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Start Over Author "Choung, Dong-Ho" Topic chemical synthesis
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1. Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent.

Author

Lee, HyeongKyu, Yun, Eunju, Min, JiHye, Yoon, KabSeog, Choung, Dong-Ho, and Lee, Sangku

Subjects
CHEMICAL synthesis, ISOXAZOLES, ANTINEOPLASTIC agents, ANTIMITOTIC agents, CANCER cells, STRUCTURE-activity relationship in pharmacology
Abstract

A diaryl isoxazole compound, KRIBB3, which exhibits strong antimigratory and antimitotic activities against cancer cells, was prepared in a practical synthetic way. The synthetic method may provide easy access to KRIBB3 analogs with various substituents at an aryl moiety for structure–activity relationships (SAR), as well as a large quantity of KRIBB3 for in vivo studies. [ABSTRACT FROM PUBLISHER]

Published
2012
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