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The present study investigates the anti-inflammatory, analgesic effect, and gastric disturbance of curcumin compared with celecoxib and prednisolone. Sixty male rats divided into (Group 1 and G2: control, G3, G4, and G5: orally received celecoxib, prednisolone, and curcumin respectively then received carrageenan in paw after 14 days. Edema, oxidative markers, analgesic, ulcerogenic activity, skin expression of (nuclear factor kappa-β (NF-kappaβ), tumor necrosis factor-alpha (TNF-α), Interleukin-1β (IL1β), IL 6 and IL 10) and gastric mRNA expression of (Heme oxygenase-1 (HO-1), interleukin 8 (IL8), nuclear factor erythroid 2-related factor 2 (Nrf2), NFκβ and Superoxide dismutase (SOD)) were measured. This result revealed that curcumin significantly improved edema, ulcerogenic, analgesic activity, and oxidative markers like celecoxib and prednisolone effect when compared with carrageenan. Curcumin significantly downregulated mRNA expression of the inflammatory markers of skin and gastric mucosae like celecoxib and prednisolone effect when compared with carrageenan. Curcumin, celecoxib, and prednisolone significantly upregulated skin (IL10) compared with carrageenan. Curcumin significantly upregulated Ho-1, SOD, and Nrf2 compared with carrageenan, celecoxib, and prednisolone. Based on the above it could conclude that curcumin displayed anti-inflammatory and analgesic with minimum gastric disturbance, unlike celecoxib and prednisolone.

Several 2-[1-(1,2-dihydroinden-3-ylidene) hydrazono]-5-aryldiazo-4-methyl-1,3-thiazoles were synthesized by reaction of 1-(1,2-Dihydroinden-3-ylidene) thiosemicarbazide with different hydrazonyl chlorides. The products are water insoluble and UV absorbers, expressed UPF-rating values, and their H2O/DMF solutions were used in simultaneous dyeing and resin finishing of cotton fabrics. Results obtained show that finishing of cotton samples in presence of any of that dyes, irrespective of dye concentration, brings about an improvement in percent nitrogen, wrinkle recovery angle (WRA), dyeability, and UV protection rating values along with slight decrease of tensile strength (TS) compared with the untreated samples. Irrespective of dye structure, increasing the dye concentration from 0.5 and up to 1.7% results in an improvement in the percent nitrogen, TS and a remarkable improvement in both the dyeability, UPF-rating values along with slight decrease in WRA and lower fastness properties of the treated fabrics. The treated fabrics was characterized using energy dispersive X-ray analysis indicating the entrapped dye within the fabric structure. © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009