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Triazoles are a class of chemical compounds known for their diversity and usefulness in chemistry and medicine [1,2]. Their structure allows obtaining of a wide range of derivatives [3]. The most widely used method of synthesis of 1,2,3-triazole derivatives is the "Click Chemistry" reaction between azides and marginal alkynes in Cu (I) catalysis [4]. Using a series of four marginal alkynes and 2-azido-1-(4-methoxyphenyl)ethanone (1), the 1,2,3-triazolic derivative (2a) known in the literature and three new derivatives (2b-d) were obtained by the click method. In order to increase the azide transformation yield, changes were made in the synthesis mode, thus establishing the optimal path to obtain the desired triazole derivatives. All synthesized compounds were purified and characterized physically and spectrally (IR, ¹H-NMR, 13C-NMR). [ABSTRACT FROM AUTHOR]

A mild and efficient α-aza-amidoalkylation for the synthesis of 5-arylaminopyrrolidinones is presented. The key step of this reaction is the intermolecular interception of an N-acyliminium species, generated under the acidic conditions, with nitrogen nucleophiles such as N-silylamines. [ABSTRACT FROM AUTHOR]

A new synthesis of ethynyldimethoxytriazine 1, an important platform-compound for developing new chemical entities for anticancer research and for other biological applications, is described. Compound 1 was further reacted with azides 5a- i to provide triazin-triazoles 2a- i, which were tested on human farnesyltransferase and on the NCI-60 human tumor cell lines. Synthesis of other dimethoxytriazine derivatives 15 and 16, linked to a sp or a sp carbon atom were also studied. Graphical Abstract: [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]

A direct and highly selective synthesis of octahydropyrrolo[ 2,1,5-cd]indolizin-6-one derivatives has been accomplished by a double dipolar cycloaddition of olefinic dipolarophiles to p-(dimethylamino) pyridinium ylides. [ABSTRACT FROM AUTHOR]

Abstract: New Schiff base dimers based on phenothiazine heterocycle have been obtained with high yield and purity by condensation of 3-formyl-10-methyl-phenothiazine with various amines. The structural characterization was performed by elemental analysis, FTIR, 1D and 2D NMR spectroscopy and single crystal and powder wide angle X-ray diffraction. The obtained compounds have high thermal stability and some of them self-assemble into cubic mesophase and form stable molecular glass. The thermotropic study performed by polarized optical microscopy and differential scanning calorimetry revealed the possibility to control the compound morphology by thermal annealing and blending miscible components. The photophysical characterization indicates green light emission, with good absolute fluorescence quantum yield, large Stokes shift and high purity and fully saturated color. The special thermal behavior and photophysical properties appear to be significantly dependent on the special supramolecular architecture generated by the hockey-stick shape of the imino-phenothiazine mesogenic core. Collectively, the properties of these azomethines provide a starting point for new compounds with great advantages for optoelectronic applications. [Copyright &y& Elsevier]