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A series of 4-(substituted benzylidene-amino)-2,3-dimethyl-1-phenyl- 3-pyrazoline-5-ones (3a-l) was obtained using sonochemical assisted reaction. The synthesized Schiff bases were evaluated for their antiviral, antibacterial, anticandida, DPPH scavenging and anti-tyrosinase activities in vitro. The antimicrobial screening results revealed that amongst the tested imines, compound 3l appeared to be а promising one (with a minimal inhibitory concentration 47 ug/ml). The most potent DPPH scavengers were azometines 3a and 3g. No significant inhibition on the monophenolase activity in vitro of mushroom tyrosinase was observed. [ABSTRACT FROM AUTHOR]

Highlights: [•] Eight N-hydroxycinnamoylamides of fluorinated amino acids have been synthesized, among them five are new. [•] We evaluated their antioxidative activities by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging test. [•] Among the tested amides, N-sinapoyl-3-fluorotyrosine methyl ester (5) exhibited the highest radical-scavenging activity. [•] SA-Trp(6-F)-OMe (4) inhibited the most significantly the formation of dopachrome in anti-tyrosinase assay. [ABSTRACT FROM AUTHOR]