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As a new type of biologically compatible material, TiO2 NPs are widely used in the industry as additives, drug carriers, and components of skin care products. Due to their wide use, residual TiO2 NPs in the environment are a safety concern that has attracted extensive attention. In this study, the ovarian cell line BmN of the model organism Bombyx mori was used to reveal the damaging effects of TiO2 NPs exposure. The results demonstrated that TiO2 NPs exhibited a dose-dependent effect on the relative cell viability, with significant toxic effects being observed above 20 mg/L. Oxidative damage analysis showed that ROS accumulated significantly in BmN cells after exposure to TiO2 NPs (P ≤ 0.05) and induced DNA damage. Further analysis revealed that the transcriptional levels of key superoxide dismutase genes (SOD) decreased significantly, while the transcriptions of key genes of the MAPK/NF-κB signaling pathway (P38, MEK, ERK and REL) and the downstream inflammatory factor genes (IL6 and TNFSF5) were all significantly up-regulated (P ≤ 0.05). Overall, our results indicate that exposure to TiO2 NPs leads to reduced transcription of antioxidant genes, accumulation of peroxides, and inflammation. These findings provide valuable data for the safety evaluation of environmental residues of TiO2 NPs.

A zwitterionic surfactant, hexadecyl hydroxypropyl sulfo betaine, was examined for its ability to stabilize supercritical CO2 (SC-CO2) foam, with the goal of improving the oil recovery from mature ...

High temperature-resistant polymer (HTP) was synthesized by in-situ cross-linking of interpenetrating reaction using H-2 monomer containing amide bond and H-1 molecule containing hydroxyl as raw materials. IR spectra result showed that there were characteristic functional groups of H-1 and H-2 cross bond at the same time, that was to say that H-1 cross-linking reaction and H-2 polymerization could simultaneously take place. The interpenetrating cross-linking structure, extension properties at room temperature and long-term heat resistance properties of the material were tested. The experiment results showed that in the whole range of observations, HTP material cross-links and interpenetrates uniformly. The SEM pictures confirmed the interpenetration structure of HTP material. After cross-linking and interpenetration, the scale of HTP structure became smaller than before. This material had tensile resistance, dispersion stability in water, volume expansion, and could reach the maximum swelling ratio of 1.69 within 1.5 h at room temperature. At 90 °C, 120 °C and 140 °C, after soaking 130 days in formation water, HTP volume reduction rate was 1.57%, 3.24% and 6.82%, respectively.