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2-[(2-Hydroxyphenylimino)methyl]phenol (HL) and 1-[(2-hydroxyphenylimino)methyl]naphthalen-2-ol (HL) reacted with copper(II) acetate hydrate and sulfanilamide (Sf), sulfathiazole (Sf), sulfaethidole (Sf), sulfadiazine (Sf), and sulfadimidine (Sf) in ethanol to give mixed-ligand copper chelates with the composition Cu(Sf)(L) · n HO ( n = 1, 2). All these complexes are monomeric. Salicylaldehyde imines (HL and HL) behave as doubly deprotonated tridentate O,N,O ligands, whereas sulfanilamides (Sf) are unidentate ligands. Thermolysis of the synthesized complexes includes dehydration at 70–90°C, followed by complete thermal decomposition (290–380°C). The complexes [Cu(Sf)(L)] · 2HO and [Cu(Sf)(L)] · HO at a concentration of 10 M inhibited growth and reproduction of 100% of human myeloid leukemia cells (HL-60). The inhibitory effect was 90 and 75%, respectively, at a concentration of 10 M, whereas no antitumor activity was observed at a concentration of 10 M. [ABSTRACT FROM AUTHOR]

2-Formylpyridine semicarbazone L reacts with cobalt, nickel, copper and zinc chlorides, nitrates and perchlorites to form coordination compounds of compositions ML2X2· nH2O (M=Co, Ni, Cu, Zn; X = Cl, NO3, ClO4; L = NC5H4-CH=N-NH-C(O)-NH2; n = 0, 1) and CuLX2· nH2O (X = Cl, Br, NO3; n = 0−0.5). Complex CuL(NO3)2 has polynuclear, CuLX2·0.5H2O (X = Cl, Br), binuclear, and other compounds, mononuclear structures. Azomethine L behaves in them as tridental N,N,O-ligand. Thermolysis of these complexes proceeds through such stages as dehydration (80–95°C), deactivation (145–155°C) and complete theral degradation (170–590°C). Complexes CuLX2· nH2O (X = Cl, NO3; n = 0−0.5) were established to inhibit in vitro the growth and reproduction of 100% of cancer cells of human mieloid leukaemia HL-60 at 10−4 M concentration. At 10−5 M concentration they inhibit only 10% of cells, and at 10−6 M concentration they do not possess anticancer activity. [ABSTRACT FROM AUTHOR]