1. An Approach to the Efficient Syntheses of Chiral Phosphino- Carboxylic Acid Esters.
- Author
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Chew, Renta Jonathan, Sepp, Kristel, Li, Bin ‐ Bin, Li, Yongxin, Zhu, Peng ‐ Cheng, Tan, Nguan Soon, and Leung, Pak ‐ Hing
- Subjects
CARBOXYLIC acids ,CHEMICAL synthesis ,BENZOTRIAZOLE ,PHOSPHINE synthesis ,PALLADIUM catalysts ,MICHAEL reaction ,CHEMICAL amplification - Abstract
The catalytic hydrophosphination reaction is one of the most sustainable chemical transformations today. Here, the palladium-catalyzed asymmetric PH addition of diarylphosphines with N-enoylbenzotriazoles and analogues is described. Chiral phosphine products are obtained in 100% atom economy and without cumbersome protection-deprotection manipulations. The obtained products can be subsequently transformed to bear various functionalities, including phosphino-carboxylic esters which play critical roles in catalysis and as synthetic aids. Anti-tumour activities of the corresponding gold-phosphine complexes have been explored, contributing to existing chemotherapeutic research in cancer treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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