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Your search keyword '"Moran Zhang"' showing total 5 results
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5 results on '"Moran Zhang"'

1. Multiwalled carbon nanotubes co-delivering sorafenib and epidermal growth factor receptor siRNA enhanced tumor-suppressing effect on liver cancer

Author

Yuliang Feng, Shanwen Chen, Li Guo, Lijun Wan, Xiaohua Yan, Lingyan Lian, Youwen Hu, Hongyan Huang, Degejirifu, Moran Zhang, Qian Yang, Zhili Wen, and Kedong Xu

Subjects
Sorafenib, Aging, Clone (cell biology), Mice, Nude, Antineoplastic Agents, Apoptosis, multiwalled carbon nanotubes, liver cancer, Mice, Drug Delivery Systems, In vivo, medicine, Animals, Humans, Epidermal growth factor receptor, RNA, Small Interfering, Cell Proliferation, biology, Nanotubes, Carbon, Cell growth, Chemistry, Liver Neoplasms, Hep G2 Cells, Cell Biology, medicine.disease, Molecular biology, In vitro, ErbB Receptors, Liver, biology.protein, epidermal growth factor receptor, Liver cancer, Neoplasm Transplantation, Research Paper, medicine.drug
Abstract

Objective This study aimed to investigate the effects of multiwalled carbon nanotubes (MWNTs) co-delivering sorafenib (Sor) and epidermal growth factor receptor (EGFR) siRNA (MWNT/Sor/siRNA) on tumor growth in liver cancer (LC). Results MWNT/Sor/siRNA was proved to possess increased Sor release, high siRNA stability, and enhanced cellular uptake. In addition, MWNT treatment has few effects on cell proliferation and apoptosis in HepG2 cells; however, MWNT/Sor/siRNA treatment significantly inhibited clone number and induced cell apoptosis, which shows a more favorable antitumor effect than MWNT/Sor and free Sor and free siRNA in HepG2 cells. Moreover MWNT/Sor/siRNA treatment has the most significant antitumor effect in vivo. Conclusions MWNT/Sor/siRNA exhibited a superior antitumor effect in vitro and in vivo. Methods The MWNT/Sor and MWNT/Sor/siRNA were prepared, and then the morphologies of MWNT/Sor/siRNA were analyzed. In vitro Sor release assay, siRNA stability and cellular uptake of MWNT/Sor/siRNA were performed as well. Next, the effects of MWNT, free Sor, free siRNA, MWNT/Sor and MWNT/Sor/siRNA were evaluated by colony-forming assay, and cell apoptosis assay in HepG2 cells. Meanwhile, the level of EGFR and proteins associated with apoptosis was tested. Furthermore, the anti-tumor effects of MWNT/Sor/siRNA on LC xenograft mice were also unraveled.

Published
2021
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2. Combined application of gallate ester and α-tocopherol in oil-in-water emulsion: Their distribution and antioxidant efficiency

Author

Shaoping Nie, YangLing Wang, Wu Chen, Mingyong Xie, XiaoYa Zhou, Yi Chen, and MoRan Zhang

Subjects
chemistry.chemical_classification, Chromatography, Antioxidant, Polymers and Plastics, medicine.medical_treatment, 02 engineering and technology, Gallate, 021001 nanoscience & nanotechnology, Surfaces, Coatings and Films, Oil in water, chemistry.chemical_compound, 020401 chemical engineering, chemistry, Emulsion, medicine, Distribution (pharmacology), lipids (amino acids, peptides, and proteins), Gallic acid, Tocopherol, 0204 chemical engineering, Physical and Theoretical Chemistry, 0210 nano-technology, Alkyl
Abstract

Gallic acid or its alkyl ester was added in combination with α-tocopherol in the oil-in-water (O/W) emulsion to investigate their interaction in emulsions. Results showed that all the tested gallat...

Published
2019
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3. Gold-Catalyzed Intermolecular Carboalkoxylation of Alkenes

Author

Qiang Yuan, Shaofei Zhang, Moran Zhang, Xiangdong Hu, Fenfen Xiao, Wenmin Dong, Wu Liu, and Yunxia Wang

Subjects
chemistry.chemical_compound, chemistry, Reagent, Organic Chemistry, Acetal, Intermolecular force, Organic chemistry, Catalysis
Abstract

A gold-catalyzed intermolecular carboalkoxylation of ­alkenes has been developed. Readily available and inexpensive ­dimethyl acetals have been employed as a facile reagent to achieve the carboalkoxylation of alkenes.

Published
2012
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4. An Alternative Approach to Direct Aldol Reaction Based on Gold-Catalyzed Methoxyl Transfer

Author

Moran Zhang, Xiangdong Hu, Yunxia Wang, and Yang Yang

Subjects
Aldol reaction, Stereochemistry, Ligand, Chemistry, organic chemicals, polycyclic compounds, General Chemistry, Combinatorial chemistry, Catalysis
Abstract

A mild and catalyzed alternative to the direct aldol reaction has been developed based on the gold-catalyzed methoxy group transfer from dimethyl acetals to terminal alkynes. Due to the simultaneous activation of the acetals, this aldol approach is only functional for acetals but not aldehydes. A ligand effect from the gold complex has also been observed.

Published
2012
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5. ChemInform Abstract: An Alternative Approach to Direct Aldol Reaction Based on Gold-Catalyzed Methoxyl Transfer

Author

Xiangdong Hu, Moran Zhang, Yang Yang, and Yunxia Wang

Subjects
Aldol reaction, Ligand, Chemistry, organic chemicals, polycyclic compounds, General Medicine, Combinatorial chemistry, Catalysis
Abstract

A mild and catalyzed alternative to the direct aldol reaction has been developed based on the gold-catalyzed methoxy group transfer from dimethyl acetals to terminal alkynes. Due to the simultaneous activation of the acetals, this aldol approach is only functional for acetals but not aldehydes. A ligand effect from the gold complex has also been observed.

Published
2012
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