1. A Novel Heterocyclic System Based on Natural Epoxyalantolactone
- Author
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Sergey G. Klochkov, Sergey A. Pukhov, Svetlana V. Afanasieva, Margarita E. Neganova, Ivan V. Ananiev, Marco Avila-Rodriguez, Vadim V. Tarasov, and Gjumrakch Aliev
- Subjects
sesquiterpene lactones ,epoxyalantolactone ,synthesis ,new heterocyclic system ,Michael reaction ,Chemistry ,QD1-999 - Abstract
Natural sesquiterpene lactones which contain an exocyclic methylene group in the β-position of the lactone ring react readily with N-nucleophiles. When studying the reaction of the natural epoxyalantolactone with the primary amines we demonstrate the formation of a new heterocyclic system—the hydrogenated benzo[g]furo[4,3,2-cd]indol-3(1H)-one. Spectral data on the characteristics of the synthesized compounds are presented. The data on the reaction mechanisms and its applicability for the preparation are discussed.
- Published
- 2019
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