1. Neuroprotective Properties of Common Lady’s Mantle Infusion
- Author
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N. I. Suslov, E. V. Mazin, I. A. Samylina, V. M. Baeva, I. V. Shilova, and N. B. Lazareva
- Subjects
Pharmacology ,biology ,010405 organic chemistry ,Chemistry ,Pharmacology toxicology ,Lady's mantle ,biology.organism_classification ,Hypoxic exposure ,01 natural sciences ,Neuroprotection ,Brain homogenate ,0104 chemical sciences ,Lipid peroxidation ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Alchemilla vulgaris ,Drug Discovery - Abstract
The infusion from the aerial part of common lady’s mantle Alchemilla vulgaris L. injected preliminarily for 5 d exhibited neuroprotective properties by normalizing conditioned reflexes and orientational-exploratory behavior indicators of animals after hypoxic exposure. Infusion at a dose of 5 mL/kg was the most active. A. vulgaris infusion at a dose of 5 mL/kg with activation of lipid peroxidation after hypoxic action normalized the content of thiobarbiturate-reactive products in brain homogenate and reduced the concentration of antiradical antioxidants in the lipid extract.
- Published
- 2020