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242 results on '"Malagoli A"'

1. C3H Expression Is Crucial for Methyl Jasmonate Induction of Chicoric Acid Production by Echinacea purpurea (L.) Moench Cell Suspension Cultures

Author

Laura Ravazzolo, Benedetto Ruperti, Marco Frigo, Oriana Bertaiola, Giovanna Pressi, Mario Malagoli, and Silvia Quaggiotti

Subjects
Echinacea purpurea, chicoric acid, plant cell culture, gene expression, methyl jasmonate, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Echinacea purpurea (L.) Moench is one of the most economically important medicinal plants, cultivated worldwide for its high medicinal value and with several industrial applications in both pharmaceutical and food industries. Thanks to its various phytochemical contents, including caffeic acid derivatives (CADs), E. purpurea extracts have antioxidant, anti-inflammatory, and immuno-stimulating properties. Among CADs, chicoric acid is one of the most important compounds which have shown important pharmacological properties. The present research was aimed at optimizing the production of chicoric acid in E. purpurea cell culture. Methyl jasmonate (MeJa) at different concentrations and for different duration of treatments was utilized as elicitor, and the content of total polyphenols and chicoric acid was measured. Several genes involved in the chicoric acid biosynthetic pathway were selected, and their expression evaluated at different time points of cell culture growth. This was performed with the aim of identifying the most suitable putative molecular markers to be used as a proxy for the early prediction of chicoric acid contents, without the need of expensive quantification methods. A correlation between the production of chicoric acid in response to MeJa and an increased response to oxidative stress was also proposed.

Published
2022
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2. A Comparison between Non-Localized Post-Activation Performance Enhancements Following Resistance Exercise for the Upper and the Lower Body

Author

Sandro Bartolomei, Ivan Malagoli Lanzoni, Silvia Fantozzi, and Matteo Cortesi

Subjects
strength, cross-education, acute effects, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

The aim of the present investigation was to compare the acute non-localized post-activation performance enhancement (PAPE) of an exercise protocol involving either the upper or the lower body muscles. Twenty-four resistance trained men participated in the present study and were randomly assigned to an upper body (UB) or to a lower body (LB) group. Both groups tested for upper and lower body power (bench press throw (BPT) and countermovement jump power (CMJP) tests). Participants in the UB group were tested pre and post a high-intensity (HI) and a high-power (POW) bench press protocol while participants in the LB group performed a HI squat and a jump session (POW). A significant group × time interaction was found for CMJP in HI (p = 0.012). Post hoc tests revealed that CMJP was elevated in UB group only (+1.6%; p = 0.025). No other significant interactions were detected. Results of this study indicate that a non-localized PAPE on the lower body may be induced by a HI bench press protocol while a HI squat protocol may not increase upper body power. In particular, the squat protocol performed in the present study (5 sets of 1 rep) may be too demanding to produce a non-localized PAPE.

Published
2022
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3. Long-term maintenance treatment of psoriasis: the role of calcipotriol/betamethasone dipropionate aerosol foam in clinical practice

Author

P. Calzavara Pinton, C. De Simone, Gabriella Fabbrocini, Piergiorgio Malagoli, A Martella, Paolo Dapavo, Fabbrocini, G., De Simone, C., Dapavo, P., Malagoli, P., Martella, A., and Calzavara-Pinton, P.

Subjects
Cal/BD, Psoriasis, adherence, long-term therapy, proactive management, Aerosols, Betamethasone, Calcitriol, Drug Combinations, Humans, Treatment Outcome, Dermatologic Agents, medicine.medical_specialty, Betamethasone dipropionate, Dermatology, Therapeutic approach, chemistry.chemical_compound, medicine, In patient, Calcipotriol, Aerosol Foam, business.industry, Long term maintenance, medicine.disease, Clinical Practice, chemistry, business, medicine.drug
Abstract

Most patients with psoriasis present with localized mild-to-moderate disease. In this case, the application of topical treatments in the first-line setting is recommended in most cases. Among different topical options, the fixed-dose combination of betamethasone dipropionate (BD) and vitamin D analogue (Cal) aerosol foam (Enstilar®, Leo Pharma) is approved as first-line topical therapy for the treatment of psoriasis in USA and the EU, due to its high efficacy and its favorable administration scheme. The PSO-LONG was the first trial to report on the long-term efficacy and safety of the Cal/DB foam treatment for the proactive management of psoriasis and now, the indications of Cal/BD foam included its use in the psoriasis maintenance treatment. However, the precise role of this treatment and the potential therapeutic schemes in the long-term management of psoriasis need further clarification. This Position Paper, authored by a group of Italian Expert Dermatologists, critically discusses the long-term management of psoriasis with Cal/BD foam in clinical practice. In particular, the biological rationale in the proactive treatment with Cal/BD foam and current evidence regarding this therapeutic approach are presented, along with its application also in patients with moderate-to-severe disease, difficult-to-treat lesions, or within combination regimens. In addition, strategies to improve adherence to long-term treatment of psoriasis are discussed,.

Published
2022

4. Nitrate Regulates Maize Root Transcriptome through Nitric Oxide Dependent and Independent Mechanisms

Author

Laura Ravazzolo, Sara Trevisan, Silvia Iori, Cristian Forestan, Mario Malagoli, and Silvia Quaggiotti

Subjects
maize, nitrate, nitric oxide, root, signaling, transcriptome, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Maize root responds to nitrate by modulating its development through the coordinated action of many interacting players. Nitric oxide is produced in primary root early after the nitrate provision, thus inducing root elongation. In this study, RNA sequencing was applied to discover the main molecular signatures distinguishing the response of maize root to nitrate according to their dependency on, or independency of, nitric oxide, thus discriminating the signaling pathways regulated by nitrate through nitric oxide from those regulated by nitrate itself of by further downstream factors. A set of subsequent detailed functional annotation tools (Gene Ontology enrichment, MapMan, KEGG reconstruction pathway, transcription factors detection) were used to gain further information and the lateral root density was measured both in the presence of nitrate and in the presence of nitrate plus cPTIO, a specific NO scavenger, and compared to that observed for N-depleted roots. Our results led us to identify six clusters of transcripts according to their responsiveness to nitric oxide and to their regulation by nitrate provision. In general, shared and specific features for the six clusters were identified, allowing us to determine the overall root response to nitrate according to its dependency on nitric oxide.

Published
2021
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5. Kinematic Analysis of the Racket Position during the Table Tennis Top Spin Forehand Stroke

Author

Ivan Malagoli Lanzoni, Sandro Bartolomei, Rocco Di Michele, Yaodong Gu, Julien S. Baker, Silvia Fantozzi, and Matteo Cortesi

Subjects
kinematics, technique, racket sports, table tennis, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

The present study aims to assess the position of the racket, and racket height with respect to the floor, during the table tennis top spin stroke. A stereophotogrammetric system (Smart-D, BTS, 8 cameras, 550 Hz) was used to track the table tennis racket during cross-court (CC) and long-line (LL) shots. Ten national level players completed ten CC and ten LL top spin strokes responding to a robot machine. The racket motion throughout the shot showed specific technical characteristics: the minimum height of the racket was detected during the backswing phase; racket height at the end of backswing phase (maximal distance racket/table) was higher than the minimum; height at the racket maximum velocity (ball/racket impact) was greater than the net’s height. Furthermore, the maximum height of the racket occurred at the end of the forward swing. No differences in these kinematic variables between CC and LL were found. Conversely, a higher inclination of the racket at the moment of maximum speed was detected in LL vs. CC. From a practical perspective, the present findings suggest that table tennis players need to introduce specific exercises in order to increase the height of the racket during the forehand top spin stroke, to improve its effectiveness.

Published
2021
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6. Assessment of TSPAN Expression Profile and Their Role in the VSCC Prognosis

Author

Kelly Pedrozo Ferreira, Bruna Cristine de Almeida, Laura Gonzalez dos Anjos, Glauco Baiocchi, Fernando Augusto Soares, Rafael Malagoli Rocha, Edmund Chada Baracat, Andrey Senos Dobroff, and Katia Candido Carvalho

Subjects
tetraspanins, VSCC, immunohistochemistry, HPV infection, prognosis, cell culture, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

The role and prognostic value of tetraspanins (TSPANs) in vulvar squamous cell carcinoma (VSCC) remain poorly understood. We sought to primarily determine, at both the molecular and tissue level, the expression profile of the TSPANs CD9, CD63, CD81, and CD82 in archived VSCC samples (n = 117) and further investigate their clinical relevance as prognostic markers. Our studies led us to identify CD63 as the most highly expressed TSPAN, at the gene and protein levels. Multicomparison studies also revealed that the expression of CD9 was associated with tumor size, whereas CD63 upregulation was associated with histological diagnosis and vascular invasion. Moreover, low expression of CD81 and CD82 was associated with worse prognosis. To determine the role of TSPANs in VSCC at the cellular level, we assessed the mRNA levels of CD63 and CD82 in established metastatic (SW962) and non-metastatic (SW954) VSCC human cell lines. CD82 was found to be downregulated in SW962 cells, thus supporting its metastasis suppressor role. However, CD63 was significantly upregulated in both cell lines. Silencing of CD63 by siRNA led to a significant decrease in proliferation of both SW954 and SW962. Furthermore, in SW962 particularly, CD63-siRNA also remarkably inhibited cell migration. Altogether, our data suggest that the differential expression of TSPANs represents an important feature for prognosis of VSCC patients and indicates that CD63 and CD82 are likely potential therapeutic targets in VSCC.

Published
2021
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7. A New Protocol of Computer-Assisted Image Analysis Highlights the Presence of Hemocytes in the Regenerating Cephalic Tentacles of Adult Pomacea canaliculata

Author

Giulia Bergamini, Mohamad Ahmad, Marina Cocchi, and Davide Malagoli

Subjects
adult regeneration, apple snail, blastema, hemocyte, gastropod, image analysis, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

In humans, injuries and diseases can result in irreversible tissue or organ loss. This well-known fact has prompted several basic studies on organisms capable of adult regeneration, such as amphibians, bony fish, and invertebrates. These studies have provided important biological information and helped to develop regenerative medicine therapies, but important gaps concerning the regulation of tissue and organ regeneration remain to be elucidated. To this aim, new models for studying regenerative biology could prove helpful. Here, the description of the cephalic tentacle regeneration in the adult of the freshwater snail Pomacea canaliculata is presented. In this invasive mollusk, the whole tentacle is reconstructed within 3 months. Regenerating epithelial, connective, muscular and neural components are already recognizable 72 h post-amputation (hpa). Only in the early phases of regeneration, several hemocytes are retrieved in the forming blastema. In view of quantifying the hemocytes retrieved in regenerating organs, granular hemocytes present in the tentacle blastema at 12 hpa were counted, with a new and specific computer-assisted image analysis protocol. Since it can be applied in absence of specific cell markers and after a common hematoxylin-eosin staining, this protocol could prove helpful to evidence and count the hemocytes interspersed among regenerating tissues, helping to unveil the role of immune-related cells in sensory organ regeneration.

Published
2021
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8. Relationships between Muscle Architecture and Performance in Division I Male Italian Field Hockey Players

Author

Sandro Bartolomei, Federico Nigro, Simone Ciacci, Ivan Malagoli Lanzoni, Filippo Treno, and Matteo Cortesi

Subjects
vastus lateralis, muscle morphology, agility, sprint, Technology, Engineering (General). Civil engineering (General), TA1-2040, Biology (General), QH301-705.5, Physics, QC1-999, Chemistry, QD1-999
Abstract

Muscle architecture has been proposed as one of the most important determinants of muscle strength and power performance. The purpose of the present investigation was to correlate the muscle architecture with power, agility and maximal strength in Italian division I Field Hockey (FH) players. Twenty players (age = 25.4 ± 5.2 y; body mass = 78.5 ± 9.0 kg; body height = 179.6 ± 7.8 cm) were assessed for body composition, agility, sprint and maximal isometric force in squat (ISQ). The pro-agility test (PRO) and 30-m sprint (SPRINT) were used for agility and speed assessments, respectively. In addition, the pennation angle (PA), fascicle length (FL) and muscle thickness (MT) of the vastus lateralis were assessed via B-mode ultrasound. Large positive correlations were found between PRO and both PA and MT (r = 0.62; p = 0.006 and r = 0.51; p = 0.032, respectively). Moreover, SPRINT was positively correlated with PA and negatively correlated with FL (r = 0.50, p = 0.046; and r = −0.50; p = 0.034, respectively). Large positive correlations were also detected between body fat and both PRO and SPRINT (r = 0.58; p = 0.012 and r = 0.61; p = 0.009, respectively), indicating detrimental effects of the body fat on specific performances. The present findings showed the existence of large relationships between the muscle architecture of the vastus lateralis and physical characteristics related to elite performance in FH. Low PA and long FL of the vastus lateralis appear important parameters for agility and sprint performances.

Published
2021
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9. Nitrate and Ammonium Affect the Overall Maize Response to Nitrogen Availability by Triggering Specific and Common Transcriptional Signatures in Roots

Author

Laura Ravazzolo, Sara Trevisan, Cristian Forestan, Serena Varotto, Stefania Sut, Stefano Dall’Acqua, Mario Malagoli, and Silvia Quaggiotti

Subjects
ammonium, amino acids, gene expression, maize, nitrate, plant development, rna-seq, root, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Nitrogen (N) is an essential macronutrient for crops. Plants have developed several responses to N fluctuations, thus optimizing the root architecture in response to N availability. Nitrate and ammonium are the main inorganic N forms taken up by plants, and act as both nutrients and signals, affecting gene expression and plant development. In this study, RNA-sequencing was applied to gain comprehensive information on the pathways underlying the response of maize root, pre-treated in an N-deprived solution, to the provision of nitrate or ammonium. The analysis of the transcriptome shows that nitrate and ammonium regulate overlapping and distinct pathways, thus leading to different responses. Ammonium activates the response to stress, while nitrate acts as a negative regulator of transmembrane transport. Both the N-source repress genes related to the cytoskeleton and reactive oxygen species detoxification. Moreover, the presence of ammonium induces the accumulation of anthocyanins, while also reducing biomass and chlorophyll and flavonoids accumulation. Furthermore, the later physiological effects of these nutrients were evaluated through the assessment of shoot and root growth, leaf pigment content and the amino acid concentrations in root and shoot, confirming the existence of common and distinct features in response to the two nitrogen forms.

Published
2020
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10. Xeroderma Pigmentosum: Low Prevalence of Germline XPA Mutations in a Brazilian XP Population

Author

Karina Miranda Santiago, Amanda França de Nóbrega, Rafael Malagoli Rocha, Silvia Regina Rogatto, and Maria Isabel Achatz

Subjects
xeroderma pigmentosum syndrome, XPA gene, skin cancer, neurodegeneration, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder characterized by DNA repair defects that cause photophobia, sunlight-induced cancers, and neurodegeneration. Prevalence of germline mutations in the nucleotide excision repair gene XPA vary significantly in different populations. No Brazilian patients have been reported to carry a germline mutation in this gene. In this study, the germline mutational status of XPA was determined in Brazilian patients exhibiting major clinical features of XP syndrome. The study was conducted on 27 unrelated patients from select Brazilian families. A biallelic inactivating transition mutation c.619C>T (p.Arg207Ter) was identified in only one patient with a history of neurological impairment and mild skin abnormalities. These findings suggest that XP syndrome is rarely associated with inherited disease-causing XPA mutations in the Brazilian population. Additionally, this report demonstrates the effectiveness of genotype-phenotype correlation as a valuable tool to guide direct genetic screening.

Published
2015
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11. A Comparison between Non-Localized Post-Activation Performance Enhancements Following Resistance Exercise for the Upper and the Lower Body

Author

Ivan Malagoli Lanzoni, Sandro Bartolomei, MATTEO CORTESI, Silvia Fantozzi, and Bartolomei S, Malagoli Lanzoni I, Fantozzi S, Cortesi M

Subjects
Fluid Flow and Transfer Processes, Technology, acute effects, QH301-705.5, Physics, QC1-999, Process Chemistry and Technology, General Engineering, strength, cross-education, Engineering (General). Civil engineering (General), Computer Science Applications, Chemistry, General Materials Science, TA1-2040, Biology (General), QD1-999, Instrumentation
Abstract

The aim of the present investigation was to compare the acute non-localized post-activation performance enhancement (PAPE) of an exercise protocol involving either the upper or the lower body muscles. Twenty-four resistance trained men participated in the present study and were randomly assigned to an upper body (UB) or to a lower body (LB) group. Both groups tested for upper and lower body power (bench press throw (BPT) and countermovement jump power (CMJP) tests). Participants in the UB group were tested pre and post a high-intensity (HI) and a high-power (POW) bench press protocol while participants in the LB group performed a HI squat and a jump session (POW). A significant group × time interaction was found for CMJP in HI (p = 0.012). Post hoc tests revealed that CMJP was elevated in UB group only (+1.6%; p = 0.025). No other significant interactions were detected. Results of this study indicate that a non-localized PAPE on the lower body may be induced by a HI bench press protocol while a HI squat protocol may not increase upper body power. In particular, the squat protocol performed in the present study (5 sets of 1 rep) may be too demanding to produce a non-localized PAPE.

Published
2022
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12. HE-LHC: The High-Energy Large Hadron Collider Future Circular Collider Conceptual Design Report Volume 4

Author

Pushpalatha C Bhat, B. Seeber, C. Pagliarone, Marco Statera, Victor P. Goncalves, Daria Astapovych, W. Bartmann, S. Iwamoto, M. Mentink, Alessandro Tricoli, E. R. Bielert, Laurent Chevalier, Patrick Koppenburg, Marco Calviani, C. Montag, P. Spiller, Jan Uythoven, P. Di Nezza, G. Guillermo Canton, B. Sailer, Markus Elsing, Sara Khatibi, Luca Vecchi, Luigi Palumbo, J. P. Penttinen, T. Podzorny, Maneesh Kumar, J. M. Rifflet, C. Kotnig, Jean Zinn-Justin, Christopher B. Verhaaren, A. Chernoded, Alessandro Bertarelli, L. M. Tkachenko, C. Koeberl, P. J. Mallon, M. Takeuchi, W. Venturini Delsolaro, G. Lamanna, S. Weinzierl, J. Gao, W. Kaabi, David D'Enterria, D. Barna, Paolo Castelnovo, Rajat Gupta, Oliver Boine-Frankenheim, Adarsh Pyarelal, Andreas Salzburger, Tessa Charles, M.E. Biagini, O. Panella, M. Stuart, A. Kollegger, V. Garcia Diaz, Olcay Bolukbasi, Maurizio Pierini, H. Aksakal, Tord Riemann, Abhishek M. Iyer, V. Shiltsev, D. Buttazzo, J. Blümlein, Prateek Agrawal, L. Sestini, Martin Bauer, Felicitas Pauss, S. Fiorendi, F. Bossu, Marco Nardecchia, C. Leonidopoulos, Wojciech Kotlarski, A. Saba, I. Bautista-Guzmán, W. Hillert, Giorgio Ambrosio, T. Lehtinen, Michael Andrew Parker, Silvia Taroni, Gian F. Giudice, Ph. Lebrun, Johann A. Briffa, T. Risselada, Giuseppe Lerner, A. Lechner, L. S. Miralles, M. Kuze, J. M. Valet, P. S. B. Dev, S. Holleis, Ph. Schwemling, M. Biglietti, S. Banerjee, Thomas Schörner-Sadenius, A. Sanz Ull, V. Tikhomirov, S. Savelyeva, Jiayin Gu, D. Zhou, Federico Ravotti, S. A. Bogacz, Daniele Mirarchi, R. Tomás García, Yann Coadou, F. Yu, Y. Cai, T. Lari, F. Holdener, D. Shwartz, C. Bhat, Ramesh Gupta, Markus Klute, E. Palmieri, P. Collier, Branislav Sitar, Yves Sirois, Livio Fanò, S. Rojas-Torres, E. Locci, Ruben Garcia Alia, I. Božović Jelisavić, R. Chehab, J. A. Aguilar-Saavedra, M. Pasquali, A. Di Cicco, Bernhard Auchmann, Klaus Heinemann, Alessia Tricomi, D. Lucchesi, B. Haerer, M. Morrone, Paolo Giacomelli, Sonia Carra, A. Senol, Ivan Koop, Luca Silvestrini, Anna Stakia, Heather Gray, E. Skordis, A. D. Kovalenko, Paul Langacker, R. Li, Bernardo Bordini, R. Rata, Arjan Verweij, Shehu S. AbdusSalam, Andrey Karyukhin, U. van Rienen, Gianluigi Arduini, Bernhard Holzer, S. A. Nikitin, S. S. Kozub, Satoshi Mishima, B. Di Micco, S. Izquierdo Bermudez, N. Pukhaeva, Nigel Watson, F. Prino, Jean-Michel Sallese, Sotirios Vlachos, Alessandro Vicini, A. Valassi, Daniel Treille, F. Dordei, A. M. Fernandez Navarro, B. Dziewit, Marcello Abbrescia, J. M. Hauptman, I. Chaikovska, Paolo Giubellino, Michael J. Baker, V.V. Kashikhin, Friedrich Lackner, Filippo Sala, A. Langner, D. Pulikowski, H. Eriksson, Matteo Turri, Andrea Wulzer, M. Aiba, Lisa Borgonovi, I. Morozov, V. Haurylavets, J. F. Croteau, S. Boselli, L. A. Gonzalez Gomez, Claudia Tambasco, F. Mahmoudi, Sébastien Descotes-Genon, A. Luciani, Pavel Piminov, M. Varasteh, T. Herzig, Sandra Aumon, Cristina Bernini, Joseph Bramante, Roberta Arnaldi, G. Zick, Daniel Schulte, R. Santoro, Anna Kulesza, I. Turk Cakir, M. Nonis, Silvia Posada Arias, Livia Soffi, T. Wojtoń, E. Cennini, Florian Bauer, B. Rousset, J.-L. Grenard, C. Neubüser, Frederic Derue, Loukas Gouskos, Rainer Wallny, G. Calderini, M. Merk, M. Mühlegger, Roberto Cimino, M. Ramsey-Musolf, P. Rebello Teles, Mario Galanti, Mikhail Shaposhnikov, A. Andreazza, Maria Vittoria Garzelli, Masaya Ishino, José W. F. Valle, Colin Bernet, G. Velev, Cristina Botta, E. Fischer, J. Malclés, Giuseppe Montenero, Tripurari Srivastava, E. Renner, Shahnam Gorgi Zadeh, D. Cantore-Cavalli, Paul Laycock, J. Komppula, Simon C. Hopkins, Helmut Burkhardt, Eric Lancon, I. Aichinger, Andre Sznajder, F. Bordry, Massimo Giovannozzi, Aidan Robson, Anna Giunta, A. Carvalho, S. Farinon, Daniel Wollmann, M. Fouaidy, Martti Raidal, R. Gerard, Giovanni Volpini, U. Niedermayer, A. Alekou, Alexander J.G. Lunt, Vincenzo Cavasinni, Andrzej Siodmok, U. Kaya, Matthias Schott, Marumi Kado, S. A. Arsenyev, José Zurita, John Osborne, Patrick Meade, Gianmarco Bovone, G. Li, Klaus Schlenga, Antti Stenvall, D. Duellmann, Werner Riegler, I. Garzia, Yasuyuki Okumura, G. Pikurs, F. Maltoni, Massimo Sorbi, M. Arzeo, B. Strauss, Y. W. Baek, Mauro Chiesa, K. Ilyina-Brunner, Javier L. Albacete, R. Farinelli, C. Pes, Nicolas Morange, S. M. Zernov, U. Wagner, Emmanuelle Perez, G. G. Da Silveira, J. Neundorf, Néstor Armesto, T. Hahn, Roman N. Lee, Roderik Bruce, B. Y. Sharkov, T. du Pree, G. Cibinetto, Evelin Meoni, R. Rinaldesi, James A. Ellison, Radim Slovak, Silvia Franchino, Mikko Laine, T. Pugnat, S. P. Das, Yuji Enari, Emanuela Barzi, Cihan Bayindir, R. Boels, Jana Faltova, M. Moreno Llácer, Scott A. Yost, Michael Spannowsky, Florian Burkart, Marcin Chrzaszcz, K. Suzuki, Luca Trentadue, S. Masciocchi, Gilad Perez, Steve Peggs, K. Sugita, Eleonora Belli, Carmine Senatore, K. Y. Oyulmaz, Aldo Deandrea, Irakli Minashvili, Desmond P. Barber, M. I. Martínez-Hernández, A. Apyan, S. Petracca, Mikael Chala, Urs Achim Wiedemann, T. Sian, Olivier Deschamps, R. Monge, G. Avrillaud, Jan Kieseler, Hubert Spiesberger, J. Maitre, G. D. Shirkov, M. Hofer, Emanuela Sirtori, Sinan Kuday, Kirill Skovpen, Sara Casalbuoni, Johann Usovitsch, N. Chen, G. Tejeda-Muñoz, F. Bellini, E. Chyhyrynets, Michael Stöger-Pollach, M. Vogel, J. G. Mendes Saraiva, A. Rivetti, M. Podeur, Luc Poggioli, V. A. Gromov, R. Sirvinskaite, S. B. Leith, Giancarlo D'Ambrosio, Tony Price, Philippe Mermod, Rabindra N. Mohapatra, T. Mitshuhashi, Koji Terashi, Leonel Ferreira, L. Vale Silva, N. Muchnoi, J. L. Stanyard, Thomas Marriott-Dodington, A. Andriatis, Oleg Solovyanov, A. Daljevec, A. Butterworth, S. Myers, D. Chanal, Tatiana Pieloni, M. Rodríguez-Cahuantzi, G. Nardini, D. Boscherini, Kazuhito Ohmi, James Molson, S. Kowalski, Christoph Haberstroh, Martin Aleksa, K. Kershaw, M. Mulder, Leonid Rivkin, G. Vorotnikov, Luigi Salvatore Esposito, J. Kalinowski, Michele Cascella, Francesco Giffoni, Alessandro Polini, Georges Azuelos, M. Prioli, Wolfgang Altmannshofer, S. K. Patra, H. J. He, J. J. Aguilera-Verdugo, Hannu Paukkunen, P. Chomaz, Shoji Asai, Nicolas Magnin, Gavin P. Salam, R. Wang, F. Avino, Alexander Romanenko, A. Rossi, Steve Muanza, Richard Ruiz, Dmitry Teytelman, S. Klöppel, S. Atieh, M. Mohammadi Najafabadi, L. Apolinario, Andrea Tesi, M. Maggiora, A. Falkowski, Janusz Gluza, M. Sauvain, Hamzeh Khanpour, S. Chance, Ansgar Denner, Ma. Greco, Andreas Papaefstathiou, Manuela Boscolo, Joydeep Chakrabortty, E. Franco, R. R. Bosley, G. Peón, Fred Olness, Simone Alioli, Andrea Gaddi, M. K. Sullivan, M. Segreti, M. Panareo, Florian Goertz, Z. G. Zhao, H. Chanal, O. Martin, P. Azzurri, Agnieszka Chmielinska, M. Kordiaczyńska, O. Brunner, J. Von Ahnen, Jose Santiago, K. Foraz, Y. Alexahin, Marcello Mannelli, Christian Schwanenberger, S. Ganjour, Simone Marzani, T. M. Taylor, S. Di Vita, J. Womersley, I. Karpov, Valentina Morretta, Saverio D'Auria, Patrick Draper, B. Hacışahinoğlu, E. Gorini, Andrew J. Long, S. La Mendola, G. Zevi Dell Porta, I. Abdyukhanov, M. Cobal, Luca Marzola, E. Rochepault, A. Kusina, German Rodrigo, R. Schmidt, Jan Steggemann, E. Premat, P. Slavich, F. Gianotti, P. Jarry, Ram Krishna Dewanjee, L. Felsberger, T. Martinez, A. Niemi, Jürgen Reuter, P. A. Bruckman de Renstrom, Ryu Sawada, J. T. Childers, Gelsomina Catalano, P. Barjhoux, O. R. Blanco-García, Pilar Hernández, H. Correia-Rodrigues, V. Ippolito, S. De Curtis, Juan Rojo, Ayberk Yilmaz, S. Baird, Morteza Khatiri Yanehsari, Enrico Scomparin, Daniel Appelö, J. Kozaczuk, Matthew Jones, B. Caiffi, C. Del Bo, Susanna Guiducci, Giuliano Panico, M. Knecht, J. Coupard, M. Ciuchini, H. Kritscher, Claire Gwenlan, P. Costa Pinto, Thibaut Lefèvre, N. Bellegarde, Christian Scheuerlein, P. Ferreira da Silva, M. Verducci, X. Ruan, H. Pikhartova, Juan M. O'Callaghan, Kazuro Furukawa, D. Saez de Jauregui, Maria Rescigno, Stephan Eisenhardt, Andrea Dainese, Z. Drásal, G. H. Corral, J. M. Camalich, John Ellis, E. Gabrielli, L. Rumyantsev, A. Caliskan, K. Brunner, K. Tang, P. Sopicki, J. Fan, Marcin Kucharczyk, S. Gorgi Zadeh, Carlos A. Salgado, Simone Bologna, Y. Muttoni, A. Chancé, Patrick Jenny, Mark Boland, G. Yang, G. Wilkinson, Roger J. Hernández-Pinto, M. Novák, Gennady Stupakov, E. Jensen, Lance D. Cooley, Torbjörn Sjöstrand, S. Su, Matthew Luzum, J. Casas, Per Osland, T. Robens, Oscar A. Sampayo, Evgeny Levichev, P. N. Ratoff, G. Rolandi, M. A. Valdivia Garcia, Anthony Keith Morley, L. van Riesen-Haupt, A. Sublet, M. A. Mazzoni, J.L. Gutierrez, A. Abramov, Abbas Kenan Ciftci, A. Provino, L. Delle Rose, John Fox, Barry M. Dillon, V. Smirnov, G. N. Taylor, Anke-Susanne Müller, C. Pira, Fulvio Piccinini, A. Faus-Golfe, Pietro Antonioli, S. Sanfilippo, Julien Cogan, A. Ribon, Andrew Hutton, Frank Zimmermann, Lev Dudko, Erez Etzion, J. Polinski, G. Bencivenni, M. 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Gobbi, Michael Hance, A. J. Barr, V. Del Duca, V. Guzey, M. Pont, Michele Selvaggi, Oliver Brüning, J. Barreiro Guimarães da Costa, A. Drago, Y. Zhang, Giovanni Punzi, Viktor Matveev, Anadi Canepa, Clemens Lange, B. L. Militsyn, Martijn Mulders, Max Klein, V. D’Auria, M. Mylona, Valeria Braccini, S. DasBakshi, David Calvet, Sophia Borowka, David Marzocca, S. Jadach, A. A. Pankov, Christophe Ochando, A. A. Tudora, I. Masina, Jure Zupan, A. Preinerstorfer, Benjamin Fuks, H. K. Soltveit, G. Rolando, E.E. Perepelkin, T. G. Rizzo, Saleh Sultansoy, Federico Roncarolo, K. Elsener, R. Q. Pan, P. Zhuang, David Attié, Jac Perez, K. Kravalis, F. Anulli, V. Ruhlmann-Kleider, S. Malvezzi, Steffen A. Bass, E. La Francesca, Heinz Pernegger, K. Grzanka, M. T. Tiirakari, Alberto Ventura, Alessandro Cerri, Marco Peruzzi, Eric Montesinos, O. Etisken, F. Grancagnolo, S. Kartal, H. Humer, Oliver Fischer, M. Primavera, Marco Toliman Lucchini, P. Vedrine, Felix Kling, M. Altınlı, Sergio Calatroni, C. Han, Olivier Leroy, R. T. D’Agnolo, N. Klinkenberg, A. Audurier, Tatsushi Nakamoto, Ali Bozbey, Bernd A. Kniehl, Carl J. Debono, I. P. J. Shipsey, Gregorio Bernardi, Paolo Nason, William James Fawcett, J. M. Jiménez, D. Denisov, M. Serluca, David Curtin, Arif Akhundov, M. García Pérez, Iacopo Vivarelli, Emanuele Bacchiocchi, Markus Zerlauth, Julia Hrdinka, F. Butin, F. Müller, D. Tikhonov, Jorg Wenninger, A. Kilic, Fabrizio Ferro, J. Tanaka, S. A. Antipov, Miroslav Atanasov, S. Kuttimalai, A. Y. Starikov, F. R. Blánquez, S. V. Furuseth, G. Gaudio, L. Malgeri, J. Curti, B. Turbiarz, S. Li, A. Romanov, Costas G. Papadopoulos, Brennan Goddard, Frank Krauss, Lidija Zivkovic, Toms Torims, Michaela Lackner, D. A. Lyubimtsev, G. Borghello, J. F. Grosse-Oetringhaus, A. Bogomyagkov, H. Duran Yildiz, N. Foppiani, Arthur Schaffer, J. Zhou, D. Liberati, Vincenzo Guidi, Naeem A. Tahir, M. Besançon, Daniel Schoerling, Joe Incandela, Giacomo Polesello, O. Cakir, I. Ruehl, Ruggero Vaglio, Z. 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Zurita, J, Işık Üniversitesi, Mühendislik Fakültesi, İnşaat Mühendisliği Bölümü, Işık University, Faculty of Engineering, Department of Civil Engineering, Bayındır, Cihan, Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. RF&MW - Grup de Recerca de sistemes, dispositius i materials de RF i microones, Abada A., Abbrescia M., AbdusSalam S.S., Abdyukhanov I., Abelleira Fernandez J., Abramov A., Aburaia M., Acar A.O., Adzic P.R., Agrawal P., Aguilar-Saavedra J.A., Aguilera-Verdugo J.J., Aiba M., Aichinger I., Aielli G., Akay A., Akhundov A., Aksakal H., Albacete J.L., Albergo S., Alekou A., Aleksa M., Aleksan R., Alemany Fernandez R.M., Alexahin Y., Alia R.G., Alioli S., Alipour Tehrani N., Allanach B.C., Allport P.P., Altinli M., Altmannshofer W., Ambrosio G., Amorim D., Amstutz O., Anderlini L., Andreazza A., Andreini M., Andriatis A., Andris C., Andronic A., Angelucci M., Antinori F., Antipov S.A., Antonelli M., Antonello M., Antonioli P., Antusch S., Anulli F., Apolinario L., Apollinari G., Apollonio A., Appelo D., Appleby R.B., Apyan A., Arbey A., Arbuzov A., Arduini G., Ari V., Arias S., Armesto N., Arnaldi R., Arsenyev S.A., Arzeo M., Asai S., Aslanides E., Assmann R.W., Astapovych D., Atanasov M., Atieh S., Attie D., Auchmann B., Audurier A., Aull S., Aumon S., Aune S., Avino F., Avrillaud G., Aydin G., Azatov A., Azuelos G., Azzi P., Azzolini O., Azzurri P., Bacchetta N., Bacchiocchi E., Bachacou H., Baek Y.W., Baglin V., Bai Y., Baird S., Baker M.J., Baldwin M.J., Ball A.H., Ballarino A., Banerjee S., Barber D.P., Barducci D., Barjhoux P., Barna D., Barnafoldi G.G., Barnes M.J., Barr A., Barranco Garcia J., Barreiro Guimaraes da Costa J., Bartmann W., Baryshevsky V., Barzi E., Bass S.A., Bastianin A., Baudouy B., Bauer F., Bauer M., Baumgartner T., Bautista-Guzman I., Bayindir C., Beaudette F., Bedeschi F., Beguin M., Bellafont I., Bellagamba L., Bellegarde N., Belli E., Bellingeri E., Bellini F., Bellomo G., Belomestnykh S., Bencivenni G., Benedikt M., Bernardi G., Bernardi J., Bernet C., Bernhardt J.M., Bernini C., Berriaud C., Bertarelli A., Bertolucci S., Besana M.I., Besancon M., Beznosov O., Bhat P., Bhat C., Biagini M.E., Biarrotte J.-L., Bibet Chevalier A., Bielert E.R., Biglietti M., Bilei G.M., Bilki B., Biscari C., Bishara F., Blanco-Garcia O.R., Blanquez F.R., Blekman F., Blondel A., Blumlein J., Boccali T., Boels R., Bogacz S.A., Bogomyagkov A., Boine-Frankenheim O., Boland M.J., Bologna S., Bolukbasi O., Bomben M., Bondarenko S., Bonvini M., Boos E., Bordini B., Bordry F., Borghello G., Borgonovi L., Borowka S., Bortoletto D., Boscherini D., Boscolo M., Boselli S., Bosley R.R., Bossu F., Botta C., Bottura L., Boughezal R., Boutin D., Bovone G., Bozovic Jelisavic I., Bozbey A., Bozzi C., Bozzini D., Braccini V., Braibant-Giacomelli S., Bramante J., Braun-Munzinger P., Briffa J.A., Britzger D., Brodsky S.J., Brooke J.J., Bruce R., Bruckman De Renstrom P., Bruna E., Bruning O., Brunner O., Brunner K., Bruzzone P., Buffat X., Bulyak E., Burkart F., Burkhardt H., Burnet J.-P., Butin F., Buttazzo D., Butterworth A., Caccia M., Cai Y., Caiffi B., Cairo V., Cakir O., Calaga R., Calatroni S., Calderini G., Calderola G., Caliskan A., Calvet D., Calviani M., Camalich J.M., Camarri P., Campanelli M., Camporesi T., Canbay A.C., Canepa A., Cantergiani E., Cantore-Cavalli D., Capeans M., Cardarelli R., Cardella U., Cardini A., Carloni Calame C.M., Carra F., Carra S., Carvalho A., Casalbuoni S., Casas J., Cascella M., Castelnovo P., Castorina G., Catalano G., Cavasinni V., Cazzato E., Cennini E., Cerri A., Cerutti F., Cervantes J., Chaikovska I., Chakrabortty J., Chala M., Chamizo-Llatas M., Chanal H., Chanal D., Chance S., Chance A., Charitos P., Charles J., Charles T.K., Chattopadhyay S., Chehab R., Chekanov S.V., Chen N., Chernoded A., Chetvertkova V., Chevalier L., Chiarelli G., Chiarello G., Chiesa M., Chiggiato P., Childers J.T., Chmielinska A., Cholakian A., Chomaz P., Chorowski M., Chou W., Chrzaszcz M., Chyhyrynets E., Cibinetto G., Ciftci A.K., Ciftci R., Cimino R., Ciuchini M., Clark P.J., Coadou Y., Cobal M., Coccaro A., Cogan J., Cogneras E., Collamati F., Colldelram C., Collier P., Collot J., Contino R., Conventi F., Cook C.T.A., Cooley L., Corcella G., Cornell A.S., Corral G.H., Correia-Rodrigues H., Costanza F., Costa Pinto P., Couderc F., Coupard J., Craig N., Crespo Garrido I., Crivellin A., Croteau J.F., Crouch M., Cruz Alaniz E., Cure B., Curti J., Curtin D., Czech M., Dachauer C., D'Agnolo R.T., Daibo M., Dainese A., Dalena B., Daljevec A., Dallapiazza W., D'Aloia Schwartzentruber L., Dam M., D'Ambrosio G., Das S.P., DasBakshi S., da Silva W., da Silveira G.G., D'Auria V., D'Auria S., David A., Davidek T., Deandrea A., de Blas J., Debono C.J., De Curtis S., De Filippis N., de Florian D., Deghaye S., de Jong S.J., Del Bo C., Del Duca V., Delikaris D., Deliot F., Dell'Acqua A., Delle Rose L., Delmastro M., De Lucia E., Demarteau M., Denegri D., Deniau L., Denisov D., Denizli H., Denner A., d'Enterria D., de Rijk G., De Roeck A., Derue F., Deschamps O., Descotes-Genon S., Dev P.S.B., de Vivie de Regie J.B., Dewanjee R.K., Di Ciaccio A., Di Cicco A., Dillon B.M., Di Micco B., Di Nezza P., Di Vita S., Doblhammer A., Dominjon A., D'Onofrio M., Dordei F., Drago A., Draper P., Drasal Z., Drewes M., Duarte L., Dubovyk I., Duda P., Dudarev A., Dudko L., Duellmann D., Dunser M., du Pree T., Durante M., Duran Yildiz H., Dutta S., Duval F., Duval J.M., Dydyshka Y., Dziewit B., Eisenhardt S., Eisterer M., Ekelof T., El Khechen D., Ellis S.A., Ellis J., Ellison J.A., Elsener K., Elsing M., Enari Y., Englert C., Eriksson H., Eskola K.J., Esposito L.S., Etisken O., Etzion E., Fabbricatore P., Falkowski A., Falou A., Faltova J., Fan J., Fano L., Farilla A., Farinelli R., Farinon S., Faroughy D.A., Fartoukh S.D., Faus-Golfe A., Fawcett W.J., Felici G., Felsberger L., Ferdeghini C., Fernandez Navarro A.M., Fernandez-Tellez A., Ferradas Troitino J., Ferrara G., Ferrari R., Ferreira L., Ferreira da Silva P., Ferrera G., Ferro F., Fiascaris M., Fiorendi S., Fiorio C., Fischer O., Fischer E., Flieger W., Florio M., Fonnesu D., Fontanesi E., Foppiani N., Foraz K., Forkel-Wirth D., Forte S., Fouaidy M., Fournier D., Fowler T., Fox J., Francavilla P., Franceschini R., Franchino S., Franco E., Freitas A., Fuks B., Furukawa K., Furuseth S.V., Gabrielli E., Gaddi A., Galanti M., Gallo E., Ganjour S., Gao J., Garcia Diaz V., Garcia Perez M., Garcia Tabares L., Garion C., Garzelli M.V., Garzia I., Gascon-Shotkin S.M., Gaudio G., Gay P., Ge S.-F., Gehrmann T., Genest M.H., Gerard R., Gerigk F., Gerwig H., Giacomelli P., Giagu S., Gianfelice-Wendt E., Gianotti F., Giffoni F., Gilardoni S.S., Gil Costa M., Giovannetti M., Giovannozzi M., Giubellino P., Giudice G.F., Giunta A., Gladilin L.K., Glukhov S., Gluza J., Gobbi G., Goddard B., Goertz F., Golling T., Goncalves V.P., Goncalo R., Gonzalez Gomez L.A., Gorgi Zadeh S., Gorine G., Gorini E., Gourlay S.A., Gouskos L., Grancagnolo F., Grassellino A., Grau A., Graverini E., Gray H.M., Greco M., Grenard J.-L., Grimm O., Grojean C., Gromov V.A., Grosse-Oetringhaus J.F., Grudiev A., Grzanka K., Gu J., Guadagnoli D., Guidi V., Guiducci S., Guillermo Canton G., Gunaydin Y.O., Gupta R., Gupta R.S., Gutierrez J., Gutleber J., Guyot C., Guzey V., Gwenlan C., Haberstroh C., Hacisahinoglu B., Haerer B., Hahn K., Hahn T., Hammad A., Han C., Hance M., Hannah A., Harris P.C., Hati C., Haug S., Hauptman J., Haurylavets V., He H.-J., Hegglin A., Hegner B., Heinemann K., Heinemeyer S., Helsens C., Henriques A., Hernandez P., Hernandez-Pinto R.J., Hernandez-Sanchez J., Herzig T., Hiekkanen I., Hillert W., Hoehn T., Hofer M., Hofle W., Holdener F., Holleis S., Holzer B., Hong D.K., Honorato C.G., Hopkins S.C., Hrdinka J., Hug F., Humann B., Humer H., Hurth T., Hutton A., Iacobucci G., Ibarrola N., Iconomidou-Fayard L., Ilyina-Brunner K., Incandela J., Infantino A., Ippolito V., Ishino M., Islam R., Ita H., Ivanovs A., Iwamoto S., Iyer A., Izquierdo Bermudez S., Jadach S., Jamin D.O., Janot P., Jarry P., Jeff A., Jenny P., Jensen E., Jensen M., Jiang X., Jimenez J.M., Jones M.A., Jones O.R., Jowett J.M., Jung S., Kaabi W., Kado M., Kahle K., Kalinovskaya L., Kalinowski J., Kamenik J.F., Kannike K., Kara S.O., Karadeniz H., Karaventzas V., Karpov I., Kartal S., Karyukhin A., Kashikhin V., Katharina Behr J., Kaya U., Keintzel J., Keinz P.A., Keppel K., Kersevan R., Kershaw K., Khanpour H., Khatibi S., Khatiri Yanehsari M., Khoze V.V., Kieseler J., Kilic A., Kilpinen A., Kim Y.-K., Kim D.W., Klein U., Klein M., Kling F., Klinkenberg N., Kloppel S., Klute M., Klyukhin V.I., Knecht M., Kniehl B., Kocak F., Koeberl C., Kolano A.M., Kollegger A., Kolodziej K., Kolomiets A.A., Komppula J., Koop I., Koppenburg P., Koratzinos M., Kordiaczynska M., Korjik M., Kortner O., Kostka P., Kotlarski W., Kotnig C., Kottig T., Kotwal A.V., Kovalenko A.D., Kowalski S., Kozaczuk J., Kozlov G.A., Kozub S.S., Krainer A.M., Kramer T., Kramer M., Krammer M., Krasnov A.A., Krauss F., Kravalis K., Kretzschmar L., Kriske R.M., Kritscher H., Krkotic P., Kroha H., Kucharczyk M., Kuday S., Kuendig A., Kuhlmann G., Kulesza A., Kumar M., Kusina A., Kuttimalai S., Kuze M., Kwon T., Lackner F., Lackner M., La Francesca E., Laine M., Lamanna G., La Mendola S., Lancon E., Landsberg G., Langacker P., Lange C., Langner A., Lankford A.J., Lansberg J.P., Lari T., Laycock P.J., Lebrun P., Lechner A., Lee K., Lee S., Lee R., Lefevre T., Le Guen P., Lehtinen T., Leith S.B., Lenzi P., Leogrande E., Leonidopoulos C., Leon-Monzon I., Lerner G., Leroy O., Lesiak T., Levai P., Leveratto A., Levichev E., Li G., Li S., Li R., Liberati D., Liepe M., Lissauer D.A., Liu Z., Lobko A., Locci E., Logothetis Agaliotis E., Lombardo M.P., Long A.J., Lorin C., Losito R., Louzguiti A., Low I., Lucchesi D., Lucchini M.T., Luciani A., Lueckhof M., Lunt A.J.G., Luzum M., Lyubimtsev D.A., Maggiora M., Magnin N., Mahmoud M.A., Mahmoudi F., Maitre J., Makarenko V., Malagoli A., Malcles J., Malgeri L., Mallon P.J., Maltoni F., Malvezzi S., Malyshev O.B., Mancinelli G., Mandrik P., Manfrinetti P., Mangano M., Manil P., Mannelli M., Marchiori G., Marhauser F., Mariani V., Marinozzi V., Mariotto S., Marquard P., Marquet C., Marriott-Dodington T., Martin R., Martin O., Martin Camalich J., Martinez T., Martinez Bruzual H., Martinez-Hernandez M.I., Martins D.E., Marzani S., Marzocca D., Marzola L., Masciocchi S., Masina I., Massimiliano A., Massironi A., Masubuchi T., Matveev V.A., Mazzoni M.A., McCullough M., McIntosh P.A., Meade P., Medina L., Meier A., Meignan J., Mele B., Mendes Saraiva J.G., Menez F., Mentink M., Meoni E., Meridiani P., Merk M., Mermod P., Mertens V., Mether L., Metral E., Migliorati M., Milanese A., Milardi C., Milhano G., Militsyn B.L., Millet F., Minashvili I., Minervini J.V., Miralles L.S., Mirarchi D., Mishima S., Missiaen D.P., Mitselmakher G., Mitshuhashi T., Mnich J., Mohammadi Najafabadi M., Mohapatra R.N., Mokhov N., Molson J.G., Monge R., Montag C., Montagna G., Monteil S., Montenero G., Montesinos E., Moortgat F., Morange N., Morello G., Moreno Llacer M., Moretti M., Moretti S., Morley A.K., Moros A., Morozov I., Morretta V., Morrone M., Mostacci A., Muanza S., Muchnoi N., Muhlegger M., Mulder M., Mulders M., Muller B., Muller F., Muller A.-S., Munilla J., Murray M.J., Muttoni Y., Myers S., Mylona M., Nachtman J., Nakamoto T., Nardecchia M., Nardini G., Nason P., Nergiz Z., Nesterenko A.V., Netto J.A., Nettstrater A., Neubuser C., Neundorf J., Niccoli F., Nicrosini O., Nie Y., Niedermayer U., Niedziela J., Niemi A., Nikitin S.A., Nisati A., No J.M., Nonis M., Nosochkov Y., Novak M., Novokhatski A., O'Callaghan J.M., Ochando C., Ogur S., Ohmi K., Oide K., Okorokov V.A., Okumura Y., Oleari C., Olness F.I., Onel Y., Ortino M., Osborne J., Osland P., Otto T., Oyulmaz K.Y., Ozansoy A., Ozcan V., Ozdemir K., Pagliarone C.E., Pais da Silva H.F., Palmieri E., Palumbo L., Pampaloni A., Pan R.-Q., Panareo M., Panella O., Panico G., Panizzo G., Pankov A.A., Pantsyrny V., Papadopoulos C.G., Papaefstathiou A., Papaphilippou Y., Parker M.A., Parma V., Pasquali M., Patra S.K., Patterson R., Paukkunen H., Pauss F., Peggs S., Penttinen J.-P., Peon G., Perepelkin E.E., Perez E., Perez J.C., Perez G., Perez F., Perez Codina E., Perez Morales J., Perfilov M., Pernegger H., Peruzzi M., Pes C., Peters K., Petracca S., Petriello F., Pezzotti L., Pfeiffer S., Piccinini F., Pieloni T., Pierini M., Pikhartova H., Pikurs G., Pilicer E., Piminov P., Pira C., Pittau R., Placzek W., Plagge M., Plehn T., Pleier M.-A., Ploskon M., Podeur M., Podlech H., Podzorny T., Poggioli L., Poiron A., Polesello G., Poli Lener M., Polini A., Polinski J., Polozov S.M., Ponce L., Pont M., Pontecorvo L., Portaluri T., Potamianos K., Prasse C., Prausa M., Preinerstorfer A., Premat E., Price T., Primavera M., Prino F., Prioli M., Proudfoot J., Provino A., Pugnat T., Pukhaeva N., Pulawski S., Pulikowski D., Punzi G., Putti M., Pyarelal A., Quack H., Quispe M., Racioppi A., Rafique H., Raginel V., Raidal M., Ramirez-Uribe N.S., Ramsey-Musolf M.J., Rata R., Ratoff P., Ravotti F., Rebello Teles P., Reboud M., Redaelli S., Renner E., Renteria-Olivo A.E., Rescigno M., Reuter J., Ribon A., Ricci A.M., Riegler W., Riemann S., Riemann B., Riemann T., Rifflet J.M., Rimmer R.A., Rinaldesi R., Rinolfi L., Rios Rubiras O., Risselada T., Rivetti A., Rivkin L., Rizzo T., Robens T., Robert F., Robson A.J., Rochepault E., Roda C., Rodrigo G., Rodriguez-Cahuantzi M., Rogan C., Roig M., Rojas-Torres S., Rojo J., Rolandi G., Rolando G., Roloff P., Romanenko A., Romanov A., Roncarolo F., Rosado Sanchez A., Rosaz G., Rossi L., Rossi A., Rossmanith R., Rousset B., Royon C., Ruan X., Ruehl I., Ruhlmann-Kleider V., Ruiz R., Rumyantsev L., Ruprecht R., Ryazanov A.I., Saba A., Sadykov R., Saez de Jauregui D., Sahin M., Sailer B., Saito M., Sala F., Salam G.P., Salfeld-Nebgen J., Salgado C.A., Salini S., Sallese J.M., Salmi T., Salzburger A., Sampayo O.A., Sanfilippo S., Santiago J., Santopinto E., Santoro R., Sanz Ull A., Sarasola X., Sarpun I.H., Sauvain M., Savelyeva S., Sawada R., Sborlini G.F.R., Schaffer A., Schaumann M., Schenk M., Scheuerlein C., Schienbein I., Schlenga K., Schmickler H., Schmidt R., Schoerling D., Schoning A., Schorner-Sadenius T., Schott M., Schulte D., Schwaller P., Schwanenberger C., Schwemling P., Schwerg N., Scibile L., Sciuto A., Scomparin E., Sebastiani C., Seeber B., Segreti M., Selva P., Selvaggi M., Senatore C., Senol A., Serin L., Serluca M., Serra N., Seryi A., Sestini L., Sfyrla A., Shaposhnikov M., Shaposhnikova E., Sharkov B.Y., Shatilov D., Shelton J., Shiltsev V., Shipsey I.P., Shirkov G.D., Shivaji A., Shwartz D., Sian T., Sidorov S., Siemko A., Silvestrini L., Simand N., Simon F., Singh B.K., Siodmok A., Sirois Y., Sirtori E., Sirvinskaite R., Sitar B., Sjostrand T., Skands P., Skordis E., Skovpen K., Skrzypek M., Slade E., Slavich P., Slovak R., Smaluk V., Smirnov V., Snoeys W., Soffi L., Sollander P., Solovyanov O., Soltveit H.K., Song H., Sopicki P., Sorbi M., Spallino L., Spannowsky M., Spataro B., Sphicas P., Spiesberger H., Spiller P., Spira M., Srivastava T., Stachel J., Stakia A., Stanyard J.L., Starchenko E., Starikov A.Y., Stasto A.M., Statera M., Steerenberg R., Steggemann J., Stenvall A., Stivanello F., Stockinger D., Stoel L.S., Stoger-Pollach M., Strauss B., Stuart M., Stupakov G., Su S., Sublet A., Sugita K., Sulak L., Sullivan M.K., Sultansoy S., Sumida T., Suzuki K., Sylva G., Syphers M.J., Sznajder A., Taborelli M., Tahir N.A., Takeuchi M., Tal Hod E., Tambasco C., Tanaka J., Tang K., Tapan I., Taroni S., Tartarelli G.F., Tassielli G., Tavian L., Taylor T.M., Taylor G.N., Teixeira A.M., Tejeda-Munoz G., Telnov V.I., Tenchini R., ten Kate H.H.J., Terashi K., Tesi A., Testa M., Tetrel C., Teytelman D., Thaler J., Thamm A., Thomas S., Tiirakari M.T., Tikhomirov V., Tikhonov D., Timko H., Tisserand V., Tkachenko L.M., Tkaczuk J., Tock J.P., Todd B., Todesco E., Tomas Garcia R., Tommasini D., Tonelli G., Toral F., Torims T., Torre R., Townsend Z., Trant R., Treille D., Trentadue L., Tricoli A., Tricomi A., Trischuk W., Tropin I.S., Tuchming B., Tudora A.A., Turbiarz B., Turk Cakir I., Turri M., Tydecks T., Usovitsch J., Uythoven J., Vaglio R., Valassi A., Valchkova F., Valdivia Garcia M.A., Valente P., Valente R.U., Valente-Feliciano A.-M., Valentino G., Vale Silva L., Valet J.M., Valizadeh R., Valle J.W.F., Vallecorsa S., Vallone G., van Leeuwen M., van Rienen U.H., van Riesen-Haupt L., Varasteh M., Vecchi L., Vedrine P., Velev G., Veness R., Ventura A., Venturini Delsolaro W., Verducci M., Verhaaren C.B., Vernieri C., Verweij A.P., Verwilligen O., Viazlo O., Vicini A., Viehhauser G., Vignaroli N., Vignolo M., Vitrano A., Vivarelli I., Vlachos S., Vogel M., Vogt D.M., Volkl V., Volkov P., Volpini G., von Ahnen J., Vorotnikov G., Voutsinas G.G., Vysotsky V., Wagner U., Wallny R., Wang L.-T., Wang R., Wang K., Ward B.F.L., Watson T.P., Watson N.K., Ws Z., Weiland C., Weinzierl S., Welsch C.P., Wenninger J., Widorski M., Wiedemann U.A., Wienands H.-U., Wilkinson G., Williams P.H., Winter A., Wohlfahrt A., Wojton T., Wollmann D., Womersley J., Woog D., Wu X., Wulzer A., Yanehsari M.K., Yang G., Yang H.J., Yao W.-M., Yazgan E., Yermolchik V., Yilmaz A., Yoo H.-D., Yost S.A., You T., Young C., Yu T.-T., Yu F., Zaborowska A., Zadeh S.G., Zahnd M., Zanetti M., Zanotto L., Zawiejski L., Zeiler P., Zerlauth M., Zernov S.M., Zevi Dell Porta G., Zhang Z., Zhang Y., Zhang C., Zhang H., Zhao Z., Zhong Y.-M., Zhou J., Zhou D., Zhuang P., Zick G., Zimmermann F., Zinn-Justin J., Zivkovic L., Zlobin A.V., Zobov M., Zupan J., Zurita J., BAİBÜ, Fen Edebiyat Fakültesi, Fizik Bölümü, Denizli, Haluk, TOBB ETU, Faculty of Engineering, Department of Electrical & Electronics Engineering, TOBB ETU, Faculty of Engineering, Department of Material Science & Nanotechnology Engineering, TOBB ETÜ, Mühendislik Fakültesi, Elektrik ve Elektronik Mühendisliği Bölümü, TOBB ETÜ, Mühendislik Fakültesi, Malzeme Bilimi ve Nanoteknoloji Mühendisliği Bölümü, Bozbey, Ali, Sultansoy, Saleh, Özdemir, Kadri, Giresun Üniversitesi, UCL - SST/IRMP - Institut de recherche en mathématique et physique, and Ege Üniversitesi

Subjects
Beam losses, IMPACT, Physics::Instrumentation and Detectors, Physics beyond the Standard Model, EVENT BUILDER, hadron collider, General Physics and Astronomy, Mathematics and natural science: 400::Physics: 430::Nuclear and elementary particle physics: 431 [VDP], 01 natural sciences, 7. Clean energy, law.invention, Subatomär fysik, chemistry.chemical_compound, Conceptual design, Colliding beam accelerators, law, HE-LHC, Subatomic Physics, General Materials Science, Hadron colliders, Física::Física de partícules::Hadrons [Àrees temàtiques de la UPC], Large Hadron Collider, Acceleradors de partícules, Physics, Settore FIS/01 - Fisica Sperimentale, Beams (radiation), Settore FIS/02 - Fisica Teorica, Modelli e Metodi Matematici, Upgrade, Impact, collimators, partikkelfysikk, Future Circular Collider, High-Energy, Systems engineering, HE-LHC: The High-Energy Large Hadron Collider, Col·lisionadors d'hadrons, Applied physics, Collimators, Socio-culturale, Fizik, Hadrons, Accelerator Physics and Instrumentation, HE-LHC physics, Condensed Matter::Materials Science, 0103 physical sciences, Physics::Atomic and Molecular Clusters, beam losses, ddc:530, High Energy Physics, partikkelakselerator, Physical and Theoretical Chemistry, Niobium-tin, 010306 general physics, Collider, Particle Physics, Beams (radiation) | Collimators | Beam losses, Energies::Energia nuclear [Àrees temàtiques de la UPC], Large Hadron Collider HE-LHC, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Colliders (Nuclear physics), Acceleratorfysik och instrumentering, Event builder, Accelerators and Storage Rings, Particle accelerators, chemistry, Experimental High Energy Physics, Physics::Accelerator Physics, High Energy Physics::Experiment, Future Colliders
Abstract

Authors: A. AbadaM. AbbresciaS. S. AbdusSalamI. AbdyukhanovJ. Abelleira FernandezA. AbramovM. AburaiaA. O. AcarP. R. AdzicP. AgrawalJ. A. Aguilar-SaavedraJ. J. Aguilera-VerdugoM. AibaI. AichingerG. AielliA. AkayA. AkhundovH. AksakalJ. L. AlbaceteS. AlbergoA. AlekouM. AleksaR. AleksanR. M. Alemany FernandezY. AlexahinR. G. AlíaS. AlioliN. Alipour TehraniB. C. AllanachP. P. AllportM. AltınlıW. AltmannshoferG. AmbrosioD. AmorimO. AmstutzL. AnderliniA. AndreazzaM. AndreiniA. AndriatisC. AndrisA. AndronicM. AngelucciF. AntinoriS. A. AntipovM. AntonelliM. AntonelloP. AntonioliS. AntuschF. AnulliL. ApolinárioG. ApollinariA. ApollonioD. AppelöR. B. ApplebyA. ApyanA. ApyanA. ArbeyA. ArbuzovG. ArduiniV. ArıS. AriasN. ArmestoR. ArnaldiS. A. ArsenyevM. ArzeoS. AsaiE. AslanidesR. W. AßmannD. AstapovychM. AtanasovS. AtiehD. AttiéB. AuchmannA. AudurierS. AullS. AumonS. AuneF. AvinoG. AvrillaudG. AydınA. AzatovG. AzuelosP. AzziO. AzzoliniP. AzzurriN. BacchettaE. BacchiocchiH. BachacouY. W. BaekV. BaglinY. BaiS. BairdM. J. BakerM. J. BaldwinA. H. BallA. BallarinoS. BanerjeeD. P. BarberD. BarducciP. BarjhouxD. BarnaG. G. BarnaföldiM. J. BarnesA. BarrJ. Barranco GarcíaJ. Barreiro Guimarães da CostaW. BartmannV. BaryshevskyE. BarziS. A. BassA. BastianinB. BaudouyF. BauerM. BauerT. BaumgartnerI. Bautista-GuzmánC. BayındırF. BeaudetteF. BedeschiM. BéguinI. BellafontL. BellagambaN. BellegardeE. BelliE. BellingeriF. BelliniG. BellomoS. BelomestnykhG. BencivenniM. BenediktG. BernardiJ. BernardiC. BernetJ. M. BernhardtC. BerniniC. BerriaudA. BertarelliS. BertolucciM. I. BesanaM. BesançonO. BeznosovP. BhatC. BhatM. E. BiaginiJ. -L. BiarrotteA. Bibet ChevalierE. R. BielertM. BigliettiG. M. BileiB. BilkiC. BiscariF. BisharaO. R. Blanco-GarcíaF. R. BlánquezF. BlekmanA. BlondelJ. BlümleinT. BoccaliR. BoelsS. A. BogaczA. BogomyagkovO. Boine-FrankenheimM. J. BolandS. BolognaO. BolukbasiM. BombenS. BondarenkoM. BonviniE. BoosB. BordiniF. BordryG. BorghelloL. BorgonoviS. BorowkaD. BortolettoD. BoscheriniM. BoscoloS. BoselliR. R. BosleyF. BossuC. BottaL. BotturaR. BoughezalD. BoutinG. BovoneI. Božović JelisavićA. BozbeyC. BozziD. BozziniV. BracciniS. Braibant-GiacomelliJ. BramanteP. Braun-MunzingerJ. A. BriffaD. BritzgerS. J. BrodskyJ. J. BrookeR. BruceP. Brückman De RenstromE. BrunaO. BrüningO. BrunnerK. BrunnerP. BruzzoneX. BuffatE. BulyakF. BurkartH. BurkhardtJ. -P. BurnetF. ButinD. ButtazzoA. ButterworthM. CacciaY. CaiB. CaiffiV. CairoO. CakirR. CalagaS. CalatroniG. CalderiniG. CalderolaA. CaliskanD. CalvetM. CalvianiJ. M. CamalichP. CamarriM. CampanelliT. CamporesiA. C. CanbayA. CanepaE. CantergianiD. Cantore-CavalliM. CapeansR. CardarelliU. CardellaA. CardiniC. M. Carloni CalameF. CarraS. CarraA. CarvalhoS. CasalbuoniJ. CasasM. CascellaP. CastelnovoG. CastorinaG. CatalanoV. CavasinniE. CazzatoE. CenniniA. CerriF. CeruttiJ. CervantesI. ChaikovskaJ. ChakraborttyM. ChalaM. Chamizo-LlatasH. ChanalD. ChanalS. ChanceA. ChancéP. CharitosJ. CharlesT. K. CharlesS. ChattopadhyayR. ChehabS. V. ChekanovN. ChenA. ChernodedV. ChetvertkovaL. ChevalierG. ChiarelliG. ChiarelloM. ChiesaP. ChiggiatoJ. T. ChildersA. ChmielińskaA. CholakianP. ChomazM. ChorowskiW. ChouM. ChrzaszczE. ChyhyrynetsG. CibinettoA. K. CiftciR. CiftciR. CiminoM. CiuchiniP. J. ClarkY. CoadouM. CobalA. CoccaroJ. CoganE. CognerasF. CollamatiC. ColldelramP. CollierJ. CollotR. ContinoF. ConventiC. T. A. CookL. CooleyG. CorcellaA. S. CornellG. H. CorralH. Correia-RodriguesF. CostanzaP. Costa PintoF. CoudercJ. CoupardN. CraigI. Crespo GarridoA. CrivellinJ. F. CroteauM. CrouchE. Cruz AlanizB. CuréJ. CurtiD. CurtinM. CzechC. DachauerR. T. D’AgnoloM. DaiboA. DaineseB. DalenaA. DaljevecW. DallapiazzaL. D’Aloia SchwartzentruberM. DamG. D’AmbrosioS. P. DasS. DasBakshiW. da SilvaG. G. da SilveiraV. D’AuriaS. D’AuriaA. DavidT. DavidekA. DeandreaJ. de BlasC. J. DebonoS. De CurtisN. De FilippisD. de FlorianS. DeghayeS. J. de JongC. Del BoV. Del DucaD. DelikarisF. DeliotA. Dell’AcquaL. Delle RoseM. DelmastroE. De LuciaM. DemarteauD. DenegriL. DeniauD. DenisovH. DenizliA. DennerD. d’EnterriaG. de RijkA. De RoeckF. DerueO. DeschampsS. Descotes-GenonP. S. B. DevJ. B. de Vivie de RégieR. K. DewanjeeA. Di CiaccioA. Di CiccoB. M. DillonB. Di MiccoP. Di NezzaS. Di VitaA. DoblhammerA. DominjonM. D’OnofrioF. DordeiA. DragoP. DraperZ. DrasalM. DrewesL. DuarteI. DubovykP. DudaA. DudarevL. DudkoD. DuellmannM. DünserT. du PreeM. DuranteH. Duran YildizS. DuttaF. DuvalJ. M. DuvalY. DydyshkaB. DziewitS. EisenhardtM. EistererT. EkelofD. El KhechenS. A. EllisJ. EllisJ. A. EllisonK. ElsenerM. ElsingY. EnariC. EnglertH. ErikssonK. J. EskolaL. S. EspositoO. EtiskenE. EtzionP. FabbricatoreA. FalkowskiA. FalouJ. FaltovaJ. FanL. FanòA. FarillaR. FarinelliS. FarinonD. A. FaroughyS. D. FartoukhA. Faus-GolfeW. J. FawcettG. FeliciL. FelsbergerC. FerdeghiniA. M. Fernandez NavarroA. Fernández-TéllezJ. Ferradas TroitinoG. FerraraR. FerrariL. FerreiraP. Ferreira da SilvaG. FerreraF. FerroM. FiascarisS. FiorendiC. FiorioO. FischerE. FischerW. FliegerM. FlorioD. FonnesuE. FontanesiN. FoppianiK. ForazD. Forkel-WirthS. ForteM. FouaidyD. FournierT. FowlerJ. FoxP. FrancavillaR. FranceschiniS. FranchinoE. FrancoA. FreitasB. FuksK. FurukawaS. V. FurusethE. GabrielliA. GaddiM. GalantiE. GalloS. GanjourJ. GaoJ. GaoV. Garcia DiazM. García PérezL. García TabarésC. GarionM. V. GarzelliI. GarziaS. M. Gascon-ShotkinG. GaudioP. GayS. -F. GeT. GehrmannM. H. GenestR. GerardF. GerigkH. GerwigP. GiacomelliS. GiaguE. Gianfelice-WendtF. GianottiF. GiffoniS. S. GilardoniM. Gil CostaM. GiovannettiM. GiovannozziP. GiubellinoG. F. GiudiceA. GiuntaL. K. GladilinS. GlukhovJ. GluzaG. GobbiB. GoddardF. GoertzT. GollingV. P. GoncalvesR. GonçaloL. A. Gonzalez GomezS. Gorgi ZadehG. GorineE. GoriniS. A. GourlayL. GouskosF. GrancagnoloA. GrassellinoA. GrauE. GraveriniH. M. GrayMa. GrecoMi. GrecoJ. -L. GrenardO. GrimmC. GrojeanV. A. GromovJ. F. Grosse-OetringhausA. GrudievK. GrzankaJ. GuD. GuadagnoliV. GuidiS. GuiducciG. Guillermo CantonY. O. GünaydinR. GuptaR. S. GuptaJ. GutierrezJ. GutleberC. GuyotV. GuzeyC. GwenlanC. HaberstrohB. HacışahinoğluB. HaererK. HahnT. HahnA. HammadC. HanM. HanceA. HannahP. C. HarrisC. HatiS. HaugJ. HauptmanV. HaurylavetsH. -J. HeA. HegglinB. HegnerK. HeinemannS. HeinemeyerC. HelsensA. HenriquesA. HenriquesP. HernandezR. J. Hernández-PintoJ. Hernandez-SanchezT. HerzigI. HiekkanenW. HillertT. HoehnM. HoferW. HöfleF. HoldenerS. HolleisB. HolzerD. K. HongC. G. HonoratoS. C. HopkinsJ. HrdinkaF. HugB. HumannH. HumerT. HurthA. HuttonG. IacobucciN. IbarrolaL. Iconomidou-FayardK. Ilyina-BrunnerJ. IncandelaA. InfantinoV. IppolitoM. IshinoR. IslamH. ItaA. IvanovsS. IwamotoA. IyerS. Izquierdo BermudezS. JadachD. O. JaminP. JanotP. JarryA. JeffP. JennyE. JensenM. JensenX. JiangJ. M. JiménezM. A. JonesO. R. JonesJ. M. JowettS. JungW. KaabiM. KadoK. KahleL. KalinovskayaJ. KalinowskiJ. F. KamenikK. KannikeS. O. KaraH. KaradenizV. KaraventzasI. KarpovS. KartalA. KaryukhinV. 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LehtinenS. B. LeithP. LenziE. LeograndeC. LeonidopoulosI. Leon-MonzonG. LernerO. LeroyT. LesiakP. LévaiA. LeverattoE. LevichevG. LiS. LiR. LiD. LiberatiM. LiepeD. A. LissauerZ. LiuA. LobkoE. LocciE. Logothetis AgaliotisM. P. LombardoA. J. LongC. LorinR. LositoA. LouzguitiI. LowD. LucchesiM. T. LucchiniA. LucianiM. LueckhofA. J. G. LuntM. LuzumD. A. LyubimtsevM. MaggioraN. MagninM. A. MahmoudF. MahmoudiJ. MaitreV. MakarenkoA. MalagoliJ. MalclésL. MalgeriP. J. MallonF. MaltoniS. MalvezziO. B. MalyshevG. MancinelliP. MandrikP. ManfrinettiM. ManganoP. ManilM. MannelliG. MarchioriF. MarhauserV. MarianiV. MarinozziS. MariottoP. MarquardC. MarquetT. Marriott-DodingtonR. MartinO. MartinJ. Martin CamalichT. MartinezH. Martinez BruzualM. I. Martínez-HernándezD. E. MartinsS. MarzaniD. MarzoccaL. MarzolaS. MasciocchiI. MasinaA. MassimilianoA. MassironiT. MasubuchiV. A. MatveevM. A. MazzoniM. McCulloughP. A. McIntoshP. MeadeL. MedinaA. MeierJ. MeignanB. MeleJ. G. Mendes SaraivaF. MenezM. MentinkE. MeoniP. MeridianiM. MerkP. MermodV. MertensL. MetherE. MétralM. MiglioratiA. MilaneseC. MilardiG. MilhanoB. L. MilitsynF. MilletI. MinashviliJ. V. MinerviniL. S. MirallesD. MirarchiS. MishimaD. P. MissiaenG. MitselmakherT. MitshuhashiJ. MnichM. Mohammadi NajafabadiR. N. MohapatraN. MokhovJ. G. MolsonR. MongeC. MontagG. MontagnaS. MonteilG. MonteneroE. MontesinosF. MoortgatN. MorangeG. MorelloM. Moreno LlácerM. MorettiS. MorettiA. K. MorleyA. MorosI. MorozovV. MorrettaM. MorroneA. MostacciS. MuanzaN. MuchnoiM. MühleggerM. MulderM. MuldersB. MüllerF. MüllerA. -S. MüllerJ. MunillaM. J. MurrayY. MuttoniS. MyersM. MylonaJ. NachtmanT. NakamotoM. NardecchiaG. NardiniP. NasonZ. NergizA. V. NesterenkoJ. A. NettoA. NettsträterC. NeubüserJ. NeundorfF. NiccoliO. NicrosiniY. NieU. NiedermayerJ. NiedzielaA. NiemiS. A. NikitinA. NisatiJ. M. NoM. NonisY. NosochkovM. NovákA. NovokhatskiJ. M. O’CallaghanC. OchandoS. OgurK. OhmiK. OideV. A. OkorokovY. OkumuraC. OleariF. I. OlnessY. OnelM. OrtinoJ. 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PuttiA. PyarelalH. QuackM. QuispeA. RacioppiH. RafiqueV. RaginelM. RaidalN. S. Ramírez-UribeM. J. Ramsey-MusolfR. RataP. RatoffF. RavottiP. Rebello TelesM. ReboudS. RedaelliE. RennerA. E. Rentería-OlivoM. RescignoJ. ReuterA. RibonA. M. RicciW. RieglerS. RiemannB. RiemannT. RiemannJ. M. RiffletR. A. RimmerR. RinaldesiL. RinolfiO. Rios RubirasT. RisseladaA. RivettiL. RivkinT. RizzoT. RobensF. RobertA. J. RobsonE. RochepaultC. RodaG. RodrigoM. Rodríguez-CahuantziC. RoganM. RoigS. Rojas-TorresJ. RojoG. RolandiG. RolandoP. RoloffA. RomanenkoA. RomanovF. RoncaroloA. Rosado SanchezG. RosazL. RossiA. RossiR. RossmanithB. RoussetC. RoyonX. RuanI. RuehlV. Ruhlmann-KleiderR. RuizL. RumyantsevR. RuprechtA. I. RyazanovA. SabaR. SadykovD. Saez de JaureguiM. SahinB. SailerM. SaitoF. SalaG. P. SalamJ. Salfeld-NebgenC. A. SalgadoS. SaliniJ. M. SalleseT. SalmiA. SalzburgerO. A. SampayoS. SanfilippoJ. SantiagoE. SantopintoR. SantoroA. Sanz UllX. SarasolaI. H. SarpünM. SauvainS. SavelyevaR. SawadaG. F. R. SborliniA. SchafferM. SchaumannM. SchenkC. ScheuerleinI. SchienbeinK. SchlengaH. SchmicklerR. SchmidtD. SchoerlingA. SchoningT. Schörner-SadeniusM. SchottD. SchulteP. SchwallerC. SchwanenbergerP. SchwemlingN. SchwergL. ScibileA. SciutoE. ScomparinC. SebastianiB. SeeberM. SegretiP. SelvaM. SelvaggiC. SenatoreA. SenolL. SerinM. SerlucaN. SerraA. SeryiL. SestiniA. SfyrlaM. ShaposhnikovE. ShaposhnikovaB. Y. SharkovD. ShatilovJ. SheltonV. ShiltsevI. P. ShipseyG. D. ShirkovA. ShivajiD. ShwartzT. SianS. SidorovA. SiemkoL. SilvestriniN. SimandF. SimonB. K. SinghA. SiódmokY. SiroisE. SirtoriR. SirvinskaiteB. SitarT. SjöstrandP. SkandsE. SkordisK. SkovpenM. SkrzypekE. SladeP. SlavichR. SlovakV. SmalukV. SmirnovW. SnoeysL. SoffiP. SollanderO. SolovyanovH. K. SoltveitH. SongP. SopickiM. SorbiL. SpallinoM. SpannowskyB. SpataroP. SphicasH. SpiesbergerP. SpillerM. SpiraT. SrivastavaJ. StachelA. StakiaJ. L. StanyardE. StarchenkoA. Y. StarikovA. M. StaśtoM. StateraR. SteerenbergJ. SteggemannA. StenvallF. StivanelloD. StöckingerL. S. StoelM. Stöger-PollachB. StraussM. StuartG. StupakovS. SuA. SubletK. SugitaL. SulakM. K. SullivanS. SultansoyT. SumidaK. SuzukiG. SylvaM. J. SyphersA. SznajderM. TaborelliN. A. TahirM. TakeuchiE. Tal HodC. TambascoJ. TanakaK. TangI. TapanS. TaroniG. F. TartarelliG. TassielliL. TavianT. M. TaylorG. N. TaylorA. M. TeixeiraG. Tejeda-MuñozV. I. TelnovR. TenchiniH. H. J. ten KateK. TerashiA. TesiM. TestaC. TetrelD. TeytelmanJ. ThalerA. ThammS. ThomasM. T. TiirakariV. TikhomirovD. TikhonovH. TimkoV. TisserandL. M. TkachenkoJ. TkaczukJ. P. TockB. ToddE. TodescoR. Tomás GarciaD. TommasiniG. TonelliF. ToralT. TorimsR. TorreZ. TownsendR. TrantD. TreilleL. TrentadueA. TricoliA. TricomiW. TrischukI. S. TropinB. TuchmingA. A. TudoraB. TurbiarzI. Turk CakirM. TurriT. TydecksJ. UsovitschJ. UythovenR. VaglioA. ValassiF. ValchkovaM. A. Valdivia GarciaP. ValenteR. U. ValenteA. -M. Valente-FelicianoG. ValentinoL. Vale SilvaJ. M. ValetR. ValizadehJ. W. F. ValleS. VallecorsaG. ValloneM. van LeeuwenU. H. van RienenL. van Riesen-HauptM. VarastehL. VecchiP. VedrineG. VelevR. VenessA. VenturaW. Venturini DelsolaroM. VerducciC. B. VerhaarenC. VernieriA. P. VerweijO. VerwilligenO. ViazloA. ViciniG. ViehhauserN. VignaroliM. VignoloA. VitranoI. VivarelliS. VlachosM. VogelD. M. VogtV. VölklP. VolkovG. VolpiniJ. von AhnenG. VorotnikovG. G. VoutsinasV. VysotskyU. WagnerR. WallnyL. -T. WangR. WangK. WangB. F. L. WardT. P. WatsonN. K. WatsonZ. WsC. WeilandS. WeinzierlC. P. WelschJ. WenningerM. WidorskiU. A. WiedemannH. -U. WienandsG. WilkinsonP. H. WilliamsA. WinterA. WohlfahrtT. WojtońD. WollmannJ. WomersleyD. WoogX. WuA. WulzerM. K. YanehsariG. YangH. J. YangW. -M. YaoE. YazganV. YermolchikA. YilmazA. YilmazH. -D. YooS. A. YostT. YouC. YoungT. -T. YuF. YuA. ZaborowskaS. G. ZadehM. ZahndM. ZanettiL. ZanottoL. ZawiejskiP. ZeilerM. ZerlauthS. M. ZernovG. Zevi Dell PortaZ. ZhangY. ZhangC. ZhangH. ZhangZ. ZhaoY. -M. ZhongJ. ZhouD. ZhouP. ZhuangG. ZickF. ZimmermannEmail authorJ. Zinn-JustinL. ZivkovicA. V. ZlobinM. ZobovJ. ZupanJ. Zuritathe FCC Collaboration, In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the fourth volume of the FCC Conceptual Design Report, devoted to the High-Energy Large Hadron Collider HE-LHC. It summarizes the HE-LHC physics discovery opportunities, presents the HE-LHC accelerator design, performance reach, and operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the HE-LHC design aims at a hadron collider with about twice the centre-of-mass collision energy that the LHC can reach. Its performance aims at exploring physics beyond the Standard Model, signi cantly extending the LHC's direct and indirect sensitivity to new physics and discoveries.

Published
2020

13. Mineralisation of distinct biogas digestate qualities directly after application to soil

Author

Mario Malagoli, Stefanie Wentzel, Rainer Georg Joergensen, Reiner Schmidt, and Laura Barduca

Subjects
Denitrification, Chemistry, Soil Science, Biomass, 04 agricultural and veterinary sciences, 010501 environmental sciences, engineering.material, 01 natural sciences, Microbiology, Biogas, Digestate, 040103 agronomy & agriculture, engineering, 0401 agriculture, forestry, and fisheries, Fermentation, Fertilizer, Food science, Energy source, Agronomy and Crop Science, Chemical composition, 0105 earth and related environmental sciences
Abstract

Biogas is an important energy source produced by the anaerobic fermentation of raw faecal slurries and plant residues. Separation of the total digestate increases the fertilizer quality of the liquid fraction and the carbon sequestration potential of the solid fraction. A 12-day incubation study was carried out to investigate the relationships between the chemical composition of different digestate qualities and the immediate response of soil microbial activity and biomass indices. The highest cumulative (Σ) CO2-C efflux was observed after adding the solid fraction and lowest after adding the liquid fraction to soil, which was even lower than that of the control. The ΣCO2-C efflux showed the strongest negative correlation with the raw ash and strong positive correlations with the raw fibre concentration and the C/N ratio of the different digestate qualities. The highest and similar ΣN2O-N efflux was observed after adding the total digestate or the liquid fraction, which were equivalent to approximately 1% of added N. This relatively low percentage indicates a possible origin from nitrifier denitrification. Total digestate and its liquid fraction exhibited considerable net-N mineralisation rates, which could mainly be predicted by the C/N ratios of the different digestate qualities. Microbial biomass C did not respond to the application of any digestate quality, whereas the fungal ergosterol content increased after applying the solid and the composted solid fractions. This raw fibre–induced fungal growth led to strong net-N immobilisation in soil after applying these two digestate qualities.

Published
2020

14. Effect of freezing on the quality of breast meat from broilers affected by White Striping myopathy

Author

Rodrigo F. Oliveira, Fábio Ferrari, Pedro Alves de Souza, Heloisa de Almeida Fidelis, Juliana Lolli Malagoli de Mello, Erick Alonso Villegas-Cayllahua, Mateus Roberto Pereira, Erika Nayara Freire Cavalcanti, A. Giampietro-Ganeco, Hirasilva Borba, Universidade Estadual Paulista (UNESP), Agricultural Sciences and Technologies Center – CCTA, and Universidade de São Paulo (USP)

Subjects
Male, Meat, white striping, PROCESSING AND PRODUCT, SF1-1100, Pectoralis Muscles, meat quality, Chicken breast, storage, chemistry.chemical_compound, Meat tenderness, chicken breast meat, Animal science, Muscular Diseases, Lipid oxidation, Freezing, medicine, Animals, Myopathy, Cholesterol, Pectoralis major muscle, food and beverages, General Medicine, Animal culture, Tenderness, chemistry, Animal Science and Zoology, medicine.symptom, Chickens, Mineral matter
Abstract

Made available in DSpace on 2022-05-01T11:39:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The aim of this study was to evaluate possible changes in the quality of chicken breast meat containing white stripes during freezing for 12 mo. Samples of Pectoralis major muscle from male Cobb 500 broilers containing white stripes in moderate and severe degrees were used, as well as samples from a control group (normal – absence of myopathies). Part of the samples (n = 60; n = 20 for each severity degree) were analyzed on the day of collection (beginning) and the rest (n = 240) was frozen (−20°C) for up to 12 mo. At the end of each proposed freezing period (3, 6, 9, and 12 mo), color, pH, water holding capacity, cooking loss, tenderness, lipid oxidation, chemical composition, cholesterol and collagen concentrations, myofibrillary fragmentation, and sarcomere length were analyzed. Microbiological analysis of samples was performed at the beginning and after 12 mo of freezing. Myopathy linked to freezing showed results of increased meat tenderness, with reduction of crude protein and mineral matter and increase of moisture, fat, and cholesterol, without affecting the meat's collagen percentages. However, these variations with the onset of myopathy do not compromise the consumption of broiled chicken breast meat, kept frozen for up to 12 mo. Paulista State University - UNESP Technology Department Darcy Ribeiro State University of Northern Fluminense – UENF Agricultural Sciences and Technologies Center – CCTA University of São Paulo - USP Faculty of Animal Science and Food Engineering Paulista State University - UNESP Technology Department FAPESP: 2018/25447-1

Published
2022

15. Relationships between muscle architecture and performance in division i male italian field hockey players

Author

Matteo Cortesi, Federico Nigro, Simone Ciacci, Ivan Malagoli Lanzoni, Filippo Treno, Sandro Bartolomei, Bartolomei S., Nigro F., Ciacci S., Malagoli Lanzoni I., Treno F., and Cortesi M.

Subjects
Technology, Field hockey, QH301-705.5, Body height, QC1-999, Squat, Isometric exercise, 030204 cardiovascular system & hematology, Biology, Muscle morphology, 03 medical and health sciences, 0302 clinical medicine, Animal science, General Materials Science, Sprint, Biology (General), QD1-999, Instrumentation, Fluid Flow and Transfer Processes, Physics, Process Chemistry and Technology, General Engineering, Power performance, 030229 sport sciences, Engineering (General). Civil engineering (General), Computer Science Applications, Chemistry, Vastus lateralis, Fascicle length, Agility, TA1-2040, Muscle architecture
Abstract

Muscle architecture has been proposed as one of the most important determinants of muscle strength and power performance. The purpose of the present investigation was to correlate the muscle architecture with power, agility and maximal strength in Italian division I Field Hockey (FH) players. Twenty players (age = 25.4 ± 5.2 y, body mass = 78.5 ± 9.0 kg, body height = 179.6 ± 7.8 cm) were assessed for body composition, agility, sprint and maximal isometric force in squat (ISQ). The pro-agility test (PRO) and 30-m sprint (SPRINT) were used for agility and speed assessments, respectively. In addition, the pennation angle (PA), fascicle length (FL) and muscle thickness (MT) of the vastus lateralis were assessed via B-mode ultrasound. Large positive correlations were found between PRO and both PA and MT (r = 0.62, p = 0.006 and r = 0.51, p = 0.032, respectively). Moreover, SPRINT was positively correlated with PA and negatively correlated with FL (r = 0.50, p = 0.046, and r = −0.50, p = 0.034, respectively). Large positive correlations were also detected between body fat and both PRO and SPRINT (r = 0.58, p = 0.012 and r = 0.61, p = 0.009, respectively), indicating detrimental effects of the body fat on specific performances. The present findings showed the existence of large relationships between the muscle architecture of the vastus lateralis and physical characteristics related to elite performance in FH. Low PA and long FL of the vastus lateralis appear important parameters for agility and sprint performances.

Published
2021

16. Nitrate regulates maize root transcriptome through nitric oxide dependent and independent mechanisms

Author

Cristian Forestan, Laura Ravazzolo, Silvia Quaggiotti, Sara Trevisan, Mario Malagoli, Silvia Iori, Ravazzolo L., Trevisan S., Iori S., Forestan C., Malagoli M., and Quaggiotti S.

Subjects
QH301-705.5, maize, Benzoates, Plant Roots, Zea mays, Catalysis, Article, Nitric oxide, Inorganic Chemistry, Transcriptome, chemistry.chemical_compound, Nitrate, Gene Expression Regulation, Plant, nitrate, nitric oxide, Biology (General), Physical and Theoretical Chemistry, KEGG, Fertilizers, QD1-999, Molecular Biology, Transcription factor, Spectroscopy, Nitrates, Organic Chemistry, Lateral root, Imidazoles, RNA, General Medicine, root, Computer Science Applications, Cell biology, Chemistry, chemistry, Signal transduction, signaling, transcriptome
Abstract

Maize root responds to nitrate by modulating its development through the coordinated action of many interacting players. Nitric oxide is produced in primary root early after the nitrate provision, thus inducing root elongation. In this study, RNA sequencing was applied to discover the main molecular signatures distinguishing the response of maize root to nitrate according to their dependency on, or independency of, nitric oxide, thus discriminating the signaling pathways regulated by nitrate through nitric oxide from those regulated by nitrate itself of by further downstream factors. A set of subsequent detailed functional annotation tools (Gene Ontology enrichment, MapMan, KEGG reconstruction pathway, transcription factors detection) were used to gain further information and the lateral root density was measured both in the presence of nitrate and in the presence of nitrate plus cPTIO, a specific NO scavenger, and compared to that observed for N-depleted roots. Our results led us to identify six clusters of transcripts according to their responsiveness to nitric oxide and to their regulation by nitrate provision. In general, shared and specific features for the six clusters were identified, allowing us to determine the overall root response to nitrate according to its dependency on nitric oxide.

Published
2021

17. Kinematic analysis of the racket position during the table tennis top spin forehand stroke

Author

Sandro Bartolomei, Julien S. Baker, Rocco Di Michele, Matteo Cortesi, Yaodong Gu, Ivan Malagoli Lanzoni, Silvia Fantozzi, Malagoli Lanzoni I., Bartolomei S., Di Michele R., Gu Y., Baker J.S., Fantozzi S., and Cortesi M.

Subjects
Technology, QH301-705.5, QC1-999, racket sports, 030209 endocrinology & metabolism, Kinematics, Table (information), 03 medical and health sciences, 0302 clinical medicine, Position (vector), Racket, General Materials Science, National level, Stroke (engine), Biology (General), QD1-999, Instrumentation, Mathematics, computer.programming_language, Fluid Flow and Transfer Processes, business.industry, Physics, Process Chemistry and Technology, General Engineering, 030229 sport sciences, Structural engineering, Swing, Engineering (General). Civil engineering (General), Kinematic, Computer Science Applications, Chemistry, Racket sport, kinematics, Table tenni, Technique, TA1-2040, business, computer, Spin (aerodynamics), table tennis
Abstract

The present study aims to assess the position of the racket, and racket height with respect to the floor, during the table tennis top spin stroke. A stereophotogrammetric system (Smart-D, BTS, 8 cameras, 550 Hz) was used to track the table tennis racket during cross-court (CC) and long-line (LL) shots. Ten national level players completed ten CC and ten LL top spin strokes responding to a robot machine. The racket motion throughout the shot showed specific technical characteristics: the minimum height of the racket was detected during the backswing phase, racket height at the end of backswing phase (maximal distance racket/table) was higher than the minimum, height at the racket maximum velocity (ball/racket impact) was greater than the net’s height. Furthermore, the maximum height of the racket occurred at the end of the forward swing. No differences in these kinematic variables between CC and LL were found. Conversely, a higher inclination of the racket at the moment of maximum speed was detected in LL vs. CC. From a practical perspective, the present findings suggest that table tennis players need to introduce specific exercises in order to increase the height of the racket during the forehand top spin stroke, to improve its effectiveness.

Published
2021

18. Impact of deep pectoral myopathy on chemical composition and quality parameters of chicken breast fillet

Author

Fábio Ferrari, Juliana Lolli Malagoli de Mello, Xiao Sun, A. Giampietro-Ganeco, Casey M. Owens, Hirasilva Borba, Erika Nayara Freire Cavalcanti, Marco Antonio Trindade, Rodrigo Fortunato de Oliveira, Larissa Tátero Carvalho, Rodrigo A. de Souza, Universidade de São Paulo (USP), University of Arkansas, Universidade Estadual Paulista (UNESP), and Chuzhou University

Subjects
PROCESSING AND PRODUCT, Biology, broiler, Sarcomere, SF1-1100, Pectoralis Muscles, meat, Animal science, Muscular Diseases, medicine, Animals, Pectoralis minor, Cooking, Myopathy, chemistry.chemical_classification, Pectoralis major, business.industry, Pectoralis major muscle, Pectoralis minor muscle, Broiler, Fatty acid, food and beverages, General Medicine, Poultry farming, Animal culture, chemistry, quality, Pectoralis Minor, Animal Science and Zoology, medicine.symptom, business, Chickens
Abstract

Made available in DSpace on 2022-05-01T07:58:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01 One of the current myopathies affecting the chicken meat industry is deep pectoral myopathy (DPM), also known as green muscle disease or Oregon disease, the condition is considered a major problem in poultry processing lines. Thus, the present study proposes to examine the meat quality of the Pectoralis major muscle (breast fillet) from carcasses of broilers affected by DPM in Pectoralis minor muscle (tender) and from a control group. Breast fillets samples were harvested from Ross AP95 broilers that were slaughtered at 42 days of age and were selected to the occurrence of the myopathy (score 2 and score 3) and from a control group without (score 0) the presence of myopathy. Chemical composition, cholesterol, fatty acid profile, pH, color, water-holding capacity, cooking loss, shear force, sarcomere length, and collagen were analyzed in the breast fillet. And with the results it was observed the samples classified as DPM score 2 had a higher moisture and a lower protein percentage. The higher values lipid was found in the samples from broilers affected by DPM. There was no difference (P > 0.05) fatty acid profile only to C10:0, C15:0, C17:0, C20:0, and C18:2c9,t11. Differences were detected (P < 0.05) for the pH, WHC, SF, and sarcomere length of the samples from broilers affected by DPM. The higher pH observed in the samples from birds classified as DPM score 2 and the higher WHC values were observed in the samples affected by DPM (score 2 and 3). The SF (P < 0.05) among samples, with the most tender samples (lower SF values) being those unaffected by the condition DPM (score 0). The dorsal side surface, where the Pectoralis major muscle is in contact with the Pectoralis minor muscle, higher L* values were found in the meat affected by the myopathy. Although deep pectoral myopathy affects the Pectoralis minor muscle of broilers, it can also alter the qualitative characteristics and chemical composition of the breast fillets (Pectoralis major muscle). Department of Food Engineering Faculty of Animal Science and Food Engineering University of São Paulo - USP Departament of Poutry Science & The Center of Excellence for Poultry Science University of Arkansas, 1260 W. Maple Department of Technology University of Agricultural and Veterinary Sciences - UNESP School of Biological and Food Engineering Chuzhou University Department of Technology University of Agricultural and Veterinary Sciences - UNESP

Published
2021

19. The role of texturing and thickness of oxide buffer layers in the superconducting properties of Fe(Se,Te) Coated Conductors

Author

Antonella Mancini, Carlo Ferdeghini, Alessia Provino, Nicola Manca, M. Lisitskiy, Giulia Sylva, Andrea Malagoli, Mario Putti, Angelo Vannozzi, G. Celentano, Pietro Manfrinetti, Valeria Braccini, Emilio Bellingeri, I. Pallecchi, A. Leveratto, C. Bernini, Sylva, G., Bellingeri, E., Bernini, C., Celentano, G., Ferdeghini, C., Leveratto, A., Lisitskiy, M., Malagoli, A., Manca, N., Mancini, A., Manfrinetti, P., Pallecchi, I., Provino, A., Putti, M., Vannozzi, A., and Braccini, V.

Subjects
Superconductivity, Materials science, Condensed matter physics, Transition temperature, Fe(Se, RABiTS, Metals and Alloys, Oxide, chemistry.chemical_element, Hastelloy, Te), Condensed Matter Physics, Nickel, chemistry.chemical_compound, chemistry, Buffer Layers, Coated Conductors, Materials Chemistry, Ceramics and Composites, Electrical and Electronic Engineering, Thin film, Electric current, Current density, Electrical conductor
Abstract

In this paper the roles of texturing and thickness of different buffer layers employed in the fabrication of Fe(Se,Te) coated conductors are studied. Fe(Se,Te) thin films were deposited either on rolling assisted biaxially textured substrates substrates with highly textured CeO2 buffer layer and on HASTELLOY® C276 substrates with a randomly oriented native oxide grown through different oxidizing processes. It was found that the buffer layer has to be both thick enough to block Ni interdiffusion from the metallic tape to the Fe(Se,Te) overlayer, and textured enough to ensure good in-plane alignment of the superconducting film, and consequently good critical current densities (Jc). The best results in terms of critical temperature (Tc) and critical current were obtained using a highly textured 350 nm thick CeO2 buffer layer, but a fairly good Jc of 1.2 104 A cm−2 in self field at 5 K was also obtained using an HASTELLOY® C276 substrate with a 400 nm thick randomly oriented native oxide. The obtained results indicate that the superconducting properties of the Fe(Se,Te) coated conductors are determined by a trade-off between degree of texturing of the substrate and inhibition of Nickel interdiffusion.

Published
2020

20. Nitrate and ammonium affect the overall maize response to nitrogen availability by triggering specific and common transcriptional signatures in roots

Author

Cristian Forestan, Stefano Dall'Acqua, Mario Malagoli, Sara Trevisan, Laura Ravazzolo, Silvia Quaggiotti, Stefania Sut, Serena Varotto, Ravazzolo L., Trevisan S., Forestan C., Varotto S., Sut S., Dall'acqua S., Malagoli M., and Quaggiotti S.

Subjects
0106 biological sciences, 0301 basic medicine, Nitrate, Plant Roots, 01 natural sciences, lcsh:Chemistry, Transcriptome, chemistry.chemical_compound, Zea may, Nutrient, Gene Expression Regulation, Plant, Ammonium Compounds, Cluster Analysis, RNA-Seq, ammonium, amino acids, gene expression, maize, nitrate, plant development, root, lcsh:QH301-705.5, Spectroscopy, food and beverages, Gene Expression Regulation, Developmental, General Medicine, Nitrogen, Computer Science Applications, Amino acid, Shoot, Ammonium, Ammonium Compound, chemistry.chemical_element, Zea mays, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Botany, Plant development, Physical and Theoretical Chemistry, Molecular Biology, Nitrates, Cluster Analysi, Sequence Analysis, RNA, Organic Chemistry, fungi, Plant Root, Membrane transport, Maize, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, chemistry, Root, Chlorophyll, Gene expression, 010606 plant biology & botany
Abstract

Nitrogen (N) is an essential macronutrient for crops. Plants have developed several responses to N fluctuations, thus optimizing the root architecture in response to N availability. Nitrate and ammonium are the main inorganic N forms taken up by plants, and act as both nutrients and signals, affecting gene expression and plant development. In this study, RNA-sequencing was applied to gain comprehensive information on the pathways underlying the response of maize root, pre-treated in an N-deprived solution, to the provision of nitrate or ammonium. The analysis of the transcriptome shows that nitrate and ammonium regulate overlapping and distinct pathways, thus leading to different responses. Ammonium activates the response to stress, while nitrate acts as a negative regulator of transmembrane transport. Both the N-source repress genes related to the cytoskeleton and reactive oxygen species detoxification. Moreover, the presence of ammonium induces the accumulation of anthocyanins, while also reducing biomass and chlorophyll and flavonoids accumulation. Furthermore, the later physiological effects of these nutrients were evaluated through the assessment of shoot and root growth, leaf pigment content and the amino acid concentrations in root and shoot, confirming the existence of common and distinct features in response to the two nitrogen forms.

Published
2020

21. Qualitative traits of aged m. triceps brachii and m. gluteus biceps from lambs on supplemented feed

Author

Pedro Alves de Souza, Viviane Borba Ferrari, Hirasilva Borba, Fábio Ferrari, A. Giampietro-Ganeco, Juliana Lolli Malagoli de Mello, Rodrigo Fortunato de Oliveira, Flavia Biondi Fernandes de Lima, and Rodrigo A. de Souza

Subjects
oksidacija lipida, indeks fragmentacije mišićnih vlakana, crvenilo, rok trajanja, smična sila, nježnost, žutilo, Animal science, General Veterinary, Chemistry, lipid oxidation, myofibrillar fragmentation index, redness, shelf life, shear force, tenderness, yellowness, Biceps
Abstract

The aim of this study was to evaluate the effect of the supplementation and aging in the gluteus biceps and triceps brachii muscles of lamb. Forty-eight Santa Inês lambs, with 15 kg average initial weight were slaughtered at 32 kg average final weight, after five months of supplementation. Twenty-four animals were allocated to sixteen pastures with residual leaf area index (2.6) and unsupplemented, the other twenty-four animals were allocated to the same conditions but were supplemented. The treatments were cross factorial between rLAI (2.6) and supplemented or not, totalizing 8 treatments. In this experiment, the slaughter criterion was the age of the animals. In the gluteus biceps and triceps brachii muscles, storage for seven days increased lipid oxidation. The values​​ of cooking loss and water holding capacity increased with time of aging and were higher in the gluteus biceps, by 29.40% and 71.30%, respectively. The supplementation implies an increase in production costs, but its use provides the quantitative and qualitative characteristics favorable to the product, aiming to satisfy the consumer market. The supplementation decreased the shelf life, increasing the lipid oxidation during time of aging and affected the lightness and the hue of yellow, which may sffect consumers’ intention to purchase., Mišići triceps brachii i gluteus biceps analizirani su kako bi se ocijenio učinak dodataka prehrani na zrenje janjećeg mesa. Ukupno 48 janjadi pasmine Santa Inês imalo je početnu prosječnu tjelesnu masu 15 kg, a nakon pet mjeseci različite prehrane prosječna je tjelesna masa bila 32 kg. Životinje su razmještene na 16 pašnjaka s rezidualnim indeksom lisne površine 2,6, pod jednakim uvjetima, pri čemu su 24 životinje dobivale dodatke prehrani. Uzevši u obzir indeks lisne površine te dodatke hrani formirano je osam skupina koje su uspoređene faktorijalnom analizom. Kriterij za klanje bila je dob životinja. Povećana oksidacija lipida ustanovljena je nakon sedam dana zrenja mesa mišića triceps brachii i gluteus biceps. Vrijednosti gubitaka nastalih kuhanjem i spososbnost zadržavanja vode povećale su se s duljinom zrenja te su u m. gluteus biceps bile više, 29,40 % odnosno 71,30 %. Dodaci prehrani podrazumijevaju povećane troškove proizvodnje, ali njihova uporaba omogućuje bolje kvantitativne i kvalitativne značajke, s ciljem da se zadovolji tržište. Dodaci prehrani skraćuju rok trajanja mesa, povećavaju oksidaciju lipida za vrijeme zrenja te utječu na svjetloću i žutilo zbog čega potrošači mogu dvojiti pri kupnji mesa.

Published
2018

22. A New Protocol of Computer-Assisted Image Analysis Highlights the Presence of Hemocytes in the Regenerating Cephalic Tentacles of Adult Pomacea canaliculata

Author

Bergamini, Giulia, Ahmad, Mohamad, Cocchi, Marina, and Malagoli, Davide

Subjects
Chemistry, hemocyte, gastropod, QH301-705.5, image analysis, mollusk, Biology (General), adult regeneration, blastema, apple snail, immunity, QD1-999
Abstract

In humans, injuries and diseases can result in irreversible tissue or organ loss. This well-known fact has prompted several basic studies on organisms capable of adult regeneration, such as amphibians, bony fish, and invertebrates. These studies have provided important biological information and helped to develop regenerative medicine therapies, but important gaps concerning the regulation of tissue and organ regeneration remain to be elucidated. To this aim, new models for studying regenerative biology could prove helpful. Here, the description of the cephalic tentacle regeneration in the adult of the freshwater snail Pomacea canaliculata is presented. In this invasive mollusk, the whole tentacle is reconstructed within 3 months. Regenerating epithelial, connective, muscular and neural components are already recognizable 72 h post-amputation (hpa). Only in the early phases of regeneration, several hemocytes are retrieved in the forming blastema. In view of quantifying the hemocytes retrieved in regenerating organs, granular hemocytes present in the tentacle blastema at 12 hpa were counted, with a new and specific computer-assisted image analysis protocol. Since it can be applied in absence of specific cell markers and after a common hematoxylin-eosin staining, this protocol could prove helpful to evidence and count the hemocytes interspersed among regenerating tissues, helping to unveil the role of immune-related cells in sensory organ regeneration.

Published
2021
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23. Assessment of TSPAN Expression Profile and Their Role in the VSCC Prognosis

Author

Rafael Malagoli Rocha, Andrey Senos Dobroff, Katia Candido Carvalho, Bruna Cristine de Almeida, Edmund Chada Baracat, Kelly Pedrozo Ferreira, Fernando Augusto Soares, Glauco Baiocchi, and Laura Gonzalez Dos Anjos

Subjects
0301 basic medicine, Vulvar Squamous Cell Carcinoma, Kaplan-Meier Estimate, 0302 clinical medicine, Risk Factors, Biology (General), Spectroscopy, Vulvar Neoplasms, CD63, Cell migration, General Medicine, Middle Aged, Computer Science Applications, tetraspanins, Gene Expression Regulation, Neoplastic, Chemistry, 030220 oncology & carcinogenesis, immunohistochemistry, Carcinoma, Squamous Cell, Female, Disease Susceptibility, Adult, endocrine system, QH301-705.5, Biology, Models, Biological, Article, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Downregulation and upregulation, Humans, Gene silencing, Metastasis suppressor, Physical and Theoretical Chemistry, VSCC, Molecular Biology, QD1-999, Aged, Neoplasm Staging, cell culture, Organic Chemistry, 030104 developmental biology, siRNA, Cancer research, HPV infection, prognosis, Neoplasm Grading, Transcriptome, CD82, CD81
Abstract

The role and prognostic value of tetraspanins (TSPANs) in vulvar squamous cell carcinoma (VSCC) remain poorly understood. We sought to primarily determine, at both the molecular and tissue level, the expression profile of the TSPANs CD9, CD63, CD81, and CD82 in archived VSCC samples (n = 117) and further investigate their clinical relevance as prognostic markers. Our studies led us to identify CD63 as the most highly expressed TSPAN, at the gene and protein levels. Multicomparison studies also revealed that the expression of CD9 was associated with tumor size, whereas CD63 upregulation was associated with histological diagnosis and vascular invasion. Moreover, low expression of CD81 and CD82 was associated with worse prognosis. To determine the role of TSPANs in VSCC at the cellular level, we assessed the mRNA levels of CD63 and CD82 in established metastatic (SW962) and non-metastatic (SW954) VSCC human cell lines. CD82 was found to be downregulated in SW962 cells, thus supporting its metastasis suppressor role. However, CD63 was significantly upregulated in both cell lines. Silencing of CD63 by siRNA led to a significant decrease in proliferation of both SW954 and SW962. Furthermore, in SW962 particularly, CD63-siRNA also remarkably inhibited cell migration. Altogether, our data suggest that the differential expression of TSPANs represents an important feature for prognosis of VSCC patients and indicates that CD63 and CD82 are likely potential therapeutic targets in VSCC.

Published
2021

24. Quality of breast meat from broiler chickens raised in Brazil affected by white striping myopathy

Author

Fábio Ferrari, Rodrigo Alves de Souza, Erick Alonso Villegas-Cayllahua, Mateus Roberto Pereira, Hirasilva Borba, Pedro Alves de Souza, Juliana Lolli Malagoli de Mello, Heloisa de Almeida Fidelis, A. Giampietro-Ganeco, Daniel Rodrigues Dutra, Erika Nayara Freire Cavalcanti, and Rodrigo Fortunato de Oliveira

Subjects
Chemical composition, Nutritional quality, Biology, Pectoralis major, Chicken breast, 03 medical and health sciences, chemistry.chemical_compound, Animal science, medicine, Terneza, Composición química, Maciez, Anormalidades musculares, Myopathy, Anomalías musculares, 030304 developmental biology, General Environmental Science, 0303 health sciences, Cholesterol, Pectoralis major muscle, Muscle abnormalities, 0402 animal and dairy science, Broiler, food and beverages, Composição química, 04 agricultural and veterinary sciences, 040201 dairy & animal science, White (mutation), chemistry, Softness, General Earth and Planetary Sciences, medicine.symptom
Abstract

The aim of this study was to characterize the breast meat from broilers affected by the white striping myopathy and examine its influence on meat quality. 180 breast samples from male broilers, slaughtered at 42-d-old, were used. Samples were classified according to the severity degree of apparent white stripes on the Pectoralis major muscle surface (“normal” [n=60], “moderate” [n=60], or “severe” [n=60]). Birds affected by the myopathy produced breast meat with higher L*, a* and b* values on the outer surface. Cooking loss decreased as the severity degree increased (30.94% [normal] to 21.65% [severe]). Toughness increased in the samples classified as moderately and severely affected. There was also an increase in the concentrations of lipids (1.60% [normal] to 2.57% [affected samples], on average), cholesterol (84.60 mg/100 g [normal] to 91.73 mg/100 g [severe degree]) and collagen as the severity degree increased. Although there are statistical differences for some evaluated parameters and, even so, these results are considered numerically normal based on previously published literature, we emphasize that the white striping abnormality alters chicken breast meat quality, especially regarding to the protein and fat concentrations, which can offer consumers products with nutritional quality different from the average specified on the packaging. El objetivo de este estudio fue caracterizar la carne de pechuga de pollos de engorde afectados por las estrías blancas y evaluar su influencia en la calidad de la carne. Se utilizaron 180 muestras de pechuga de pollos, machos, sacrificados a los 42 días de edad. Las muestras se clasificaron según el grado de severidad de las estrías blancas presentes en la superficie del músculo pectoral mayor ("normal" [n=60], "moderado" [n=60] o "grave" [n=60]). Las aves afectadas por la miopatía produjeron una carne de pechuga con mayores valores de L*, a* y b* cuando se evaluó la superficie externa. Las pérdidas por cocción disminuyeron a medida que aumentaba el grado de severidad de la miopatía (30,94% [normal] a 21,65% [grave]). La dureza fue mayor en las muestras afectadas por los grados moderado y severo. También hubo un aumento en las concentraciones de lípidos (1,60% [normal] a 2,57% [muestras afectadas por la miopatia], en promedio), colesterol (84,60 mg/100 g [normal] a 91,73 mg/100 g [grave]) y colágeno a medida que aumentaba el grado de severidad. Si bien existen diferencias estadísticas para algunos parámetros evaluados y, aun así, estos resultados se consideran numéricamente normales en base a la literatura publicada anteriormente, destacamos que la presencia de las estrías blancas altera la calidad de la carne de pechuga de pollo, especialmente en lo que respecta a las concentraciones de proteínas y grasas, que pueden ofrecer a los consumidores productos con una calidad nutricional diferente al promedio especificado en el empaque. O objetivo deste estudo foi caracterizar a carne de peito de frangos de corte acometidos por estrias brancas e examinar sua influência na qualidade da carne. Foram utilizadas 180 amostras de peito de frangos de corte machos, abatidos aos 42 dias de idade. As amostras foram classificadas de acordo com o grau de severidade das estrias brancas aparentes na superfície do músculo peitoral maior (“normal” [n = 60], “moderado” [n = 60] ou “severo” [n = 60]). As aves afetadas pela miopatia produziram carne de peito com maiores valores L*, a* e b* quando avaliada a superfície externa. As perdas por cozimento diminuíram conforme o grau de severidade da miopatia aumentou (30,94% [normal] para 21,65% [severo]). A dureza foi maior em amostras afetadas pelos graus moderado e severo. Também houve aumento nas concentrações de lipídios (1,60% [normal] para 2,57% [amostras afetadas], em média), colesterol (84,60 mg / 100 g [normal] para 91,73 mg / 100 g [grau severo]) e colágeno conforme o grau de severidade aumentou. Embora existam diferenças estatísticas para alguns parâmetros avaliados e, mesmo assim, esses resultados sejam considerados numericamente normais com base na literatura publicada anteriormente, ressaltamos que a presença de estrias brancas altera a qualidade da carne de peito de frango, principalmente no que se refere às concentrações de proteínas e gorduras, o que pode oferecer ao consumidor produtos com qualidade nutricional diferente da média especificada nas embalagens.

Published
2021

25. Physical, Chemical and Histological Characterization of Pectoralis major Muscle of Broilers Affected by Wooden Breast Myopathy

Author

Rodrigo Alves de Souza, Pedro Alves de Souza, Juliana Lolli Malagoli de Mello, Maísa Santos Fávero, Lizandra Amoroso, Fábio Ferrari, Mateus Roberto Pereira, Heloisa de Almeida Fidelis, Erika Nayara Freire Cavalcanti, Hirasilva Borba, Erick Alonso Villegas-Cayllahua, A. Giampietro-Ganeco, Rodrigo Fortunato de Oliveira, Universidade Estadual Paulista (Unesp), and Universidade de São Paulo (USP)

Subjects
Tenderness, Article, meat quality, Chicken breast, Wooden breast, chicken breast meat, Animal science, Physical chemical, lcsh:Zoology, medicine, lcsh:QL1-991, Meat quality, Myopathy, lcsh:Veterinary medicine, General Veterinary, Chemistry, Chicken breast meat, Pectoralis major muscle, Broiler, Pale color, myodegeneration, wooden breast, tenderness, Myodegeneration, lcsh:SF600-1100, Animal Science and Zoology, medicine.symptom, Myofibril
Abstract

This study aimed to characterize the effects of wooden breast myopathy (WBM) on quality of broiler chicken breast meat. Normal samples (absence of myopathy), moderate-degree samples (hardness only in one area of the breast fillet) and severe-degree samples (hardness throughout the breast fillet) were classified. In macroscopic analysis, the pectoral muscle affected by the WBM showed, in general, pale color with stiff, irregular and reddish regions (suffusions and petechiae), with the presence of white striations. In microscopic analysis, the myopathy was characterized by loss of the polygonal aspect of the muscle fibers. Samples with moderate degree of the myopathy showed greater (p = 0.0266) water retention capacity. There was an increase (p = 0.004) in total collagen concentration in samples from the severe-degree group 0.29% in normal samples to 0.43 and 0.48% in samples from moderate- and severe-degree groups, respectively. Samples of chicken breast affected by the severe-degree WBM showed lower (p &lt, 0.0001) myofibrillar fragmentation index (64.51) and lower (p = 0.0002) fat concentration (2.17%) than normal chicken samples (80.45 and 3.79%, respectively). Samples affected by WBM are larger and heavier and present poorer physical quality when compared to normal chicken meat. Histologically it is possible to observe loss of the polygonal aspect of muscle fibers.

Published
2021

26. Internal Quality of Commercial Eggs Stored Under Conditions That Simulate Storage from Laying to Consumption

Author

Rodrigo Alves de Souza, Fábio Ferrari, Carla Cachoni Pizzolante, Pedro Alves de Souza, A. Giampietro-Ganeco, H. Borba, Juliana Lolli Malagoli de Mello, Universidade Estadual Paulista (Unesp), and APTA

Subjects
food.ingredient, Chemistry, oxidation, laying hens, Humidity, fresh eggs, Internal quality, storage, food, Animal science, Lipid oxidation, Yolk, embryonic structures, Animal Science and Zoology, Haugh unit, yolk index
Abstract

Made available in DSpace on 2021-06-25T10:53:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01 This study evaluated the effects on the internal quality of eggs of various storage environments through which eggs may pass between being laid and being consumed. Commercial eggs (N = 648) from Dekalb White hens were used. Treatments consisted of T1: 28 days at 4 °C; T2: 28 days at 20 °C; T3: 7 days at room temperature (27 °C ± 2 °C) (humidity 55%) and 21 days at 4 °C; T4: 7 days at room temperature and 21 days at 20 °C; T5: 14 days at room temperature and 14 days at 4 °C; T6: 14 days at room temperature and 14 days at 20 °C; T7: 21 days at room temperature and 7 days at 4 °C; T8: 21 days at room temperature and 7 days at 20 °C; and T9: 28 days at room temperature. The characteristics that were evaluated consisted of Haugh unit (HU), yolk index (YI), colour (L*, a* and b*), albumen pH, yolk pH and lipid oxidation. Eggs stored 28 days were darker (L*), and had greater yolk pH and lipid oxidation than fresh eggs. Eggs stored under T1 and T3 conditions had greater HU and YI than eggs stored in the other environments. The albumin pH of eggs stored at room temperature (T9) was highest of the treatments. Yellowness was increased in eggs stored under T4, T6, T8, and T9 conditions. Eggs should be stored under refrigeration as this promotes maintenance of internal quality and mitigates negative effects of previous storage conditions. São Paulo State University (UNESP) Department of Technology, Jaboticabal Institute of Animal Science and Pastures – IZ APTA, Nova Odessa São Paulo State University (UNESP) Department of Technology, Jaboticabal

Published
2021

27. Successful extraction of insect DNA from recent copal inclusions: limits and perspectives

Author

Martina Lari, Guidantonio Malagoli Tagliazucchi, Alessandra Modi, Chiara Vergata, Cristina Zilli, Stefania Vai, David Caramelli, Cristian Taccioli, and Chiara Vischioni

Subjects
0301 basic medicine, Insecta, Molecular biology, media_common.quotation_subject, Genomic data, Science, Insect, Biology, Article, Amber, Animals, DNA, Ancient, Resins, Plant, Sequence Analysis, DNA, Fossils, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Extant taxon, Potential source, media_common, Multidisciplinary, Ecology, Extraction (chemistry), Biological techniques, Genetic data, Environmental sciences, 030104 developmental biology, Ancient DNA, chemistry, Evolutionary biology, Medicine, 030217 neurology & neurosurgery, DNA
Abstract

Insects entombed in copal, the sub-fossilized resin precursor of amber, represent a potential source of genetic data for extinct and extant, but endangered or elusive, species. Despite several studies demonstrated that it is not possible to recover endogenous DNA from insect inclusions, the preservation of biomolecules in fossilized resins samples is still under debate. In this study, we tested the possibility of obtaining endogenous ancient DNA (aDNA) molecules from insects preserved in copal, applying experimental protocols specifically designed for aDNA recovery. We were able to extract endogenous DNA molecules from one of the two samples analyzed, and to identify the taxonomic status of the specimen. Even if the sample was found well protected from external contaminants, the recovered DNA was low concentrated and extremely degraded, compared to the sample age. We conclude that it is possible to obtain genomic data from resin-entombed organisms, although we discourage aDNA analysis because of the destructive method of extraction protocols and the non-reproducibility of the results.

Published
2020

28. Comparison of Methodologies to Estimate Dietary Cadmium Intake in an Italian Population

Author

Bernhard Michalke, Carlotta Malagoli, Giorgia Adani, Kristen Upson, Tommaso Filippini, Marco Vinceti, and Claudia Baraldi

Subjects
inorganic chemicals, Male, cadmium, Health, Toxicology and Mutagenesis, food frequency questionnaire, Dietary Cadmium, Population, chemistry.chemical_element, lcsh:Medicine, 010501 environmental sciences, biomarker, dietary intake, estimation, 01 natural sciences, Article, 03 medical and health sciences, Animal science, Interquartile range, Humans, Medicine, education, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, Cadmium, education.field_of_study, Food Frequency Questionnaire, Biomarker, Dietary Intake, Estimation, business.industry, Dietary intake, lcsh:R, Public Health, Environmental and Occupational Health, Food frequency questionnaire, Feeding Behavior, Middle Aged, Italian population, Diet Records, Diet, Italy, chemistry, Female, business, Body mass index
Abstract

Cadmium is a metal that is toxic to humans, and the major source of cadmium exposure in the non-smoking general population is diet. To identify major food sources and lower exposure from diet, an accurate estimate of dietary cadmium intake is needed. Hence, the objectives of this study are to develop a method to assess dietary cadmium intake using a biomarker measurement and to improve the estimation of dietary cadmium intake when using a food frequency questionnaire (FFQ). In a random sample of an Italian population, we collected dietary habits by FFQ and measured cadmium in foods and beverages. These data were used to compute the estimated weekly dietary intake (WDI) of cadmium (&micro, g) by kilogram (kg) of body weight (bw) (WDIFFQ). We also measured fasting serum cadmium levels by inductively-coupled plasma mass spectrometry. We used these data to develop a model for the estimation of the biomarker-derived dietary cadmium intake (WDIbio). In the 51 subjects recruited, the median level of serum cadmium was 0.041 &micro, g/L (interquartile range (IQR): 0.030&ndash, 0.054). The median WDIFFQ and WDIbio were 1.34 &micro, g/kg bw/week (IQR: 0.86&ndash, 1.70) and 0.72 &micro, g/kg bw/week (IQR: 0.55&ndash, 1.11), respectively. The correlation between the two estimates was low-to-moderate (r = 0.291). In exploratory analyses, the correlation was slightly higher in women and participants ages &lt, 50 years, and markedly higher in participants with body mass index &lt, 25 kg/m2 and smokers. Our approach allows for the dietary contribution to be isolated from the overall cadmium exposure measured with a biomarker, the estimated dietary cadmium intake was roughly similar to that estimated using the FFQ, especially in select subgroups. Future refinements to the biomarker-derived dietary cadmium intake approach should take into consideration additional sources of cadmium exposure, as well as factors affecting its absorption and metabolism.

Published
2020

29. Sulfur metabolic engineering enhances cadmium stress tolerance and root to shoot iron translocation in Brassica napus L

Author

Muhammad Sayyar Khan, Mario Malagoli, Markus Wirtz, Hala Rajab, Rüdiger Hell, and Fariha Qahar

Subjects
0106 biological sciences, 0301 basic medicine, Physiology, Chromosomal translocation, Plant Science, medicine.disease_cause, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, Serine acetyltransferase, Genetics, medicine, Cysteine, Brassica napus, NtSAT4, food and beverages, Glutathione, Lyase, Cytosol, 030104 developmental biology, chemistry, Biochemistry, Heavy metals, Shoot, Oxidative stress, 010606 plant biology & botany
Abstract

Serine acetyltransferase (SAT) (EC 2.3.1.30) is the rate-limiting enzyme of cysteine (Cys) biosynthesis, providing the decisive precursor for the ubiquitous defense thiol glutathione (GSH). Together with O-acetylserine (thiol) lyase (OAS-TL; EC 2.5.1.47) SAT generates Cys in the cytosol, plastids, and mitochondria of vascular plants. The current study aimed to overproduce Cys and GSH for enhanced stress tolerance via overexpression of the feedback-insensitive isoform of serine acetyltransferase from tobacco, i.e., NtSAT4. Constitutive overexpression of NtSAT4 in Brassica napus resulted in the 2.6-fold-4-fold higher SAT activity in different subcellular compartment-specific lines. This higher SAT activity led to a 2.5-fold-3.5-fold higher steady-state level of free Cys and 2.2-fold-5.3-fold elevated level of GSH in leaves compared with nontransformed plants. Among the compartment-specific lines, the mitochondrial targeted NtSAT4 overexpressor line M-182 showed the highest levels of Cys (3.5-fold) and GSH (5.3-fold) compared with wild-type plants. Overexpression of NtSAT4 conferred a physiological advantage in terms of enhanced tolerance against oxidative stress with hydrogen peroxide and the heavy metal cadmium (Cd). The NtSAT4 overexpressor lines showed a significantly higher amount of iron (Fe) translocation from roots to shoots compared with nontransformed plants. Overall, these results suggest that overexpression of NtSAT4 is a promising approach to creating plants with tolerance to heavy metals and oxidative stress and, in addition, may potentially improve plant nutrition in terms of enhanced Fe translocation from roots to shoots.

Published
2020

30. Advances in Plant Sulfur Research

Author

Jean-Christophe Avice, Dimitris L. Bouranis, Mario Malagoli, Elke Bloem, Agricultural University of Athens, University of Padova [Padova, Italy], Ecophysiologie Végétale, Agronomie et Nutritions NCS (EVA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Julius Kühn-Institut (JKI)

Subjects
0106 biological sciences, 0301 basic medicine, Sulfur nutrition physiology, Brassica, [SDV.SA.AGRO]Life Sciences [q-bio]/Agricultural sciences/Agronomy, chemistry.chemical_element, Plant Science, Root hair, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Arabidopsis, Botany, Arabidopsis thaliana, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Ecology, Evolution, Behavior and Systematics, 2. Zero hunger, Ecology, biology, Lateral root, fungi, food and beverages, 15. Life on land, Sulfur deficiency, biology.organism_classification, Sulfur, Sulfur interactions, 030104 developmental biology, Editorial, chemistry, Glucosinolate, QK1-989, Phaseolus, 010606 plant biology & botany
Abstract

As an essential nutrient required for plant growth and development, sulfur (S) deficiency in productive systems limits yield and quality. This special issue hosts a collection of original research articles, mainly based on contributions from the 11th International Plant Sulfur Workshop held on 16−20 September 2018 in Conegliano, Italy, focusing on the following topics: (1) The germinative and post-germinative behaviour of Brassica napus seeds when severe S limitation is applied to the parent plants; (2) the independence of S deficiency from the mRNA degradation initiation enzyme PARN in Arabidopsis; (3) the glucosinolate distribution in the aerial parts of sel1-10, a disruption mutant of the sulfate transporter SULTR1;2, in mature Arabidopsis thaliana plants; (4) the accumulation of S-methylcysteine as its γ-glutamyl dipeptide in Phaseolus vulgaris; and (5) the role of ferric iron chelation-strategy components in the leaves and roots of maize, have provided new insights into the effect of S availability on plant functionality. Moreover, the role of S deficiency in root system functionality has been highlighted, focusing on (6) the contribution of root hair development to sulfate uptake in Arabidopsis, and (7) the modulation of lateral root development by the CLE-CLAVATA1 signaling pathway under S deficiency. The role of S in plants grown under drought conditions has been investigated in more detail focusing (8) on the relationship between S-induced stomata closure and the canonical ABA signal transduction machinery. Furthermore, (9) the assessment of S deficiency under field conditions by single measurements of sulfur, chloride, and phosphorus in mature leaves, (10) the effect of fertilizers enriched with elemental S on durum wheat yield, and (11,12) the impact of elemental S on the rhizospheric bacteria of durum wheat contributed to enhance the scientific knowledge on S nutrition under field conditions.

Published
2020

31. Modelling nitrogen and light sharing in pea-wheat intercrops to design decision rules for N fertilisation according to farmers’ expectations

Author

Christophe Naudin, Marie-Hélène Jeuffroy, Mathilde Sester, Guénaëlle Corre-Hellou, Philippe Malagoli, Sylvain Vrignon-Brenas, Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant - Clermont Auvergne (PIAF), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Ecole supérieure d'Agricultures d'Angers (ESA), Écophysiologie des Plantes sous Stress environnementaux (LEPSE), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro), Agroécologie et Intensification Durables des cultures annuelles (UPR AIDA), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad), Agronomie, AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), This work was jointly funded by ADEME (Agence de l’Environnement et de la Maîtrise de l’Énergie, France), CASDAR n°431 (Compte d'Affectation Spéciale pour le Développement Agricole et Rural, France), Conseil Général of Maine-et-Loire, and UNIP (Union National des plantes riches en Protéines, France)., Légumineuses, Ecophysiologie Végétale, Agroécologie (LEVA), Ecole supérieure d'Agricultures d'Angers (ESA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Département Performances des systèmes de production et de transformation tropicaux (Cirad-PERSYST), CASDAR n°431 (Compte d'Affectation Spéciale pour le Développement Agricole et Rural, France), Conseil Général of Maine-et-Loire, UNIP (Union National des plantes riches en Protéines, France)., and ADEME (Agence de l’Environnement et de la Maîtrise de l’Énergie, France)

Subjects
0106 biological sciences, [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, Light, Disponibilité nutriments (sol), Agricultural engineering, 01 natural sciences, Climatic data, Triticum, media_common, Mathematics, 2. Zero hunger, biology, U10 - Informatique, mathématiques et statistiques, Intercropping, 04 agricultural and veterinary sciences, Nitrogen, Variable (computer science), [SDE]Environmental Sciences, Intercrop, Interception, media_common.quotation_subject, Soil Science, chemistry.chemical_element, Lumière, Competition (biology), Fertilisation, Culture intercalaire, Scenarios, Pisum sativum, Modélisation des cultures, Engrais azoté, Climatic variability, Decision rule, 15. Life on land, biology.organism_classification, chemistry, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, Agronomy and Crop Science, 010606 plant biology & botany, F04 - Fertilisation
Abstract

International audience; Cereal-legume intercropping has gained increased interest in Europe. Nevertheless, performance and especially the percentage of each species at harvest are often considered highly variable. Nitrogen (N) fertilisation can be a relevant driving factor affecting the percentage of each species at harvest. Soil N availability influences competition for light and nitrogen in cereal-legume intercrops. However, management of N fertilisation still remains unclear for intercrops. Few references on the effects of a range of strategies of N fertilisation are available to guide farmers with relevant decision rules considering their expectations. Here, a modelling approach was proposed to simulate interactions between light and N acquisition of a pea-wheat intercrop and to test different scenarios for the management of such intercrops. A model (Azodyn-IC) was built resulting from the combination of two existing individual-crop models (AZODYN and AFISOL) and by applying rules of light and soil inorganic nitrogen sharing between the intercropped pea and wheat. Evaluation of the model outputs with experimental data showed satisfactory predictions of the studied variables (N accumulation, LAI, and crop dry weight). The model validated both resource sharing and light-N interactions. Furthermore, the model was able to respond to increases in inorganic N availability based upon straightforward formalisms. Simulating unmeasured variables, such as root growth and light interception and use by each species, improved our understanding of the relative dominance of each species for acquiring resources. Eventually, the model was used to simulate different scenarios of N fertilisation over 26 years of climatic data to account for climatic variability. We demonstrated the interest of such a modelling approach to design decision rules of N fertilisation according to farmers’ expectations.

Published
2020

32. Cancer incidence following long-term consumption of drinking water with high inorganic selenium content

Author

Paola Ballotari, Marco Vinceti, Paolo Giorgi Rossi, Tommaso Filippini, Carlotta Malagoli, Massimo Vicentini, Claudio Sacchettini, Lauren A. Wise, and Marcella Malavolti

Subjects
Male, 0301 basic medicine, Environmental Engineering, Prevalence, Physiology, chemistry.chemical_element, 010501 environmental sciences, 01 natural sciences, Selenate, Dietary Exposure, Selenium, 03 medical and health sciences, chemistry.chemical_compound, Water Supply, Neoplasms, Drinking water, Humans, Environmental Chemistry, Medicine, Cancer, Cohort study, Incidence, Waste Management and Disposal, Pollution, 0105 earth and related environmental sciences, business.industry, Drinking Water, Incidence (epidemiology), Mortality rate, medicine.disease, 030104 developmental biology, Italy, chemistry, Etiology, Female, business, Water Pollutants, Chemical, Environmental Monitoring
Abstract

Selenium, a trace element to which humans are exposed mainly through diet, has been involved in the etiology of human cancer. We investigated the long-term effects of selenium exposure on cancer incidence using data from a natural experiment in Northern Italy. During the 1970s-1980s, in a part of the Italian municipality of Reggio Emilia, residents were inadvertently exposed to unusually high levels of inorganic hexavalent selenium (selenate) through drinking water. We followed the exposed residents for 28years, generating data on incidence (when available) and mortality rates for selected cancer sites; the remaining municipal residents comprised the unexposed (reference) group. We observed no substantial difference in overall cancer incidence comparing exposed and unexposed cohorts. We detected, however, a higher incidence of cancer at some sites, and for a few of them, namely cancers of the buccal cavity and pharynx, melanoma, urinary tract and lymphoid tissue, the excess incidence was particularly evident in the first period of follow-up but decreased over time. Overall, these results suggest that consumption of water with levels of selenium in its inorganic hexavalent form close to the European standard, 10μg/L, may have unfavourable effects on cancer incidence.

Published
2018

33. Respostas de frangos de corte criados sob estresse por calor

Author

R. Alves de Souza, M. Piatto Berton, F. Borba Ferrari, J.L. Malagoli de Mello, M. Manente Boiago, P. Alves de Souza, A. Giampietro-Ganeco, and H. Borba

Subjects
Triiodothyronine, 010504 meteorology & atmospheric sciences, medicine.diagnostic_test, Chemistry, 0402 animal and dairy science, Rectal temperature, 04 agricultural and veterinary sciences, General Medicine, Heat wave, Hematocrit, Thermoregulation, 040201 dairy & animal science, 01 natural sciences, Heat stress, Animal science, Environmental temperature, medicine, Thermal balance, 0105 earth and related environmental sciences
Abstract

Para avaliar a influência do estresse por calor por até 72 horas, e o possível efeito acumulativo do estresse sobre as respostas fisiológicas de frangos de corte criados sob condições simuladas de ondas de calor, 500 frangos de corte machos, da linhagem Cobb, foram criados em duas câmaras climáticas equipadas com sistemas de aquecimento e refrigeração, por até 45 dias. Metade das aves foram criadas sob conforto térmico (ajustado de acordo com o ideal para cada idade) e as demais aves foram submetidas a ondas de calor (32 °C ± 0,5 °C por até 72 horas) em três idades (com início aos 21, 35 e 42 dias de idade). No início de cada simulação de onda de calor e após 24, 48 e 72 horas de exposição ao calor, foram avaliados parâmetros fisiológicos como temperatura retal e frequência respiratória. Além disso foram coletadas amostras de sangue para determinação de níveis hormonais (T3 e T4) e hematócrito. O aumento da frequência respiratória das aves foi verificado após 24 horas de exposição a altas temperaturas nas três ondas de calor simuladas. Durante a terceira onda de calor não houve variação da temperatura retal. A temperatura ambiente não influenciou o valor do hematócrito e os níveis de hormônios tireoidianos T3 e T4. Submeter aves a períodos de estresse por calor agudo intermitente, como durante a simulação de ondas de calor, influencia a frequência respiratória e a temperatura retal dos frangos de corte, evidenciando o consequente efeito do estresse por calor sobre o metabolismo das aves e o equilíbrio térmico corporal. As ondas de calor não afetam a secreção de tri-iodotironina e tiroxina, e a porcentagem de glóbulos vermelhos.

Published
2018

34. An Approach to Alleviate the Impact of Drought Stress with Selenium Amendment

Author

Leila Radhouane, Nesrine Aissa, and Mario Malagoli

Subjects
0106 biological sciences, Chlorophyll content, Drought stress, General Mathematics, Amendment, General Physics and Astronomy, chemistry.chemical_element, Biology, 01 natural sciences, Field capacity, Water content, Abiotic component, fungi, food and beverages, 04 agricultural and veterinary sciences, General Chemistry, Sorghum, biology.organism_classification, chemistry, Agronomy, 040103 agronomy & agriculture, 0401 agriculture, forestry, and fisheries, General Earth and Planetary Sciences, General Agricultural and Biological Sciences, Selenium, 010606 plant biology & botany
Abstract

Selenium (Se), an essential microelement for humans and animals, has recently gained in importance in the plant systems due to its effects on antioxidative defense system. Several studies demonstrated that low concentrations of Se protect plants against various types of biotic and abiotic stresses. We conducted a pot experiment for 2 months, using Sorghum (Sorghum vulgarea L.), to investigate the protective role of a low dose of Se (20 mg Se/l) against a drought stress. Specifically, we submitted treated and non-treated plants to three different condition of water availability: control condition (100% field capacity), low drought condition (70% field capacity), and high drought condition (35% field capacity) and we measured growth and several physiological traits of these plants. We found that Se treatment stimulates growth and significantly increases the relative water content (RWC) and the chlorophyll content. These findings suggest that Se could alleviate drought stress by promoting growth and regulating water status of sorghum.

Published
2018

35. Charge-transfer transitions in triarylamine mixed-valence systems: A joint density functional theory and vibronic coupling study

Author

Coropceanu, V., Malagoli, M., Andre, J.M., and Bredas, J.L.

Subjects
Amines -- Properties, Charge transfer -- Research, Density functionals -- Usage, Chemistry
Abstract

The electronic coupling parameter is evaluated at the density functional and time dependent density functional theory (TD-DFT) levels. The influence on the optical properties of diagonal and nondiagonal vibronic couplings is discussed.

Published
2002

36. Pesticides, polychlorinated biphenyls and polycyclic aromatic hydrocarbons in cerebrospinal fluid of amyotrophic lateral sclerosis patients: a case-control study

Author

Elizabeth E. Hatch, Federica Violi, Marco Vinceti, Manolis Tzatzarakis, Aristides M. Tsatsakis, Nicola Fini, Carlotta Malagoli, Antonio Fasano, Jessica Mandrioli, Olga-Ioanna Kalantzi, and Valerii N. Rakitskii

Subjects
Risk, Male, Metabolite, Amyotrophic lateral sclerosis, Case-control study, Environment, Persistent organic pollutants, Pesticides, Physiology, 010501 environmental sciences, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cerebrospinal fluid, Hydrocarbons, Chlorinated, Odds Ratio, medicine, Humans, Polycyclic Aromatic Hydrocarbons, 0105 earth and related environmental sciences, General Environmental Science, medicine.diagnostic_test, Chemistry, Lumbar puncture, Amyotrophic Lateral Sclerosis, Middle Aged, Pesticide, medicine.disease, Congener, Italy, Case-Control Studies, Environmental chemistry, Etiology, Environmental Pollutants, Female, 030217 neurology & neurosurgery, Environmental Monitoring
Abstract

Neurotoxic chemicals including several pesticides have been suggested to play a role in the etiology of amyotrophic lateral sclerosis (ALS). We investigated the relation between organochlorine pesticides and their metabolites (OCPs), polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) in the etiology of sporadic ALS, determining for the first time their levels in cerebrospinal fluid as indicator of antecedent exposure. We recruited 38 ALS patients and 38 controls referred to an Italian clinical center for ALS care, who underwent a lumbar puncture for diagnostic purposes between 1994-2013, and had 1mL of cerebrospinal fluid available for the determination of OCPs, PCBs and PAHs. Many chemicals were undetectable in both case and control CSF samples, and we found little evidence of any increased disease risk according to higher levels of exposure. Among males >60 years, we found a slight but statistically very unstable increased ALS risk with higher levels of the congener PCB 28 and the OCP metabolite p,p'-DDE. Overall, these results do not suggest an involvement of the neurotoxic chemicals investigated in this study in disease etiology, although small numbers limited the precision of our results.

Published
2017

37. Molecular Imaging of Vascular Calcification with 18F-Sodium-Fluoride in Patients Infected with Human Immunodeficiency Virus

Author

Napoleone Prandini, Francesco Esposito, Giovanni Braglia, Cristina Mussini, Guido Ligabue, Barbara Beghetto, Paolo Raggi, Giulia Nardini, Enrica Roncaglia, Giulia Besutti, Riccardo Scaglioni, Jovana Milic, Giovanni Guaraldi, and Andrea Malagoli

Subjects
Male, Aortic arch, Fluorine Radioisotopes, Human immunodeficiency virus (HIV), HIV Infections, Coronary Artery Disease, 030204 cardiovascular system & hematology, medicine.disease_cause, lcsh:Chemistry, calcification, chemistry.chemical_compound, 0302 clinical medicine, Positron Emission Tomography Computed Tomography, sodium fluoride, 030212 general & internal medicine, Circumflex, Prospective cohort study, lcsh:QH301-705.5, Spectroscopy, atherosclerosis, immune deficiency syndrome, Catalysis, Molecular Biology, Computer Science Applications1707 Computer Vision and Pattern Recognition, Physical and Theoretical Chemistry, Organic Chemistry, Inorganic Chemistry, General Medicine, Middle Aged, Plaque, Atherosclerotic, Computer Science Applications, Right coronary artery, Disease Progression, Cardiology, cardiovascular system, Female, medicine.medical_specialty, Article, 03 medical and health sciences, medicine.artery, Internal medicine, Sodium fluoride, medicine, Humans, In patient, Vascular Calcification, Aged, business.industry, HIV, medicine.disease, body regions, lcsh:Biology (General), lcsh:QD1-999, chemistry, business, Calcification
Abstract

18F-Sodium Fluoride (NaF) accumulates in areas of active hydroxyapatite deposition and potentially unstable atherosclerotic plaques. We assessed the presence of atherosclerotic plaques in 50 adult patients with HIV (HIV+) who had undergone two cardiac computed tomography scans to measure coronary artery calcium (CAC) progression. CAC and its progression are predictive of an unfavorable prognosis. Tracer uptake was quantified in six arterial territories: aortic arch, innominate carotid artery, right and left internal carotid arteries, left coronary (anterior descending and circumflex) and right coronary artery. Thirty-one patients showed CAC progression and 19 did not. At least one territory with high NaF uptake was observed in 150 (50%) of 300 arterial territories. High NaF uptake was detected more often in non-calcified than calcified areas (68% vs. 32%), and in patients without than in those with prior CAC progression (68% vs. 32%). There was no correlation between clinical and demographic variables and NaF uptake. In clinically stable HIV+ patients, half of the arterial territories showed a high NaF uptake, often in the absence of macroscopic calcification. NaF uptake at one time point did not correlate with prior progression of CAC. Prospective studies will demonstrate the prognostic significance of high NaF uptake in HIV+ patients.

Published
2019
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38. Triterpene Acid and Phenolics from Ancient Apples of Friuli Venezia Giulia as Nutraceutical Ingredients: LC-MS Study and In Vitro Activities

Author

Filippo Maggi, Mario Malagoli, Stefano Dall'Acqua, Gokhan Zengin, Stefania Sut, Selçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, and Zengin, Gökhan

Subjects
triterpene acids, Malus, chlorogenic acid, Flavonoid, Pharmaceutical Science, 01 natural sciences, ancient apple, Article, Analytical Chemistry, Ancient apple, Chlorogenic acid, Enzyme inhibition, LC-MS, Polyphenols, Triterpene acids, Chemistry (miscellaneous), Molecular Medicine, 3003, Drug Discovery3003 Pharmaceutical Science, Physical and Theoretical Chemistry, Organic Chemistry, lcsh:QD241-441, chemistry.chemical_compound, 0404 agricultural biotechnology, Nutraceutical, Triterpene, Phenols, lcsh:Organic chemistry, Tandem Mass Spectrometry, Drug Discovery, Amylase, Cultivar, Food science, enzyme inhibition, polyphenols, chemistry.chemical_classification, biology, 010401 analytical chemistry, 04 agricultural and veterinary sciences, biology.organism_classification, 040401 food science, Triterpenes, 0104 chemical sciences, chemistry, Polyphenol, Fruit, biology.protein, Chromatography, Liquid
Abstract

Triterpene acid and phenolic constituents from nine ancient varieties of apple (Malus domestica) fruits cultivated in Fanna, Friuli Venezia Giulia region, northeast Italy, were analyzed and compared with four commercial apples (&lsquo, Golden Delicious&rsquo, &lsquo, Red Delicious&rsquo, Granny Smith&rsquo, and &lsquo, Royal Gala&rsquo, ). Total phenolic and flavonoid contents were measured by spectrophotometric assays. The quali-quantitative fingerprint of secondary metabolites including triterpene acid was obtained by LC-DAD-(ESI)-MS and LC-(APCI)-MS, respectively. Based on the two LC-MS datasets, multivariate analysis was used to compare the composition of ancient fruit varieties with those of four commercial apples. Significant differences related mainly to the pattern of triterpene acids were found. Pomolic, euscaphyc, maslinic and ursolic acids are the most abundant triterpene in ancient varieties pulps and peels, while ursolic and oleanolic acids were prevalent in the commercial fruits. Also, the content of the phenolic compounds phloretin-2-O-xyloglucoside and quercetin-3-O-arabinoside was greater in ancient apple varieties. The antioxidant (radical scavenging, reducing power, metal chelating and phosphomolybdenum assays) and enzyme inhibitory effects (against cholinesterase, tyrosinase, amylase and glucosidase) of the samples were investigated in vitro. Antioxidant assays showed that the peels were more active than pulps. However, all the samples exhibited similar enzyme inhibitory effects. Ancient Friuli Venezia Giulia apple cultivars can be a source of chlorogenic acid and various triterpene acids, which are known for their potential anti-inflammatory activity and beneficial effects on lipid and glucose metabolism. Our results make these ancient varieties suitable for the development of new nutraceutical ingredients.

Published
2019

39. Selenium and selenium species in the etiology of Alzheimer's dementia: The potential for bias of the case-control study design

Author

Bernhard Michalke, Manuela Tondelli, Marco Vinceti, Marcel Eichmüller, Carlotta Malagoli, Annalisa Bargellini, Giovanna Zamboni, Giulia Vinceti, Tommaso Filippini, and Annalisa Chiari

Subjects
Male, Population, chemistry.chemical_element, Physiology, Disease, 010501 environmental sciences, 01 natural sciences, Biochemistry, Inorganic Chemistry, Cohort Studies, 03 medical and health sciences, Selenium, 0302 clinical medicine, Selenium deficiency, Alzheimer Disease, medicine, Dementia, Humans, education, 0105 earth and related environmental sciences, Aged, chemistry.chemical_classification, education.field_of_study, business.industry, Case-control study, medicine.disease, chemistry, Case-Control Studies, Disease Progression, Molecular Medicine, Alzheimer's dementia, Cerebrospinal fluid, Mild cognitive impairment, Selenium species, Female, Selenoprotein, business, 030217 neurology & neurosurgery, Cohort study
Abstract

Several human studies imply that the trace element selenium and its species may influence the onset of neurological disease, including Alzheimer's dementia (AD). Nevertheless, the literature is conflicting, with reported associations between exposure and risk in opposite direction, possibly due to biases in exposure assessment. After conducting a cohort study that detected an excess AD risk associated with higher levels of inorganic-hexavalent selenium in subjects with mild cognitive impairment (MCI), we investigated the relation between selenium and AD using a case-control study design. We determined cerebrospinal fluid levels of selenium species in 56 MCI participants already included in the cohort study, considered as referents, and in 33 patients with established AD. AD risk was inversely correlated with inorganic selenium species and with the organic form bound to selenoprotein P. Selenium bound to other organo-selenium species was positively correlated with AD risk, suggesting compensatory selenoprotein upregulation following increased oxidative stress. The finding of an increased AD risk associated with inorganic-hexavalent selenium from the cohort study was not replicated. This case-control study yielded entirely different results than those generated by a cohort study with a partially overlapping participant population, suggesting that case-control design does not allow to reliably assess the role of selenium exposure in AD etiology. This inability appears to be due to exposure misclassification, falsely indicating an etiologic role of selenium deficiency likely due to reverse causation, and involving most selenium species. The case-control design may instead lend insights into the pathologic process underlying disease progression.

Published
2019

40. Partial replacement of meat and fat with hydrated wheat fiber in beef burgers decreases caloric value without reducing the feeling of satiety after consumption

Author

Judite Lapa-Guimarães, Paulo E.S. Munekata, Juliana Lolli Malagoli de Mello, Isabela Rodrigues, Larissa Tátero Carvalho, Juliana Cristina Baldin, Manoela Alves Pires, Yana Jorge Polizer, Marco Antonio Trindade, Francisco Allan Leandro de Carvalho, Universidade de São Paulo (USP), and Universidade Estadual Paulista (Unesp)

Subjects
Dietary Fiber, Caloric value, Swine, Meat product, ANÁLISE SENSORIAL DE ALIMENTOS, Satiation, Affective sensory evaluation, Animals, Humans, Fiber, Food science, Fat Substitutes, Insoluble fiber, Triticum, Chemistry, Caloric theory, Hunger satisfaction, Consumer Behavior, Lipids, Dietary fiber, Caloric intake, Meat Products, Cattle, Nutritive Value, Brazil, Food Science
Abstract

Made available in DSpace on 2019-10-04T12:31:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) The aim of this study was to evaluate the effects of different levels of hydrated wheat fiber replacing meat and fat in beef burgers on technological characteristics, sensory acceptance and hunger satisfaction. The different levels of hydrated wheat fiber (1 g fiber: 6 g water) were 0, 1.25, 2.5, 3.75 and 5.0 g of fiber/80 g burger portion. Results showed that the greater the addition of hydrated wheat fiber, the lower the protein (P < .0001) and lipid (P = .0006) content and consequently the greater the reduction in caloric value. Burgers with up to 3.75 g fiber/80 g portion showed the same (P > .05) sensory acceptance as the Control burgers (those without added fiber). Sandwiches comprised of burgers with 2.5 and 5.0 g fiber/80 g portion caused the same (P > .05) hunger satisfaction (satiety feeling) as those comprised of Control burgers for up to 3 h after consumption. Burgers containing 3.75 g fiber/80 g burger may represent an interesting alternative for people who want to reduce caloric intake and/or increase the proportion of insoluble fiber in their diet. Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Food Engn, Pirassununga, Brazil Sao Paulo State Univ, Sch Agr & Vet Sci, Dept Technol, Jaboticabal, Brazil Sao Paulo State Univ, Sch Agr & Vet Sci, Dept Technol, Jaboticabal, Brazil

Published
2019

42. Dietary cadmium intake and risk of cutaneous melanoma: An Italian population-based case-control study

Author

Lauren A. Wise, Tommaso Filippini, Marco Vinceti, Marcella Malavolti, Giovanni Pellacani, and Carlotta Malagoli

Subjects
Male, Risk, medicine.medical_specialty, Skin Neoplasms, Population, Dietary Cadmium, chemistry.chemical_element, 010501 environmental sciences, 01 natural sciences, Biochemistry, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Risk Factors, Internal medicine, medicine, Confidence Intervals, Odds Ratio, Humans, education, Melanoma, 0105 earth and related environmental sciences, Cadmium, education.field_of_study, business.industry, Confounding, Case-control study, Odds ratio, Middle Aged, Spline, Diet, chemistry, Italy, Case-Control Studies, Cutaneous melanoma, Molecular Medicine, Regression Analysis, Female, business, 030217 neurology & neurosurgery
Abstract

Introduction Exposure to the heavy metal cadmium has been associated with many adverse health effects, such as atherosclerosis, diabetes, and cancer, possibly melanoma. In non-occupationally exposed individuals, food intake is a major source of cadmium exposure, after smoking. We aimed to assess the risk of melanoma in relation to dietary cadmium intake. Methods Using a population-based case-control study design, we recruited 380 incident cases of newly-diagnosed cutaneous melanoma and 719 matched controls in the Emilia-Romagna Region, Northern Italy in the years 2005-2006. We evaluated dietary intake using a semi-quantitative food frequency questionnaire. We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (CIs) for melanoma according to quintiles of dietary cadmium intake, adjusting for several potential confounders, and we modeled the association non-parametrically, using restricted cubic splines. Results Median energy-adjusted intake of cadmium was 6.11 μg/day (interquartile range 5.38–6.91) among cases and 5.97 μg/day (5.15–6.79) among controls. For each 1 μg/day-increase in cadmium intake, the OR for melanoma was 1.11 (95% CI 1.00–1.24). Melanoma risk generally increased with increasing quintile of cadmium exposure, with ORs of 1.55 (95% CI 0.99–2.42), 1.54 (95% CI 0.99-2-40), 1.75 (95% CI 1.12–2.75), and 1.65 (95% CI 1.05–2.61) for the second through fifth quintiles, compared with the lowest quintile. Sex-stratified analysis showed ORs per 1 μg/day-increase in cadmium intake of 1.10 (95% CI 0.93-1-29) among men and 1.15 (95% CI 0.99–1.33) among women. Using spline regression analysis, we observed a generally linear increase in melanoma risk up to 6 μg/day of cadmium intake, after which the risk appeared to plateau. Conclusions We observed a positive non-linear association between dietary cadmium intake and risk of cutaneous melanoma in a Northern Italy population. However, further studies are needed to elucidate this association, due to concerns about exposure misclassification, unmeasured confounding, and the limited and conflicting evidence from epidemiological findings.

Published
2019

43. Sulfate-Induced Stomata Closure Requires the Canonical ABA Signal Transduction Machinery

Author

Muhammad Sayyar Khan, Hala Rajab, Mario Malagoli, Markus Wirtz, and Rüdiger Hell

Subjects
0106 biological sciences, 0301 basic medicine, Evolution, Phosphatase, Mutant, Plant Science, sulfate, reactive oxygen species (ROS), 01 natural sciences, Article, abscisic acid, 03 medical and health sciences, chemistry.chemical_compound, Behavior and Systematics, Abscisic acid, Ecology, Evolution, Behavior and Systematics, chemistry.chemical_classification, Reactive oxygen species, NADPH oxidase, biology, Ecology, fungi, Botany, food and beverages, Protein phosphatases 2C, ABI1, stomatal closure, Cell biology, Phytohormone synthesis, Reactive oxygen species (ROS), Stomatal closure, Sucrose non-fermenting Related Kinase 2 (SnRK2), Sulfate, 030104 developmental biology, chemistry, phytohormone synthesis, QK1-989, Second messenger system, biology.protein, 010606 plant biology & botany, Cysteine
Abstract

Phytohormone abscisic acid (ABA) is the canonical trigger for stomatal closure upon abiotic stresses like drought. Soil-drying is known to facilitate root-to-shoot transport of sulfate. Remarkably, sulfate and sulfide&mdash, a downstream product of sulfate assimilation&mdash, have been independently shown to promote stomatal closure. For induction of stomatal closure, sulfate must be incorporated into cysteine, which triggers ABA biosynthesis by transcriptional activation of NCED3. Here, we apply reverse genetics to unravel if the canonical ABA signal transduction machinery is required for sulfate-induced stomata closure, and if cysteine biosynthesis is also mandatory for the induction of stomatal closure by the gasotransmitter sulfide. We provide genetic evidence for the importance of reactive oxygen species (ROS) production by the plasma membrane-localized NADPH oxidases, RBOHD, and RBOHF, during the sulfate-induced stomatal closure. In agreement with the established role of ROS as the second messenger of ABA-signaling, the SnRK2-type kinase OST1 and the protein phosphatase ABI1 are essential for sulfate-induced stomata closure. Finally, we show that sulfide fails to close stomata in a cysteine-biosynthesis depleted mutant. Our data support the hypothesis that the two mobile signals, sulfate and sulfide, induce stomatal closure by stimulating cysteine synthesis to trigger ABA production.

Published
2019

44. Modelling Nitrogen Uptake in Plants and Phytoplankton: Advantages of Integrating Flexibility into the Spatial and Temporal Dynamics of Nitrate Absorption

Author

Philippe Malagoli, Erwan Le Deunff, Marie-Laure Decau, Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant - Clermont Auvergne (PIAF), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), UE 1373 Fourrages Environnement Ruminants Lusignan, Institut National de la Recherche Agronomique (INRA)-Physiologie Animale et Systèmes d'Elevage (PHASE), Institut National de la Recherche Agronomique (INRA)-Environnement et Agronomie (E.A.)-Biologie et Amélioration des Plantes (BAP)-Fourrages Environnement Ruminants Lusignan (FERLUS), Laboratoire de Physique et Physiologie Intégratives de l’Arbre en environnement Fluctuant (PIAF), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Fourrages Environnement Ruminants Lusignan (FERLUS), and Institut National de la Recherche Agronomique (INRA)

Subjects
0106 biological sciences, root growth, cell populations, chemistry.chemical_element, Root system, 01 natural sciences, nitrogen, Diffusion layer, lcsh:Agriculture, 03 medical and health sciences, chemistry.chemical_compound, population cellulaire, Nutrient, Nitrate, nitrate, Phytoplankton, ion transport models, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, Diffusion (business), modèle logistique, nitrateion transport models, logistic models, nutrient uptake-kinetics, diffusion, root aging, phytoplankton, cell population, 030304 developmental biology, Thermodynamic process, logistic model, 0303 health sciences, Vegetal Biology, phytoplancton, nitrogène, lcsh:S, transport d'ion, Nitrogen, croissance racinaire, chemistry, Biological system, Agronomy and Crop Science, Biologie végétale, 010606 plant biology & botany
Abstract

Under field conditions, plants need to optimize nutrient ion and water acquisition in their fluctuating environment. One of the most important variables involved in variations of ion uptake processes is temperature. It modifies the thermodynamic processes of root uptake and ion diffusion in soil throughout day⁻night and ontogenetic cycles. Yet, most models of nitrogen (N) uptake in plants are built from set values of microscopic kinetic parameters, Vm and Km, derived from a Michaelis⁻Menten (MM) interpretation of nutrient isotherms. An isotherm is a curve depicting the response of root nitrate influx to external nitrate concentrations at a given temperature. Models using the MM formalism are based on several implicit assumptions that do not always hold, such as homothetic behavior of the kinetic parameters between the different root biological scales, i.e., the epidermis cell, root segments, root axes, and the whole root system. However, in marine phytoplankton, it has been clearly demonstrated that the macroscopic behavior in the nutrient uptake of a colony cannot be confounded with the microscopic behavior of individual cells, due to the cell diffusion boundary layer. The same is also true around plant root segments. Improved N uptake models should either take into account the flexibility of the kinetic parameters of nitrate uptake at the cellular level (porter⁻diffusion approach) or use the more realistic macroscopic kinetic parameters proposed by the flow⁻force approach. Here we present recent solutions proposed in marine phytoplankton and plant nutrient uptake models to make a more flexible description of the nutrient ion uptake process. Use of the mechanistic porter⁻diffusion approach developed in marine phytoplankton introduces more flexibility in response to cell characteristics and physical processes driven by temperature (diffusion and convection). The thermodynamic flow⁻force interpretation of plant-based nutrient uptake isotherms introduces more flexibility in response to environmental cues and root aging. These two approaches could help solve many problems that modelers encounter in these two research areas.

Published
2019

45. Aluminum and tin: Food contamination and dietary intake in an Italian population

Author

Federica Violi, Silvia Cilloni, Tommaso Filippini, Carlotta Malagoli, Annalisa Bargellini, Marco Vinceti, Stefano Tancredi, Luciano Vescovi, and Marcella Malavolti

Subjects
Adult, Male, Adolescent, Aluminum, Tin, Dietary intake, Food contamination, Food safety, Population, chemistry.chemical_element, Food Contamination, Food contamination, 010501 environmental sciences, 01 natural sciences, Biochemistry, Mass Spectrometry, Food safety, Inorganic Chemistry, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Animal science, Interquartile range, Humans, Medicine, Processed meat, education, Aged, 0105 earth and related environmental sciences, Aged, 80 and over, education.field_of_study, business.industry, Dietary intake, food and beverages, Nutrients, Middle Aged, Italian population, Italy, chemistry, Tin, Molecular Medicine, Female, business, 030217 neurology & neurosurgery, Food contaminant, Aluminum
Abstract

Aluminum and tin are ubiquitous in the environment. In normal biological systems, however, they are present only in trace amounts and have no recognized biological functions in humans. High exposure to these metals can result in adverse health effects such as neurodegenerative diseases. In non-occupationally exposed subjects, diet is the primary source of exposure. In this study, we aimed at estimating dietary aluminum and tin intake in an Italian adult population. We measured aluminum and tin concentrations through inductively-coupled plasma mass spectrometry in 908 food samples. We also estimated dietary intake of these two metals, by using a validated semi-quantitative food-frequency questionnaire administered to 719 subjects (319 men and 400 women) recruited from the general population of the Emilia Romagna region, Northern Italy. We found the highest aluminum levels in legumes, sweets, and cereals, while the highest tin levels were in sweets, meat and seafood. The estimated median daily dietary intake of aluminum was 4.1 mg/day (Interquartile range – IQR: 3.3–5.2), with a major contribution from beverages (28.6%), cereals (16.9%), and leafy vegetables (15.2%). As for tin, we estimated a median intake of 66.8 μg/day (IQR: 46.7–93.7), with a major contribution from vegetables (mainly tomatoes) (24.9%), fruit (15.5%), aged cheese (12.2%), and processed meat (10.4%). This study provides an updated estimate of the dietary intake of aluminum and tin in a Northern-Italy adult population, based on data from a validated food-frequency questionnaire. The intake determined for this population does not exceed the established thresholds of tolerable intake.

Published
2019

46. Impact of prolonged maraviroc treatment on non-AIDS-related comorbidities in HIV-positive patients: a retrospective cohort study

Author

Elena Ricci, Stefano Zona, Federica Carli, Stefania Piconi, Jovana Milic, Antonella Foschi, Giuliano Rizzardini, Andrea Malagoli, and Giovanni Guaraldi

Subjects
Adult, Male, 0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Time Factors, Anti-HIV Agents, Population, HIV Infections, Comorbidity, CCR5 receptor antagonist, Gastroenterology, Maraviroc, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Antiretroviral Therapy, Highly Active, Statistical significance, Internal medicine, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, education, Retrospective Studies, Pharmacology, education.field_of_study, business.industry, Incidence, Incidence (epidemiology), Retrospective cohort study, Middle Aged, Viral Load, medicine.disease, CD4 Lymphocyte Count, Treatment Outcome, 030104 developmental biology, Infectious Diseases, chemistry, CCR5 Receptor Antagonists, Female, business, Lipoprotein
Abstract

Objectives This retrospective study evaluates the effect of maraviroc, the first CCR5 receptor antagonist, on non-AIDS-related comorbidity incidence and its impact on inflammatory and lipid parameters. Methods Seventy-four HIV patients on maraviroc treatment were compared with 312 patients never exposed to maraviroc (matched for sex, age and CD4 nadir). Results At baseline (T0), maraviroc patients presented a longer duration of HIV infection, a higher prevalence of comorbidities and a greater frequency of polypharmacy. Non-AIDS-defining disease incidence was lower in the maraviroc group than in the non-maraviroc group (without achieving statistical significance). Except triglycerides (TGL), which dropped only in the maraviroc group, inflammatory and immunological parameters did not significantly change in either group by the end of the study period (T3). At T3, high-sensitivity C-reactive protein (hsCRP) and high-density lipoprotein were inversely correlated in both groups (Spearman’s rho: maraviroc −0.30, P = 0.05; non-maraviroc −0.23, P = 0.0003). Only in the non-maraviroc group was the positive correlation between hsCRP and lipids observed both at T0 (hsCRP/low-density lipoprotein (LDL) +0.17, P = 0.004; hsCRP/total cholesterol +0.20, P = 0.0007; hsCRP/TGL +0.12, P = 0.04) and T3 (hsCRP/LDL +0.26, P Conclusions These data suggest a possible protective role of maraviroc in the incidence of non-AIDS-related comorbidities in a population with longer-lasting infection and allow us to hypothesize its role in the modulation of lipid-dependent inflammation.

Published
2019

47. Quality of turkeys breast meat affected by white striping myopathy

Author

Pedro Alves de Souza, Fábio Ferrari, Francisco Allan Leandro de Carvalho, Lizandra Amoroso, Marco Antonio Trindade, A. Giampietro-Ganeco, Casey M. Owens, Juliana Lolli Malagoli de Mello, Hirasilva Borba, Larissa Tátero Carvalho, Rodrigo Alves de Souza, Universidade de São Paulo (USP), University of Arkansas, and Universidade Estadual Paulista (Unesp)

Subjects
Male, Dorsum, Turkeys, Meat, white striping, PROCESSING AND PRODUCT, CARNES E DERIVADOS, Sarcomere, Pectoralis Muscles, chemistry.chemical_compound, Animal science, Muscular Diseases, medicine, Animals, turkey, softness, Myopathy, Quality characteristics, connective tissue, lcsh:SF1-1100, chemistry.chemical_classification, Chemistry, Cholesterol, Pectoralis major muscle, Fatty acid, General Medicine, Breed, Female, Animal Science and Zoology, lcsh:Animal culture, medicine.symptom, Chickens, pectoralis major, Brazil
Abstract

Made available in DSpace on 2021-06-25T10:54:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01 ASCRS Research Foundation The aim of this study was to characterize the breast meat of turkeys affected by different degrees of severity (normal [NORM], moderate [MOD], and severe [SEV]) of the white striping (WS) myopathy, as well as to evaluate the influence of this myopathy on meat quality. Twenty-nine samples of the pectoralis major muscles of each treatment were obtained from Nicholas breed male and female turkeys, reared and slaughtered in the center-west region of Brazil. The whole breasts of the turkeys were used for macroscopic classification, weight evaluation, and morphometric measurements. Then, the pectoralis major muscle was separated for histological evaluation and qualitative physicochemical analyses, namely ventral and dorsal color (L∗, a∗, and b∗), pH value, water holding capacity (WHC), cooking loss (CL), shear force (SF) (Meullenet-Owens Razor Shear [MORS] and Warner-Bratzler), sarcomere length, total, soluble, and insoluble collagen contents, proximate composition (protein, lipids, moisture, and ash), cholesterol content, and fatty acid profile. The results showed that muscles affected by myopathy, both MOD and SEV, exhibited larger weights (around 2.8 kg) compared to NORM muscles (1.3 kg) and a significant increase (P < 0.05) in the diameter of the fibers. The increase in the degree of severity of the myopathy increased (P < 0.05) the value of L∗ of the dorsal part and ventral part of the muscle. No differences (P > 0.05) were observed in the pH, CL, and WHC values of the muscles, whereas the MORS and Warner-Bratzler SF of the SEV fillets resulted in significantly lower shear values (P < 0.05) compared to the NORM fillets. In addition, the MOD and SEV fillets presented lower values of protein (P < 0.05) than NORM fillets. No significant differences (P > 0.05) were observed for moisture and lipid and cholesterol contents. Meat with MOD and SEV severity of WS myopathy had higher (P < 0.05) concentrations of total and insoluble collagen. Thus, the presence of WS myopathy in MOD and SEV degrees affected a large part of the histological and quality characteristics evaluated. Department of Food Engineering Faculty of Animal Science and Food Engineering University of São Paulo - USP Avenida Duque de Caxias Norte Department of Poultry Science University of Arkansas Department of Technology University of Agricultural and Veterinary Sciences - UNESP Jaboticabal SP Brazil Via de Acesso Professor Paulo Donato Castellane Department of Technology University of Agricultural and Veterinary Sciences - UNESP Jaboticabal SP Brazil Via de Acesso Professor Paulo Donato Castellane

Published
2021

48. Highly dipolar, optically nonlinear adducts of tetracyano-p-quinodimethane: synthesis, physical characterization, and theoretical aspects

Author

Szablewski, Marek, Thomas, Philip R., Thornton, Anna, Bloor, David, Cross, Graham H., Cole, Jacqueline M., Howard, Judith A.K., Malagoli, Massimo, Meyers, Fabienne, Bredas, Jean-Luc, Wenseleers, Wim, and Goovaerts, Etienne

Subjects
Spectrum analysis -- Usage, Nuclear magnetic resonance spectroscopy -- Usage, Dipole moments -- Analysis, Polarization (Light) -- Analysis, Methane -- Research, Quantum chemistry -- Analysis, Chemistry
Abstract

The synthesis, physical characterization and theoretical aspects of a new series of nonlinear optical molecules were investigated using nuclear magnetic resonance spectroscopy and quantum-chemical calculations. The molecules which were synthesized via the reaction of tertiary amines with tetracyano-p-quinodimethane, were found to exhibit a charge-separated ground state structure. The polarization properties of the molecules were also found to evolve with increasing solvent polarity.

Published
1997

49. System analysis of metabolism and the transcriptome in Arabidopsis thaliana roots reveals differential co-regulation upon iron, sulfur and potassium deficiency

Author

Mario Malagoli, Norbert Gretz, Michael Reichelt, Carsten Sticht, Markus Wirtz, Ruediger Hell, Malcolm J. Hawkesford, and Ilaria Forieri

Subjects
0106 biological sciences, 0301 basic medicine, biology, Physiology, chemistry.chemical_element, Plant Science, Metabolism, biology.organism_classification, 01 natural sciences, Sulfur, Transcriptome, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Nutrient, Sulfur assimilation, chemistry, Biochemistry, Arabidopsis, Potassium deficiency, Abscisic acid, 010606 plant biology & botany
Abstract

Deprivation of mineral nutrients causes significant retardation of plant growth. This retardation is associated with nutrient-specific and general stress-induced transcriptional responses. In this study, we adjusted the external supply of iron, potassium and sulfur to cause the same retardation of shoot growth. Nevertheless, limitation by individual nutrients resulted in specific morphological adaptations and distinct shifts within the root metabolite fingerprint. The metabolic shifts affected key metabolites of primary metabolism and the stress-related phytohormones, jasmonic, salicylic and abscisic acid. These phytohormone signatures contributed to specific nutrient deficiency-induced transcriptional regulation. Limitation by the micronutrient iron caused the strongest regulation and affected 18% of the root transcriptome. Only 130 genes were regulated by all nutrients. Specific co-regulation between the iron and sulfur metabolic routes upon iron or sulfur deficiency was observed. Interestingly, iron deficiency caused regulation of a different set of genes of the sulfur assimilation pathway compared with sulfur deficiency itself, which demonstrates the presence of specific signal-transduction systems for the cross-regulation of the pathways. Combined iron and sulfur starvation experiments demonstrated that a requirement for a specific nutrient can overrule this cross-regulation. The comparative metabolomics and transcriptomics approach used dissected general stress from nutrient-specific regulation in roots of Arabidopsis.

Published
2016

50. Fine-tuning of root elongation by ethylene: a tool to study dynamic structure–function relationships between root architecture and nitrate absorption

Author

Philippe Malagoli, Erwan Le Deunff, Julien Lecourt, Ecophysiologie Végétale, Agronomie et Nutritions (EVA), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Recherche Agronomique (INRA), East Malling Research, Laboratoire de Physique et Physiologie Intégratives de l'Arbre Fruitier et Forestier (PIAF), Institut National de la Recherche Agronomique (INRA)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Institut National de la Recherche Agronomique (INRA)-Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)

Subjects
0106 biological sciences, 0301 basic medicine, Ethylene, Nitrogen assimilation, transporter nrt2.1, Reviews, Plant Science, Root system, root architecture, 1-aminocyclopropane-1-carboxylic acid, Biology, lateral root, 01 natural sciences, nitrogen use efficiency, soil, 03 medical and health sciences, chemistry.chemical_compound, Biosynthesis, architecture racinaire, Auxin, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, 1-Aminocyclopropane-1-carboxylic acid, cell elongation, chemistry.chemical_classification, response, arabidopsis-thaliana root, aminotransferases, predicting solute uptake, Lateral root, Nitrate uptake, auxin biosynthesis, ethylene biosynthesis, Meristem, precursor 1-aminocyclopropane-1-carboxylic acid, aminocyclopentane, aminotransférase, gene-expression, independently measured, plant-growth, 030104 developmental biology, Biochemistry, chemistry, Biophysics, biosynthesis, l-aminoethoxyvinyl-glycine, auxin, 010606 plant biology & botany
Abstract

Background Recently developed genetic and pharmacological approaches have been used to explore NO3- /ethylene signalling interactions and how the modifications in root architecture by pharmacological modulation of ethylene biosynthesis affect nitrate uptake. Key Results Structure-function studies combined with recent approaches to chemical genomics highlight the non-specificity of commonly used inhibitors of ethylene biosynthesis such as AVG (L-aminoethoxyvinylglycine). Indeed, AVG inhibits aminotransferases such as ACC synthase (ACS) and tryptophan aminotransferase (TAA) involved in ethylene and auxin biosynthesis but also some aminotransferases implied in nitrogen (N) metabolism. In this framework, it can be assumed that the products of nitrate assimilation and hormones may interact through a hub in carbon (C) and N metabolism to drive the root morphogenetic programme (RMP). Although ethylene/auxin interactions play a major role in cell division and elongation in root meristems, shaping of the root system depends also on energetic considerations. Based on this finding, the analysis is extended to nutrient ion-hormone interactions assuming a fractal or constructal model for root development. Conclusion Therefore, the tight control of root structure-function in the RMP may explain why over-expressing nitrate transporter genes to decouple structure-function relationships and improve nitrogen use efficiency (NUE) has been unsuccessful.

Published
2016

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