1. Cover Picture: Chemoproteomics‐Enabled Identification of 4‐Oxo‐β‐Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 (Angew. Chem. Int. Ed. 47/2022).
- Author
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Carvalho, Luís A. R., Ross, Breyan, Fehr, Lorenz, Bolgi, Oguz, Wöhrle, Svenja, Lum, Kenneth M., Podlesainski, David, Vieira, Andreia C., Kiefersauer, Reiner, Félix, Rita, Rodrigues, Tiago, Lucas, Susana D., Groß, Olaf, Geiss‐Friedlander, Ruth, Cravatt, Benjamin F., Huber, Robert, Kaiser, Markus, and Moreira, Rui
- Subjects
CD26 antigen ,PEPTIDASE ,CHEMICAL biology ,REACTIVE oxygen species ,X-ray diffraction - Abstract
Cover Picture: Chemoproteomics-Enabled Identification of 4-Oxo- -Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 (Angew. Keywords: Activity-Based Protein Profiling; Dipeptidyl Peptidases 8/9; 4-Oxo- -Lactams; Proteomics; X-Ray Diffraction EN Activity-Based Protein Profiling Dipeptidyl Peptidases 8/9 4-Oxo- -Lactams Proteomics X-Ray Diffraction 1 1 1 11/16/22 20221121 NES 221121 B A lone 4-oxo- I i -lactam molecule b moves towards the catalytic site of an illuminated dipeptidyl peptidase 8 (DPP8) in a vast universe of chemical space. The 4-oxo- I i -lactams, identified by a chemoproteomics platform as DPP8/9 inhibitors, may hold the key to the highly sought DPP8/9 selectivity via an unprecedented DPP8-specific mechanism, as demonstrated through X-ray diffraction by Markus Kaiser, Rui Moreira et al. in their Research Article (e202210498). [Extracted from the article]
- Published
- 2022
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