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Rational utilization of biomass waste into usable energy is of great significance. In this work, a facile method was proposed to prepare porous carbon as supercapacitor electrode by using biomass waste-kapok flower as a precursor. The obtained porous carbon exhibited hierarchical pores rich in microporous and mesoporous, containing oxygen from kapok flowers. The optimal porous carbon ACF-4.5, which was achieved with a mass ratio of KOH to the precursor obtained from kapok flower was 4.5:1, showed a remarkable electrochemical performance with a capacitance as high as 286.8 F/g at 1 A/g current density. It was worth noting that the capacitance retention rate can still reach 97.4% after 5000 cycles, which indicated that the ACF-4.5 supercapacitor electrode has excellent cyclic stability. Therefore, a strategy that not only utilizes biomass waste, but also produces high-performance supercapacitor electrode in industry effectively was realized.

Currently, advanced glycation end product (RAGE) is receiving much attention in carcinogenesis research due to its involvement in cancer progression and metastasis. We therefore sought to examine the association of circulating soluble RAGE (sRAGE) with all types of cancer by a meta-analysis. The PubMed and EMBASE databases were searched before March 1, 2014. Data and study quality were assessed in duplicate. Effect estimates were expressed as weighted mean difference (WMD) and its 95 % confidence interval (CI). Altogether, nine eligible articles including 1,337 cancer patients and 1,839 controls were analyzed. The overall analysis indicated that circulating sRAGE was remarkably reduced by 222.07 pg/ml in cancer patients compared with controls (95 % CI: −373.77 to −70.37; P = 0.004), with heterogeneity and without publication bias. In subgroup analyses, this reduction was weakened yet still significant in prospective studies (WMD = −87.62; 95 % CI: −138.60 to −36.63; P = 0.001) with improved heterogeneity (I 2 = 56.5 %; P = 0.056). Restricting analyses to the large studies (total number of subjects ≥200) identified significant reduction of circulating sRAGE in cancer patients relative to controls (WMD = −231.34; 95 % CI: −450.10 to −12.58; P = 0.038). Further meta-regression analysis showed that smoking status explained some part of heterogeneity for the association of circulating sRAGE with cancer risk (regression coefficient: −67.02; P = 0.046). Our findings demonstrate a protective role of circulating sRAGE in the development of cancer, especially in patients without diabetes mellitus or with normal renal function.

Chloroquine (CQ) has been revealed to exhibit antitumor activity in several human tumors including lung cancer as mono‑ or add‑on therapy. The antitumor effect of CQ appears to depend on the tumor type, stage and genetic context. Few studies have focused on the mechanism concerning the antitumor effect of CQ monotherapy and the cause and effect relationship among autophagy, apoptosis and CQ in human lung A549 cells. Therefore, the present study aimed to identify the antitumor effect of CQ monotherapy and analyze the possible mechanism. In the present study, we demonstrated that CQ suppressed human A549 cell growth in a dose‑ and time‑dependent manner. CQ‑mediated growth inhibition in A549 cells was characterized by the targeting of the PI3K/AKT pathway, thus, inducing mitochondria‑mediated apoptosis at relatively higher concentrations by downregulating Bcl‑2 expression, increasing the expression level of Bax, decreasing mitochondrial membrane potential, releasing cytochrome c from the mitochondria into the cytosol, activating caspase‑3 and cleaving PARP. Collectively, these findings may offer a new rationale for using CQ as a lung cancer therapy drug in clinical practice.

This study was conducted to investigate the free radical-scavenging activity and antioxidant activity of silk sericin hydrolysates (SSH). SSH were obtained by hydrolysis of silk sericin with alcalase, trypsin, neutrase, bromelin, papain and flavourzyme. Its ability to scavenge 2,2′-azinobis (3-ethylbenzothiazoline-6-sulfonicacid) (ABTS) cation radicals and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals was determined by ultraviolet spectrophotometry. The antioxidant activities of the SSH, including lipid peroxidation in linoleic acid system, reducing power and ferrous ion chelating ability, were evaluated. The results showed that different protease hydrolysates possessed different ability to quench the ABTS cation radicals and DPPH radicals. Among those tested, alcalase hydrolysate exhibits the highest scavenging activity than other proteases (P

Haoyaoerhudong gold deposit is located in Inner Mongolia Wulate county. We analysis the characteristics of fluid composition. Salinity values range is from 3.40% to 20.40%; The density of the fluid is from 0.68 to 0.97 g/cm3;Ore-forming pressure is from 11.44 to 58.42MPa;According them, We can separate the fluid into Quartz-pyrite stage, Ore-forming fluid is divided into four stages in Haoyaoerhudong gold deposit. It is quartz calcite phase, the late stage of quartz vein, quartz polymetallic sulfide phase and quartz Pyrite phase. Quartz polymetallic sulfide phase and quartz Pyrite phase is the main metallogenic period in Haoyaoerhudong gold deposit.