999 - Abstract
The miniaturization of optical switches is a promising prospect with the use of phase-change materials (PCMs), and exploring various strategies to effectively integrate PCMs with integrated optical waveguides represents an intriguing research question. In this study, an ultra-compact integrated optical switch based on PCM is proposed. This device consists of a Ge2Sb2Te5 nano-disk and an inverse-designed pixelated sub-wavelength structure. The pixelated sub-wavelength structure offers customized refractive indices that conventional materials or structures cannot achieve, leading to an improved insertion loss (IL) and extinction ratio (ER) performance of the device. Furthermore, this structure enhances the interaction between the optical field and GST, resulting in a reduction of the device size and the inserted GST footprint. With an ultra-compact device footprint of 0.9 µm × 1.5 µm, the simulation results exhibit a low IL of 0.45 dB, and a high ER of 18.0 dB at 1550 nm. Additionally, relevant studies show that this device is able to perform reliably despite minor variations in the manufacturing process.
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- 2023
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21. A Hybrid Deep Learning Framework Based on Diffusion Model and Deep Residual Neural Network for Defect Detection in Composite Plates
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Tianrui Huang, Yang Gao, Zhenglin Li, Yue Hu, and Fuzhen Xuan
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structural health monitoring ,diffusion model ,DenseNet ,Lamb wave ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The establishment of a structural health monitoring (SHM) system for the damage and defects of composite structures is of great theoretical and engineering value to ensure their production and operational safety. Advanced machine learning technologies, such as deep learning, have become one of the main driving forces for state monitoring and predictive analysis of these structures. However, it is difficult to obtain sufficient data to train the deep learning model, which may fail to build an accurate and efficient SHM model. To overcome this problem, a new method based on Lamb waves and the diffusion model (DM) is proposed to realize the identification and classification of different defects for carbon-fiber-reinforced polymer (CFRP) structures. In this study, DM is used as the generation model of data enhancement, and the optimized and improved DDPM model is constructed in this experiment. The deep residual neural network (DenseNet) is used to identify and classify the defect features from the Lamb wave signals. Experimental and test results show that the deep learning framework designed in this study based on DenseNet classification and DDPM data enhancement can accurately detect and classify damage signals of common defects in CFRP composite plates.
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- 2023
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22. Dynamic Characteristics Analysis of a Rod Fastening Rotor System Considering Contact Roughness
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Wei Zhao, Yang Gao, Xiu Ren, Kuan Lu, and Yang Yang
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rod fastening rotor system ,contact roughness ,fractal theory ,dynamic characteristics ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
A rod fastening rotor is the core component of gas turbines, which affects the working stability and service life of the whole machine. The characterization of the contact mechanism of a joint’s interface is a key problem in dynamic prediction. The aim of this paper is to gain insight into the influence of the joint’s interface on the dynamic characteristics of the rod fastening rotor system. According to the equivalent bending stiffness of the joint’s interface, the natural frequency of the system is obtained by the analytical method, where the normal contact stiffness of the joint’s interface related to the frequency index is established on the theory of fractal contact analysis. After that, the effects of key parameters on the contact stiffness are discussed in detail. Finally, the variations in the vibration frequency are further revealed as well.
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- 2023
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23. LINC01393, a Novel Long Non-Coding RNA, Promotes the Cell Proliferation, Migration and Invasion through MiR-128-3p/NUSAP1 Axis in Glioblastoma
- Author
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Deheng Li, Junda Hu, Sen Li, Changshuai Zhou, Mingtao Feng, Liangdong Li, Yang Gao, Xin Chen, Xiaojun Wu, Yiqun Cao, Bin Hao, and Lei Chen
- Subjects
competing endogenous RNA ,glioblastoma ,LINC01393 ,miR-128-3p ,nucleolar and spindle-associated protein 1 ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Nucleolar and spindle-associated protein 1 (NUSAP1) is a potential molecular marker and intervention target for glioblastoma (GBM). In this study, we aim to investigate upstream regulatory lncRNAs and miRNAs of NUSAP1 through both experimental and bioinformatic methods. We screened upstream lncRNAs and miRNAs of NUSAP1 through multiple databases based on ceRNA theory. Then, in vitro and in vivo experiments were performed to elucidate the relevant biological significance and regulatory mechanism among them. Finally, the potential downstream mechanism was discussed. LINC01393 and miR-128-3p were screened as upstream regulatory molecules of NUSAP1 by TCGA and ENCORI databases. The negative correlations among them were confirmed in clinical specimens. Biochemical studies revealed that overexpression or knockdown of LINC01393 respectively enhanced or inhibited malignant phenotype of GBM cells. MiR-128-3p inhibitor reversed LINC01393 knockdown-mediated impacts on GBM cells. Then, dual-luciferase reporter assay and RNA immunoprecipitation assay were conducted to validate LINC01393/miR-128-3p/NUSAP1 interactions. In vivo, LINC01393-knockdown decreased tumor growth and improved mice survival, while restoration of NUSAP1 partially reversed these effects. Additionally, enrichment analysis and western blot revealed that the roles of LINC01393 and NUSAP1 in GBM progression were associated with NF-κB activation. Our findings showed that LINC01393 sponged miR-128-3p to upregulate NUSAP1, thereby promoting GBM development and progression via activating NF-κB pathway. This work deepens understanding of GBM mechanisms and provides potential novel therapeutic targets for GBM.
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- 2023
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24. Effects of Warming and Drought Stress on the Coupling of Photosynthesis and Transpiration in Winter Wheat (Triticum aestivum L.)
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Qian Li, Yang Gao, Abdoul Kader Mounkaila Hamani, Yuanyuan Fu, Junming Liu, Hongbo Wang, and Xingpeng Wang
- Subjects
warming ,drought stress ,winter wheat ,stomatal conductance ,photosynthetic rate ,transpiration rate ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The coupling of photosynthesis and transpiration in plant leaves forms the basis of carbon–water coupling in terrestrial ecosystems. Previous studies have attributed the coupling of leaf photosynthesis and transpiration to joint stomata control, but they lack analyses of the coupling mechanism. In this study, winter wheat (Triticum aestivum L.) was selected as a plant material on the North China Plain. Under the conditions of warming and drought stress, the photosynthetic rate (An), transpiration rate (Tr), water pressure saturation (VPD), and leaf temperature (T1) of wheat were recorded on clear days at the jointing, flowering, and grain-filling stages from 9:00 to 12:00 a.m. Then, the measured values were fitted to the simulated values obtained using the Ball–Berry and Penman–Monteith models. The results showed that the stomatal size, stomatal conductance, An, and Tr of winter wheat leaves were decreased by warming, drought stress, and their synergistic effects. Based on the Ball–Berry model, different fitting effects were observed in the treatments of adequate water supply with warming (R-g), water deficit with warming (R-d), adequate water supply without warming (N-g), and water deficit without warming (N-d). The R2 values of the R-g, R-d, N-g, and N-d treatments were 0.962, 0.958, 0.964, and 0.943, respectively. The Tr values were fitted based on the Penman–Monteith model. In the R-g, R-d, N-g, and N-d treatments, the R2 values of the R-g, R-d, N-g, and N-d treatments were 0.923, 0.849, 0.934, and 0.919, respectively. In conclusion, both warming and water deficit reduce stomatal conductance, An, Tr, and the coupling effect of photosynthesis and transpiration.
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- 2023
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25. Genome-Wide Characterization and Functional Analysis of ABCG Subfamily Reveal Its Role in Cutin Formation in Cotton
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Xuehan Huo, Ao Pan, Mingyang Lei, Zhangqiang Song, Yu Chen, Xin Wang, Yang Gao, Jingxia Zhang, Shengli Wang, Yanxiu Zhao, Furong Wang, and Jun Zhang
- Subjects
Gossypium ,ABCG ,function ,cutin formation ,ultrastructure ,VIGS ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
ATP-binding cassette transporter G (ABCG) has been shown to be engaged in export of broad-spectrum compounds with structural differences, but little is known concerning its role in cutin formation of cotton (Gossypium spp.). In this study, we conduct a genome-wide survey and detected 69, 71, 124 and 131 ABCG genes within G. arboretum, G. raimondii, G. hirsutum and G. barbadense, separately. The above ABCGs could be divided into four groups (Ia, Ib, Ic, II). Some ABCG genes such as GhABCG15, whose homologous gene transports cuticular lipid in Arabidopsis, was preferentially expressed in the development of fiber. A weighted gene co-expression network analysis (WGCNA) demonstrated that GhABCG expression was significantly associated with the amount of 16-Hydroxypalmitate (a main component of cutin precursor) in cotton fibers. Further, silencing of GhABCG15 by virus-induced gene silencing (VIGS) in cotton generated brightened and crinkled leaves as well as reduced thickness of cuticle and increased permeability. Chemical composition analysis showed the cutin content in GhABCG15-silenced leaves had decreased while the wax content had increased. Our results provide an insight for better understanding of the role of the Gossypium ABCG family and revealed the essential role of GhABCGs in cotton cutin formation.
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- 2023
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26. Understanding the Hydrogen-Bonded Clusters of Ammonia (NH3)n (n = 3–6): Insights from the Electronic Structure Theory
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Bo Wang, Pugeng Hou, Yongmao Cai, Zhendong Guo, Dandan Han, Yang Gao, and Lei Zhao
- Subjects
Chemistry ,QD1-999 - Published
- 2020
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27. Characterization of Electrogenic Gut Bacteria
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Mehdi Tahernia, Ellie Plotkin-Kaye, Maedeh Mohammadifar, Yang Gao, Melissa R. Oefelein, Laura C. Cook, and Seokheun Choi
- Subjects
Chemistry ,QD1-999 - Published
- 2020
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28. Portable, Disposable, Paper-Based Microbial Fuel Cell Sensor Utilizing Freeze-Dried Bacteria for In Situ Water Quality Monitoring
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Jong Hyun Cho, Yang Gao, Jihyun Ryu, and Seokheun Choi
- Subjects
Chemistry ,QD1-999 - Published
- 2020
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29. Selective Extraction of Light Lanthanides(III) by N,N‑Di(2-ethylhexyl)-diglycolamic Acid: A Comparative Study with N,N‑Dimethyl-diglycolamic Acid as a Chelator in Aqueous Solutions
- Author
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Sherif M. Ibrahim, Yan Zhang, Yun Xue, Suliang Yang, Fuqiu Ma, Yang Gao, Yu Zhou, and Guoxin Tian
- Subjects
Chemistry ,QD1-999 - Published
- 2019
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30. Development and Application of Similar Materials for Foundation Pit Excavation Model Test of Metro Station
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Zeyao Zhang, Yang Gao, Xinyu Zheng, Jiarui Cao, and Yong Chen
- Subjects
foundation pit excavation ,mechanical properties ,orthogonal experiment ,range analysis ,geomechanical model test ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Geomechanical model tests provide an intuitive and convenient method for observing physical phenomenon due to their easy implementation compared to in situ tests and prototype tests. The success of model tests depends heavily on the appropriate selection of model materials and proportions. Therefore, a new similar material is developed by utilizing the orthogonal experimental design method to conduct a series of proportioning tests. The new material is mixed with barite powder, iron ore powder, quartz sand, liquid paraffin, rosin, gypsum powder, and water. The physical and mechanical properties are studied through uniaxial compressive tests, Brazilian splitting tests, and direct shear tests. The influences of various raw material factors on the parameters of the similar material are systematically studied through range analysis. The results demonstrate that the mechanical parameters of similar materials have wide variation ranges; the adjustment range is 42.0–279.0 MPa for the elastic modulus, 0.37–5.37 MPa for the uniaxial compressive strength and 2.23–2.65 g/cm3 for the density. The new similar material has illustrated advantages in terms of performance stability, low price, and convenient production, which can simulate the similar relationship with different geomechanical model tests. The similar material is applied to a 3D geomechanical model test of the foundation pit excavation of Shenzhen metro station, which proves that the similar material can realistically reflect the change of earth pressure in the excavation process. With the deepening of excavation, the earth pressure curve shows significant fluctuations, and as the retaining structure is displaced, the parts with large earth pressure changes should be strengthened. The research methods and results can provide reference for further geological engineering research.
- Published
- 2022
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31. Protection Effect of Ammonia on CeNbTi NH3-SCR Catalyst from SO2 Poisoning
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Yang Gao, Li Cao, Xiaodong Wu, Xu Zhang, Ziran Ma, Rui Ran, Zhichun Si, Duan Weng, and Baodong Wang
- Subjects
ceria ,SCR ,sulfur ,NH3 ,TPD ,DRIFTS ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
CeNbTi catalyst was poisoned in different sulfur poisoning atmospheres at 300 °C for 6 h and then was evaluated for selective catalytic reduction (SCR) of NOx with NH3. The catalyst deactivation upon SO2 exposure was effectively inhibited in the presence of NH3. Temperature-programmed decomposition (TPD) analyses were applied to identify deposit species on the poisoned catalysts by comparison with several groups of reference samples. Diffuses reflectance infrared Fourier transform spectroscopy (DRIFTS) over CeNbTi catalysts with different poisoning pretreatments and gas purging sequences were designed to investigate the roles of NH3 in the removal of surface sulfites and sulfates. More ammonium sulfates including ammonium bisulfate and ammonium cerium sulfate were generated instead of inert cerium sulfate in these conditions. The mechanisms about the formation and transformation of surface deposits upon sulfur poisoning w/wo NH3 were explored, which provided a basis for developing Ce-based mixed oxides as SCR catalysts for stationary sources.
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- 2022
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32. Myostatin Knockout Affects Mitochondrial Function by Inhibiting the AMPK/SIRT1/PGC1α Pathway in Skeletal Muscle
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Mingjuan Gu, Zhuying Wei, Xueqiao Wang, Yang Gao, Dong Wang, Xuefei Liu, Chunling Bai, Guanghua Su, Lei Yang, and Guangpeng Li
- Subjects
myostatin ,CRISPR/Cas9 ,knockout ,mitochondrial ,skeletal muscle ,AMPK/SIRT1/PGC-1α ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Myostatin (Mstn) is a major negative regulator of skeletal muscle mass and initiates multiple metabolic changes. The deletion of the Mstn gene in mice leads to reduced mitochondrial functions. However, the underlying regulatory mechanisms remain unclear. In this study, we used CRISPR/Cas9 to generate myostatin-knockout (Mstn-KO) mice via pronuclear microinjection. Mstn-KO mice exhibited significantly larger skeletal muscles. Meanwhile, Mstn knockout regulated the organ weights of mice. Moreover, we found that Mstn knockout reduced the basal metabolic rate, muscle adenosine triphosphate (ATP) synthesis, activities of mitochondrial respiration chain complexes, tricarboxylic acid cycle (TCA) cycle, and thermogenesis. Mechanistically, expressions of silent information regulator 1 (SIRT1) and phosphorylated adenosine monophosphate-activated protein kinase (pAMPK) were down-regulated, while peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) acetylation modification increased in the Mstn-KO mice. Skeletal muscle cells from Mstn-KO and WT were treated with AMPK activator 5-aminoimidazole-4-carboxamide riboside (AICAR), and the AMPK inhibitor Compound C, respectively. Compared with the wild-type (WT) group, Compound C treatment further down-regulated the expression or activity of pAMPK, SIRT1, citrate synthase (CS), isocitrate dehydrogenase (ICDHm), and α-ketoglutarate acid dehydrogenase (α-KGDH) in Mstn-KO mice, while Mstn knockout inhibited the AICAR activation effect. Therefore, Mstn knockout affects mitochondrial function by inhibiting the AMPK/SIRT1/PGC1α signaling pathway. The present study reveals a new mechanism for Mstn knockout in regulating energy homeostasis.
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- 2022
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33. Wideband E00-E10 Silicon Mode Converter Based on 180 nm CMOS Technology
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Yan Xu, Yang Gao, Songyue Liu, Tingyu Liu, Xiaoqiang Sun, Bo Tang, Peng Zhang, and Daming Zhang
- Subjects
integrated optical devices ,silicon waveguide ,mode multiplexing ,mode converter ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Mode division multiplexing (MDM) is a promising technology for the capacity enlargement of the optical transmission network. As a key element in the MDM system, the mode converter plays an important role in signal processing. In this work, a wideband E00-E10 silicon mode converter constructed by Y-branch and cascaded multimode interference coupler is demonstrated. The theoretical mode crosstalk is less than –29.2 dB within the wavelength range from 1540 nm to 1600 nm. By 180 nm standard CMOS fabrication, the tested mode conversion efficiency of 91.5% and the crosstalk of −10.3 dB can be obtained at 1575.9 nm. The 3 dB bandwidth is over 60 nm. The proposed E00-E10 silicon mode converter is applicable in mode multiplexing.
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- 2022
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34. An Infrared Ultra-Broadband Absorber Based on MIM Structure
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Meichen Li, Guan Wang, Yang Gao, and Yachen Gao
- Subjects
metamaterial ,infrared ,ultra-broadband absorption ,local surface plasmon resonance ,Chemistry ,QD1-999 - Abstract
We designed an infrared ultra-broadband metal–insulator–metal (MIM)-based absorber which is composed of a top layer with four different chromium (Cr) nano-rings, an intermediate media of aluminum trioxide (Al2O3), and a bottom layer of tungsten (W). By using the finite-difference time-domain (FDTD), the absorption performance of the absorber was studied theoretically. The results indicate that the average absorption of the absorber can reach 94.84% in the wavelength range of 800–3000 nm. The analysis of the electric and magnetic field indicates that the ultra-broadband absorption rate results from the effect of local surface plasmon resonance (LSPR). After that, the effect of structural parameters, metal and dielectric materials on the absorptivity of the absorber was also discussed. Finally, the effect of incidence angle on absorption was investigated. It was found that it is not sensitive to incidence angle; even when incidence angle is 30°, average absorptivity can reach 90%. The absorber is easy to manufacture and simple in structure, and can be applied in infrared detection and optical imaging.
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- 2022
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35. Dual-Channel Mid-Infrared Toroidal Metasurfaces for Wavefront Modulation and Imaging Applications
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Jingyu Zhang, Chang Liu, Hengli Feng, Dongchao Fang, Jincheng Wang, Zuoxin Zhang, Yachen Gao, and Yang Gao
- Subjects
metasurface ,two channels ,programmable imaging ,thermal imaging ,Chemistry ,QD1-999 - Abstract
In this paper, we propose a dual-channel mid-infrared toroidal metasurface that consists of split equilateral triangular rings. The electromagnetic responses are analyzed by the finite-difference-time-domain (FDTD) method and temporal coupled-mode theory (TCMT). The results show that one channel of the metasurface is insensitive to the polarization angle of the incident light and temperature, while the other channel is sensitive. The reflectance and resonance wavelength can be manipulated by the polarization angle and temperature independently. Based on such a mechanism, we propose metasurfaces for two-bit programmable imaging and thermal imaging. The metasurfaces are believed to have potential applications in information processing and thermal radiation manipulation.
- Published
- 2022
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36. Signal Enhancement of Helicopter Rotor Aerodynamic Noise Based on Cyclic Wiener Filtering
- Author
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Chengfeng Wu, Chunhua Wei, Yong Wang, and Yang Gao
- Subjects
rotor ,aerodynamic noise ,cyclic Wiener filtering ,long-distance detection ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The research on helicopter rotor aerodynamic noise becomes imperative with the wide use of helicopters in civilian fields. In this study, a signal enhancement method based on cyclic Wiener filtering was proposed given the cyclostationarity of rotor aerodynamic noise. The noise was adaptively filtered out by performing a group of frequency shifts on the input signal. According to the characteristics of rotor aerodynamic noise, a detection function was constructed to realize the long-distance detection of helicopters. The flight data of the Robinson R44 helicopter was obtained through the field flight experiment and employed as the research object for analysis. The detection range of the Robinson R44 helicopter after cyclic Wiener filtering was increased from 4.114 km to 17.75 km, verifying the feasibility and effectiveness of the proposed method. The efficacy of the proposed detection method was demonstrated and compared in the far-field flight test measurements of the Robinson R44 helicopter.
- Published
- 2022
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37. Silicon Controls Bacterial Wilt Disease in Tomato Plants and Inhibits the Virulence-Related Gene Expression of Ralstonia solanacearum
- Author
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Lei Wang, Yang Gao, Nihao Jiang, Jian Yan, Weipeng Lin, and Kunzheng Cai
- Subjects
silicon ,Ralstonia solanacearum ,tomato ,bacterial wilt ,biofilm ,virulence-related genes ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Silicon (Si) has a multifunctional role in improving plant growth and enhancing plant disease resistance, but its mechanisms are not fully understood. In this study, we investigated the impacts of silicon application on the control of bacterial wilt and elucidated the molecular mechanisms using transcriptome sequencing. Compared to non-Si treatment, Si application (0.5–2 mM) significantly reduces tomato bacterial wilt index by 46.31–72.23%. However, Si does not influence the growth of R. solanacearum. Si application negatively influences R. solanacearum exopolysaccharide (EPS) synthesis and biofilm formation. Transcriptome analysis showed that Si treatment significantly downregulates the expression of virulence genes’ transcriptional regulator (xpsR), EPS synthesis-related genes (epsD and tek), and type III effectors (HrpB2, SpaO, and EscR) in R. solanacearum. In addition, Si remarkably upregulates the expression of twitch motor-related genes (pilE2, pilE, fimT, and PilX). These findings suggest that silicon-suppressed tomato wilt incidence may be due to the regulation of the virulence-related genes of R. solanacearum by Si. Our research adds new knowledge to the application of Si in the field of disease control.
- Published
- 2022
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38. Switchable Terahertz Absorber from Single Broadband to Dual Broadband Based on Graphene and Vanadium Dioxide
- Author
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Guan Wang, Tong Wu, Yang Jia, Yang Gao, and Yachen Gao
- Subjects
terahertz ,graphene ,vanadium dioxide ,impedance matching ,absorption ,Chemistry ,QD1-999 - Abstract
A multifunctional switchable terahertz (THz) absorber based on graphene and vanadium dioxide (VO2) is presented. The properties of the absorber are studied theoretically by the finite-difference time-domain (FDTD) method. The results illustrate that the structure switches between the single-broadband or double-broadband absorption depending on the temperature of VO2. Moreover, the amplitude of the absorptivity can be adjusted by changing the Fermi energy level (EF) of graphene or the conductivity of VO2 separately. Via impedance matching theory, the physical mechanism of the absorber is researched. Furthermore, the effects of incidence angle on absorption have also been studied. It is found that the absorber is insensitive to the polarization of electromagnetic waves.
- Published
- 2022
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39. Tunable Dual-Broadband Terahertz Absorber with Vanadium Dioxide Metamaterial
- Author
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Hengli Feng, Zuoxin Zhang, Jingyu Zhang, Dongchao Fang, Jincheng Wang, Chang Liu, Tong Wu, Guan Wang, Lehui Wang, Lingling Ran, and Yang Gao
- Subjects
terahertz ,metamaterial ,multi-functional ,dual-broadband absorber ,Chemistry ,QD1-999 - Abstract
A dual broadband terahertz bifunction absorber that can be actively tuned is proposed. The optical properties of the absorber were simulated and numerically calculated using the finite-difference time-domain (FDTD) method. The results show that when the conductivity of vanadium dioxide is less than σ0=8.5×103 S/m, the absorptance can be continuously adjusted between 2% and 100%. At vanadium dioxide conductivity greater than σ0=8.5×103 S/m, the absorption bandwidth of the absorber can be switched from 3.4 THz and 3.06 THz to 2.83 THz and none, respectively, and the absorptance remains above 90%. This achieves perfect modulation of the absorptance and absorption bandwidth. The physical mechanism of dual-broadband absorptions and perfect absorption is elucidated by impedance matching theory and electric field distribution. In addition, it also has the advantage of being polarization insensitive and maintaining stable absorption at wide angles of oblique incidence. The absorber may have applications in emerging fields such as modulators, stealth and light-guided optical switches.
- Published
- 2022
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40. Dynamic Modulation of THz Absorption Frequency, Bandwidth, and Amplitude via Strontium Titanate and Graphene
- Author
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Tong Wu, Guan Wang, Yang Jia, Yabin Shao, Yang Gao, and Yachen Gao
- Subjects
terahertz ,multi-functional ,absorber ,broadband absorption ,Chemistry ,QD1-999 - Abstract
A multi-functional broadband absorber based on graphene and strontium titanate (STO) film was designed. Additionally, the frequency, bandwidth, and amplitude of the absorber could be tuned by adjusting temperature and Fermi level of the graphene. By using the finite-difference time-domain (FDTD) method, the numerical calculation result shows that, when keeping the device temperature at 230 K and setting graphene Fermi level to be 1 eV, three absorption peaks at 1.72 THz, 2.08 THz, and 2.59 THz were realized and combined into a broadband absorption from 1.68 to 2.74 THz. As the STO temperature was increased from 230 K to 310 K, the center frequency moved from 2.2 THz to 2.45 THz; correspondingly, the broadband absorption range was widened from 1.06 THz to 1.24 THz. When the temperature was fixed at 230 K and the graphene Fermi level was tuned from 1 eV to 0.7 eV, the absorption bandwidth decreased from 1.06 THz to 0.64 THz. While the Fermi level was tuned continually to be 0.01 eV, only a single absorption peak with an absorption rate of 0.29 existed. The broadband absorption and tuning mechanism of the absorber were analyzed using impedance matching theory. Furthermore, we also studied the effect of incident angle and polarization direction on the properties of the absorber. The multi-functional tunable absorber provides potential applications for the design of more efficient terahertz functional devices in the future.
- Published
- 2022
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41. Experimental Study on the Impact of CO2 Treatment on Different Lithofacies in Shale Oil Reservoirs
- Author
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Jiaping Tao, Siwei Meng, Dongxu Li, Gang Cao, Yang Gao, and He Liu
- Subjects
shale oil ,lithofacies ,CO2 treatment ,micromorphology ,porosity and permeability ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
CO2 technology has been progressively used in the development of shale oil. After injection, CO2 can react with formation water to form carbonic acid, which then reacts with carbonate and silicate minerals, resulting in changes in porosity and permeability. However, there are some debates as to whether the effect of CO2 improves or damages porosity and permeability. So, in this paper, systematic experiments were carried out to clarify the interaction between CO2 and shale in different lithofacies and to draw a pertinent conclusion. The results showed that the shale in Qingshankou Formation could be divided into three main lithofacial types: foliaceous shale, laminated feisic shale and laminated diamictic shale. There were relatively more pores, some natural microfractures and small mineral particles in foliaceous shale, a few micropores and large mineral particles in laminated feisic shale, some biogenic calcium carbonate minerals and hardly any micropores in laminated diamictic shale. Due to the diversity of micromorphology and mineral composition, the effects of CO2 treatment had significant differences. For foliaceous shale, CO2 treatment had both improving and damaging effects on porosity and permeability; for laminated shale, both porosity and permeability improved significantly. So, it is necessary to identify the main lithofacies of target formation before the application of CO2 technology in shale oil reservoirs.
- Published
- 2022
- Full Text
- View/download PDF
42. Multi-Channel High-Performance Absorber Based on SiC-Photonic Crystal Heterostructure-SiC Structure
- Author
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Jing Han, Jijuan Jiang, Tong Wu, Yang Gao, and Yachen Gao
- Subjects
optical Tamm state ,Tamm phonon polariton ,mode coupling ,epsilon-near-zero phonon polariton ,multi-channel absorber ,Chemistry ,QD1-999 - Abstract
The multi-channel high-efficiency absorber in the mid-infrared band has broad application prospects. Here, we propose an SiC-photonic crystal (PhC) heterostructure-SiC structure to realize the absorber. The absorption characteristics of the structure are studied theoretically. The results show that the structure can achieve high-efficiency multi-channel absorption in the mid-infrared range. The absorption peaks come from the coupling of the dual Tamm phonon polariton (TPhP) mode formed at the interface between the two SiC layers and the photonic crystal, and the optical Tamm state (OTS) mode formed in the PhC heterostructure. By adjusting the thickness of the air dielectric layer and the period of the PhC in the heterostructure, the mode coupling intensity can be regulated; thereby, the position and intensity of the absorption peak can be adjusted. In addition, the absorption peaks of TE and TM polarized light can be controlled by changing the incident angle. Adjusting the incident angle can also control the excitation and intensity of the epsilon-near-zero (ENZ) phonon polariton mode produced by TM polarized light. This kind of light absorber may have potential applications in sensors, filters, modulators, switches, thermal radiators, and so on.
- Published
- 2022
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- View/download PDF
43. DNA Polymerase-Parental DNA Interaction Is Essential for Helicase-Polymerase Coupling during Bacteriophage T7 DNA Replication
- Author
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Chen-Yu Lo and Yang Gao
- Subjects
DNA replication ,helicase ,polymerase ,bacteriophage T7 ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
DNA helicase and polymerase work cooperatively at the replication fork to perform leading-strand DNA synthesis. It was believed that the helicase migrates to the forefront of the replication fork where it unwinds the duplex to provide templates for DNA polymerases. However, the molecular basis of the helicase-polymerase coupling is not fully understood. The recently elucidated T7 replisome structure suggests that the helicase and polymerase sandwich parental DNA and each enzyme pulls a daughter strand in opposite directions. Interestingly, the T7 polymerase, but not the helicase, carries the parental DNA with a positively charged cleft and stacks at the fork opening using a β-hairpin loop. Here, we created and characterized T7 polymerases each with a perturbed β-hairpin loop and positively charged cleft. Mutations on both structural elements significantly reduced the strand-displacement synthesis by T7 polymerase but had only a minor effect on DNA synthesis performed against a linear DNA substrate. Moreover, the aforementioned mutations eliminated synergistic helicase-polymerase binding and unwinding at the DNA fork and processive fork progressions. Thus, our data suggested that T7 polymerase plays a dominant role in helicase-polymerase coupling and replisome progression.
- Published
- 2022
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44. Advances and challenges on springback control for creep age forming of aluminum alloy
- Author
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Changhui Wu, Yang Gao, Heng Li, Liwen Zhang, Bian Tianjun, and Chao Lei
- Subjects
Materials science ,Bending (metalworking) ,business.industry ,Mechanical Engineering ,Alloy ,Aerospace Engineering ,chemistry.chemical_element ,Mechanical engineering ,Age forming ,engineering.material ,Precipitation hardening ,chemistry ,Creep ,Aluminium ,Residual stress ,engineering ,Aerospace ,business - Abstract
Creep age forming (CAF) is an advanced forming technology that combines creep deformation and age hardening processes. When compared with the conventional forming technologies including roll bending and shot-peen forming, CAF has many advantages of low residual stress, excellent dimensional stability, good service performance and short production cycle. It is an optimal technique for precise manufacturing for shape and properties of large-scale complicated thin-walled components of light-weight and high strength aluminum alloys in the aviation and aerospace industries. Nevertheless, CAF has an inevitable disadvantage that a large amount of springback occurs after unloading, which brings a challenge on the accurate shape forming and property tailoring of components. Therefore, how to achieve accurate prediction and control of springback has always been a bottleneck hindering the development of CAF to more industrial applications. After the factors of affecting springback and measures of reducing springback are summarized from the internal and external aspects, constitutive models for predicting springback and springback compensation methods for CAF of aluminum alloy panel components are reviewed. Then, a review of research progresses on tool design for CAF is presented. Finally, in view of the key issue that it is difficult to predict and control the shape and properties of components during CAF, the technical challenges are discussed and future development trends of CAF are prospected.
- Published
- 2022
45. The Progress and Perspective of Organic Molecules With Switchable Circularly Polarized Luminescence
- Author
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Yang Gao, Can Ren, Xiaodong Lin, and Tingchao He
- Subjects
circularly polarized luminescence ,asymmetrical emission factor ,organic material ,multiple stimuli ,reversible switch ,Chemistry ,QD1-999 - Abstract
Circularly polarized luminescence (CPL) has been under intense research for future applications in high-resolution 3D displays, smart sensors, and information technologies. Different types of CPL materials have been developed, but neither the handedness nor the asymmetrical luminescence degree can be inferred from the material composition or the components. CPL materials with switchable handedness or emission wavelength play an important role, reducing the need for repetitive bottom-up synthesis. Here, we have presented switchable CPL behaviors toward multiple reported stimuli, including light irradiation, host–guest interaction, metal ions, pH, solvent, temperature, etc. This summary and discussion of the effective stimuli is aimed to promote rational future material exploration and boost related multidisciplinary applications.
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- 2020
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46. Preparation and Photocatalytic Properties of N-Doped Graphene/TiO2 Composites
- Author
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Jing Liu, Kun-Yu Chen, Jie Wang, Min Du, Zheng-Yang Gao, and Chun-Xiao Song
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Chemistry ,QD1-999 - Abstract
N-doped graphene (NG)/TiO2 composites were prepared by a two-step hydrothermal method using HF as the surface etchant and urea as the nitrogen source. The morphology, structure, and bonding conditions of the NG/TiO2 composites were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), X-ray photoelectron spectroscopy (XPS), Raman spectroscopy, UV-visible diffuse reflectance spectroscopy (UV-Vis DRS), and photoluminescence (PL) spectroscopy. The effects of NG on the lifetime of photogenerated electron-hole pairs, adsorption capacity, and photocatalytic activity of the composite photocatalysts were also investigated. The photocatalytic activity was evaluated under ultraviolet light and sunlight irradiation. The recovery testing was completed under ultraviolet light irradiation. The results show that TiO2 was uniformly loaded on the NG surface by chemical bonding. The introduction of NG effectively inhibited the recombination of photogenerated electron-hole pairs and improved both the adsorption capacity and photocatalytic activity of the composites. The 7 wt % NG/TiO2 showed the best adsorption capacity of methyl orange (MO). The best photocatalytic activity occurred for 5 wt % NG/TiO2 composites, and after four recovery tests, the photocatalytic degradation of MO under 60 min ultraviolet light irradiation exceeded 90%.
- Published
- 2020
- Full Text
- View/download PDF
47. Visualizing Structural Transformation and Guest Binding in a Flexible Metal–Organic Framework under High Pressure and Room Temperature
- Author
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Hui Yang, Feng Guo, Prem Lama, Wen-Yang Gao, Hui Wu, Leonard J. Barbour, Wei Zhou, Jian Zhang, Briana Aguila, and Shengqian Ma
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Chemistry ,QD1-999 - Published
- 2018
- Full Text
- View/download PDF
48. Anti-Inflammatory, Antioxidant, and Antifibrotic Effects of Gingival-Derived MSCs on Bleomycin-Induced Pulmonary Fibrosis in Mice
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Xishuai Wang, Shiyu Zhao, Junhui Lai, Weijun Guan, and Yang Gao
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lung fibrosis ,mesenchymal stem cells ,neutrophils ,inflammation ,oxidative stress ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Background: Mesenchymal stem cell (MSC) intervention has been associated with lung protection. We attempted to determine whether mouse gingival-derived mesenchymal stem cells (GMSCs) could protect against bleomycin-induced pulmonary fibrosis. Methods: Mice were divided into three groups: control (Con), bleomycin (Bl), and bleomycin + MSCs (Bl + MSCs). Mice were treated with 5 mg/kg bleomycin via transtracheal instillation to induce pulmonary fibrosis. We assessed the following parameters: histopathological severity of injury in the lung, liver, kidney, and aortic tissues; the degree of pulmonary fibrosis; pulmonary inflammation; pulmonary oedema; profibrotic factor levels in bronchoalveolar lavage fluid (BALF) and lung tissue; oxidative stress-related indicators and apoptotic index in lung tissue; and gene expression levels of IL-1β, IL-8, TNF-α, lysophosphatidic acid (LPA), lysophosphatidic acid receptor 1 (LPA1), TGF-β, matrix metalloproteinase 9 (MMP-9), neutrophil elastase (NE), MPO, and IL-10 in lung tissue. Results: GMSC intervention attenuated bleomycin-induced pulmonary fibrosis, pulmonary inflammation, pulmonary oedema, and apoptosis. Bleomycin instillation notably increased expression levels of the IL-1β, IL-8, TNF-α, LPA, LPA1, TGF-β, MMP-9, NE, and MPO genes and attenuated expression levels of the IL-10 gene in lung tissue, and these effects were reversed by GMSC intervention. Bleomycin instillation notably upregulated MDA and MPO levels and downregulated GSH and SOD levels in lung tissue, and these effects were reversed by GMSC intervention. GMSC intervention prevented upregulation of neutrophil content in the lung, liver, and kidney tissues and the apoptotic index in lung tissue. Conclusions: GMSC intervention exhibits anti-inflammatory and antioxidant capacities. Deleterious accumulation of neutrophils, which is reduced by GMSC intervention, is a key component of bleomycin-induced pulmonary fibrosis. GMSC intervention impairs bleomycin-induced NE, MMP-9, LPA, APL1, and TGF-β release.
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- 2021
- Full Text
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49. Dual-Spectral Plasmon-Induced Transparent Terahertz Metamaterial with Independently Tunable Amplitude and Frequency
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Tong Wu, Guan Wang, Yang Jia, Yabin Shao, Chen Chen, Jing Han, Yang Gao, and Yachen Gao
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plasmon-induced transparency ,terahertz ,graphene ,strontium titanate ,slow light ,Chemistry ,QD1-999 - Abstract
A bifunctional tunable metamaterial composed of pattern metal structure, graphene, and strontium titanate (STO) film is proposed and studied numerically and theoretically. The dual plasmon-induced transparency (PIT) window is obtained by coupling the bright state cut wire (CW) and two pairs of dark state dual symmetric semiring resonators (DSSRs) with different parameters. Correspondingly, slow light effect can also be realized. When shifting independently, the Fermi level of the graphene strips, the amplitudes of the two PIT transparency windows and slow light effect can be tuned, respectively. In addition, when independently tuning the temperature of the metamaterial, the frequency of the dual PIT windows and slow light effect can be tuned. The physical mechanism of the dual-PIT was analyzed theoretically by using a three-harmonic oscillator model. The results show that the regulation function of the PIT peak results from the change of the oscillation damping at the dark state DSSRs by tuning conductivity of graphene. Our design presents a new structure to realize the bifunctional optical switch and slow light.
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- 2021
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50. Localization and Imaging of Micro-Cracks Using Nonlinear Lamb Waves with Imperfect Group-Velocity Matching
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Jichao Xu, Wujun Zhu, Yanxun Xiang, Yang Gao, and Xunlin Qiu
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nonlinear lamb waves ,group velocity ,S0 mode ,localization ,micro-crack ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Nonlinear Lamb waves have attracted increasing attention for detecting and identifying microstructural changes in structural health monitoring. However, most identification methods that determine the damage locations based on the intersections of the elliptical loci will inevitably cause positioning errors due to the change of the group velocity before and after interaction with the damage. In this work, a method focusing on elliptical rings was proposed for localization and imaging of micro-cracks in a three-dimensional structure using nonlinear Lamb waves with imperfect group-velocity matching. The width of the elliptical rings can be determined by the degree of the group-velocity mismatching of nonlinear S0 modes. The mode pair S0-s0, satisfying approximate group-velocity matching, is mainly introduced by interacting with the micro-crack. The effectiveness of the proposed methodology for damage localization is verified by the experimental testing and numerical simulation. Although the length of the being-tested small crack (about 1 mm) is smaller than the wavelength of the incident fundamental Lamb wave (around 20 mm), it can be well identified and localized using nonlinear Lamb waves. The experimental results show that the proposed method enables more reliable localization of the small crack with the crossover areas, as compared with the intersections based on the ellipse method. Furthermore, a breathing crack not situated in the propagation path can also be well localized by the proposed method in comparison with those by the probability-based diagnostic imaging in the simulation cases.
- Published
- 2021
- Full Text
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