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Your search keyword '"Hormone receptors -- Genetic aspects"' showing total 6 results
Start Over Descriptor "Hormone receptors -- Genetic aspects" Topic chemistry
6 results on '"Hormone receptors -- Genetic aspects"'

1. Synthesis and biological evaluation in vitro of selective, high affinity peptide antagonists of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1

Author

Bednarek, Maria A., Hreniuk, Donna L., Tan, Carina, Palyha, Oksana C., MacNeil, Douglas J., Ploeg, Lex H. Y. van der, Howard, Andrew D., and Feighner, Scott D.

Subjects
Biochemistry -- Research, Hormone receptors -- Genetic aspects, Peptides -- Physiological aspects, Melanin -- Physiological aspects, Calcium -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the human melanine-concentrating hormone receptors. The syntheses and biological evaluation of the cyclic peptide human melanine-concentrating hormone receptors have been carried out and the details are presented.

Published
2002

2. Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain

Author

Lee, Wen-yi and Noy, Noa

Subjects
Biochemistry -- Research, Ligand binding (Biochemistry) -- Physiological aspects, Hormone receptors -- Genetic aspects, Acids -- Physiological aspects, Phenylalanine -- Genetic aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the RXR, a nuclear hormone receptor activated by the vitamin A metabolite retionic acid. Results indicate that helix 11 phenylalanine residue mutation diminishes the RXR ability to associate with the coactivators.

Published
2002

3. Modulation of nuclear receptor interactions by ligands: kinetic analyses using surface plasmon resonance

Author

Cheskis, Boris and Freedman, Leonard P.

Subjects
Ligands (Biochemistry) -- Genetic aspects, Plasma spectroscopy -- Usage, Hormone receptors -- Genetic aspects, Biological sciences, Chemistry
Abstract

The reaction rates of protein-protein and protein-DNA interactions by the human 1,25-dihydroxyvitamin D3 receptor (VDR) and 9-cis-retinoic acid receptor (RXR) with or without their cognate ligands was characterized by surface plasmon resonance. Results showed that 1,25 dihydroxyvitamin D3 binding enhances VDR-RXR heterodimerization. As a consequence, the amount of VDR-RXR heterodimers in solution is increased which in turn results to an enlarged VDR-RXR complex formation on DNA.

Published
1996

4. Animal and plant cell lysates share a conserved chaperone system that assembles the glucocorticoid receptor into a functional heterocomplex with hsp90

Author

Stancato, Louis F., Hutchison, Kevin A., Krishna, Priti, and Pratt, William B.

Subjects
Steroid hormones -- Receptors, Heat shock proteins -- Genetic aspects, Hormone receptors -- Genetic aspects, Chemical evolution -- Research, Biological sciences, Chemistry
Abstract

A study was conducted to compare the roles of the heat shock protein 70 (hsp70) from wheat germ lysate and hsp90 from rabbit reticulocyte lysate in the assembly of high-affinity glucocorticoid receptors (GR). Previous studies have shown that hsp90 binds with the hormone-binding domain of GR to form a heterocomplex with high-affinity for steroids. The results show that components of hsp70 interact with the protein-folding system of rabbit hsp90, indicating that the components of the protein-folding system in the assembly of functional GR heterocomplex were preserved during the evolution of plants and animals.

Published
1996

5. Ligand specificity of nuclear hormone receptors: sifting through promiscuity

Author

Noy, Noa

Subjects
Hormone receptors -- Genetic aspects, Ligands (Biochemistry) -- Research, Promiscuity -- Research, Genetic transcription -- Research, Biological sciences, Chemistry
Abstract

The transcriptional activities of the nuclear receptors can be regulated by the small molecules comprised of hydrophobic compounds. Examples of such promiscuous receptors are discussed and strategies, which can be employed in shedding light on the nature of bona fide ligands for such receptors are outlined.

Published
2007

6. Identification of the putative MAP kinase docking site in the thyroid hormone receptor-(beta)1 DNA-binding domain: functional consequences of mutations at the docking site

Author

Lin, Hung-Yun, Zhang, ShenLi, West, Brian L., Tang, Heng-Yuan, Passaretti, Teresa, Davis, Faith B., and Davis, Paul J.

Subjects
Biochemistry -- Research, Protein kinases -- Physiological aspects, Protein kinases -- Genetic aspects, Hormone receptors -- Physiological aspects, Hormone receptors -- Genetic aspects, DNA binding proteins -- Genetic aspects, Gene mutations -- Physiological aspects, Thyroid hormones -- Physiological aspects, Thyroid hormones -- Genetic aspects, Mitogens -- Physiological aspects, Thyroxine -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on nuclear thyroid hormone receptor TR(beta)1.The authors report the identification of the thyroid hormone receptor's serine phosphorylation site in receptor's DNA-binding domain, and the identifications of mitogen-activated protein kinase docking site on thyroid hormone receptor induced by L-thyroxine.

Published
2003

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