962 results on '"Li, Luo"'
Search Results
2. Tora3D: an autoregressive torsion angle prediction model for molecular 3D conformation generation
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Zimei Zhang, Gang Wang, Rui Li, Lin Ni, RunZe Zhang, Kaiyang Cheng, Qun Ren, Xiangtai Kong, Shengkun Ni, Xiaochu Tong, Li Luo, Dingyan Wang, Xiaojie Lu, Mingyue Zheng, and Xutong Li
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Conformations generation ,Autoregressive ,Transformer ,Deep learning ,Small molecules ,Information technology ,T58.5-58.64 ,Chemistry ,QD1-999 - Abstract
Abstract Three-dimensional (3D) conformations of a small molecule profoundly affect its binding to the target of interest, the resulting biological effects, and its disposition in living organisms, but it is challenging to accurately characterize the conformational ensemble experimentally. Here, we proposed an autoregressive torsion angle prediction model Tora3D for molecular 3D conformer generation. Rather than directly predicting the conformations in an end-to-end way, Tora3D predicts a set of torsion angles of rotatable bonds by an interpretable autoregressive method and reconstructs the 3D conformations from them, which keeps structural validity during reconstruction. Another advancement of our method over other conformational generation methods is the ability to use energy to guide the conformation generation. In addition, we propose a new message-passing mechanism that applies the Transformer to the graph to solve the difficulty of remote message passing. Tora3D shows superior performance to prior computational models in the trade-off between accuracy and efficiency, and ensures conformational validity, accuracy, and diversity in an interpretable way. Overall, Tora3D can be used for the quick generation of diverse molecular conformations and 3D-based molecular representation, contributing to a wide range of downstream drug design tasks. Graphical Abstract
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- 2023
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3. Photo-Luminescent Photonic Crystals for Anti-Counterfeiting
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Chenjing Xu, Changgeng Huang, Dongpeng Yang, Li Luo, and Shaoming Huang
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Chemistry ,QD1-999 - Published
- 2022
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4. A Highly Efficient Composite Catalyst (Au/Ta3N5)/CdS for Photocatalytic Hydrogen Production
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Jinfeng Tian, Xing Wen, Wenfeng Hu, Li Luo, Wei Wang, Keying Lin, Haijuan Zhan, and Baojun Ma
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co-catalyst ,Ta3N5 ,capacitance catalysis ,photocatalytic hydrogen production ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
As non-noble metal co-catalysts, Nitrides have received extensive attention for their high efficiency and low cost in photocatalytic hydrogen production. In this study, we develop a novel composite co-catalyst of Au/Ta3N5 that significantly enhanced the photocatalytic hydrogen production activity of CdS. The activity of photocatalyst (Au/Ta3N5)/CdS is 7.3 times of bare CdS and 2.2 times of Ta3N5/CdS. The proper capacitance and enhanced activity of Ta3N5 demonstrates the capacitance catalysis effect of Ta3N5, which improves the charges separation and storing of the photoexcited electrons from CdS. Au acts as an active site for proton reduction to further improve the activity.
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- 2023
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5. Experimental and Numerical Analysis of the Progressive Damage and Failure of SiCf/TC4 Composite Shafts
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Li Luo, Jingxuan Wang, Yundong Sha, Yanping Hao, and Fengtong Zhao
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SiCf/TC4 composite shaft ,progressive damage ,failure modes ,cross-scale models ,experiment ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Long fibre-reinforced metal matrix composite materials, which are widely used in industry, have complex and diverse damage modes due to their structural characteristics. In this study, the progressive damage process and failure mode analysis of the SiCf/TC4 composite shafts were thoroughly investigated under single torsional loads. A bearing performance test was carried out, the damage process was monitored using acoustic emissions, and the fracture specimens were analysed using a scanning electron microscope (SME). More specifically, under reverse torque loading, the damage process was slow-varying, the interface was subjected to tensile force, and fracture occurred mostly in the form of interface cracking; further, the breaking load of the specimen was 11,812 Nm. Under forward loading, the damage process was fast-varying. The fibres were subjected to tensile forces, and the fracture form was mostly fibre fracture; the breaking load of the specimen was 10,418 Nm. Under torque loading, the first damage to the specimens appeared in the outermost layer of the composite material’s reinforced section, and the initial cracking position was at the interface, expanding from the outside to the inside. Based on the principles of macro-mechanics and micro-mechanics theory, the cross-scale models were proposed, which contain the shaft with the same dimensions as the specimen and a micro-mechanics representative volume element (RVE) model. The initial interface damage load was 6552 Nm under reverse torque loading. Under forward loading, the initial interface damage load was 9108 Nm. In comparison to the acoustic emission test results, the main goal was to calculate the progressive damage process under the same conditions as the experiment, verifying the effectiveness of the cross-scale models.
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- 2023
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6. High-Performance P- and N-Type SiGe/Si Strained Super-Lattice FinFET and CMOS Inverter: Comparison of Si and SiGe FinFET
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Yi-Ju Yao, Ching-Ru Yang, Ting-Yu Tseng, Heng-Jia Chang, Tsai-Jung Lin, Guang-Li Luo, Fu-Ju Hou, Yung-Chun Wu, and Kuei-Shu Chang-Liao
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super-lattice ,strain ,SiGe ,FinFET ,inverter ,ON–OFF current ratio ,Chemistry ,QD1-999 - Abstract
This research presents the optimization and proposal of P- and N-type 3-stacked Si0.8Ge0.2/Si strained super-lattice FinFETs (SL FinFET) using Low-Pressure Chemical Vapor Deposition (LPCVD) epitaxy. Three device structures, Si FinFET, Si0.8Ge0.2 FinFET, and Si0.8Ge0.2/Si SL FinFET, were comprehensively compared with HfO2 = 4 nm/TiN = 80 nm. The strained effect was analyzed using Raman spectrum and X-ray diffraction reciprocal space mapping (RSM). The results show that Si0.8Ge0.2/Si SL FinFET exhibited the lowest average subthreshold slope (SSavg) of 88 mV/dec, the highest maximum transconductance (Gm, max) of 375.2 μS/μm, and the highest ON–OFF current ratio (ION/IOFF), approximately 106 at VOV = 0.5 V due to the strained effect. Furthermore, with the super-lattice FinFETs as complementary metal–oxide–semiconductor (CMOS) inverters, a maximum gain of 91 v/v was achieved by varying the supply voltage from 0.6 V to 1.2 V. The simulation of a Si0.8Ge0.2/Si super-lattice FinFET with the state of the art was also investigated. The proposed Si0.8Ge0.2/Si strained SL FinFET is fully compatible with the CMOS technology platform, showing promising flexibility for extending CMOS scaling.
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- 2023
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7. Giant Negative Electrocaloric Effect in Anti-Ferroelectric (Pb0.97La0.02)(Zr0.95Ti0.05)O3 Ceramics
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Ying-Cheng Zhao, Qiu-Xiang Liu, Xin-Gui Tang, Yan-Ping Jiang, Bi Li, Wen-Hua Li, Li Luo, and Xiao-Bin Guo
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Chemistry ,QD1-999 - Published
- 2019
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8. Photocatalytic Simultaneous Removal of Nitrite and Ammonia via a Zinc Ferrite/Activated Carbon Hybrid Catalyst under UV–Visible Irradiation
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Jia Ye, Shou-Qing Liu, Wen-Xiao Liu, Ze-Da Meng, Li Luo, Feng Chen, and Jing Zhou
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Chemistry ,QD1-999 - Published
- 2019
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9. Interlinked Microcone Resistive Sensors Based on Self-Assembly Carbon Nanotubes Film for Monitoring of Signals
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Chun-Li Luo, Jun-Yi Jiao, Xing-Jie Su, Lin-Xin Zheng, Wei-Guo Yan, and Dong-Zhou Zhong
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template transfer ,interlinked structure ,Langmuir–Blodgett ,self-assembly ,flexible ,Chemistry ,QD1-999 - Abstract
Flexible pressure sensors still face difficulties achieving a constantly adaptable micronanostructure of substrate materials. Interlinked microcone resistive sensors were fabricated by polydimethylsiloxane (PDMS) nanocone array. PDMS nanocone array was achieved by the second transferring tapered polymethyl methacrylate (PMMA) structure. In addition, self-assembly 2D carbon nanotubes (CNTs) networks as a conducting layer were prepared by a low-cost, dependable, and ultrafast Langmuir–Blodgett (LB) process. In addition, the self-assembled two-dimensional carbon nanotubes (CNTs) network as a conductive layer can change the internal resistance due to pressure. The results showed that the interlinked sensor with a nanocone structure can detect the external pressure by the change of resistivity and had a sensitive resistance change in the low pressure (
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- 2022
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10. Genome-Wide Characterization and Phylogenetic Analysis of GSK Genes in Maize and Elucidation of Their General Role in Interaction with BZR1
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Hui Li, Li Luo, Yayun Wang, Junjie Zhang, and Yubi Huang
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GSK-3 ,BRs ,gene expression ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Glycogen synthase kinase-3 (GSK-3) is a nonreceptor serine/threonine protein kinase that is involved in diverse processes, including cell development, photomorphogenesis, biotic and abiotic stress responses, and hormone signaling. In contrast with the deeply researched GSK family in Arabidopsis and rice, maize GSKs’ common bioinformatic features and protein functions are poorly understood. In this study, we identified 11 GSK genes in the maize (Zea mays L.) genome via homologous alignment, which we named Zeama;GSKs (ZmGSKs). The results of ZmGSK protein sequences, conserved motifs, and gene structures showed high similarities with each other. The phylogenetic analyses showed that a total of 11 genes from maize were divided into four clades. Furthermore, semi-quantitative RT-PCR analysis of the GSKs genes showed that ZmGSK1, ZmGSK2, ZmGSK4, ZmGSK5, ZmGSK8, ZmGSK9, ZmGSK10, and ZmGSK11 were expressed in all tissues; ZmGSK3, ZmGSK6, and ZmGSK7 were expressed in a specific organization. In addition, GSK expression profiles under hormone treatments demonstrated that the ZmGSK genes were induced under BR conditions, except for ZmGSK2 and ZmGSK5. ZmGSK genes were regulated under ABA conditions, except for ZmGSK1 and ZmGSK8. Finally, using the yeast two-hybrid and BiFC assay, we determined that clads II (ZmGSK1, ZmGSK4, ZmGSK7, ZmGSK8, and ZmGSK11) could interact with ZmBZR1. The results suggest that clade II of ZmGSKs is important for BR signaling and that ZmGSK1 may play a dominant role in BR signaling as the counterpart to BIN2. This study provides a foundation for the further study of GSK3 functions and could be helpful in devising strategies for improving maize.
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- 2022
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11. Strengthening absorption ability of Co–N–C as efficient bifunctional oxygen catalyst by modulating the d band center using MoC
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Xian-Zhu Fu, Jianwen Liu, Jing-Li Luo, Chunyi Zhi, and Ying Guo
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Materials science ,Renewable Energy, Sustainability and the Environment ,Oxygen evolution ,chemistry.chemical_element ,02 engineering and technology ,Overpotential ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Electrochemistry ,Electrocatalyst ,01 natural sciences ,Oxygen ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Adsorption ,chemistry ,Chemical engineering ,0210 nano-technology ,Bifunctional - Abstract
Co–N–C is a promising oxygen electrochemical catalyst due to its high stability and good durability. However, due to the limited adsorption ability improvement for oxygen-containing intermediates, it usually exhibits inadequate catalytic activity with 2-electron pathway and high selectivity of hydrogen peroxide. Herein, the adsorption of Co–N–C to these intermediates is modulated by constructing heterostructures using transition metals and their derivatives based on d-band theory. The heterostructured nanobelts with MoC core and pomegranate-like carbon shell consisting of Co nanoparticles and N dopant (MoC/Co–N–C) are engineered to successfully modulate the d band center of active Co–N–C sites, resulting in a remarkably enhanced electrocatalysis performance. The optimally performing MoC/Co–N–C exhibits outstanding bi-catalytic activity and stability for the oxygen electrochemistry, featuring a high wave-half potential of 0.865 V for the oxygen reduction reaction (ORR) and low overpotential of 370 mV for the oxygen evolution reaction (OER) at 10 mA cm−2. The zinc air batteries with the MoC/Co–N–C catalyst demonstrate a large power density of 180 mW cm−2 and a long cycling lifespan (2000 cycles). The density functional theory calculations with Hubbard correction (DFT + U) reveal the electron transferring from Co to Mo atoms that effectively modulate the d band center of the active Co sites and achieve optimum adsorption ability with “single site double adsorption” mode.
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- 2023
12. Genome Wide Identification of Respiratory Burst Oxidase Homolog (Rboh) Genes in Citrus sinensis and Functional Analysis of CsRbohD in Cold Tolerance
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Yueliang Zhang, Yiwu Zhang, Li Luo, Chunyi Lu, Weiwen Kong, Libao Cheng, Xiaoyong Xu, and Jihong Liu
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Citrus ,respiratory burst oxidase homologs ,cold stress ,ROS ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Respiratory burst oxidase homologs (Rbohs) are critical enzymes involved in the generation of reactive oxygen species (ROS) that play an important role in plant growth and development as well as various biotic and abiotic stresses in plants. Thus far, there have been few reports on the characterization of the Rboh gene family in Citrus. In this study, seven Rboh genes (CsRbohA~CsRbohG) were identified in the Citrus sinensis genome. The CsRboh proteins were predicted to localize to the cell membrane. Most CsRbohs contained four conserved domains, an EF-hand domain, and a transmembrane region. Phylogenetic analysis demonstrated that the CsRbohs were divided into five groups, suggesting potential distinct functions and evolution. The expression profiles revealed that these seven CsRboh genes displayed tissue-specific expression patterns, and five CsRboh genes were responsive to cold stress. Fourteen putative cis-acting elements related to stress response, hormone response, and development regulation were present within the promoters of CsRboh genes. The in-silico microRNA target transcript analyses indicated that CsRbohE might be targeted by csi-miR164. Further functional and physiological analyses showed that the knockdown of CsRbohD in trifoliate orange impaired resistance to cold stress. As a whole, our results provide valuable information for further functional studies of the CsRboh genes in response to cold stress.
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- 2022
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13. Preparation of Pd/SiO2 Catalysts by a Simple Dry Ball-Milling Method for Lean Methane Oxidation and Probe of the State of Active Pd Species
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Li Yang, Chao Fan, Li Luo, Yanyan Chen, Zhiwei Wu, Zhangfeng Qin, Mei Dong, Weibin Fan, and Jianguo Wang
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lean methane mitigation ,catalytic oxidation ,Pd/SiO2 ,ball-milling method ,active Pd species ,Chemical technology ,TP1-1185 ,Chemistry ,QD1-999 - Abstract
A series of Pd/SiO2 catalysts were prepared with different Pd precursors by a dry ball-milling method and used in the catalytic oxidation of lean methane at low temperature. The effect of Pd precursors on the catalytic performance was investigated and the state of the most active Pd species was probed. The results indicate that dry ball-milling is a simple but rather effective method to prepare the Pd/SiO2 catalysts for lean methane oxidation, and palladium acetylacetonate is an ideal precursor to obtain a highly active Pd/SiO2-Acac catalyst with well- and stably dispersed Pd species, owing to the tight contact between acetylacetonate and Si–OH on the SiO2 support. Besides the size and dispersion of Pd particles, the oxidation state of Pd species also plays a crucial role in determining the catalytic activity of Pd/SiO2 in lean methane oxidation at low temperature. A non-monotonic dependence of the catalytic activity on the Pd oxidation state is observed. The activity of various Pd species follows the order of PdOx >> Pd > PdO; the PdOx/SiO2-Acac catalysts (in particular for PdO0.82/SiO2-Acac when x = 0.82) exhibit much higher activity in lean methane oxidation at low temperature than Pd/SiO2-Acac and PdO/SiO2-Acac. The catalytic activity of PdOx/SiO2 may degrade during the methane oxidation due to the gradual transformation of PdOx to PdO in the oxygen-rich ambiance; however, such degradation is reversible and the activity of a degraded Pd/SiO2 catalyst can be recovered through a redox treatment to regain the PdOx species. This work helps to foster a better understanding of the relationship between the structure and performance of supported Pd catalysts by clarifying the state of active Pd species, which should be beneficial to the design of an active catalyst in lean methane oxidation at low temperature.
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- 2021
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14. Steering hydrogen evolution in CO2 electroreduction through tailoring various co-catalysts
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Xian-Zong Wang, Subiao Liu, Qingxia Liu, and Jing-Li Luo
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Industrial electrochemistry ,TP250-261 ,Chemistry ,QD1-999 - Abstract
Electrochemical CO2 reduction reaction (CO2RR) is a sustainable approach to producing carbon-neutral fuels when combined with renewable energies. Besides the emphatic consideration of developing efficient catalysts, a suitable conductive carbon agent served as co-catalyst with a low activity toward the competitive hydrogen evolution reaction (HER), is also highly needed. However, there have been limited studies focused on the investigation of co-catalyst during CO2RR, especially on their HER behavior. We herein explored the HER of various co-catalyst, i.e., acetylene black (AB), carbon black (CB) and graphite flake (GF) as well as carbon nanotube (CNT), and their composites with sub-25 nm Ag nanowires (NWs) as catalysts. GF and CB exhibit a higher activity toward CO2RR and HER, respectively. In contrast, CB/Ag NWs achieve the highest Faraday efficiency and partial current density for CO2RR, whereas CNT/Ag NWs prefer HER. The differences in HER suggest a critical influence of co-catalyst and this study points to a better guidance on the selection of co-catalyst for CO2RR. Keywords: Carbon dioxide reduction reaction, Hydrogen evolution reaction, Carbon support material, Ag nanowires
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- 2019
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15. An FPGA Based Energy Efficient DS-SLAM Accelerator for Mobile Robots in Dynamic Environment
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Yakun Wu, Li Luo, Shujuan Yin, Mengqi Yu, Fei Qiao, Hongzhi Huang, Xuesong Shi, Qi Wei, and Xinjun Liu
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visual semantic SLAM ,semantic segmentation ,FPGA ,hardware acceleration ,mobile robots ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The Simultaneous Localization and Mapping (SLAM) algorithm is a hotspot in robot application research with the ability to help mobile robots solve the most fundamental problems of “localization” and “mapping”. The visual semantic SLAM algorithm fused with semantic information enables robots to understand the surrounding environment better, thus dealing with complexity and variability of real application scenarios. DS-SLAM (Semantic SLAM towards Dynamic Environment), one of the representative works in visual semantic SLAM, enhances the robustness in the dynamic scene through semantic information. However, the introduction of deep learning increases the complexity of the system, which makes it a considerable challenge to achieve the real-time semantic SLAM system on the low-power embedded platform. In this paper, we realized the high energy-efficiency DS-SLAM algorithm on the Field Programmable Gate Array (FPGA) based heterogeneous platform through the optimization co-design of software and hardware with the help of OpenCL (Open Computing Language) development flow. Compared with Intel i7 CPU on the TUM dataset, our accelerator achieves up to 13× frame rate improvement, and up to 18× energy efficiency improvement, without significant loss in accuracy.
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- 2021
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16. ZnS anchored on porous N, S-codoped carbon as superior oxygen reduction reaction electrocatalysts for Al-air batteries
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Kun Xiang, Keke Zhi, Xiaomin Kang, Lei Wang, Jing-Li Luo, Xian-Zhu Fu, Linfang Cui, and Jiujun Zhang
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Battery (electricity) ,Materials science ,chemistry.chemical_element ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Gibbs free energy ,Catalysis ,Biomaterials ,Chemical kinetics ,symbols.namesake ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,chemistry ,Chemical engineering ,Imidazolate ,symbols ,Reversible hydrogen electrode ,Carbon ,Pyrolysis - Abstract
The development of non-precious based oxygen reduction reaction (ORR) catalysts with outstanding catalytic performance is desirable but still a grand challenge for practical Al-air battery. Herein, we report a vulcanization-assisted pyrolysis strategy for creating zeolitic imidazolate framework-derived catalysts with a N, S co-doped carbon support and highly exposed ZnS and Zn-Nx sites. The trithiocyanuric acid (TCA) is found not only to introduce S into the carbon derived from ZIF-8 and ZnS to adjust the electronic structure of carbon matrix during the pyrolysis, but also result in a shrinkage of carbon framework with a hierarchical porous structure. Such an architecture boosts abundant active sites exposed and accelerates remote mass transportation. As a result, the optimized 3.5ZnS/NSC-NaCl-900 delivers an impressive enhanced performance toward ORR in alkaline medium with a high half-wave potential of 0.905 V (vs. reversible hydrogen electrode), which is superior to most of non-precious metal-based catalysts. Density functional theory calculations unveil that the ZnS in 3.5ZnS/NSC-NaCl-900 can effectively lower the Gibbs energy barrier of crucial steps and therefore promotes the reaction kinetics. Furthermore, 3.5ZnS/NSC-NaCl-900 also displays greater power density and specific capacity than Pt/C in Al-air batteries.
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- 2022
17. Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress
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Kun Zhang, Yuan Zhong, Nan Wang, Guixue Wang, Wei Wu, Yi Wang, Juhui Qiu, Tian Tian, Xian Qin, Li Luo, Junli Huang, Kai Qu, and Yuliang Cui
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QH301-705.5 ,Phagocytosis ,Biomedical Engineering ,medicine.disease_cause ,Article ,Biomaterials ,In vivo ,medicine ,Shear stress ,Endothelial cell uptake ,Biology (General) ,Zebrafish ,Materials of engineering and construction. Mechanics of materials ,Blood flow shear stress ,biology ,Chemistry ,Blood flow ,biology.organism_classification ,In vitro ,Cell biology ,Endothelial stem cell ,Oxidative stress ,TA401-492 ,Nanoparticles ,Extracellular vesicles (EVs) ,Biotechnology - Abstract
Extracellular vesicles (EVs) are increasingly used as delivery vehicles for drugs and bioactive molecules, which usually require intravascular administration. The endothelial cells covering the inner surface of blood vessels are susceptible to the shear stress of blood flow. Few studies demonstrate the interplay of red blood cell-derived EVs (RBCEVs) and endothelial cells. Thus, the phagocytosis of EVs by vascular endothelial cells during blood flow needs to be elucidated. In this study, red blood cell-derived extracellular vesicles (RBCEVs) were constructed to investigate endothelial cell phagocytosis in vitro and animal models. Results showed that low magnitude shear stress including low shear stress (LSS) and oscillatory shear stress (OSS) could promote the uptake of RBCEVs by endothelial cells in vitro. In addition, in zebrafish and mouse models, RBCEVs tend to be internalized by endothelial cells under LSS or OSS. Moreover, RBCEVs are easily engulfed by endothelial cells in atherosclerotic plaques exposed to LSS or OSS. In terms of mechanism, oxidative stress induced by LSS is part of the reason for the increased uptake of endothelial cells. Overall, this study shows that vascular endothelial cells can easily engulf EVs in areas of low magnitude shear stress, which will provide a theoretical basis for the development and utilization of EVs-based nano-drug delivery systems in vivo., Graphical abstract Image 1, Highlights • We recently reported that endothelial cells were amateur phagocytic cells for RBCEVs engulfment. • Low magnitude shear stress (LSS and OSS) can increase the uptake of RBCEVs by endothelial cells in vitro and in vivo. • ROS induced by low magnitude shear stress acts as an accelerator to enhance endothelial cells uptake of RBCEVs.
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- 2022
18. In situ construction of hetero-structured perovskite composites with exsolved Fe and Cu metallic nanoparticles as efficient CO2 reduction electrocatalysts for high performance solid oxide electrolysis cells
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Xian-Zhu Fu, Xiuan Xi, Jiujun Zhang, Yun Fan, and Jing-Li Luo
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Electrolysis ,Materials science ,Renewable Energy, Sustainability and the Environment ,Oxide ,General Chemistry ,Electrochemistry ,Electrocatalyst ,Cathode ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,General Materials Science ,Composite material ,Bimetallic strip ,Faraday efficiency ,Perovskite (structure) - Abstract
Solid oxide electrolysis cells (SOECs) have been widely used for efficient conversion of CO2 into valuable fuels and chemicals utilizing clean and renewable alternative energy sources. However, the scarcity of highly active cathode materials prevents their use in real-world applications. Herein, a hetero-structured double perovskite/Ruddlesden–Popper perovskite (DP/RP-P) composites with exsolved Fe-Cu bimetallic nanoparticles are developed via in-situ reduction treatment of Sr2Fe1.25Cu0.25Mo0.5O6-σ (SFCuM) perovskite at high temperatures. The LSGM-electrolyte-supported SOEC with the composite perovskites as cathode demonstrates excellent electrochemical performance in CO2 electrolysis. At an operating temperature of 800 °C and an applied potential of 1.4 V, the current density towards CO2 electrolysis can be as high as 1.7 A cm–2, while the CO production and Faradaic efficiency can be achieved to about 12.8 ml min–1 cm–2 and 95.2%, respectively. These results indicate that the hetero-structured DP/RP-SFCuM composites with exsolved Fe–Cu bimetallic nanoparticles are promising CO2 electrolysis electrocatalysts for high-performance SOECs. Our research therefore highlights the potential for developing extremely efficient electrocatalysts for CO2 electrolysis and utilizations.
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- 2022
19. Highly selective conversion of methane to ethanol over CuFe2O4-carbon nanotube catalysts at low temperature
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Xinquan Shen, Dan Wu, Xian-Zhu Fu, and Jing-Li Luo
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Ethanol ,Materials science ,Composite number ,Alcohol ,General Chemistry ,Carbon nanotube ,Highly selective ,Methane ,law.invention ,Catalysis ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,law ,Scientific method - Abstract
Conversion of methane into liquid alcohol such as ethanol at low temperature in a straight, selective and low energy consumption process remains a topic of intense scientific research but a great challenge. In this work, CuFe2O4/CNT composite is successfully synthesized via a facile co-reduction method and used as catalysts to selectively oxidize methane. At a low temperature of 150 °C, methane is directly converted to ethanol in a single process on the as-prepared CuFe2O4/CNT composite with high selectivity. A mechanism is also proposed for the significant methane selective oxidation performance of the CuFe2O4/CNT composite catalysts.
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- 2022
20. High-Interface-Quality Hf-Based Gate Stacks on Si0.5Ge0.5 Through Aluminum Capping
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Wei-Li Lee, Meng-Chien Lee, Chao-Hsin Chien, Hung-Ru Lin, and Guang-Li Luo
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Quality (physics) ,Materials science ,chemistry ,Aluminium ,business.industry ,Interface (computing) ,Gate stack ,chemistry.chemical_element ,Optoelectronics ,Electrical and Electronic Engineering ,business ,Electronic, Optical and Magnetic Materials - Published
- 2021
21. Single-atomic Pt sites anchored on defective TiO2 nanosheets as a superior photocatalyst for hydrogen evolution
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Junying Song, Jing-Li Luo, Xiaolong Hu, Qingxia Liu, Chunquan Li, Shuilin Zheng, Zhiming Sun, and Hao Zhang
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Reaction mechanism ,Materials science ,Oxide ,Energy Engineering and Power Technology ,Catalysis ,Metal ,chemistry.chemical_compound ,Fuel Technology ,chemistry ,Chemical engineering ,visual_art ,Electrochemistry ,Photocatalysis ,visual_art.visual_art_medium ,Charge carrier ,Density functional theory ,Photocatalytic water splitting ,Energy (miscellaneous) - Abstract
Single-atomic site catalysts have drawn considerable attention because of their maximum atom-utilization efficiency and excellent catalytic activity. In this work, a highly active single-atomic Pt site photocatalyst was synthesized through employing defective TiO2 nanosheets as solid support for photocatalytic water splitting. It indicated that the surface oxygen vacancies on defective TiO2 nanosheets could effectively stabilize the single-atomic Pt sites through constructing a three-center Ti–Pt–Ti structure. The Ti–Pt–Ti structure can hold the stability of isolated single-atomic Pt sites and facilitate the separation and transfer of photoinduced charge carriers, thereby greatly improving the photocatalytic H2 evolution. Notably, our synthesized photocatalyst exhibited a remarkably enhanced H2 evolution performance, and the H2 production rate is up to 13460.7 μmol·h−1·g−1, which is up to around 29.0 and 4.7 times higher than those of TiO2 nanosheets and Pt nanoparticles-TiO2. In addition, a plausible enhanced reaction mechanism was also proposed combining with photo-electrochemical characterizations and density functional theory (DFT) calculation results. Ultimately, it is believed that this work highlights the benefits of a single-site catalyst and paves the way to rationally design the highly active and stable single-atomic site photocatalysts on metal oxide support.
- Published
- 2021
22. Fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage
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Yifang Liu, Jiaojiao Yang, Li Luo, Wei Wu, Kaijing Zhong, Jiyao Li, Mingyue Han, Lizhong Sun, Shijie Shi, and Libang He
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Lipopolysaccharide ,Cell ,Inflammation ,Article ,Proinflammatory cytokine ,chemistry.chemical_compound ,Immune system ,Escherichia coli ,Humans ,Medicine ,Pulpitis ,Fibroblast ,General Dentistry ,business.industry ,Regeneration (biology) ,RK1-715 ,Fibroblasts ,medicine.disease ,medicine.anatomical_structure ,chemistry ,Dentistry ,Cancer research ,Nanoparticles ,Bacterial infection ,medicine.symptom ,business - Abstract
Unrestrained inflammation is harmful to tissue repair and regeneration. Immune cell membrane-camouflaged nanoparticles have been proven to show promise as inflammation targets and multitargeted inflammation controls in the treatment of severe inflammation. Prevention and early intervention of inflammation can reduce the risk of irreversible tissue damage and loss of function, but no cell membrane-camouflaged nanotechnology has been reported to achieve stage-specific treatment in these conditions. In this study, we investigated the prophylactic and therapeutic efficacy of fibroblast membrane-camouflaged nanoparticles for topical treatment of early inflammation (early pulpitis as the model) with the help of in-depth bioinformatics and molecular biology investigations in vitro and in vivo. Nanoparticles have been proven to act as sentinels to detect and competitively neutralize invasive Escherichia coli lipopolysaccharide (E. coli LPS) with resident fibroblasts to effectively inhibit the activation of intricate signaling pathways. Moreover, nanoparticles can alleviate the secretion of multiple inflammatory cytokines to achieve multitargeted anti-inflammatory effects, attenuating inflammatory conditions in the early stage. Our work verified the feasibility of fibroblast membrane-camouflaged nanoparticles for inflammation treatment in the early stage, which widens the potential cell types for inflammation regulation.
- Published
- 2021
23. Macrophage membrane camouflaged reactive oxygen species responsive nanomedicine for efficiently inhibiting the vascular intimal hyperplasia
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Guixue Wang, Li Luo, Wei Wu, Kun Zhang, Kai Qu, Ali Maruf, Dan Tang, Meng Yan, Wenhua Yan, Xian Qin, Yi Wang, Shuai Wu, Yuan Zhong, and Boyan Liu
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Male ,Intimal hyperplasia ,Cell Survival ,Biomedical Engineering ,Pharmaceutical Science ,Medicine (miscellaneous) ,Bioengineering ,Applied Microbiology and Biotechnology ,Lesion ,Mice ,Immune system ,Biomimetic Materials ,medicine ,Medical technology ,Animals ,Macrophage ,R855-855.5 ,Zebrafish ,Cell Proliferation ,Sirolimus ,chemistry.chemical_classification ,Reactive oxygen species ,Hyperplasia ,business.industry ,Research ,Macrophages ,Cell Membrane ,fungi ,medicine.disease ,Molecular medicine ,ROS-responsive ,Mice, Inbred C57BL ,Nanomedicine ,chemistry ,Cancer research ,Molecular Medicine ,medicine.symptom ,Targeted delivery ,Nanoparticle Drug Delivery System ,Reactive Oxygen Species ,Tunica Intima ,business ,TP248.13-248.65 ,Homing (hematopoietic) ,Biotechnology - Abstract
Background Intimal hyperplasia caused by vascular injury is an important pathological process of many vascular diseases, especially occlusive vascular disease. In recent years, Nano-drug delivery system has attracted a wide attention as a novel treatment strategy, but there are still some challenges such as high clearance rate and insufficient targeting. Results In this study, we report a biomimetic ROS-responsive MM@PCM/RAP nanoparticle coated with macrophage membrane. The macrophage membrane with the innate “homing” capacity can superiorly regulate the recruitment of MM@PCM/RAP to inflammatory lesion to enhance target efficacy, and can also disguise MM@PCM/RAP nanoparticle as the autologous cell to avoid clearance by the immune system. In addition, MM@PCM/RAP can effectively improve the solubility of rapamycin and respond to the high concentration level of ROS accumulated in pathological lesion for controlling local cargo release, thereby increasing drug availability and reducing toxic side effects. Conclusions Our findings validate that the rational design, biomimetic nanoparticles MM@PCM/RAP, can effectively inhibit the pathological process of intimal injury with excellent biocompatibility. Graphical Abstract
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- 2021
24. The Circulating Nucleic Acid Characteristics of Non-Metastatic Soft Tissue Sarcoma Patients
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Nicholas Eastley, Aurore Sommer, Barbara Ottolini, Rita Neumann, Jin-Li Luo, Robert K. Hastings, Thomas McCulloch, Claire P. Esler, Jacqueline A. Shaw, Robert U. Ashford, and Nicola J. Royle
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Genetics ,cell free DNA ,soft tissue sarcoma ,Biology (General) ,QH301-705.5 ,Chemistry ,QD1-999 - Abstract
Soft tissue sarcomas (STS) are rare, malignant tumours with a generally poor prognosis. Our aim was to explore the potential of cell free DNA (cfDNA) and circulating tumour DNA (ctDNA) analysis to track non-metastatic STS patients undergoing attempted curative treatment. The analysed cohort (n = 29) contained multiple STS subtypes including myxofibrosarcomas, undifferentiated pleomorphic sarcomas, leiomyosarcomas, and dedifferentiated liposarcomas amongst others. Perioperative cfDNA levels trended towards being elevated in patients (p = 0.07), although did not correlate with tumour size, grade, recurrence or subtype, suggesting a limited diagnostic or prognostic role. To characterise ctDNA, an amplicon panel covering three genes commonly mutated in STSs was first trialled on serial plasma collected from nine patients throughout follow-up. This approach only identified ctDNA in 2.5% (one in 40) of the analysed samples. Next custom-designed droplet digital PCR assays and Ion AmpliSeq™ panels were developed to track single nucleotide variants identified in patients’ STSs by whole exome sequencing (1–6 per patient). These approaches identified ctDNA in 17% of patients. Although ctDNA was identified before radiologically detectable recurrence in two cases, the absence of demonstrable ctDNA in 83% of cases highlights the need for much work before circulating nucleic acids can become a useful means to track STS patients.
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- 2020
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25. Energy‐saving H 2 Generation Coupled with Oxidative Alcohol Refining over Bimetallic Phosphide Ni 2 P−CoP Junction Bifunctional Electrocatalysts
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Yan Yu, Xian-Zhu Fu, Weilin Wang, Jing-Li Luo, Jie Hao, and Dan Wu
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Electrolysis ,Materials science ,Phosphide ,General Chemical Engineering ,Oxygen evolution ,law.invention ,chemistry.chemical_compound ,General Energy ,chemistry ,Chemical engineering ,law ,Environmental Chemistry ,Water splitting ,General Materials Science ,Formate ,Methanol ,Bifunctional ,Bimetallic strip - Abstract
The realization of large-scale H2 production from electrocatalytic water splitting is severely impeded by the kinetically sluggish and economically less viable anodic oxygen evolution reaction. Here, an efficient strategy was established for the concurrent H2 production and oxidative alcohols refining into value-added formate by utilizing self-supported Ni2 P-CoP bifunctional electrocatalysts. Benefiting from high intrinsic activity, abundant active sites, and synergistic promoting effects of bimetallic phosphides, the constructed two-electrode electrolyzer required a cell voltage of around 1.3 V to achieve 10 mA cm-2 , which is more than 200 mV lower than that of pure water splitting. Moreover, simultaneous productions of H2 with near-unity conversion efficiency and formate at high faradaic efficiencies of 99.8 and 89.6 % oxidatively produced from methanol and glycerol, respectively, were achieved with excellent durability. This work presents a general and economic approach toward the fabrication of cost-effective electrocatalysts for energy-efficient and profitable large-scale renewable energy integration.
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- 2021
26. Bi2O3 Nanosheets Grown on Carbon Nanofiber with Inherent Hydrophobicity for High-Performance CO2 Electroreduction in a Wide Potential Window
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Peng-Fei Sui, Shao-Qing Liu, Jing-Li Luo, Min-Rui Gao, Hongbo Zeng, Lu Gong, Tian Tang, and Ehsan Shahini
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Materials science ,Carbon nanofiber ,General Engineering ,General Physics and Astronomy ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,7. Clean energy ,0104 chemical sciences ,Catalysis ,chemistry.chemical_compound ,Molecular dynamics ,chemistry ,Chemical engineering ,13. Climate action ,General Materials Science ,Formate ,0210 nano-technology ,Selectivity ,Triple phase boundary ,Carbon ,Faraday efficiency - Abstract
The ever-increasing concern for adverse climate changes has propelled worldwide research on the reduction of CO2 emission. In this regard, CO2 electroreduction (CER) to formate is one of the promising approaches to converting CO2 to a useful product. However, to achieve a high production rate of formate, the existing catalysts for CER fall short of expectation in maintaining the high formate selectivity and activity over a wide potential window. Through this study, we report that Bi2O3 nanosheets (NSs) grown on carbon nanofiber (CNF) with inherent hydrophobicity achieve a peak formate current density of 102.1 mA cm-2 and high formate Faradaic efficiency of >93% over a very wide potential window of 1000 mV. To the best of our knowledge, this outperforms all the relevant achievements reported so far. In addition, the Bi2O3 NSs on CNF demonstrate a good antiflooding capability when operating in a flow cell system and can deliver a current density of 300 mA cm-2. Molecular dynamics simulations indicate that the hydrophobic carbon surface can repel water molecules to form a robust solid-liquid-gas triple-phase boundary and a concentrated CO2 layer; both can boost CER activity with the local high concentration of CO2 and through inhibiting the hydrogen evolution reaction (HER) by reducing proton contacts. This water-repelling effect also increases the local pH at the catalyst surface, thus inhibiting HER further. More significantly, the concept and methodology of this hydrophobic engineering could be broadly applicable to other formate-producing materials from CER.
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- 2021
27. Iron and boron-doped carbonized zeolitic imidazolate frameworks as efficient oxygen reduction electrocatalysts for Al-Air batteries
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Guodong Fu, Lei Wang, Xian-Zhu Fu, Fengzhan Si, Xiaohui Deng, Xiaomin Kang, and Jing-Li Luo
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Materials science ,Dopant ,Renewable Energy, Sustainability and the Environment ,Carbonization ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Condensed Matter Physics ,Catalysis ,Fuel Technology ,chemistry ,Chemical engineering ,Boron ,Pyrolysis ,Carbon ,Zeolitic imidazolate framework ,Power density - Abstract
Porous boron-bearing Fe-nitrogen doped carbon electrocatalysts (Fe-BNC) are prepared by pyrolysis treatment of Fe/B co-doped zeolitic imidazolate frameworks (ZIFs). The as-obtained Fe-BNC catalysts with a high surface area (1300 m2 g−1) favor a 4-electron reduction pathway for efficient oxygen reduction reaction (ORR). The Fe-BNC catalysts demonstrate a half-wave potential of ∼0.85 V vs RHE comparable to that of Pt/C catalyst and high stability in 0.1 M KOH. The dopant of little boron and iron into nitrogen-doped carbon results in the high surface area, enhanced surface polarities, electronic properties and exposing more active sites to introduce a synergistic effect for enhanced ORR performance. Moreover, Fe-BNC electrocatalysts used as air cathode for Al-air batteries exhibit a high peak power density of 195.2 mw cm−2 and excellent stability even after discharging for 24 h at room temperature, revealing an excellent performance in application of metal-air batteries and other energy converting devices.
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- 2021
28. Microfabrication of the Ammonia Plasma-Activated Nickel Nitride–Nickel Thin Film for Overall Water Splitting in the Microfluidic Membraneless Electrolyzer
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Suddhasatwa Basu, Neeraj Khare, Anastasia L. Elias, Pawan Kumar, Jing-Li Luo, and Biswajit S. De
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Materials science ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,Nitride ,010402 general chemistry ,7. Clean energy ,01 natural sciences ,law.invention ,law ,Materials Chemistry ,Electrochemistry ,Chemical Engineering (miscellaneous) ,Electrical and Electronic Engineering ,Thin film ,Hydrogen production ,Electrolysis ,021001 nanoscience & nanotechnology ,6. Clean water ,0104 chemical sciences ,Nickel ,chemistry ,Chemical engineering ,13. Climate action ,Hydrogen fuel ,Water splitting ,0210 nano-technology ,Microfabrication - Abstract
Hydrogen production in the microfluidic alkaline membraneless electrolyzer (μAME) marks a new paradigm in sustainable energy technology. One challenge in this field is implementing a bifunctional c...
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- 2021
29. Targeting INMT and interrupting its methylation pathway for the treatment of castration resistant prostate cancer
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Jun-Li Luo, Ji-Hak Jeong, Xueyan Chen, Shangwei Zhong, Li Yang, Changhao Huang, Shohreh I. Dickinson, and Jasreman Dhillon
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Male ,Cancer Research ,Prostate cancer castration-resistance ,Apoptosis ,urologic and male genital diseases ,Gene Expression Regulation, Enzymologic ,Epigenesis, Genetic ,MSC ,Mice ,Prostate cancer ,chemistry.chemical_compound ,Bis(7)-tacrine ,MSA ,Tumor Cells, Cultured ,medicine ,Animals ,Humans ,Epigenetics ,Enzyme Inhibitors ,RC254-282 ,Cell Proliferation ,Gene knockdown ,INMT ,SMYD3 ,Research ,DMT ,Cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Histone-Lysine N-Methyltransferase ,Methyltransferases ,Methylation ,DNA Methylation ,Prognosis ,medicine.disease ,Xenograft Model Antitumor Assays ,Gene Expression Regulation, Neoplastic ,Prostatic Neoplasms, Castration-Resistant ,Methaneseleninic acid ,Oncology ,chemistry ,Tacrine ,Cancer research ,medicine.drug - Abstract
Background Castration-resistant prostate cancer (CRPC) is associated with a very poor prognosis, and the treatment of which remains a serious clinical challenge. Methods RNA-seq, qPCR, western blot and immunohistochemistry were employed to identify and confirm the high expression of indolethylamine N-methyltransferase (INMT) in CRPC and the clinical relevance. Chip assay was used to identify Histone-Lysine N-Methyltransferase (SMYD3) as a major epigenetic regulator of INMT. LC-MS/MS were used to identify new substrates of INMT methylation in CRPC tissues. Gene knockdown/overexpression, MTT and mouse cancer models were used to examine the role of INMT as well as the anticancer efficacy of INMT inhibitor N,N-dimethyltryptamine (DMT), the SMYD3 inhibitor BCl-12, the selenium compounds methaneseleninic acid (MSA) and Se-(Methyl)selenocysteine hydrochloride (MSC), and the newly identified endogenous INMT substrate Bis(7)-tacrine. Results We found that the expression of INMT was highly increased in CRPC and was correlated with poor prognosis of clinical prostate cancer (PCa). INMT promoted PCa castration resistance via detoxification of anticancer metabolites. Knockdown of INMT or treatment with INMT inhibitor N,N-dimethyltryptamine (DMT) significantly suppressed CRPC development. Histone-Lysine N-Methyltransferase SMYD3 was a major epigenetic regulator of INMT expression, treatment with SMYD3 inhibitor BCl-121 suppressed INMT expression and inhibits CRPC development. Importantly, INMT knockdown significantly increased the anticancer effect of the exogenous selenium compounds methaneseleninic acid (MSA) and Se-(Methyl)selenocysteine hydrochloride (MSC) as well as the endogenous metabolite Bis(7)-tacrine. Conclusions Our study suggests that INMT drives PCa castration resistance through detoxification of anticancer metabolites, targeting INMT or its regulator SMYD3 or/and its methylation metabolites represents an effective therapeutic avenue for CRPC treatment.
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- 2021
30. Core–Shell Structured Cu(OH)2@NiFe(OH)x Nanotube Electrocatalysts for Methanol Oxidation Based Hydrogen Evolution
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Kun Xiang, Xian-Zhu Fu, Yan Zhang, Yue Liang, Ge Zaochuan, Xuewan Wang, Jing-Li Luo, Bin Zhao, and Zhongxin Song
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Core shell ,chemistry.chemical_compound ,Nanotube ,Materials science ,chemistry ,Chemical engineering ,General Materials Science ,Hydrogen evolution ,Methanol - Published
- 2021
31. La0.5Sr0.5Fe0.9Mo0.1O3-δ-CeO2 anode catalyst for Co-Producing electricity and ethylene from ethane in proton-conducting solid oxide fuel cells
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Jun Li, Lijuan Wang, Yun Fan, Jing-Li Luo, Lin Shao, Xian-Zhu Fu, and Xiuan Xi
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010302 applied physics ,chemistry.chemical_classification ,Ethylene ,Materials science ,Hydrogen ,Process Chemistry and Technology ,Oxide ,chemistry.chemical_element ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Electrochemistry ,01 natural sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Anode ,chemistry.chemical_compound ,Hydrocarbon ,chemistry ,Chemical engineering ,0103 physical sciences ,Materials Chemistry ,Ceramics and Composites ,Ionic conductivity ,0210 nano-technology ,Perovskite (structure) - Abstract
A La0.5Sr0.5Fe0.9Mo0.1O3-δ-CeO2 (LSFM-CeO2) composite was prepared by impregnating CeO2 into porous La0.5Sr0.5Fe0.9Mo0.1O3-δ perovskite and was used as an anode material for proton-conducting solid oxide fuel cells (SOFCs). The maximum power densities of the BaZr0.1Ce0.7Y0.2O3-δ (BZCY) electrolyte-supported single cell with LSFM-CeO2 as the anode reached 291 mW cm−2 and 190 mW cm−2 in hydrogen and ethane fuel at 750 °C, respectively, which are significantly higher than those of a single cell with only LSFM as the anode. Additionally, the ethylene selectivity and ethylene yield from ethane for the fuel cell at 750 °C were as high as 93.4% and 37.1%, respectively. The single cell also showed negligible degradation in performance and no carbon deposition during continuous operation for 22 h under an ethane fuel atmosphere. The improved electrochemical performance due to the impregnation of CeO2 can be a result of enhanced electronic and ionic conductivity, abundant active sites, and a broad three-phase interface in the resultant composite anode. The LSFM-CeO2 composite is believed to be a promising anode material for proton-conducting SOFCs for co-producing electricity and high-value chemicals from hydrocarbon fuels.
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- 2021
32. Understanding the Roles of Electrogenerated Co 3+ and Co 4+ in Selectivity‐Tuned 5‐Hydroxymethylfurfural Oxidation
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Jing-Li Luo, Xiaohui Deng, Jiujun Zhang, Yue-Jiao Zhang, Xian-Zhu Fu, Lei Wang, Jian-Feng Li, and Ge-Yang Xu
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Reaction mechanism ,Chemistry ,General Medicine ,General Chemistry ,Electrochemistry ,Electrocatalyst ,Combinatorial chemistry ,Redox ,Catalysis ,chemistry.chemical_compound ,Oxidizing agent ,Carboxylate ,Selectivity - Abstract
The Co-based electrocatalyst is among the most promising candidates for electrochemical oxidation of 5-hydroxymethylfurfural (HMF). However, the intrinsic active sites and detailed mechanism of this catalyst remains unclear. We combine experimental evidence and a theoretical study to show that electrogenerated Co3+ and Co4+ species act as chemical oxidants but with distinct roles in selective HMF oxidation. It is found that Co3+ is only capable of oxidizing formyl group to produce carboxylate while Co4+ is required for the initial oxidation of hydroxyl group with significantly faster kinetics. As a result, the product distribution shows explicit dependence on the Co oxidation states and selective production of 5-hydroxymethyl-2-furancarboxylic acid (HMFCA) and 2,5-furandicarboxylic acid (FDCA) are achieved by tuning the applied potential. This work offers essential mechanistic insight on Co-catalyzed organic oxidation reactions and might guide the design of more efficient electrocatalysts.
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- 2021
33. Regeneration of Na2Q in an Electrochemical CO2 Capture System
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Bin Liang, Kejing Wu, Houfang Lu, Li Luo, Yingying Liu, Liangkun Hou, and Yingming Zhu
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Fuel Technology ,Chemical engineering ,Chemistry ,General Chemical Engineering ,Regeneration (biology) ,Energy Engineering and Power Technology ,Electrochemistry - Published
- 2021
34. High-Temperature Electrochemical Devices Based on Dense Ceramic Membranes for CO2 Conversion and Utilization
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Wenping Li and Jing-Li Luo
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Electrolytic cell ,Materials Science (miscellaneous) ,Energy Engineering and Power Technology ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,7. Clean energy ,Methane ,law.invention ,chemistry.chemical_compound ,law ,Electrochemistry ,Chemical Engineering (miscellaneous) ,Ceramic ,Process engineering ,Electrolysis ,Carbon dioxide reforming ,business.industry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Renewable energy ,Membrane ,Electricity generation ,chemistry ,13. Climate action ,visual_art ,visual_art.visual_art_medium ,Environmental science ,0210 nano-technology ,business - Abstract
The adverse effects of global warming and climate change have driven the exploration of feasible routes for CO2 capture, storage, conversion and utilization. The processes related to CO2 conversion in high-temperature electrochemical devices (HTEDs) using dense ceramic membranes are particularly appealing due to the simultaneous realization of highly efficient CO2 conversion and value-added chemical production as well as the generation of electricity and storage of renewable energy in some cases. Currently, most studies are focused on the two processes, CO2 electrolysis and H2O/CO2 co-electrolysis in oxygen-conducting solid oxide electrolysis cell (O-SOEC) reactors. Less attention has been paid to other meaningful CO2-conversion-related processes in HTEDs and systematic summary and analysis are currently not available. This review will fill the gap and classify the CO2-conversion-related processes in HTEDs reported in recent years into four types according to the related reactions, including assisted CO2 reduction to CO, H2O and CO2 co-conversion, dry reforming of methane and CO2 hydrogenation. Firstly, an overview of the fundamentals of HTED processes is presented, and then the related mechanism and research progress of each type of reactions in different HTEDs are elucidated and concluded accordingly. The remaining major technical issues are also briefly introduced. Lastly, the main challenges and feasible solutions as well as the future prospects of HTEDs for CO2-conversion-related processes are also discussed in this review.
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- 2021
35. Electronic Delocalization of Bismuth Oxide Induced by Sulfur Doping for Efficient CO2 Electroreduction to Formate
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Ren-Fei Feng, Shao-Qing Liu, Hongbo Zeng, Min-Rui Gao, Lu Gong, and Jing-Li Luo
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Materials science ,010405 organic chemistry ,Inorganic chemistry ,Doping ,Oxide ,chemistry.chemical_element ,General Chemistry ,010402 general chemistry ,Electrochemistry ,7. Clean energy ,01 natural sciences ,Sulfur ,Catalysis ,0104 chemical sciences ,Bismuth ,chemistry.chemical_compound ,chemistry ,Formate ,Faraday efficiency - Abstract
Developing efficient electrocatalysts for electrochemical CO2 reduction (ECR) to fuels and chemicals with high product faradaic efficiency (FE) and current density is desirable but remains challeng...
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- 2021
36. Mesoporous CeO2–C hybrid spheres as efficient support for platinum nanoparticles towards methanol electrocatalytic oxidation
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Jing-Li Luo, Xian-Zhu Fu, Lei Wang, Weili Li, and Qi Wang
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Materials science ,02 engineering and technology ,General Chemistry ,Carbon black ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Platinum nanoparticles ,01 natural sciences ,0104 chemical sciences ,law.invention ,Catalysis ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,Geochemistry and Petrology ,law ,Calcination ,Methanol ,0210 nano-technology ,Mesoporous material ,Hybrid material ,Methanol fuel - Abstract
The development of direct methanol fuel cells (DMFCs) is partially limited by the poor kinetics of methanol oxidation reaction (MOR) at the anode side. It was reported that the interaction between Pt and CeO2 enhances the electrocatalytic performance of Pt catalyst for MOR. In this work, a hybrid material (CeO2–C) composed of CeO2 and carbon was successfully prepared by a simple hydrothermal method followed by calcination in inert atmosphere. The hierarchically porous nanostructure and especially good electronic conductivity of CeO2–C make it an excellent support for Pt particles for application in electrocatalytic process. TEM investigation reveals that triple-phase interface of Pt, carbon and CeO2 forms in Pt/CeO2–C catalyst. Performance of the as-prepared catalyst for MOR was studied in alkaline medium. The Pt/CeO2–C catalyst shows superior catalytic performance for MOR compared with Pt/CeO2 and the physical mixture of Pt/CeO2 and acetylene black (Pt/CeO2+C). The significantly improved performance can be attributed to the synergetic effect between Pt particles and CeO2–C support, and the better conductivity of CeO2–C. This study provides a possible method to expand the application potential of CeO2 materials in MOR, and may also be used in other electrocatalytic process.
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- 2021
37. Combating marine corrosion on engineered oxide surface by repelling, blocking and capturing Cl−: A mini review
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Jing-Li Luo, Zhenbo Qin, Digby D. Macdonald, Shizhe Song, and Da-Hai Xia
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Blocking (linguistics) ,Materials science ,020209 energy ,Oxide ,Nanotechnology ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Mini review ,Corrosion ,Marine corrosion ,chemistry.chemical_compound ,chemistry ,13. Climate action ,0202 electrical engineering, electronic engineering, information engineering ,Surface modification ,14. Life underwater ,0210 nano-technology - Abstract
Cl−-induced corrosion is one ineluctable problem we face when metals and alloys are exposed to marine environment. Herein, we give a mini review covering the aspects of combating Cl−-induced corrosion from the perspective of surface chemistry. Firstly, the interaction of Cl− with oxide surface is briefly reviewed. Then, we highlight some recent strategies for repelling, blocking and capturing Cl− by using surface chemistry control and surface modification via self-assembling at molecular levels.
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- 2021
38. CCL2 regulation of MST1-mTOR-STAT1 signaling axis controls BCR signaling and B-cell differentiation
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Zhenzhen Li, Yukai Jing, Yingzi Zhu, Yu Hu, Jianlong Tang, Chaohong Liu, Qiuyue Chen, Di Yang, Quan Gong, Danqing Kang, Yanmei Huang, Ju Liu, Qianglin Chen, Xin Dai, Liru Qiu, Yan Chen, Na Li, Lu Yang, Heng Gu, Anwei Chen, Panpan Jiang, Li Luo, Heather Miller, Heng Mei, and Jiang Chang
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0301 basic medicine ,Chemokine ,Receptors, Antigen, B-Cell ,mTORC1 ,CCL2 ,Article ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Proto-Oncogene Proteins ,medicine ,Animals ,Humans ,Molecular Biology ,Chemokine CCL2 ,PI3K/AKT/mTOR pathway ,B cell ,Cell Proliferation ,biology ,Hepatocyte Growth Factor ,Chemistry ,Germinal center ,Cell Differentiation ,Cell Biology ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Proto-Oncogene Proteins c-bcr ,biology.protein ,Chemokines ,Signal transduction ,Signal Transduction - Abstract
Chemokines are important regulators of the immune system, inducing specific cellular responses by binding to receptors on immune cells. In SLE patients, decreased expression of CCL2 on mesenchymal stem cells (MSC) prevents inhibition of B-cell proliferation, causing the characteristic autoimmune phenotype. Nevertheless, the intrinsic role of CCL2 on B-cell autoimmunity is unknown. In this study using Ccl2 KO mice, we found that CCL2 deficiency enhanced BCR signaling by upregulating the phosphorylation of the MST1-mTORC1-STAT1 axis, which led to reduced marginal zone (MZ) B cells and increased germinal center (GC) B cells. The abnormal differentiation of MZ and GC B cells were rescued by in vivo inhibition of mTORC1. Additionally, the inhibition of MST1-mTORC1-STAT1 with specific inhibitors in vitro also rescued the BCR signaling upon antigenic stimulation. The deficiency of CCL2 also enhanced the early activation of B cells including B-cell spreading, clustering and signalosome recruitment by upregulating the DOCK8-WASP-actin axis. Our study has revealed the intrinsic role and underlying molecular mechanism of CCL2 in BCR signaling, B-cell differentiation, and humoral response.
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- 2021
39. Understanding the origin for propane non-oxidative dehydrogenation catalysed by d2-d8 transition metals
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Yaru Yin, Xian-Zhu Fu, Jing-Li Luo, Jianwen Liu, and Wenzhi Luo
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010405 organic chemistry ,Chemistry ,Vanadium ,chemistry.chemical_element ,010402 general chemistry ,Non oxidative ,Photochemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Propene ,chemistry.chemical_compound ,Transition metal ,Propane ,Dehydrogenation ,Physical and Theoretical Chemistry ,HOMO/LUMO - Abstract
Non-oxidative dehydrogenation of propane is a potential route to produce more valuable chemical feedstock propene. Understanding of the catalytic origin is essential for high performance catalysts design. Herein, the detailed mechanisms for non-oxidative dehydrogenation of propane catalysed by silica supported vanadium are systematically studied to elucidate a possible reaction network, in which the stepwise dissociative C-H bond activation is consistently most favourable. Consequently, stepwise dissociative C-H bond activation is used to investigate the d2–d8 transition metal-catalysed non-oxidative dehydrogenation of propane. Frontier orbital analysis reveals that non-oxidative dehydrogenation of propane originates from the interaction between the highest occupied molecular orbital (HOMO) of propane and the lowest unoccupied molecular orbital (LUMO) of the catalysts, indicating that the smaller the gap between the HOMO and LUMO, the higher the reaction activity. Moreover, the largest energy barriers for these reactions correlate with the LUMOcatalyst–HOMOpropane gap. A lower LUMOcatalyst–HOMOpropane gap leads to a lower reaction barrier and higher activity of the catalyst. This study provides a new strategy of theoretical catalyst design for non-oxidative propane dehydrogenation by modulating the gap between the HOMO of propane and the LUMO of catalysts.
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- 2021
40. Folic acid self-assembly synthesis of ultrathin N-doped carbon nanosheets with single-atom metal catalysts
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Wei Ai, Xuewan Wang, Dan Wu, Jing-Li Luo, Kun Xiang, Bin Zhao, Zhongxin Song, Xian-Zhu Fu, Tingting Li, and Jinmeng Sun
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Nanostructure ,Materials science ,Renewable Energy, Sustainability and the Environment ,Hydrogen bond ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,Electrolyte ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Catalysis ,Metal ,Chemical engineering ,chemistry ,visual_art ,visual_art.visual_art_medium ,General Materials Science ,Self-assembly ,0210 nano-technology ,Carbon ,Nanosheet - Abstract
The development of single-atom catalysts anchored on two-dimensional (2D) conductive matrix with well exposed active sites has great significance in electrocatalytic energy storage yet remains challenging. Inspired by the power of biomolecular self-assembly in making delicate nanostructures, we report a novel template-free folic acid (FA) self-assembly strategy to achieve the facile preparation of ultrathin N-doped carbon nanosheet confining single-metal-atom catalysts (M-N-C SAC, M = Co, Ni, Zn, Fe). The 2D association of FA is developed for the first time via the ribbon-like H bonding pattern and metal-FA coordination in a mixed solvent. A tunable metal loading content of the catalysts is facilely realized through a pH-tuned FA partial dissociation chemistry. As a proof of demonstration, Co-N-C SAC shows an excellent performance for lean electrolyte lithium-sulfur battery. Our findinging suggest a new and potentially scalable route for facile fabrication of M-N-C SACs for broad energy storage applications.
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- 2021
41. Broad and dynamic neurochemical alterations in the brain of alcoholic rats
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Li Luo, Xiao-Li Min, Xiang He, and Fei-Fei Shang
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Male ,medicine.medical_specialty ,hippocampus ,nucleus accumbens ,Proton Magnetic Resonance Spectroscopy ,striatum ,Hippocampus ,Striatum ,Nucleus accumbens ,medicine.disease_cause ,Pattern Recognition, Automated ,lcsh:RC321-571 ,chemistry.chemical_compound ,Neurochemical ,Metabolomics ,Internal medicine ,medicine ,Animals ,metabonomics ,rat ,Rats, Wistar ,Prefrontal cortex ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,prefrontal cortex ,Ethanol ,General Neuroscience ,Central Nervous System Depressants ,General Medicine ,ethanol consumption ,metabolomics ,Corpus Striatum ,Rats ,Alcoholism ,Disease Models, Animal ,Endocrinology ,chemistry ,Metabolome ,Oxidative stress - Abstract
Ethanol is the active ingredient in alcoholic beverages. As ethanol consumption increases from zero to very high, it is still unknown which metabolites are present at different times and which are essential to normal functioning. In this article, we used an intermittent-access 20% ethanol drinking paradigm to make Wistar male rats voluntarily drink large amounts of ethanol for 10, 20, 30, and 50 days, respectively. A hydrogen-1 nuclear magnetic resonance approach was used to investigate the time-dependent neurochemical metabolites spectra in the hippocampus, striatum, nucleus accumbens and prefrontal cortex. Multivariate pattern recognition techniques were used to analyze the hydrogen-1 nuclear magnetic resonance spectra data. Metabolic profiling was obtained, differentiating the ethanol-treated and control rats. The ethanol-affected metabolites disrupted processes associated with neurotransmitters, oxidative stress, energy metabolism and amino acids. Together, our findings demonstrate broad, dynamic, and time-dependent endogenous metabolic alterations in rats treated with ethanol.
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- 2021
42. Schottky Barrier Height Modulation of Metal/n-GeSn Contacts Featuring Low Contact Resistivity by in Situ Chemical Vapor Deposition Doping and NiGeSn Alloy Formation
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Guang-Li Luo, Hsiang-Shun Kao, Jiun-Yun Li, C. W. Liu, Kai-Ying Tien, and Yen Chuang
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Electron mobility ,Materials science ,Band gap ,business.industry ,Schottky barrier ,Doping ,Fermi level ,chemistry.chemical_element ,Hardware_PERFORMANCEANDRELIABILITY ,Chemical vapor deposition ,Electronic, Optical and Magnetic Materials ,symbols.namesake ,chemistry ,Hardware_GENERAL ,Electrical resistivity and conductivity ,Hardware_INTEGRATEDCIRCUITS ,Materials Chemistry ,Electrochemistry ,symbols ,Optoelectronics ,business ,Tin ,Hardware_LOGICDESIGN - Abstract
GeSn complementary metal-oxide-semiconductor (CMOS) devices have attracted much attention for future VLSI technology nodes due to high carrier mobility. However, Fermi-level pinning in metal/n-GeSn...
- Published
- 2021
43. Co- and N-doped carbon nanotubes with hierarchical pores derived from metal–organic nanotubes for oxygen reduction reaction
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Xuewan Wang, Pengfei Sui, Chenyu Xu, Jing-Li Luo, Xiuan Xi, Ge Huo, Renfei Feng, and Xian-Zhu Fu
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Materials science ,Energy Engineering and Power Technology ,02 engineering and technology ,Carbon nanotube ,010402 general chemistry ,Electrochemistry ,01 natural sciences ,Catalysis ,law.invention ,Metal ,chemistry.chemical_compound ,law ,Molecule ,Limiting current ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Fuel Technology ,Chemical engineering ,chemistry ,visual_art ,Yield (chemistry) ,visual_art.visual_art_medium ,Methanol ,0210 nano-technology ,Energy (miscellaneous) - Abstract
Biomolecules with a broad range of structure and heteroatom-containing groups offer a great opportunity for rational design of promising electrocatalysts via versatile chemistry. In this study, uniform folic acid–Co nanotubes (FA–Co NTs) were hydrothermally prepared as sacrificial templates for highly porous Co and N co-doped carbon nanotubes (Co–N/CNTs) with well-controlled size and morphology. The formation mechanism of FA–Co NTs was investigated and FA–Co-hydrazine coordination interaction together with the H-bond interaction between FA molecules was characterized to be the driving force for growth of one-dimensional nanotubes. Such distinct metal–ligand interaction afforded the resultant CNTs rich Co–Nx sites, hierarchically porous structure and Co nanoparticle-embedded conductive network, thus an overall good electrocatalytic activity for oxygen reduction. Electrochemical tests showed that Co–N/CNTs-900 promoted an efficient 4e− ORR process with an onset potential of 0.908 V vs. RHE, a limiting current density of 5.66 mA cm−2 at 0.6 V and a H2O2 yield lower than 5%, comparable to that of 20% Pt/C catalyst. Moreover, the catalyst revealed very high stability upon continuous operation and remarkable tolerance to methanol.
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- 2021
44. Copper-cobalt-nickel oxide nanowire arrays on copper foams as self-standing anode materials for lithium ion batteries
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Xian-Zhu Fu, Lin Shao, Chi-Wing Tsang, Jing-Li Luo, Xiaomin Kang, Guodong Fu, Xiao-Ying Lu, Xuewan Wang, and Weili Li
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Fabrication ,Materials science ,Nanowire ,Oxide ,chemistry.chemical_element ,Nanotechnology ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Copper ,Energy storage ,0104 chemical sciences ,Anode ,chemistry.chemical_compound ,chemistry ,Lithium ,0210 nano-technology ,Electrical conductor - Abstract
Numerous scientists are in the pursuit of energy storage materials with high energy and high power density by assembly of electrochemically active materials into conductive scaffolds, owing to the emerging need for next-generation energy storage devices. In this architectures, the active materials bonded to the conductive scaffold can provide a robust and free-standing structure, which is crucial to the fabrication of materials with high gravimetric capacity. Thus, hierarchical copper-cobalt-nickel ternary oxide (CuCoNi-oxide) nanowire arrays grown from copper foam were successfully fabricated as free-standing anode materials for lithium ion batteries (LIBs). CuCoNi-oxide nanowire arrays could provide more active sites owing to the hyperbranched structure, leading to a better specific capacity of 1191 mAh/g, cycle performance of 73% retention in comparison to CuO nanowire structure, which exhibited a specific capacity of 1029 mAh/g and capacity retention of 43%, respectively.
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- 2021
45. Mixed-Solvent Polarity-Assisted Phase Transition of Cesium Lead Halide Perovskite Nanocrystals with Improved Stability at Room Temperature
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Rui Yun, Li Luo, Jingqi He, Jiaxi Wang, Xiaofen Li, Weiren Zhao, Zhaogang Nie, and Zhiping Lin
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cspbbr3 ,cspb2br5 ,solvent polarity ,ctab ,phase transition ,Chemistry ,QD1-999 - Abstract
Cesium lead halide perovskite nanocrystals (NCs) have attracted enormous interest in light-emitting diode, photodetector and low-threshold lasing application in terms of their unique optical and electrical performance. However, little attention has been paid to other structures associated with CsPbBr3, such as CsPb2Br5. Herein, we realize a facile method to prepare dual-phase NCs with improved stability against polar solvents by replacing conventional oleylamine with cetyltrimethyl ammonium bromide (CTAB) in the reprecipitation process. The growth of NCs can be regulated with different ratios of toluene and ethanol depending on solvent polarity, which not only obtains NCs with different sizes and morphologies, but also controls phase transition between orthorhombic CsPbBr3 and tetragonal CsPb2Br5. The photoluminescence (PL) and defect density calculated exhibit considerable solvent polarity dependence, which is ascribed to solvent polarity affecting the ability of CTAB to passivate surface defects and improve stoichiometry in the system. This new synthetic method of perovskite material will be helpful for further studies in the field of lighting and detectors.
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- 2019
- Full Text
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46. Silver catalyzed pyridine‐directed acceptorless dehydrogenation of secondary alcohols
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Chuan-Ming Hong, Qing-Hua Li, Xin Zhuang, Zhen Luo, Li-Qing Ren, Tang-Lin Liu, Qun‐Li Luo, Jing Tao, and Zheng-Qiang Liu
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chemistry.chemical_compound ,chemistry ,Atom economy ,Pyridine ,Dehydrogenation ,General Chemistry ,Medicinal chemistry ,Catalysis - Published
- 2021
47. Transcription factor ZmPLATZ2 positively regulate the starch synthesis in maize
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Huanhuan Huang, Yufeng Hu, Yongbin Wang, Chunxia Zhang, Hanmei Liu, Yayun Wang, Tiandan Long, Guowu Yu, Qiang Yi, Hui Li, Yao Cao, Junjie Zhang, Li Luo, Qianlin Xiao, Yangping Li, Jia Du, Yinghong Liu, Yubi Huang, and Changqing Mao
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biology ,Physiology ,Starch ,Starch synthase activity ,food and beverages ,Promoter ,Plant Science ,Endosperm ,chemistry.chemical_compound ,Transactivation ,chemistry ,Biochemistry ,Gene expression ,biology.protein ,Starch synthase ,Agronomy and Crop Science ,Transcription factor - Abstract
Maize is one of the three major crops worldwide based on its yield and quality. Starch is crucial to both the yield and quality of maize as it accounts more than 60% of the seed weight, and its structure influences the quality of the crop. Starch synthase I (SSI) contributes to the majority of the starch synthase activity in the maize endosperm. An in-depth understanding of the starch synthesis regulatory mechanism would provide opportunities for improving the yield and quality of maize. In this study, ZmPLATZ2, a plant AT-rich sequence and zinc-binding protein (PLATZ) transcription factor related to starch synthesis, was selected based on co-expression analysis. The semiquantitative RT-PCR and qRT-PCR assays revealed that ZmPLATZ2 had a high expression in the endosperm, and reached the peak at 12 days after pollination (DAP). Different treatments demonstrated that ZmPLATZ2 was downregulated by the presence of sucrose. Subsequent transactivation and subcellular localization analyses showed that ZmPLATZ2 was localized in the nuclei without transactivation. Yeast one-hybrid and transient expression in maize endosperm indicated that ZmPLATZ2 could bind to the promoters of ZmSSI, ZmISA1, and ZmISA2 and increase their gene expression. After ZmPLATZ2 overexpression in rice, four starch synthesis genes were significantly upregulated in the transgenic plant, including the OsSSI gene. In vitro DAP-seq data showed that ZmPLATZ2 could bind to the CAAAAAAA element. In conclusion, our data support that ZmPLATZ2 binds to the CAAAAAAA element in the ZmSSI promoter and mediates the Glu signal pathway.
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- 2021
48. Nanomedicine-mediated ubiquitination inhibition boosts antitumor immune response via activation of dendritic cells
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Ying-Li Luo, Senbiao Chen, Ji-Long Wang, Mengwen Huang, Song Shen, and Xiao-Jiao Du
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biology ,Chemistry ,medicine.medical_treatment ,Ubiquitin-activating enzyme ,Antigen presentation ,02 engineering and technology ,Immunotherapy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,0104 chemical sciences ,Immune system ,Cancer immunotherapy ,Ubiquitin ,Antigen ,In vivo ,medicine ,biology.protein ,Cancer research ,General Materials Science ,Electrical and Electronic Engineering ,0210 nano-technology - Abstract
Tumor immunotherapy as a promising method for tumor treatment received tremendous attention. However, the problem of low clinical response rate still needs to be solved, especially in the poorly immunogenic tumors. The enhancement of tumor antigens presentation can effectively activate dendritic cells (DCs) and improve the tumor immunotherapy. In this work, TAK-243 as an inhibitor of the ubiquitin activating enzyme (UAE), was fabricated into cationic lipid-assisted nanoparticle (CLANTAK-243). The obtained CLANTAK-243 could act as an effective tumor immunotherapy enhancer to promote the maturation of DCs as well as antigen presentation, which obviously stimulated the T cells activation and proliferation. Such CLANTAK-243 injected intravenously could well trigger immune response to tumor cells in vivo. Importantly, mice treated with CLANTAK-243 could obtain a long immune memory effect to protect themselves from re-challenged tumor cells. Therefore, this work presented an effective immunotherapy strategy for poorly immunogenic tumor.
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- 2021
49. Promotion of the Asymmetric Reduction of Prochiral Ketone with Recombinant E. coli Through Strengthening Intracellular NADPH Supply by Modifying EMP and Introducing NAD Kinase
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Wei Luo, Zhong-Hua Yang, Zhi-Cheng Zou, Li Luo, Hui-Jun Du, Bright Appiah, and Rong Zeng
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Carbonyl Reductase ,biology ,010405 organic chemistry ,Dehydrogenase ,General Chemistry ,Bacillus subtilis ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Biosynthesis ,chemistry ,Biochemistry ,Biocatalysis ,Glyceraldehyde ,NAD+ kinase ,Intracellular - Abstract
The intracellular NADPH insufficient supply is the main bottleneck to the synthesis of chiral alcohols by asymmetric reduction with whole-cell catalysis. Herein, we provide a novel strategy to strengthen intracellular NADPH supply through introducing an NADP+-dependent glyceraldehyde 3-phosphate dehydrogenase (gapB from Bacillus subtilis 168) into the Embden-Meyerhof pathway and a NAD kinase (yfjB from E. coli MG1655) to further enhance the NADP(H) pool. A recombinant E. coli (E. coli BL21 (DE3)/pETDuet-1-gapB-yueD&pET28a-yfjB) was constructed to co-express gapB and yfjB with a carbonyl reductase gene yueD together. The result showed that the intracellular NADPH amount increased by 134.4% with the strategy. To the model reaction (asymmetric reduction of acetophenone to S-phenyl ethanol), the yield was 3.7-fold with this strategy compared to the control. This provides a technological route for strengthening the intracellular NADPH supply in E. coli for biocatalysis and biosynthesis.
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- 2021
50. Balancing the corrosion resistance and through-plane electrical conductivity of Cr coating via oxygen plasma treatment
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Xian-Zong Wang, Jing-Li Luo, Hong-Qiang Fan, Triratna Muneshwar, and Kenneth C. Cadien
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Materials science ,Polymers and Plastics ,Oxide ,02 engineering and technology ,Electrolyte ,engineering.material ,010402 general chemistry ,01 natural sciences ,Corrosion ,Metal ,chemistry.chemical_compound ,Coating ,Materials Chemistry ,Polarization (electrochemistry) ,Mechanical Engineering ,Contact resistance ,Metals and Alloys ,Sputter deposition ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Chemical engineering ,chemistry ,Mechanics of Materials ,visual_art ,Ceramics and Composites ,visual_art.visual_art_medium ,engineering ,0210 nano-technology - Abstract
Developing an electrically conductive and corrosion-resistant coating is essential for metal bipolar plates of polymer electrolyte membrane fuel cells (PEMFCs). Although enhanced corrosion resistance was seen for Cr coated stainless steel (Cr/SS) bipolar plates, they experience a quick decrease of through-plane electrical conductivity due to the formation of a porous and low-conductive corrosion product layer at the plate surface, thus leading to an increase in interfacial contact resistance (ICR). To tackle this issue, the multilayer Cr coatings were deposited using the magnetron sputtering with a remote inductively coupled oxygen plasma (O-ICP) in the present study. After the O-ICP treatment, a Cr oxide layer (CrO*) is formed on the specimen surface. The CrO*/Cr/SS has a remarkably lower stable corrosion rate (iss) than that of the native Cr oxides (CrOn/Cr/SS). Compared with CrOn/Cr/SS, the excellent performance of CrO*/Cr/SS is attributed to a denser and thicker surface layer of CrO* with Cr being oxidized to its highest valence state, Cr (VI). More importantly, the through-plane electrical conductivity of the specimens treated by the optimized O-ICP decreases much slowly than CrOn/Cr/SS and thus, the increament of ICR of CrO*/Cr/SS after the potentiostatic polarization test is considerably smaller than that of CrOn/Cr/SS, which is benefited from the reduced iss that mitigates the deposition of corrosion products and hinders further oxidation of Cr coating. Therefore, CrO*/Cr/SS proves to be a well balanced trade-off between corrosion resistance and through-plane electrical conductivity. The results of this study demonstrate that O-ICP treatment on a conductive metal coating is an effective strategy to improve the corrosion resistance and suppress the increase of ICR over the long-term polarization. The technique reported herein exhibits its promising potential application in preparing corrosion resistant and electrically conductive coatings on metal bipolar plates to be used in PEMFCs.
- Published
- 2021
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