Search

Your search keyword '"Renata Sano Lini"' showing total 4 results
Start Over Author "Renata Sano Lini" Topic chemistry
4 results on '"Renata Sano Lini"'

1. HIGHLY SELECTIVE HF-LPME-GC-MS FOR COCAINE AND BIOTRANSFORMATION PRODUCTS IN HUMAN HAIR TO MONITOR DRUG ADDICTS

Author

Deborah Thais Palma Scanferla, Jessica Yuri Sakurada, Luís Otávio de Oliveira, Renata Sano Lini, Raul Gomes Aguera, Mariana Aparecida Oliveira Madia, Paula Pessoa Moreira, Jessica Cristina Zoratto Romoli, Érika Bando, Miguel Machinski Junior, Camila Marchioni, and Simone Aparecida Galerani Mossini

Subjects
cocaine, hollow fiber liquid phase microextraction, hair sample, drug of abuse, Chemistry, QD1-999
Abstract

This study aimed to investigate a miniaturized extraction methodology with analysis by GC-MS for simultaneous detection and quantification of cocaine (COC), benzoylecgonine (BZE) and cocaethylene (CE) in hair to monitor drug addicts. The process was done following the international guide of the Scientific Task Force on Forensic Toxicology. After sample extraction, derivatizing solution was added, clean-up was done by the Hollow Fiber Liquid Phase Microextraction (HF-LPME) and adapted to use the ultrasonic bath, a simple and easy-to-handle device. Isobutylchloroformate was first used as derivatization reagent to convert benzoylecgonine to isobutylbenzoylecgonine. Analytes quantification occurred within a linear range of 0.1 to 20 ng mg-1 for COC and 0.05 to 5 ng mg-1 for BZE and CE, with a correlation coefficient of r > 0.99. Limits of detection were 0.05; 0.03 and 0.03 ng mg-1, whereas limits of quantification were 0.1; 0.05 and 0.05 ng mg-1 for COC; BZE and CE, respectively. There was no matrix effect interference. Intra and inter-day precision and accuracy were acceptable according to international guidelines. The analytical method HF-LPME-GC-MS was successfully applied to 14 hair samples from patients admitted in drugs detoxification programs. All samples resulted positive for cocaine (0.80-> 20 ng mg-1) and benzoylecgonine (0.20-> 5 ng mg-1), 11 samples were positive for cocaethylene (0.10-> 0.60 ng mg-1).

Published
2021
Full Text
View/download PDF

2. Elemental plasma content and urinary excretion in vineyard farmers occupationally exposed to pesticides in southern Brazil

Author

Lucilena R. Monteiro, Raul Gomes Aguera, Danielle Hoeltgebaum, Samuel Botião Nerilo, Tatiana Pedron, Miguel Machinski Junior, Silvia Capelari, Renata Sano Lini, Fernanda Pollo Paniz, Magda Lúcia Félix de Oliveira, Simone Aparecida Galerani Mossini, and Bruno Lemos Batista

Subjects
inorganic chemicals, Farms, Health, Toxicology and Mutagenesis, chemistry.chemical_element, Urine, 010501 environmental sciences, 01 natural sciences, Vineyard, Humans, Environmental Chemistry, Ecotoxicology, Pesticides, Arsenic, 0105 earth and related environmental sciences, Cadmium, Farmers, General Medicine, Pesticide, Pollution, Trace Elements, Mercury (element), Cross-Sectional Studies, chemistry, Environmental chemistry, Environmental science, Brazil, Selenium
Abstract

This is a cross-sectional study with data and biological material collection from vineyard farmers in southern Brazil. An interview was carried out through a questionnaire developed according to the reference guide of the state government. Plasma and urine samples were screened for Aluminum, Chromium, Manganese, Copper, Nickel, Cobalt, Zinc, Arsenic, Selenium, Cadmium, Antimony, Barium, Mercury, Lead and Uranium, with a technique for fast determination of these elemental contents in biological material utilizing dynamic reaction cell inductively coupled mass spectrometry. Principal component analysis was used to identify associations between these elemental contents in biological samples and the information obtained from the interviews. The farmers showed some trace elements in plasma and urine at a higher concentration than unexposed populations from other studies. This study highlights recent findings of trace elements in biological material and their association with characteristics of pesticide use. In addition, it also contributes to the gap in the literature regarding trace elements content in plasma and urine of workers exposed to pesticides.

Published
2021
Full Text
View/download PDF

3. Occurrence, exposure evaluation and risk assessment in child population for aflatoxin M1 in dairy products in Brazil

Author

Amanda Caroline Trassi Conteçotto, Simone Aparecida Galerani Mossini, Miguel Machinski Junior, Aline Amenecia de Souza, Benício Alves de Abreu Filho, Jéssica Cristina Zoratto Romoli, Jane Martha Graton Mikcha, Juliana Cristina Castro, Giseli Cristina Pante, and Renata Sano Lini

Subjects
0303 health sciences, Aflatoxin, education.field_of_study, European community, Potential risk, business.industry, Population, 04 agricultural and veterinary sciences, General Medicine, Toxicology, Food safety, 040401 food science, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, chemistry, Environmental health, Child population, Medicine, Mycotoxin, business, Risk assessment, education, 030304 developmental biology, Food Science
Abstract

This study aimed to evaluate the risk concerning child population's health because of the occurrence of AFM1 in UHT milk, powdered milk (PM) and infant formulae (IF). Determination of AFM1 was performed in 60 samples and evaluation of the mycotoxin exposure was carried out through the determination of the estimated daily intake (EDI), whereas risk characterization was evaluated with the calculation of the risk of Hepatocellular Carcinoma (HCC) and the Margin of Exposure (MOE). AFM1 ranged from 150 to 1020 ng/kg, and all the positive samples exceeded the limits stablished by European Community. The EDI for AFM1 ranged according to the age group of the population studied (0–5 years old) from 0.828 to 2.523, 0–2.113 and 0.029–0.833 ng/kg b. w./day in UHT, PM and IF, respectively. The number of HCC cases associated with AFM1 exposure (0.0015 a 0.0045) was higher than the limit of 0.001 case/100,000. MOE values for AFM1 were 728 to 239, considerably below the security margin of 10,000. These results point to a potential risk to the health of Brazilian child population exposed to AFM1 in dairy products.

Published
2021
Full Text
View/download PDF

4. Exposure to heavy metals due to pesticide use by vineyard farmers

Author

Gustavo Henrique Oliveira da Rocha, Bruno Lemos Batista, Simone Aparecida Galerani Mossini, Vanessa Cristina de Oliveira Souza, Paula Nishiyama, Érika Bando, Fernando Barbosa, Renata Sano Lini, and Samuel Botião Nerilo

Subjects
Pesticide application, Frequency of use, chemistry.chemical_element, Vineyard, Arsenic, Toxicology, Pesticide use, Nickel, Metals, Heavy, Occupational Exposure, Humans, Vitis, Pesticides, Inductively coupled plasma mass spectrometry, Manganese, Farmers, Public Health, Environmental and Occupational Health, food and beverages, Heavy metals, Pesticide, Crop Production, Zinc, chemistry, Lead, Environmental chemistry, Environmental science, Seasons, Brazil, Copper, Environmental Monitoring
Abstract

To statistically analyze serum heavy metal levels in biological samples obtained from vineyard workers from southern Brazil and check for heavy metal exposure due to pesticide use. Serum samples were obtained from 54 farmers and 108 healthy unexposed individuals. Samples from the same farmers were obtained at three different time points over a 1-year period. Levels of lead, arsenic, nickel, zinc, manganese and copper were determined for each sample using dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS). All results were statistically analyzed using the nonparametric Kruskal–Wallis test (followed by Dunn’s post hoc test). Results showed that serum heavy metal levels in farmers were twofold to fourfold higher than in controls. This difference was found for all heavy metals tested and was significant (p

Published
2014

Catalog

Books, media, physical & digital resources
See catalog results