1. Proteome analysis of cerebrospinal fluid in Guillain-Barré syndrome (GBS).
- Author
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Lehmensiek V, Süssmuth SD, Brettschneider J, Tauscher G, Felk S, Gillardon F, and Tumani H
- Subjects
- Adult, Aged, Electrophoresis, Gel, Two-Dimensional, Electrophoresis, Polyacrylamide Gel, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Cerebrospinal Fluid chemistry, Guillain-Barre Syndrome cerebrospinal fluid, Proteome analysis
- Abstract
We used two-dimensional difference in-gel electrophoresis (2-D-DIGE) for proteome analysis of cerebrospinal fluid (CSF) in Guillain-Barré syndrome (GBS). Spots showing >2-fold difference between GBS and controls were analysed using MALDI-TOF mass spectrometry. Proteins that were up-regulated in GBS included haptoglobin, serine/threonine kinase 10, alpha-1-antitrypsin, SNC73, alpha II spectrin, IgG kappa chain and cathepsin D preprotein, while transferrin, caldesmon, GALT, human heat shock protein 70, amyloidosis patient HL-heart-peptide 127aa and transthyretin were down-regulated. Some of these proteins are reported in CSF of GBS for the first time. Accordingly, the 2-D-DIGE technology may be useful to identify disease-specific proteins in patients with GBS.
- Published
- 2007
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