Search

Copper-catalysed arylative ring-closing reactions of 2-alkynylphenylcarbamates and 2-alkynylphenylureas with diaryliodonium salts gave C, N-double-arylated benzoxazin-2-ones and C-arylated benzoxazin-2-amines, respectively, both bearing fully substituted exocyclic olefins. On the other hand, the palladium-catalysed arylative ring-closing reaction of 2-alkynylphenylcarbamates gave C-arylated 2,3-disubstituted indoles. [ABSTRACT FROM AUTHOR]

We have developed efficient catalytic methods for the stereoselective and diversity synthesis of various (E)-, (Z)-, and disubstituted 3-alkylideneoxindoles and 3-alkylidene-benzofuran-2-ones via palladium-catalyzed Heck/Suzuki-Miyaura, Heck/Heck, and Heck/carbonylation/Suzuki-Miyaura domino reactions. [ABSTRACT FROM AUTHOR]

Discusses radical reactions of active aldimines towards aluminum-controlled reactivity and diasteroselectvity. Use of acrylic radicals for highly stereoselective reactions; Application of chiral auxiliaries in radical reactions with presence of Lewis-acids; Effect of trimethylaluminum on reactivity.

A one-pot approach to 3,3′-bisindolylmethane derivatives from nitrobenzene derivatives through the Bartoli indole synthesis was developed, in which the acid used to quench the reaction markedly affected its outcome. Quenching the reaction with concd HCl produced 3,3′-bisindolylmethane in contrast to the formation of 7-substituted indole by quenching with NH4Cl. [ABSTRACT FROM AUTHOR]

A new cleavage reaction of carbon–carbon triple bonds proceeds efficiently with NIS and TMSN3, giving the corresponding nitriles in moderate to good yields. [ABSTRACT FROM AUTHOR]

Abstract: The Pd(0)-catalyzed intramolecular cyanoamidation of several unsaturated cyanoformamides with alkenyl, allenyl, and alkynyl groups was investigated. In the cases of alkynyl and 1,1-disubstituted alkenyl cyanoformamides, the Pd(0)-catalyzed C–CN activation and subsequent insertion reaction proceeded smoothly and gave the corresponding lactams bearing a cyano group at the β-position in good yields. The mechanism of the reaction was also discussed. [Copyright &y& Elsevier]