1. METABOLISM OF FRUCTOSE IN DIABETES
- Author
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L. H:son Nilsson, E. Hultman, and A. E. Roch‐Norlund
- Subjects
Blood Glucose ,medicine.medical_specialty ,Fructose ,Fructokinase ,chemistry.chemical_compound ,Internal medicine ,Diabetes Mellitus ,Internal Medicine ,medicine ,Humans ,Glycogen synthase ,Glycogen ,biology ,business.industry ,Glucokinase ,Muscles ,Metabolism ,Stimulation, Chemical ,Liver Glycogen ,Glucose ,Endocrinology ,chemistry ,Glycogenesis ,Fructolysis ,Lactates ,biology.protein ,business - Abstract
Fructose and glucose (4 g/kg body-weight during 4 hours) were given intravenously to normal subjects and to patients with diabetes without insulin treatment. Liver and muscle glycogen content was determined before and after the infusion. In normal subjects glucose and fructose gave similar increases in muscle glycogen stores, while the liver glycogen increased 4 times more after fructose infusion as compared to glucose. In the diabetics only fructose gave a liver glycogen increase and neither fructose nor glucose affected the muscle glycogen content. The mechanism for the glycogen increase in the liver of diabetics after fructose infusion could be due to allosteric activation of glycogen synthetase D and/or to availability of fructokinase.
- Published
- 2009
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