1. Novel synthesis of telithromycin.
- Author
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Cao, Zhiling, Liu, Bing, Liu, Weiwei, Yao, Guowei, Liu, Wenjie, and Wan, Qianqian
- Subjects
- *
TELITHROMYCIN , *CARBONATES , *ERYTHROMYCIN , *METHYL ether synthesis , *CHEMICAL synthesis - Abstract
A novel synthesis route for telithromycin was developed based on a 11,12-cylic carbonate protection strategy to prevent formation of 9,12-hemiacetal by-product. Through a 11,12-carbonate-6-O-methylerythromycin intermediate, telithromycin was synthesised from 6-O-methylerythromycin in five steps with 33% overall yield. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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