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Start Over Author "Malta, Valéria R.S." Topic chemical synthesis
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1. 1,3-Azoles from ortho-naphthoquinones: Synthesis of aryl substituted imidazoles and oxazoles and their potent activity against Mycobacterium tuberculosis

Author

Moura, Kelly C.G., Carneiro, Paula F., Pinto, Maria do Carmo F.R., da Silva, José A., Malta, Valéria R.S., de Simone, Carlos A., Dias, Gleiston G., Jardim, Guilherme A.M., Cantos, Jéssica, Coelho, Tatiane S., da Silva, Pedro E. Almeida, and da Silva, Eufrânio N.

Subjects
*MYCOBACTERIUM tuberculosis, *NAPHTHOQUINONE, *CHEMICAL synthesis, *IMIDAZOLES, *OXAZOLES synthesis, *DRUG synergism, *X-ray crystallography
Abstract

Abstract: Twenty-three naphthoimidazoles and six naphthoxazoles were synthesised and evaluated against susceptible and rifampicin- and isoniazid-resistant strains of Mycobacterium tuberculosis. Among all the compounds evaluated, fourteen presented MIC values in the range of 0.78 to 6.25μg/mL against susceptible and resistant strains of M. tuberculosis. Five structures were solved by X-ray crystallographic analysis. These substances are promising antimycobacterial prototypes. [Copyright &y& Elsevier]

Published
2012
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