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13 results on '"Mohamed Didi Ould El-Hadj"'

1. Polysaccharides from Moroccan Green and Brown Seaweed and Their Derivatives Stimulate Natural Defenses in Olive Tree Leaves

Author

Meriem Aitouguinane, Zainab El Alaoui-Talibi, Halima Rchid, Imen Fendri, Slim Abdelkafi, Mohamed Didi Ould El-Hadj, Zakaria Boual, Pascal Dubessay, Philippe Michaud, Mounir Traïkia, Guillaume Pierre, Cherkaoui El Modafar, and Cédric Delattre

Subjects
olive tree, seaweed, polysaccharides, oligosaccharides, elicitors, PAL, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

This study aims to assess for the first time the ability of marine polysaccharides and their derivatives to stimulate natural defenses in olive tree leaves. Alginates, ALSM, and ALCM were isolated from the brown algae Sargassum muticum and Cystoseira myriophylloides, respectively. The OASM and OACM fractions were obtained after radical depolymerization of ALSM and ALCM, respectively. Three sulfated polysaccharides, arabinogalactans (AGB and AGP) and fucoidans (FUCCM) were extracted from the green alga Codium decorticatum and the brown seaweed C. myriophylloides, respectively. The extraction yield of different extracts was in the range of 0.82–32% and the average molecular weight (Mw) varied from 3000 Da to 2173 kDa. The M/G ratios of ALSM and ALCM were 0.87 and 1.12, respectively. FUCCM contained 53% of fucose and 12.83% of sulfates. The AGB and AGP fractions were characterized by the presence of a high degree of sulfation and protein (12–23% (w/w)) and were composed mainly of galactose, glucose, and arabinose. The aqueous saccharide solutions were applied to the leaf discs of the olive tree at 0.5 g/L, 1 g/L, and 2 g/L, for 24 h. These molecules triggered defense responses, by showing a differential capacity to induce the activity of the phenylalanine and tyrosine ammonia-lyase (TAL and PAL), polyphenols, and lignin contents in the leaves of the olive tree. Alginates and their derivatives as well as arabinogalactans exhibited an important induction of TAL activity compared to the PAL. The sulfated polysaccharides were more effective compared to the unsulfated polysaccharides (alginates) which were active at a low concentration. The optimum concentration for most of the studied elicitors was 2 g/L. These results suggest the valorization of these molecules derived from marine biomass as inducers of natural defenses of the olive tree to protect against phytopathogens in the context of sustainable development.

Published
2022
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2. A Novel Sulfated Glycoprotein Elicitor Extracted from the Moroccan Green Seaweed Codium decorticatum Induces Natural Defenses in Tomato

Author

Meriem Aitouguinane, Zainab El Alaoui-Talibi, Halima Rchid, Imen Fendri, Slim Abdelkafi, Mohamed Didi Ould El-Hadj, Zakaria Boual, Pascal Dubessay, Philippe Michaud, Didier Le Cerf, Christophe Rihouey, Guillaume Pierre, Cédric Delattre, and Cherkaoui El Modafar

Subjects
sulfated arabinogalactan-rich protein, green seaweed, PAL activity, polyphenols, lignin, elicitor, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Sulfated glycoproteins extracted for the first time from the Moroccan green seaweed Codium decorticatum were investigated for their ability to induce a natural defense metabolism in the roots and the upper leaves of tomato seedlings. The crude (AGB) and the purified fractions (AGP) were characterized chemically (Colorimetric assays) and structurally (SEC-MALS, GC-EI/MS, ATR-FTIR). The elicitor aqueous solutions (1 g/L) were applied by foliar spray and syringe infiltration into the internodal middle of 45-day-old tomato seedlings. Phenylalanine ammonia-lyase (PAL) activity, polyphenols, and lignin contents were measured in the roots and the leaves after 0 h, 12, 24, 48, and 72 h of treatment. The AGB and AGP extracts contained 37.67% and 48.38% of the total carbohydrates, respectively, and were mainly composed of galactose, glucose, arabinose, and a minor amount of xylose and rhamnose. They were characterized by an important molecular weight (Mw) > of 2000 × 103 g·mol−1 and a high degree of sulfation and protein (12–23% (w/w)), indicating that the extracted polysaccharides could be an arabinogalactan-rich protein present in the cell wall of the green seaweed C. decorticatum. Both crude and purified fractions exhibited an elicitor effect by inducing the PAL activity, the accumulation of phenolic compounds and lignin contents in the roots and the leaves of tomato seedlings. These responses were systemic in both the methods used (injection and foliar spray) and were mobilized throughout tissues that are not directly treated (roots and/or leaves). Regarding the elicitor activities, AGB and AGP presented globally similar patterns, which revealed the importance of crude extracts in the stimulation of plant immunity. These results suggest the new application of sulfated glycoprotein isolated from green seaweed in agriculture as inducers of natural defenses of plants.

Published
2022
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3. Structural features and rheological behavior of a water-soluble polysaccharide extracted from the seeds of Plantago ciliata Desf

Author

Jacques Desbrières, Cédric Delattre, Philippe Michaud, Faiez Hentati, Christine Gardarin, Mohamed Didi Ould El-Hadj, Zakaria Boual, Noura Addoun, Guillaume Pierre, Didier Le Cerf, Alina V. Ursu, Laboratoire de Protection des Ecosystèmes en Zones arides et semi-arides, Université Kasdi Merbah Ouargla, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institut des sciences analytiques et de physico-chimie pour l'environnement et les materiaux (IPREM), Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Hubert Curien Tassili program - Phase II (15MDU933)., Polymères Biopolymères Surfaces (PBS), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), and Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
food.ingredient, Intrinsic viscosity, 02 engineering and technology, Polysaccharide, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, food, Polysaccharides, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Structural Biology, Arabinoxylan, Side chain, Plantago, Molecular Biology, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Plantago ciliata, Aqueous solution, Viscosity, Extraction (chemistry), Water, [CHIM.MATE]Chemical Sciences/Material chemistry, General Medicine, [SDV.BV.BOT]Life Sciences [q-bio]/Vegetal Biology/Botanics, 021001 nanoscience & nanotechnology, Psyllium, Xylan, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, [CHIM.POLY]Chemical Sciences/Polymers, chemistry, Seeds, Xylans, Rheology, 0210 nano-technology, Nuclear chemistry
Abstract

International audience; A water-soluble polysaccharide (PSPC) was extracted from the seeds of Plantago ciliata Desf., a spontaneous Algerian Saharan plant by a hot aqueous extraction then purified by successive ethanolic precipitations. The final extraction yield for PSPC was close to 18.6% (w/v). PSPC was then investigated regarding its global composition, structural features and rheological properties. PSPC is a neutral arabinoxylan, composed of a β-(1,3)/β-(1,4)-D-xylan backbone with side chains of Xylp, and Araf residues attached in O-2 and O-3 positions. The macromolecular characteristics of PSPC in water was determined by SEC/MALLS, with a high molecular weight (Mw) of 700 kDa, a low polydispersity index (PDI) of 1.47 and an intrinsic viscosity [η] close to 157 mL/g. PSPC showed a pseudoplastic behavior in semi-dilute media and the critical overlay concentration (C*) was estimated around 0.32–0.37% (w/v). This current research has supplied original structural information on a new arabinoxylan which could be particularly useful as a novel source of soluble fiber belonging to psyllium.

Published
2020

4. Beneficial Health Potential of Algerian Polysaccharides Extracted from Plantago ciliata Desf. (Septentrional Sahara) Leaves and Seeds

Author

Philippe Michaud, Noura Addoun, Cédric Delattre, Christine Gardarin, Guillaume Pierre, Toufik Chouana, Fatima Benaoun, Mohamed Didi Ould El Hadj, Seddik Addaoud, Zakaria Boual, Pascal Dubessay, Laboratoire de Protection des Ecosystèmes en Zones arides et semi-arides, Université Kasdi Merbah Ouargla, Laboratoire de Biologie Médicales IBN ROCHD, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), and Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.)

Subjects
Technology, food.ingredient, Pectin, QH301-705.5, QC1-999, polysaccharides, 02 engineering and technology, Polysaccharide, 01 natural sciences, food, General Materials Science, characterization, Biology (General), Instrumentation, QD1-999, Fluid Flow and Transfer Processes, chemistry.chemical_classification, Plantago, Plantago ciliata, Traditional medicine, biology, 010405 organic chemistry, Process Chemistry and Technology, Physics, Heparin sodium, General Engineering, biological activities, 021001 nanoscience & nanotechnology, biology.organism_classification, Engineering (General). Civil engineering (General), 0104 chemical sciences, Computer Science Applications, Hot water extraction, Chemistry, chemistry, Herb, Africa, TA1-2040, 0210 nano-technology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Today, an ethnobotanical approach makes sense for identifying new active bioactive chemicals from uses of indigenous plants. Two water-soluble enriched polysaccharide fractions (L-PSPN and S-PSPN) were extracted by hot water extraction from the leaves and seeds of Plantago ciliata Desf. (1798), a Mzab indigenous herb currently used in Algeria by traditional healers. Primary investigation was performed for describing the main structural features of these polysaccharides (pectin- and heteroxylan-like compositions) by using colorimetric assays, FTIR spectroscopy, HPAEC/PAD and GC/MS-EI analyses. Some biological activities were also monitored, such as anticomplement, anti-inflammatory (phagocytic ability, NOX2 and MPO inhibitions) and anti-diabetic (α-amylase and α-glucosidase inhibitions). L-PSPC seems able to moderately modulate innate immune system (IC50 around 100 µg/mL) and contribute to wound-healing processes (IC50 close to 217 vs. 443 µg/mL for sodium heparin). S-PSPC shows some potential as an anti-hyperglycemic (IC50 around 4.7 mg/mL) and anti-inflammatory (IC50 ranging from 111 to 203 µg/mL) agent, as well as other (fiber) psyllium-like polysaccharides extracted from Plantago species.

Published
2021

5. Induction of Natural Defenses in Tomato Seedlings by Using Alginate and Oligoalginates Derivatives Extracted from Moroccan Brown Algae

Author

Soukaina Bouissil, Philippe Michaud, Meriem Aitouguinane, Slim Abdelkafi, Cherkaoui El Modafar, Imen Fendri, Cédric Delattre, Zakaria Boual, Zainab El Alaoui-Talibi, Pascal Dubessay, Anouar Mouhoub, Halima Rchid, Christine Gardarin, Mohamed Didi Ould El-Hadj, Guillaume Pierre, Laboratoire Agrobiotechnologie et Bioingénierie, Faculté des Sciences et Techniques Guéliz, Université Cadi Ayyad, Marrakech 40000, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Laboratoire de Biotechnologies et Valorisation des Ressources Végétales, Faculté des Sciences, Université Chouaib Doukkali, El Jadida 24000, Laboratoire de Biotechnologies des Plantes Appliquées à l’Amélioration des Plantes, Faculté des Sciences, Université de Sfax, Sfax 3038, Laboratoire de Génie Enzymatique et Microbiologie, Equipe de Biotechnologie des Algues, Ecole Nationale d’Ingénieurs de Sfax, Université de Sfax, Sfax 3038, Laboratoire de Protection des Ecosystèmes en Zones arides et Semi-Arides, Ouargla Université, Université Kasdi Merbah, Ouargla 30000, Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Université Cadi Ayyad [Marrakech] (UCA), Université Chouaib Doukkali (UCD), and Université de Sfax

Subjects
0106 biological sciences, Oligosaccharides, Secondary Metabolism, Pharmaceutical Science, MESH: oligoalginates, phenolic compounds, 01 natural sciences, Solanum lycopersicum, Drug Discovery, Plant defense against herbivory, alginate, Food science, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), lcsh:QH301-705.5, 2. Zero hunger, chemistry.chemical_classification, elicitation, 0303 health sciences, biology, tomato seedling, MESH: tomato seedling, MESH: phenolic compounds, MESH: elicitation, food and beverages, Elicitor, Morocco, Alginates, Biofertilizer, Context (language use), Phaeophyta, Protective Agents, Polysaccharide, Article, 03 medical and health sciences, PAL activity, Algae, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Phenylalanine Ammonia-Lyase, 030304 developmental biology, oligoalginates, Polyphenols, MESH: alginate, biology.organism_classification, Plant Leaves, Brown algae, marine seaweed, MESH: marine seaweed, MESH: PAL activity, chemistry, lcsh:Biology (General), Seedlings, Polyphenol, 010606 plant biology & botany
Abstract

International audience; Polysaccharides extracted from marine algae have attracted much attention due to their biotechnological applications, including therapeutics, cosmetics, and mainly in agriculture and horticulture as biostimulants, biofertilizers, and stimulators of the natural defenses of plants. This study aimed to evaluate the ability of alginate isolated from Bifurcaria bifurcata from the Moroccan coast and oligoalginates derivatives to stimulate the natural defenses of tomato seedlings. Elicitation was carried out by the internodal injection of bioelicitor solutions. The elicitor capacities were evaluated by monitoring the activity of phenylalanine ammonia-lyase (PAL) as well as polyphenols content in the leaves located above the elicitation site for 5 days. Alginate and oligoalginates treatments triggered plant defense responses, which showed their capacity to significantly induce the PAL activity and phenolic compounds accumulation in the leaves of tomato seedlings. Elicitation by alginates and oligoalginates showed an intensive induction of PAL activity, increasing from 12 h of treatment and remaining at high levels throughout the period of treatment. The amount of polyphenols in the leaves was increased rapidly and strongly from 12 h of elicitation by both saccharide solutions, representing peaks value after 24 h of application. Oligoalginates exhibited an effective elicitor capacity in polyphenols accumulation compared to alginate polymers. The alginate and oligosaccharides derivatives revealed a similar elicitor capacity in PAL activity whereas the accumulation of phenolic compounds showed a differential effect. Polysaccharides extracted from the brown seaweed Bifurcaria bifurcate and oligosaccharides derivatives induced significantly the phenylpropanoid metabolism in tomato seedlings. These results contribute to the valorization of marine biomass as a potential bioresource for plant protection against phytopathogens in the context of eco-sustainable green technolog

Published
2020

6. Polysaccharides and Derivatives from Africa to Address and Advance Sustainable Development and Economic Growth in the Next Decade

Author

Imen Fendri, Zainab El Alaoui-Talibi, Slim Abdelkafi, Antony Sarraf, Guillaume Pierre, Zakaria Boual, Philippe Michaud, Cherkaoui El Modafar, Emeline Verton, Cédric Delattre, Pascal Dubessay, Mohamed Didi Ould El Hadj, Noura Addoun, Polytech'Clermont-Ferrand, Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire de Protection des Ecosystèmes en Zones arides et semi-arides, Université Kasdi Merbah Ouargla, Laboratoire d’Agrobiotechnologie et Bioingénierie, Faculté des Sciences et Techniques Marrakech, Université Cadi Ayyad, Marrakesh 40000, Laboratoire de Génie Enzymatique et Microbiologie, Équipe de Biotechnologie des Algues, Département Génie Biologique, Ecole Nationale d’Ingénieurs de Sfax, Université de Sfax, Sfax 3038, Laboratoire de Biotechnologies des Plantes Appliquées à l’Amélioration des Plantes, Faculté des Sciences, Université de Sfax, Sfax 3038, Institut Pascal (IP), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Institut Universitaire de France (IUF), Ministère de l'Education nationale, de l’Enseignement supérieur et de la Recherche (M.E.N.E.S.R.), Université Cadi Ayyad [Marrakech] (UCA), and Université de Sfax

Subjects
macroalgae, Technology, QH301-705.5, Natural resource economics, QC1-999, polysaccharides, 02 engineering and technology, 01 natural sciences, ethnobotany, General Materials Science, Biology (General), QD1-999, Instrumentation, Natural medicine, 2. Zero hunger, Fluid Flow and Transfer Processes, Sustainable development, plants, 010405 organic chemistry, Physics, Process Chemistry and Technology, biological activities, General Engineering, 15. Life on land, Engineering (General). Civil engineering (General), 021001 nanoscience & nanotechnology, Human being, 3. Good health, 0104 chemical sciences, Computer Science Applications, Chemistry, Geography, Africa, TA1-2040, 0210 nano-technology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Knowledge development
Abstract

International audience; Polysaccharides are highly variable and complex biomolecules whose inventory of structures is still very incomplete, as nature still preserves unexplored biotopes. Plants, macroalgae and microalgae are an integral part of the daily life of human being regardless of culture, time, or knowledge development of a country. Natural medicine is an ancestral knowledge widely distributed throughout the world, handed down for centuries from generation to generation by those commonly referred to as “nganga” healers or shamans. It is also called alternative medicine or traditional medicine, and has been associated for millennia to legends. This review gives an emphasis regarding the ethnobotanic approach associated to the structural variability of poly- and oligosaccharides for designing the new polysaccharide-based drugs and hydrocolloids of tomorrow. The guiding thread is to survey the potential of plants (and some macroalgae) from Africa as a source of polysaccharides with original structures and, secondly, to correlate these structures with biological and/or functional properties in particular to address and advance the sustainable development and economic growth of mankind.

Published
2021

7. Etude Cinetique de la Croissance de Saccharothrix Algeriensis DSM 44581 en Fermenteur Batch en Presence d’Acide Benzoïque et d’Acide Humique = Kinetic Study of the Growth of Saccharothrix Algeriensis DSM 44581 in Batch Fermentor in the Presence of Benzoic Acid and Humic Acid

Author

Cédric Brandam, Atika Meklat, Nasserdine Sabaou, Florence Mathieu, Salim Mokrane, Omrane Toumatia, Mohamed Didi Ould El Hadj, Ahmed Lebrihi, and Noureddine Bouras

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Chromatography, chemistry, Humic acid, General Materials Science, Fermentation, Saccharothrix algeriensis, Benzoic acid
Published
2017

8. Mediterranean semi-arid plant Astragalus armatus as a source of bioactive galactomannan

Author

Zakaria Boual, Cédric Delattre, Emmanuel Petit, Mohamed Didi Ould El Hadj, Guillaume Pierre, Fatima Benaoun, Philippe Michaud, Christine Gardarin, Laboratoire de Protection des Ecosystèmes en Zones arides et semi-arides, Université Kasdi Merbah Ouargla, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Biologie des Plantes et Innovation - UR UPJV 3900 (BIOPI), Université de Picardie Jules Verne (UPJV), Université de Picardie Jules Verne (UPJV)-Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Université d'Artois (UA)-Université de Liège-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), and SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])

Subjects
chemistry.chemical_classification, Astragalus armatus, Antioxidant, Chromatography, Ion exchange, Anticomplement, Chemistry, DPPH, medicine.medical_treatment, Organic Chemistry, Fabaceae, Polysaccharide, Mass spectrometry, Biochemistry, Galactomannan, chemistry.chemical_compound, medicine, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, Gas chromatography, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Fourier transform infrared spectroscopy, Food Science
Abstract

International audience; A water-soluble polysaccharide fraction (WSPF) was extracted and purified from Astragalus armatus Lam. (Fabaceae), a spontaneous plant found in North Algerian Sahara. The structural features of WSPF were evaluated by colorimetric assays, Fourier transform infrared (FTIR) spectroscopy, high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD) and gas chromatography coupled to mass spectrometry (GC/MS). WSPF was a galactomannan-rich fraction, with a β-(1,4)-d-manp backbone with α-(1,6)-d-galp branches, and a Man:Gal ratio of 1.13. Besides, the anti-complement activity and the antioxidant potential (DPPH and hydroxyl radicals) of WSPF were evaluated. The results exhibited an anti-complementary activity, with an IC50 value of 0.39 mg/mL of the fraction, better than for heparin (0.58 mg/mL). Moreover, WSPF possessed a notable antioxidant activity on DPPH radical with an IC50 of 330 µg/mL.

Published
2015

9. Structural characterization and rheological behavior of a heteroxylan extracted from Plantago notata Lagasca (Plantaginaceae) seeds

Author

Didier Le Cerf, Fatima Benaoun, Tony Varacavoudin, Guillaume Pierre, Alina V. Ursu, Cédric Delattre, Philippe Michaud, Christine Gardarin, Anne Wadouachi, Zakaria Boual, Christophe Vial, Mohamed Didi Ould El-Hadj, Institut Pascal (IP), SIGMA Clermont (SIGMA Clermont)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Laboratoire de Protection des Ecosystèmes en Zones arides et semi-arides, Université Kasdi Merbah Ouargla, Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 (LG2A ), Université de Picardie Jules Verne (UPJV)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Polymères Biopolymères Surfaces (PBS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), SIGMA Clermont (SIGMA Clermont)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), and Institut de Chimie du CNRS (INC)-Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Magnetic Resonance Spectroscopy, Polymers and Plastics, Stomach disorder, Mucilage, 02 engineering and technology, Polysaccharide, 01 natural sciences, Xylan, Spectroscopy, Fourier Transform Infrared, Materials Chemistry, Plantaginaceae, Monosaccharide, [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], Plantago, chemistry.chemical_classification, Chromatography, biology, 010405 organic chemistry, Organic Chemistry, Notata, 021001 nanoscience & nanotechnology, biology.organism_classification, 0104 chemical sciences, chemistry, Algeria, Seeds, Xylans, Gas chromatography, 0210 nano-technology
Abstract

International audience; Plantago notata (Plantaginaceae) is a spontaneous plant from Septentrional Algerian Sahara currently used by traditional healers to treat stomach disorders, inflammations or wound healing. A water-soluble polysaccharide, called PSPN (PolySaccharide fraction from Plantago Notata), was extracted and purified from the seeds of this semi-arid plant. The structural features of this mucilage were evaluated by colorimetric assays, Fourier transformed infrared spectroscopy (FT-IR), gas chromatography coupled to mass spectrometry (GC/MS) and 1H/13C Nuclear Magnetic Resonance (NMR) spectroscopy. PSPN is a heteroxylan with a backbone composed of β-(1,3)-d-Xylp and β-(1,4)-d-Xylp highly branched, through (O)-2 and (O)-3 positions of β-(1,4)-d-Xylp by various side chains and terminal monosaccharides such as α-l-Araf-(1,3)-β-d-Xylp, β-d-Xylp-(1,2)-β-d-Xylp, terminal Xylp or terminal Araf. The physico-chemical and rheological analysis of this polysaccharide in dilute and semi diluted regimes showed that PSPN exhibites a molecular weight of 2.3 × 106 g/mol and a pseudoplastic behavior.

Published
2017

12. Polysaccharides and Derivatives from Africa to Address and Advance Sustainable Development and Economic Growth in the Next Decade

Author

Antony Sarraf, Emeline Verton, Noura Addoun, Zakaria Boual, Mohamed Didi Ould El Hadj, Zainab El Alaoui-Talibi, Cherkaoui El Modafar, Slim Abdelkafi, Imen Fendri, Cédric Delattre, Pascal Dubessay, Philippe Michaud, and Guillaume Pierre

Subjects
Africa, polysaccharides, ethnobotany, plants, macroalgae, biological activities, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Polysaccharides are highly variable and complex biomolecules whose inventory of structures is still very incomplete, as nature still preserves unexplored biotopes. Plants, macroalgae and microalgae are an integral part of the daily life of human being regardless of culture, time, or knowledge development of a country. Natural medicine is an ancestral knowledge widely distributed throughout the world, handed down for centuries from generation to generation by those commonly referred to as “nganga” healers or shamans. It is also called alternative medicine or traditional medicine, and has been associated for millennia to legends. This review gives an emphasis regarding the ethnobotanic approach associated to the structural variability of poly- and oligosaccharides for designing the new polysaccharide-based drugs and hydrocolloids of tomorrow. The guiding thread is to survey the potential of plants (and some macroalgae) from Africa as a source of polysaccharides with original structures and, secondly, to correlate these structures with biological and/or functional properties in particular to address and advance the sustainable development and economic growth of mankind.

Published
2021
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13. Beneficial Health Potential of Algerian Polysaccharides Extracted from Plantago ciliata Desf. (Septentrional Sahara) Leaves and Seeds

Author

Noura Addoun, Zakaria Boual, Cédric Delattre, Toufik Chouana, Christine Gardarin, Pascal Dubessay, Fatima Benaoun, Seddik Addaoud, Mohamed Didi Ould El Hadj, Philippe Michaud, and Guillaume Pierre

Subjects
Plantago ciliata, polysaccharides, characterization, biological activities, Africa, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Today, an ethnobotanical approach makes sense for identifying new active bioactive chemicals from uses of indigenous plants. Two water-soluble enriched polysaccharide fractions (L-PSPN and S-PSPN) were extracted by hot water extraction from the leaves and seeds of Plantago ciliata Desf. (1798), a Mzab indigenous herb currently used in Algeria by traditional healers. Primary investigation was performed for describing the main structural features of these polysaccharides (pectin- and heteroxylan-like compositions) by using colorimetric assays, FTIR spectroscopy, HPAEC/PAD and GC/MS-EI analyses. Some biological activities were also monitored, such as anticomplement, anti-inflammatory (phagocytic ability, NOX2 and MPO inhibitions) and anti-diabetic (α-amylase and α-glucosidase inhibitions). L-PSPC seems able to moderately modulate innate immune system (IC50 around 100 µg/mL) and contribute to wound-healing processes (IC50 close to 217 vs. 443 µg/mL for sodium heparin). S-PSPC shows some potential as an anti-hyperglycemic (IC50 around 4.7 mg/mL) and anti-inflammatory (IC50 ranging from 111 to 203 µg/mL) agent, as well as other (fiber) psyllium-like polysaccharides extracted from Plantago species.

Published
2021
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